NL192683C - "4"-Demethyl-epipodophyllotoxineglucoside verbinding alsmede farmaceutisch preparaat met antitumor activiteit - Google Patents

"4"-Demethyl-epipodophyllotoxineglucoside verbinding alsmede farmaceutisch preparaat met antitumor activiteit Download PDF

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Publication number
NL192683C
NL192683C NL8801934A NL8801934A NL192683C NL 192683 C NL192683 C NL 192683C NL 8801934 A NL8801934 A NL 8801934A NL 8801934 A NL8801934 A NL 8801934A NL 192683 C NL192683 C NL 192683C
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NL
Netherlands
Prior art keywords
compound
etoposide
formula
phosphate
tumor activity
Prior art date
Application number
NL8801934A
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English (en)
Dutch (nl)
Other versions
NL192683B (en:Method
NL8801934A (nl
Original Assignee
Squibb Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb Bristol Myers Co filed Critical Squibb Bristol Myers Co
Publication of NL8801934A publication Critical patent/NL8801934A/nl
Publication of NL192683B publication Critical patent/NL192683B/xx
Application granted granted Critical
Publication of NL192683C publication Critical patent/NL192683C/nl

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
  • Cable Accessories (AREA)
NL8801934A 1987-08-04 1988-08-03 "4"-Demethyl-epipodophyllotoxineglucoside verbinding alsmede farmaceutisch preparaat met antitumor activiteit NL192683C (nl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8149387A 1987-08-04 1987-08-04
US8149387 1987-08-04
US19973188 1988-05-27
US07/199,731 US4904768A (en) 1987-08-04 1988-05-27 Epipodophyllotoxin glucoside 4'-phosphate derivatives

Publications (3)

Publication Number Publication Date
NL8801934A NL8801934A (nl) 1989-03-01
NL192683B NL192683B (en:Method) 1997-08-01
NL192683C true NL192683C (nl) 1997-12-02

Family

ID=26765636

Family Applications (2)

Application Number Title Priority Date Filing Date
NL8801934A NL192683C (nl) 1987-08-04 1988-08-03 "4"-Demethyl-epipodophyllotoxineglucoside verbinding alsmede farmaceutisch preparaat met antitumor activiteit
NL970042C NL970042I1 (nl) 1987-08-04 1997-12-05 4'-Demethyl-epipodophyllotoxineglucoside verbinding, alsmede farmaceutisch preparaat met antitumor activiteit.

Family Applications After (1)

Application Number Title Priority Date Filing Date
NL970042C NL970042I1 (nl) 1987-08-04 1997-12-05 4'-Demethyl-epipodophyllotoxineglucoside verbinding, alsmede farmaceutisch preparaat met antitumor activiteit.

Country Status (34)

