MXPA03011032A - Activadores de derivados de oxazol/tiazol del receptor hppar-alfa. - Google Patents
Activadores de derivados de oxazol/tiazol del receptor hppar-alfa.Info
- Publication number
- MXPA03011032A MXPA03011032A MXPA03011032A MXPA03011032A MXPA03011032A MX PA03011032 A MXPA03011032 A MX PA03011032A MX PA03011032 A MXPA03011032 A MX PA03011032A MX PA03011032 A MXPA03011032 A MX PA03011032A MX PA03011032 A MXPA03011032 A MX PA03011032A
- Authority
- MX
- Mexico
- Prior art keywords
- hppar
- oxazol
- thiazol
- halogen
- alpha receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Un compuesto de la formula (I) y sus sales, solvatos y esteres hidrolizables, farmaceuticamente aceptables: en la que X1 representa O o S; R1 y R2 son independientemente H o alquilo C1-3 o R1 y R2 que estan unidos al mismo atomo de carbono pueden formar, junto con el atomo de carbono al que estan unidos, un anillo cicloalquilico de 3-5 miembros; R3 y R4 representan independientemente H, halogeno, -CH3 y -OCH3; R5 representa H o alquilo C1-6; X2 representa NH, NCH3 o O; Uno entre Y y Z es N y el otro es 0 o S ; R6 representa fenilo o piridilo (en el que el N esta en la posicion 2 o 3) y esta opcionalmente sustituido con uno o mas halogeno, CF3, alquilo C1-6 lineal o ramificado (opcionalmente sustituido con halogeno), con la condicion de que cuando R6 es piridilo, el N no esta sustituido.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0113231.5A GB0113231D0 (en) | 2001-05-31 | 2001-05-31 | Chemical compounds |
| PCT/EP2002/005886 WO2002096895A1 (en) | 2001-05-31 | 2002-05-29 | Oxazol/ thiazol-derivatives activators of the hppar-alpha receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA03011032A true MXPA03011032A (es) | 2004-03-19 |
Family
ID=9915636
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA03011032A MXPA03011032A (es) | 2001-05-31 | 2002-05-29 | Activadores de derivados de oxazol/tiazol del receptor hppar-alfa. |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US7157479B2 (es) |
| EP (1) | EP1399430B1 (es) |
| JP (1) | JP2004532267A (es) |
| KR (1) | KR100859591B1 (es) |
| CN (1) | CN1307166C (es) |
| AR (1) | AR034051A1 (es) |
| AU (1) | AU2002317765B2 (es) |
| BR (1) | BR0209785A (es) |
| CA (1) | CA2448205A1 (es) |
| CO (1) | CO5540297A2 (es) |
| CY (1) | CY1107206T1 (es) |
| CZ (1) | CZ20033252A3 (es) |
| DE (1) | DE60223805T2 (es) |
| DK (1) | DK1399430T3 (es) |
| ES (1) | ES2296965T3 (es) |
| GB (1) | GB0113231D0 (es) |
| HK (1) | HK1064367A1 (es) |
| HU (1) | HUP0400043A3 (es) |
| IL (1) | IL158929A0 (es) |
| MX (1) | MXPA03011032A (es) |
| MY (1) | MY132656A (es) |
| NO (1) | NO20035209L (es) |
| NZ (1) | NZ529754A (es) |
| PL (1) | PL367248A1 (es) |
| PT (1) | PT1399430E (es) |
| SI (1) | SI1399430T1 (es) |
| TW (1) | TWI245760B (es) |
| WO (1) | WO2002096895A1 (es) |
| ZA (1) | ZA200309095B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL161351A0 (en) * | 2001-10-12 | 2004-09-27 | Nippon Chemiphar Co | ACTIVATOR FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR delta |
