ES2140393T3 - Compuestos de penem. - Google Patents

Compuestos de penem.

Info

Publication number
ES2140393T3
ES2140393T3 ES91914603T ES91914603T ES2140393T3 ES 2140393 T3 ES2140393 T3 ES 2140393T3 ES 91914603 T ES91914603 T ES 91914603T ES 91914603 T ES91914603 T ES 91914603T ES 2140393 T3 ES2140393 T3 ES 2140393T3
Authority
ES
Spain
Prior art keywords
pct
group
sec
aryl
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91914603T
Other languages
English (en)
Inventor
Hiromitsu Iwata
Takashi Nakatsuka
Rie Tanaka
Masaji Ishiguro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Suntory Ltd
Original Assignee
Suntory Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suntory Ltd filed Critical Suntory Ltd
Application granted granted Critical
Publication of ES2140393T3 publication Critical patent/ES2140393T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/86—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
  • Pens And Brushes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE PRESENTAN COMPUESTOS ANTIBIOTICOS DE PENEM QUE SE REPRESENTAN MEDIANTE LA FORMULA (I), EN LA QUE R REPRESENTA UN GRUPO DE LAS FORMULAS (II) O (III) EN DONDE R1 ES UN GRUPO DE ALQUIL C1-C6 LINEAL O RAMIFICADO, R2 ES UN GRUPO DE ALQUIL, ARIL O ARALQUIL PARTICULAR SUBSTITUIDO O INSUBSTITUIDO, N ES UN ENTERO QUE REPRESENTA 1 O 2, Y R3 REPRESNTA UN GRUPO DE ALQUIL, ARIL O ARALQUIL ESPECIFICO, SUSTITUIDO O INSUSTITUIDO. TAMBIEN SE DESCRIBEN COMPOSICIONES ANTIBIOTICAS PARA ADMINISTRACION ORAL.
ES91914603T 1990-08-20 1991-08-16 Compuestos de penem. Expired - Lifetime ES2140393T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP21854390 1990-08-20

Publications (1)

Publication Number Publication Date
ES2140393T3 true ES2140393T3 (es) 2000-03-01

Family

ID=16721580

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91914603T Expired - Lifetime ES2140393T3 (es) 1990-08-20 1991-08-16 Compuestos de penem.

Country Status (12)

Country Link
US (1) US5703068A (es)
EP (1) EP0544906B1 (es)
JP (1) JP3148236B2 (es)
KR (1) KR0178957B1 (es)
AT (1) ATE186537T1 (es)
AU (1) AU8333991A (es)
CA (1) CA2089366C (es)
DE (1) DE69131774T2 (es)
ES (1) ES2140393T3 (es)
IE (1) IE912909A1 (es)
IL (2) IL99244A0 (es)
WO (1) WO1992003444A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6271222B1 (en) * 1998-05-28 2001-08-07 Merck & Co., Inc. Penem antibacterial compounds, compositions and methods of treatment
EP1548017A4 (en) * 2002-10-02 2010-06-02 Nippon Soda Co PROCESS FOR PRODUCING ORGANIC COMPOUNDS
EP1636240A1 (en) * 2003-06-05 2006-03-22 Pfizer Products Inc. Beta-lactamase inhibitor prodrug
PE20080940A1 (es) * 2006-06-28 2008-07-09 Pfizer Prod Inc Profarmacos de penem
EP2212325A4 (en) * 2007-11-23 2011-03-02 Kukje Pharm Ind Co Ltd 2-ARYLMETHYLAZETIDINCARBAPENEM-3-CARBOXYLENE DERTERIVATE OR SALT, METHOD FOR THE PRODUCTION THEREOF AND THEREOF COMPRISING PHARMACEUTICAL COMPOSITION
WO2019070973A1 (en) * 2017-10-04 2019-04-11 Gladius Pharmaceuticals Corporation CEPHAM COMPOUNDS HAVING LATENT REACTIVE GROUPS

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6019908B2 (ja) * 1980-04-30 1985-05-18 カネボウ株式会社 １，３−ジオキソレン−２−オン誘導体
US4654331A (en) * 1981-07-13 1987-03-31 Merck & Co., Inc. Oral absorption enhancement of carboxylic acid pharmaceuticals using (5-alkyl-2-oxo-1,3-dioxolen-4-yl)methyl ester group
US4479947A (en) * 1981-07-13 1984-10-30 Merck & Co., Inc. Oral absorption enhancement of carboxylic acid pharmaceuticals using (5-alkyl-2-oxo-1,3-dioxolen-4-yl)methyl ester group
JPS58159496A (ja) * 1983-03-02 1983-09-21 Kyoto Yakuhin Kogyo Kk セフエム系化合物
JPH075463B2 (ja) * 1985-03-09 1995-01-25 サントリー株式会社 抗菌剤
EP0252885A1 (de) * 1986-07-10 1988-01-13 Ciba-Geigy Ag Bicyclische Thiaazaverbindungen
JP2526046B2 (ja) * 1986-12-26 1996-08-21 サントリー株式会社 ペネム誘導体、その製造法およびその用途
EP0275002A1 (en) * 1987-01-09 1988-07-20 Hoechst Aktiengesellschaft Process for the production of 7-oxo-4-thia-1-aza-bicyclo [3.2.0] hept-2-ene derivatives
GB8713515D0 (en) * 1987-06-10 1987-07-15 Erba Farmitalia Methoxymethyl compounds
GB2220203B (en) * 1988-07-04 1991-09-11 Erba Carlo Spa Process for penems
DE3839987A1 (de) * 1988-11-26 1990-05-31 Hoechst Ag Penemderivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
US5703068A (en) 1997-12-30
JP3148236B2 (ja) 2001-03-19
DE69131774T2 (de) 2000-06-21
DE69131774D1 (de) 1999-12-16
KR0178957B1 (ko) 1999-03-20
EP0544906A1 (en) 1993-06-09
WO1992003444A1 (en) 1992-03-05
EP0544906B1 (en) 1999-11-10
ATE186537T1 (de) 1999-11-15
IE912909A1 (en) 1992-02-26
IL99244A0 (en) 1992-07-15
AU8333991A (en) 1992-03-17
CA2089366C (en) 2001-10-16
JPH06503805A (ja) 1994-04-28
KR930701454A (ko) 1993-06-11
IL99244A (en) 1996-11-14
CA2089366A1 (en) 1992-02-21

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