Country Link
US (3) US4904768A (en:Method)
JP (1) JPH0699465B2 (en:Method)
KR (1) KR900006230B1 (en:Method)
CN (1) CN1027169C (en:Method)
AT (1) AT398974B (en:Method)
BE (1) BE1002982A4 (en:Method)
CA (1) CA1310637C (en:Method)
CH (1) CH676716A5 (en:Method)
CY (1) CY1625A (en:Method)
CZ (1) CZ286893B6 (en:Method)
DD (2) DD274423A5 (en:Method)
DE (1) DE3826562A1 (en:Method)
DK (2) DK169344B1 (en:Method)
ES (1) ES2010775A6 (en:Method)
FI (1) FI87790C (en:Method)
FR (1) FR2622193B1 (en:Method)
GB (1) GB2207674B (en:Method)
GR (1) GR1000490B (en:Method)
HK (1) HK6392A (en:Method)
HU (3) HU208147B (en:Method)
IE (1) IE61040B1 (en:Method)
IL (1) IL87290A (en:Method)
IT (1) IT1226825B (en:Method)
LU (2) LU87290A1 (en:Method)
MX (1) MX173843B (en:Method)
MY (1) MY104321A (en:Method)
NL (2) NL192683C (en:Method)
NO (4) NO170284C (en:Method)
NZ (1) NZ225615A (en:Method)
PT (1) PT88186B (en:Method)
SE (1) SE502214C2 (en:Method)
SG (1) SG101291G (en:Method)
SK (1) SK541288A3 (en:Method)
YU (3) YU143688A (en:Method)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5191071A (en) * 1987-08-21 1993-03-02 Novo Nordisk A/S Monoesters of glycosides and a process for enzymatic preparation thereof
US4965348A (en) * 1989-05-19 1990-10-23 Bristol-Myers Company Dimeric epipodophyllotoxin glucoside derivatives
US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
US5066645A (en) * 1989-09-01 1991-11-19 Bristol-Myers Company Epipodophyllotoxin altroside derivatives
US6610299B1 (en) 1989-10-19 2003-08-26 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US7241595B2 (en) 1989-10-20 2007-07-10 Sanofi-Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US6475486B1 (en) 1990-10-18 2002-11-05 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US5552154A (en) * 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5034380A (en) * 1989-11-20 1991-07-23 Bristol-Myers Squibb Company Alkoxymethylidene epipodophyllotoxin glucosides
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides
US4997931A (en) * 1990-06-11 1991-03-05 Bristol-Myers Squibb Company Epipodophyllotoxin glycosides
TW260671B (en:Method) * 1991-04-29 1995-10-21 Bristol Myers Squibb Co
IT1250692B (it) * 1991-07-23 1995-04-21 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
US5648474A (en) * 1991-10-08 1997-07-15 Bristol-Myers Squibb Crystalline etoposide 4'-phosphate diethanolate
JPH07632B2 (ja) * 1991-12-23 1995-01-11 ブリストル−マイヤーズ スクイブ カンパニー エトポシド４’−ホスフェート二ナトリウム塩の安定な六水和物
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
JP3061476B2 (ja) * 1992-04-24 2000-07-10 日本化薬株式会社 エトポシド燐酸エステルの製造法
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide
FR2725990B1 (fr) * 1994-10-21 1997-01-10 Pf Medicament Derives hydrosolubles d'epipodophyllotoxine, leur procede de preparation, leur utilisation a titre de medicament, et leur utilisation destinee aux traitements anticancereux
US5942386A (en) * 1995-06-07 1999-08-24 Thomas Jefferson University Anti-fungal agents and methods of identifying and using the same
PT907379E (pt) 1996-04-01 2004-09-30 Epix Medical Inc Agentes de contraste bioactivados para imagiologia de diagnostico
US6207673B1 (en) 1997-03-12 2001-03-27 The University Of North Carolina At Chapel Hill Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
WO1999032499A1 (en) * 1997-12-23 1999-07-01 Korea Research Institute Of Chemical Technology 4'-O-DEMETHYL-EPIPODOPHYLLOTOXIN-β-D-GLUCOSIDE ACETAL DERIVATIVES
HK1049787B (en) 1999-10-01 2014-07-25 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
US6506739B1 (en) 2001-05-01 2003-01-14 Telik, Inc. Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
JP2005511550A (ja) * 2001-10-26 2005-04-28 サントル・ナショナル・ドゥ・ラ・ルシェルシュ・シャンティフィク エトポシドおよび類似体の誘導体、ならびにそれを含有する医薬組成物
CA2894009C (en) 2002-07-15 2016-12-06 Board Of Regents, The University Of Texas System Selected antibodies binding to anionic phospholipids and aminophospholipids and their use in treatment
EP2260874A1 (en) * 2003-01-06 2010-12-15 Angiochem Inc. Aprotinin analogs as carriers across the blood-brain barrier
CN100334090C (zh) * 2005-02-02 2007-08-29 南京医科大学 吡啶类鬼臼毒素化合物及其制备方法和在制备杀虫剂中的应用
US20090016959A1 (en) * 2005-02-18 2009-01-15 Richard Beliveau Delivery of antibodies to the central nervous system
RU2408605C2 (ru) * 2005-02-18 2011-01-10 Анджиокем Инк. Полипептид, способный преодолевать гематоэнцефалический барьер, и его конъюгат
ES2424242T3 (es) 2005-07-15 2013-09-30 Angiochem Inc. Uso de polipéptidos de aprotinina como portadores en conjugados farmacéuticos
CN100410266C (zh) * 2006-01-11 2008-08-13 重庆华邦制药股份有限公司 鬼臼毒素磷酸酯衍生物的合成方法
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
PE20070978A1 (es) * 2006-02-14 2007-11-15 Novartis Ag COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks)
AR060358A1 (es) * 2006-04-06 2008-06-11 Novartis Vaccines & Diagnostic Quinazolinas para la inhibicion de pdk 1
GB0625283D0 (en) * 2006-12-19 2007-01-24 Cyclacel Ltd Combination
US9365634B2 (en) * 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
US8263644B2 (en) * 2007-09-13 2012-09-11 Bristol-Myers Squibb Company Cytotoxic xanthone compounds
KR101502267B1 (ko) 2007-11-09 2015-03-18 페레그린 파마수티컬즈, 인크 항-ｖｅｇｆ 항체 조성물 및 방법
CA2710122A1 (en) 2007-12-20 2009-07-02 Novartis Ag Thiazole derivatives used as pi 3 kinase inhibitors
WO2009127072A1 (en) * 2008-04-18 2009-10-22 Angiochem Inc. Pharmaceutical compositions of paclitaxel, paclitaxel analogs or paclitaxel conjugates and related methods of preparation and use
AU2009304560A1 (en) 2008-10-15 2010-04-22 Angiochem Inc. Conjugates of GLP-1 agonists and uses thereof
CN102245636A (zh) 2008-10-15 2011-11-16 安吉奥开米公司 用于药物递送的依托泊苷和多柔比星结合物
CA2745524C (en) * 2008-12-05 2020-06-09 Angiochem Inc. Conjugates of neurotensin or neurotensin analogs and uses thereof
EP2373789A4 (en) 2008-12-17 2012-08-29 Angiochem Inc MEMBRANTYP-1 MATRIX METALLOPROTEINASE INHIBITORS AND THEIR USE
MX2011011023A (es) 2009-04-20 2012-01-20 Angiochem Inc Tratamiento de cancer de ovarios usando un agente anti-cancer conjugado con un analogo de angiopep-2.
US8293753B2 (en) 2009-07-02 2012-10-23 Novartis Ag Substituted 2-carboxamide cycloamino ureas
JP5932642B2 (ja) 2009-07-02 2016-06-08 アンジオケム インコーポレーテッド 多量体ペプチドコンジュゲートおよびその使用
WO2011101429A1 (en) 2010-02-22 2011-08-25 F. Hoffmann-La Roche Ag Pyrido[3,2-d]pyrimidine pi3k delta inhibitor compounds and methods of use
US9586954B2 (en) 2010-06-22 2017-03-07 Demerx, Inc. N-substituted noribogaine prodrugs
AR082418A1 (es) 2010-08-02 2012-12-05 Novartis Ag Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico
JP5963777B2 (ja) 2011-01-31 2016-08-03 ノバルティス アーゲー 新規ヘテロ環誘導体
US9617274B1 (en) 2011-08-26 2017-04-11 Demerx, Inc. Synthetic noribogaine
PH12014500912A1 (en) 2011-10-28 2014-06-09 Novartis Ag Novel purine derivatives and their use in the treatment of disease
WO2013085922A1 (en) * 2011-12-09 2013-06-13 Demerx, Inc. Phosphate esters of noribogaine
BR112014028420A2 (pt) 2012-05-16 2017-09-19 Novartis Ag regime de dosagem para um inibidor de quinase pi-3
EP2934541A4 (en) 2012-12-20 2016-08-03 Demerx Inc NORIBOGAINE SUBSTITUTE
KR20160095035A (ko) 2013-12-06 2016-08-10 노파르티스 아게 알파-이소형 선택성 포스파티딜이노시톨 3-키나제 억제제를 위한 투여 요법
DK3307326T3 (da) 2015-06-15 2020-10-19 Angiochem Inc Fremgangsmåder til behandling af leptomeningeal karcinomatose
CA3002954A1 (en) 2015-11-02 2017-05-11 Novartis Ag Dosage regimen for a phosphatidylinositol 3-kinase inhibitor
WO2018060833A1 (en) 2016-09-27 2018-04-05 Novartis Ag Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib
KR102378151B1 (ko) 2020-05-11 2022-03-24 주식회사 제이앤씨사이언스 베타-아포피크로포도필린의 신규한 유도체

