MX2019003886A - Receptores de antigenos quimericos para el tratamiento del cancer. - Google Patents

Receptores de antigenos quimericos para el tratamiento del cancer.

Info

Publication number
MX2019003886A
MX2019003886A MX2019003886A MX2019003886A MX2019003886A MX 2019003886 A MX2019003886 A MX 2019003886A MX 2019003886 A MX2019003886 A MX 2019003886A MX 2019003886 A MX2019003886 A MX 2019003886A MX 2019003886 A MX2019003886 A MX 2019003886A
Authority
MX
Mexico
Prior art keywords
car
chimeric antigen
cancer
treatment
antigen receptors
Prior art date
Application number
MX2019003886A
Other languages
English (en)
Spanish (es)
Inventor
Brannetti Barbara
Brogdon Jennifer
Lei Ming
Huang Lu
Zhang Jimin
ENGELS Boris
Granda Brian
Li Na
Guimaraes Carla
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2019003886A publication Critical patent/MX2019003886A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001111—Immunoglobulin superfamily
    • A61K39/001112—CD19 or B4
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    • A61K39/0011—Cancer antigens
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    • A61K39/001113—CD22, BL-CAM, siglec-2 or sialic acid- binding Ig-related lectin 2
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    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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    • C12N5/0602—Vertebrate cells
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
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    • C12N2710/10011—Adenoviridae
    • C12N2710/10041—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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  • Proteomics, Peptides & Aminoacids (AREA)
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MX2019003886A 2016-10-07 2017-10-06 Receptores de antigenos quimericos para el tratamiento del cancer. MX2019003886A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662405520P 2016-10-07 2016-10-07
PCT/US2017/055627 WO2018067992A1 (en) 2016-10-07 2017-10-06 Chimeric antigen receptors for the treatment of cancer

Publications (1)

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MX2019003886A true MX2019003886A (es) 2019-08-05

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MX2019003886A MX2019003886A (es) 2016-10-07 2017-10-06 Receptores de antigenos quimericos para el tratamiento del cancer.
MX2025007532A MX2025007532A (es) 2016-10-07 2019-04-03 Receptores de antigenos quimericos para el tratamiento del cancer

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MX2025007532A MX2025007532A (es) 2016-10-07 2019-04-03 Receptores de antigenos quimericos para el tratamiento del cancer

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EP (1) EP3523331A1 (cg-RX-API-DMAC7.html)
JP (3) JP7467117B2 (cg-RX-API-DMAC7.html)
KR (2) KR102717188B1 (cg-RX-API-DMAC7.html)
CN (2) CN117866991A (cg-RX-API-DMAC7.html)
AR (2) AR110676A1 (cg-RX-API-DMAC7.html)
AU (2) AU2017341047B2 (cg-RX-API-DMAC7.html)
BR (1) BR112019006781A2 (cg-RX-API-DMAC7.html)
CA (1) CA3039646A1 (cg-RX-API-DMAC7.html)
IL (1) IL265755A (cg-RX-API-DMAC7.html)
MX (2) MX2019003886A (cg-RX-API-DMAC7.html)
MY (1) MY200337A (cg-RX-API-DMAC7.html)
PH (1) PH12019500750A1 (cg-RX-API-DMAC7.html)
SA (1) SA519401494B1 (cg-RX-API-DMAC7.html)
SG (1) SG10201913823VA (cg-RX-API-DMAC7.html)
TW (2) TWI797091B (cg-RX-API-DMAC7.html)
WO (1) WO2018067992A1 (cg-RX-API-DMAC7.html)
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Families Citing this family (89)

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