| US7553867B2 (en) | 2002-09-06 | 2009-06-30 | Takeda Pharmaceutical Company Limited | Furan or thiophene derivative and medicinal use thereof |
| GB0314370D0 (en) * | 2003-06-19 | 2003-07-23 | Glaxo Group Ltd | Chemical compounds |
| GB0323702D0 (en) * | 2003-10-09 | 2003-11-12 | Smithkline Beecham Corp | Chemical compound |
| CN1875002B (zh) | 2003-11-05 | 2011-08-03 | 霍夫曼-拉罗奇有限公司 | 作为ppar激动剂的苯基衍生物 |
| FR2882359A1 (fr) * | 2005-02-24 | 2006-08-25 | Negma Lerads Soc Par Actions S | Derives activateurs de ppar, procede de preparation et application en therapeutique |
| CN101007790B (zh) * | 2006-01-27 | 2011-03-30 | 北京摩力克科技有限公司 | 草氨酸衍生物、其制备方法和医药用途 |
| FR2901792A1 (fr) * | 2006-06-06 | 2007-12-07 | Negma Lerads Soc Par Actions S | DERIVES ACTIVATEURS DE PPARs, PROCEDE DE PREPARATION ET APPLICATION EN THERAPEUTIQUE |
| US8497382B2 (en) * | 2008-12-01 | 2013-07-30 | Mitsubishi Tanabe Pharma Corporation | Carboxylic acid derivative containing thiazole ring and pharmaceutical use thereof |
| CN110803996B (zh) * | 2019-11-13 | 2022-01-11 | 台州市创源工业技术有限公司 | 一种羟基苄胺的合成方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ53699A3 (cs) * | 1996-08-19 | 1999-07-14 | Japan Tobacco Inc. | Deriváty propionové kyseliny a jejich použití |
| KR100620337B1 (ko) | 1998-03-10 | 2006-09-13 | 오노 야꾸힝 고교 가부시키가이샤 | 카르복실산 유도체와 그 유도체를 유효 성분으로서함유하는 약제 |
| CZ20013834A3 (cs) | 1999-04-28 | 2002-04-17 | Aventis Pharma Deutschland Gmbh | Deriváty kyselin se třemi arylovými zbytky jako ligandy receptorů PPAR a farmaceutické prostředky, které je obsahují |
| GB9914977D0 (en) * | 1999-06-25 | 1999-08-25 | Glaxo Group Ltd | Chemical compounds |
| AU7073400A (en) | 1999-08-27 | 2001-03-26 | Eli Lilly And Company | Biaryl-oxa(thia)zole derivatives and their use as ppars modulators |
| PE20011010A1 (es) * | 1999-12-02 | 2001-10-18 | Glaxo Group Ltd | Oxazoles y tiazoles sustituidos como agonista del receptor activado por el proliferador de peroxisomas humano |
| GB0113233D0 (en) * | 2001-05-31 | 2001-07-25 | Glaxo Group Ltd | Chemical compounds |
-
2001
- 2001-05-31 GB GBGB0113231.5A patent/GB0113231D0/en not_active Ceased
-
2002
- 2002-05-29 HU HU0400043A patent/HUP0400043A3/hu unknown
- 2002-05-29 CN CNB028149424A patent/CN1307166C/zh not_active Expired - Fee Related
- 2002-05-29 ES ES02747331T patent/ES2296965T3/es not_active Expired - Lifetime
- 2002-05-29 SI SI200230654T patent/SI1399430T1/sl unknown
- 2002-05-29 NZ NZ529754A patent/NZ529754A/en unknown
- 2002-05-29 DE DE60223805T patent/DE60223805T2/de not_active Expired - Fee Related
- 2002-05-29 JP JP2003500074A patent/JP2004532267A/ja active Pending
- 2002-05-29 BR BR0209785-0A patent/BR0209785A/pt not_active IP Right Cessation
- 2002-05-29 IL IL15892902A patent/IL158929A0/xx unknown
- 2002-05-29 AU AU2002317765A patent/AU2002317765B2/en not_active Ceased
- 2002-05-29 US US10/478,936 patent/US7157479B2/en not_active Expired - Fee Related
