EA201690987A1 - Низкодозовые иммуностимулирующие ингибиторы mtor и их применения - Google Patents
Низкодозовые иммуностимулирующие ингибиторы mtor и их примененияInfo
- Publication number
- EA201690987A1 EA201690987A1 EA201690987A EA201690987A EA201690987A1 EA 201690987 A1 EA201690987 A1 EA 201690987A1 EA 201690987 A EA201690987 A EA 201690987A EA 201690987 A EA201690987 A EA 201690987A EA 201690987 A1 EA201690987 A1 EA 201690987A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- low
- multibidation
- applications
- mtor inhibitors
- dose immune
- Prior art date
Links
- 229940124302 mTOR inhibitor Drugs 0.000 title abstract 2
- 239000003628 mammalian target of rapamycin inhibitor Substances 0.000 title abstract 2
- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 abstract 1
- 102000013530 TOR Serine-Threonine Kinases Human genes 0.000 abstract 1
- 108010065917 TOR Serine-Threonine Kinases Proteins 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 229960005167 everolimus Drugs 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000003308 immunostimulating effect Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
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-
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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- C12N2760/16011—Orthomyxoviridae
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Abstract
Настоящее изобретение относится отчасти к композициям и способам для усиления иммунного ответа посредством частичного ингибирования mTOR, например, низкими иммуностимулирующими дозами ингибитора mTOR, такого как RAD001.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361903636P | 2013-11-13 | 2013-11-13 | |
US201462027121P | 2014-07-21 | 2014-07-21 | |
US201462052629P | 2014-09-19 | 2014-09-19 | |
US201462076142P | 2014-11-06 | 2014-11-06 | |
PCT/US2014/065408 WO2015073644A1 (en) | 2013-11-13 | 2014-11-13 | Mtor inhibitors for enhancing the immune response |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201690987A1 true EA201690987A1 (ru) | 2016-10-31 |
Family
ID=53057999
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201690987A EA201690987A1 (ru) | 2013-11-13 | 2014-11-13 | Низкодозовые иммуностимулирующие ингибиторы mtor и их применения |
Country Status (12)
Country | Link |
---|---|
US (4) | US20150140036A1 (ru) |
EP (1) | EP3068435A1 (ru) |
JP (2) | JP2016537345A (ru) |
KR (1) | KR20160084438A (ru) |
CN (1) | CN105899232A (ru) |
AU (3) | AU2014348657A1 (ru) |
BR (1) | BR112016010716A8 (ru) |
CA (1) | CA2929181A1 (ru) |
EA (1) | EA201690987A1 (ru) |
MX (1) | MX2016006316A (ru) |
TW (1) | TWI679976B (ru) |
WO (1) | WO2015073644A1 (ru) |
Families Citing this family (59)
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US9259399B2 (en) | 2007-11-07 | 2016-02-16 | Cornell University | Targeting CDK4 and CDK6 in cancer therapy |
WO2009085216A2 (en) | 2007-12-20 | 2009-07-09 | Squicor | Compositions and methods for detecting or elimninating senescent cells to diagnose or treat disease |
US20110224235A1 (en) | 2008-07-16 | 2011-09-15 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase for the treatment of solid tumors |
NZ772688A (en) | 2010-06-03 | 2022-09-30 | Pharmacyclics Llc | The use of inhibitors of bruton’s tyrosine kinase (btk) |
WO2012177927A1 (en) | 2011-06-21 | 2012-12-27 | Mayo Foundation For Medical Education And Research | Transgenic animals capable of being induced to delete senescent cells |
AU2012283775A1 (en) | 2011-07-13 | 2014-01-23 | Pharmacyclics Llc | Inhibitors of Bruton's tyrosine kinase |
AU2012352177A1 (en) | 2011-12-13 | 2014-07-10 | Buck Institute For Research On Aging | Methods for improving medical therapies |
US20150064137A1 (en) | 2012-04-17 | 2015-03-05 | Kythera Biopharmaceuticals, Inc. | Use of engineered viruses to specifically kill senescent cells |
KR20180088926A (ko) | 2012-07-24 | 2018-08-07 | 파마싸이클릭스 엘엘씨 | 브루톤 티로신 키나제(btk)의 억제제에 대한 내성과 관련된 돌연변이 |
US9901081B2 (en) | 2012-08-23 | 2018-02-27 | Buck Institute For Research On Aging | Transgenic mouse for determining the role of senescent cells in cancer |
US9901080B2 (en) | 2012-08-23 | 2018-02-27 | Buck Institute For Research On Aging | Transgenic mouse having a transgene that converts a prodrug into a cytotoxic compound in senescent cells |
CA2920534A1 (en) | 2013-08-12 | 2015-02-19 | Pharmacyclics Llc | Methods for the treatment of her2 amplified cancer |
US20150140036A1 (en) | 2013-11-13 | 2015-05-21 | Novartis Institutes For Biomedical Research, Inc. | Low, immune enhancing, dose mtor inhibitors and uses thereof |
EP3099380B1 (en) | 2014-01-28 | 2021-08-11 | Buck Institute for Research on Aging | Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders |
WO2015116735A1 (en) | 2014-01-28 | 2015-08-06 | Mayo Foundation For Medical Education And Research | Methods and combinations for killing senescent cells and for treating senescence-associated diseases and disorders |
US10328058B2 (en) | 2014-01-28 | 2019-06-25 | Mayo Foundation For Medical Education And Research | Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques |
CA2942528A1 (en) | 2014-03-20 | 2015-09-24 | Pharmacyclics Inc. | Phospholipase c gamma 2 and resistance associated mutations |
WO2016014530A1 (en) | 2014-07-21 | 2016-01-28 | Novartis Ag | Combinations of low, immune enhancing. doses of mtor inhibitors and cars |
ES2805475T3 (es) | 2014-07-21 | 2021-02-12 | Novartis Ag | Tratamiento del cáncer utilizando un receptor antigénico quimérico de CD33 |
WO2016025880A1 (en) | 2014-08-14 | 2016-02-18 | Novartis Ag | Treatment of cancer using gfr alpha-4 chimeric antigen receptor |
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EP3206717B1 (en) * | 2014-10-17 | 2020-11-25 | Novartis AG | Combination of ceritinib with an egfr inhibitor |
US11083725B2 (en) | 2014-10-24 | 2021-08-10 | St. Jude Children's Research Hospital | Coordinated metabolic reprogramming in response to productive viral infections |
WO2016066608A1 (en) * | 2014-10-28 | 2016-05-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treatment of pulmonary cell senescence and peripheral aging |
JP7114457B2 (ja) | 2015-04-17 | 2022-08-08 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | キメラ抗原受容体発現細胞の有効性および増殖を改善するための方法 |
JP6857141B2 (ja) * | 2015-05-20 | 2021-04-14 | ノバルティス アーゲー | エベロリムスとダクトリシブとの薬学的組合せ |
PE20180395A1 (es) | 2015-06-04 | 2018-02-28 | Pfizer | Formas de dosificacion solidas de palbociclib |
BR112018002139A2 (pt) * | 2015-07-31 | 2018-09-11 | Pharmacyclics Llc | combinações de inibidor de tirosina quinase de bruton e usos da mesma |
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AU2019246853A1 (en) | 2019-10-31 |
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TWI679976B (zh) | 2019-12-21 |
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CA2929181A1 (en) | 2015-05-21 |
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CN105899232A (zh) | 2016-08-24 |
US20200054742A1 (en) | 2020-02-20 |
JP2020097589A (ja) | 2020-06-25 |
EP3068435A1 (en) | 2016-09-21 |
BR112016010716A8 (pt) | 2020-04-22 |
TW201609095A (zh) | 2016-03-16 |
AU2017245411B2 (en) | 2019-07-11 |
MX2016006316A (es) | 2016-07-26 |
US10286069B2 (en) | 2019-05-14 |
US10004803B2 (en) | 2018-06-26 |
AU2017245411A1 (en) | 2017-11-02 |
US20180369370A1 (en) | 2018-12-27 |
US20170281753A1 (en) | 2017-10-05 |
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