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1171314A (fr) * 1955-05-13 1959-01-23 Sandoz Ag Produits de condensation de glucosides avec des composés carbonyliques et leur préparation
NL6613143A (en:Method) * 1965-09-21 1967-03-22
CH464957A (de) * 1965-12-14 1968-11-15 Sandoz Ag Verfahren zur Herstellung eines neuen Glucosids
CH481913A (de) * 1966-12-13 1969-11-30 Sandoz Ag Verfahren zur Herstellung neuer Glucoside
CH514578A (de) * 1968-02-27 1971-10-31 Sandoz Ag Verfahren zur Herstellung von Glucosiden
CH543502A (de) * 1970-11-20 1973-10-31 Sandoz Ag Verfahren zur Herstellung neuer Glucoside
GB1395820A (en) * 1971-06-05 1975-05-29 Villax I Preparation of 21-inorganic esters of corticosteroids and salts thereof
CH589668A5 (en) * 1973-06-07 1977-07-15 Sandoz Ag Cytostatic (4')-demethyl substd. epipodophyllotoxin - prepd. from the corresp. glucopyranoside with (3)-thiophene-carboxaldehyde
FR2397425A1 (fr) * 1977-07-11 1979-02-09 Rhone Poulenc Ind Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent
EP0111058B1 (en) * 1982-11-26 1987-11-04 Nippon Kayaku Kabushiki Kaisha Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
US4567253A (en) * 1984-02-03 1986-01-28 Tony Durst 2-Substituted derivatives of podophyllotoxin and etoposide
JPS60208910A (ja) * 1984-03-31 1985-10-21 Green Cross Corp:The 水難溶性薬物・リン脂質複合体の製造方法
JPS60246393A (ja) * 1984-05-22 1985-12-06 Nippon Kayaku Co Ltd エトポシドの新規製造法
US4739046A (en) * 1985-08-19 1988-04-19 Luzio Nicholas R Di Soluble phosphorylated glucan
IL77334A (en) * 1985-12-16 1991-04-15 Univ Bar Ilan Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor
US4916217A (en) * 1987-01-08 1990-04-10 Bristol-Myers Company Phosphorus containing derivatives of epipodophyllotoxin
JPS63192793A (ja) * 1987-02-06 1988-08-10 Nippon Kayaku Co Ltd ４′−デメチル−エピポドフイロトキシン誘導体の新規エステル
US4874851A (en) * 1987-07-01 1989-10-17 Bristol-Meyers Company 3',4'-dinitrogen substituted epipodophyllotoxin glucoside derivatives

Also Published As

Publication number Publication date
CN1061225A (zh) 1992-05-20
GR880100512A (en) 1989-05-25
US5041424A (en) 1991-08-20
NO172440C (no) 1993-07-21
LU87290A1 (fr) 1990-02-07
FR2622193B1 (fr) 1993-12-17
DD299067A5 (de) 1992-03-26
USRE35524E (en) 1997-06-03
YU10390A (en) 1990-06-30
AU2030688A (en) 1989-06-08
IL87290A (en) 1993-01-31
SE8802815D0 (sv) 1988-08-03
KR900006230B1 (ko) 1990-08-27
DK169344B1 (da) 1994-10-10
IT8821535A0 (it) 1988-07-28
DK434088D0 (da) 1988-08-03
IE882378L (en) 1989-02-04
SG101291G (en) 1992-01-17
IL87290A0 (en) 1989-01-31
BE1002982A4 (fr) 1991-10-15
IT1226825B (it) 1991-02-19
FI883596A7 (fi) 1989-02-05
DE3826562A1 (de) 1989-02-16
NL192683B (en:Method) 1997-08-01
MX173843B (es) 1994-03-30
ATA195588A (de) 1994-07-15
CZ541288A3 (cs) 1999-12-15
NL8801934A (nl) 1989-03-01
HUT47303A (en) 1989-02-28
IE61040B1 (en) 1994-09-07
NO170284B (no) 1992-06-22
HK6392A (en) 1992-01-17
YU10490A (en) 1990-06-30
MX9202851A (es) 1992-06-30
JPH01100188A (ja) 1989-04-18
MY104321A (en) 1994-03-31
NO920277D0 (no) 1992-01-22
CZ286893B6 (cs) 2000-07-12
GR1000490B (el) 1992-07-30
ES2010775A6 (es) 1989-12-01
GB2207674B (en) 1991-09-11
PT88186A (pt) 1989-06-30
HU208147B (en) 1993-08-30
CN1027169C (zh) 1994-12-28
NO920665D0 (no) 1992-02-20
US4904768A (en) 1990-02-27
CA1310637C (en) 1992-11-24
NO883299D0 (no) 1988-07-26
PT88186B (pt) 1995-07-03
HU202547B (en) 1991-03-28
SE502214C2 (sv) 1995-09-18
LU90138I2 (fr) 1997-11-26
NZ225615A (en) 1991-06-25
SE8802815L (sv) 1989-02-05
NO920277L (no) 1989-02-24
SK279325B6 (sk) 1998-10-07
FI883596A0 (fi) 1988-08-01
AU610619B2 (en) 1991-05-23
DK434088A (da) 1989-02-05
FI87790B (fi) 1992-11-13
DK11992A (da) 1992-01-31
DD274423A5 (de) 1989-12-20
SK541288A3 (en) 1998-10-07
HU905862D0 (en) 1991-03-28
NL970042I2 (en:Method) 2005-06-01
KR890003790A (ko) 1989-04-18
GB2207674A (en) 1989-02-08
AT398974B (de) 1995-02-27
DE3826562C2 (en:Method) 1993-04-08
NL970042I1 (nl) 1998-03-02
YU143688A (en) 1990-04-30
NO920665L (no) 1989-02-24
NO170284C (no) 1992-09-30
NO883299L (no) 1989-02-24
NO172440B (no) 1993-04-13
JPH0699465B2 (ja) 1994-12-07
FI87790C (fi) 1993-02-25
CY1625A (en) 1992-07-10
HU211960A9 (en) 1996-01-29
GB8818462D0 (en) 1988-09-07
DK11992D0 (da) 1992-01-31
NO1998002I1 (no) 1998-01-14
FR2622193A1 (fr) 1989-04-28
CH676716A5 (en:Method) 1991-02-28

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