- 2002-05-29 CZ CZ20033252A patent/CZ20033252A3/cs unknown
- 2002-05-29 MX MXPA03011032A patent/MXPA03011032A/es active IP Right Grant
- 2002-05-29 WO PCT/EP2002/005886 patent/WO2002096895A1/en active IP Right Grant
- 2002-05-29 PL PL02367248A patent/PL367248A1/xx not_active Application Discontinuation
- 2002-05-29 AR ARP020101999A patent/AR034051A1/es unknown
- 2002-05-29 TW TW091111392A patent/TWI245760B/zh not_active IP Right Cessation
- 2002-05-29 MY MYPI20021973A patent/MY132656A/en unknown
- 2002-05-29 DK DK02747331T patent/DK1399430T3/da active
- 2002-05-29 PT PT02747331T patent/PT1399430E/pt unknown
- 2002-05-29 EP EP02747331A patent/EP1399430B1/en not_active Expired - Lifetime
- 2002-05-29 KR KR1020037015678A patent/KR100859591B1/ko not_active IP Right Cessation
- 2002-05-29 CA CA002448205A patent/CA2448205A1/en not_active Abandoned
-
2003
- 2003-11-21 ZA ZA200309095A patent/ZA200309095B/en unknown
- 2003-11-24 NO NO20035209A patent/NO20035209L/no not_active Application Discontinuation
- 2003-12-03 CO CO03106490A patent/CO5540297A2/es not_active Application Discontinuation
-
2004
- 2004-09-13 HK HK04106944A patent/HK1064367A1/xx not_active IP Right Cessation
-
2008
- 2008-02-19 CY CY20081100202T patent/CY1107206T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB0113233D0 (en) | Chemical compounds | |
| CY1107206T1 (el) | Παραγωγα οξαζολιου/θειαζολιου ενεργοποιητες του υποδοχεα hppar-a | |
| TR200401772T4 (tr) | hPPAR alfa aktivatörleri olarak ikame edilmiş oksazol ve tiyazol türevleri. | |
| HK1072770A1 (en) | Bicyclic compound | |
| IL159607A0 (en) | 7-amino triazolopyrimidines for controlling harmful fungi | |
| EP0040639A4 (en) | ISOXAZOLE DERIVATIVES. | |
| MY132009A (en) | Pharmaceutical compounds. | |
| NZ331613A (en) | Piperazinyl or piperidinyl substituted 1,2,3,4-tetrahydronaphthalene derivatives | |
| TW354787B (en) | 2-carbocyclic and 2-heterocyclic quinoline-4-carboxylic acids and salts thereof useful as immunosuppressive agents | |
| BG102959A (en) | Benzooxazinon antagonists of domamine d4 receptor | |
| TW197421B (es) | ||
| NO20053302D0 (no) | Imidazolderivater med affinitet for alfa 2-reseptoraktivitet. | |
| WO2002060878A1 (en) | Benzimidazolidinone derivatives | |
| GB0003257D0 (en) | Heterocyclic compounds and their therapeutic use | |
| BG106048A (en) | 6-[[(aryl and heteroaryl)oxy]methyl]naphthalene-2-carboximidamide derivatives, preparation and therapeutic application thereof | |
| AU2002244985A1 (en) | Thiazolidinedione derivatives and pharmaceutical composition comprising the same | |
| MX9708422A (es) | Esteres de carbapenemas. | |
| TW200503733A (en) | T-shaped channel blockers | |
| HU9401512D0 (en) | 2-amino-pyrazine-5-carboxamide derivatives process for producing them and their therapeutic application | |
| DK0516486T3 (da) | Azetidinonderivater egnede til fremstilling af carbapenemantibiotika | |
| ECSP951529A (es) | Compuestos farmaceuticos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |