MX2010009156A - Terapia de combinacion 238. - Google Patents
Terapia de combinacion 238.Info
- Publication number
- MX2010009156A MX2010009156A MX2010009156A MX2010009156A MX2010009156A MX 2010009156 A MX2010009156 A MX 2010009156A MX 2010009156 A MX2010009156 A MX 2010009156A MX 2010009156 A MX2010009156 A MX 2010009156A MX 2010009156 A MX2010009156 A MX 2010009156A
- Authority
- MX
- Mexico
- Prior art keywords
- combination therapy
- patient
- kinase inhibitor
- cancer
- tor
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
La invención proporciona sistema de recipientes, equipos y métodos para soluciones de diálisis peritoneal (PD). Tal sistema, por ejemplo, incluye un primer compartimiento que contiene un agente osmótico de PD y un segundo compartimiento que contiene un agente amortiguador de PD. Los compartimientos mantienen sus respectivos contenidos separadamente entre sí para propósitos de transporte, almacenamiento y/o esterilización. Sin embargo, los compartimientos se pueden acoplar de manera fluida, de modo que sus respectivos contenidos se puedan combinar entre sí, por ejemplo, después de la esterilización de los agentes y antes de su introducción en el abdomen del paciente. La invención proporciona, en otros aspectos, tales sistemas, equipos y métodos que proporcionan estructuras protectoras que inhiben el rompimiento de un sello previamente entre el segundo compartimiento y una salida del sistema, antes de romper un sello entre el primero y segundo compartimientos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3029908P | 2008-02-21 | 2008-02-21 | |
US4860508P | 2008-04-29 | 2008-04-29 | |
PCT/GB2009/050167 WO2009104019A1 (en) | 2008-02-21 | 2009-02-20 | Combination therapy 238 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2010009156A true MX2010009156A (es) | 2010-09-09 |
Family
ID=40552051
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010009156A MX2010009156A (es) | 2008-02-21 | 2009-02-20 | Terapia de combinacion 238. |
Country Status (11)
Country | Link |
---|---|
US (1) | US20110028471A1 (es) |
EP (1) | EP2262504A1 (es) |
JP (1) | JP2011512395A (es) |
KR (1) | KR20100135754A (es) |
CN (1) | CN102014912A (es) |
AU (1) | AU2009215375A1 (es) |
BR (1) | BRPI0908100A2 (es) |
CA (1) | CA2715181A1 (es) |
MX (1) | MX2010009156A (es) |
RU (1) | RU2010138647A (es) |
WO (1) | WO2009104019A1 (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101909433B1 (ko) | 2011-12-02 | 2018-10-18 | 고쿠리츠다이가쿠호우진 야마구치 다이가쿠 | 키나제 저해제의 부작용 저감제 |
JP2015520231A (ja) * | 2012-06-25 | 2015-07-16 | バイエル・ヘルスケア・エルエルシーBayer HealthCareLLC | セジラニブを含んでいる眼科用局所医薬組成物 |
BR112016010716A8 (pt) | 2013-11-13 | 2020-04-22 | Novartis Ag | dose de reforço imunológico, baixa, de um inibidor de mtor, seu uso, e adjuvante de vacina |
JP6779785B2 (ja) | 2013-12-19 | 2020-11-04 | ノバルティス アーゲー | ヒトメソテリンキメラ抗原受容体およびその使用 |
WO2015090229A1 (en) | 2013-12-20 | 2015-06-25 | Novartis Ag | Regulatable chimeric antigen receptor |
ES2939760T3 (es) | 2014-03-15 | 2023-04-26 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico para antígenos |
PL3129470T3 (pl) | 2014-04-07 | 2021-11-29 | Novartis Ag | Leczenie nowotworu złośliwego z zastosowaniem chimerycznego receptora antygenowego anty-CD19 |
JP2017514806A (ja) | 2014-04-16 | 2017-06-08 | シグナル ファーマシューティカルズ,エルエルシー | Torキナーゼ阻害剤組み合わせ療法を使用して癌を治療する方法 |
JP2017528433A (ja) | 2014-07-21 | 2017-09-28 | ノバルティス アーゲー | 低い免疫増強用量のmTOR阻害剤とCARの組み合わせ |
KR102594343B1 (ko) | 2014-07-21 | 2023-10-26 | 노파르티스 아게 | Cd33 키메라 항원 수용체를 사용한 암의 치료 |
WO2016014553A1 (en) | 2014-07-21 | 2016-01-28 | Novartis Ag | Sortase synthesized chimeric antigen receptors |
ES2781175T3 (es) | 2014-07-31 | 2020-08-31 | Novartis Ag | Subconjunto optimizado de células T que contienen un receptor de antígeno quimérico |
CA2958200A1 (en) | 2014-08-14 | 2016-02-18 | Novartis Ag | Treatment of cancer using a gfr alpha-4 chimeric antigen receptor |
CN107108744B (zh) | 2014-08-19 | 2020-09-25 | 诺华股份有限公司 | 抗cd123嵌合抗原受体(car)用于癌症治疗 |
BR112017005390A2 (pt) | 2014-09-17 | 2017-12-12 | Novartis Ag | células citotóxicas alvo com receptores quiméricos para imunoterapia adotiva |
JP6815992B2 (ja) | 2014-10-08 | 2021-01-20 | ノバルティス アーゲー | キメラ抗原受容体療法に対する治療応答性を予測するバイオマーカーおよびその使用 |
US20180140602A1 (en) | 2015-04-07 | 2018-05-24 | Novartis Ag | Combination of chimeric antigen receptor therapy and amino pyrimidine derivatives |
EP4234685A3 (en) | 2015-04-17 | 2023-09-06 | Novartis AG | Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells |
WO2016172583A1 (en) | 2015-04-23 | 2016-10-27 | Novartis Ag | Treatment of cancer using chimeric antigen receptor and protein kinase a blocker |
WO2017031427A1 (en) * | 2015-08-19 | 2017-02-23 | 3-V Biosciences, Inc. | COMPOUNDS AND METHODS FOR INHIBITING mTOR |
CA3014674A1 (en) * | 2016-02-15 | 2017-08-24 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods comprising fixed intermittent dosing of cediranib |
CN109641947B (zh) | 2016-07-20 | 2023-04-14 | 犹他大学研究基金会 | Cd229 car t细胞及其使用方法 |
BR112019006781A2 (pt) | 2016-10-07 | 2019-07-30 | Novartis Ag | receptores de antígeno quiméricos para o tratamento de câncer |
US10467795B2 (en) * | 2017-04-08 | 2019-11-05 | Intel Corporation | Sub-graph in frequency domain and dynamic selection of convolution implementation on a GPU |
WO2018201056A1 (en) | 2017-04-28 | 2018-11-01 | Novartis Ag | Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor |
EP3784351A1 (en) | 2018-04-27 | 2021-03-03 | Novartis AG | Car t cell therapies with enhanced efficacy |
EP3788369A1 (en) | 2018-05-01 | 2021-03-10 | Novartis Ag | Biomarkers for evaluating car-t cells to predict clinical outcome |
KR102371269B1 (ko) * | 2020-03-11 | 2022-03-07 | 연세대학교 산학협력단 | VEGFR-3 발현 조절을 통한 mTOR 관련 질환의 예방 또는 치료 방법 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9718972D0 (en) * | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
CN1167422C (zh) * | 1999-02-10 | 2004-09-22 | 阿斯特拉曾尼卡有限公司 | 用作血管生成抑制剂的喹唑啉衍生物 |
KR100881105B1 (ko) * | 1999-11-05 | 2009-02-02 | 아스트라제네카 아베 | Vegf 억제제로서의 퀴나졸린 유도체 |
CA2604983A1 (en) * | 2005-03-17 | 2006-09-28 | The Regents Of The University Of California | Biomarker for sensitivity to mtor inhibitor therapy in kidney cancer |
PL1954699T3 (pl) * | 2005-11-22 | 2013-01-31 | Kudos Pharm Ltd | Pochodne pirydo-, pirazo- i pirymidopirymidyny jako inhibitory mTOR |
LT2057156T (lt) * | 2006-08-23 | 2017-05-25 | Kudos Pharmaceuticals Limited | 2-metilmorfolino pirido-, pirazo- ir pirimidopirimidino dariniai kaip mtor slopikliai |
ES2398423T3 (es) * | 2008-06-20 | 2013-03-19 | Astrazeneca Ab | Composiciones con y procedimiento para pirido[2,3-D]pirimidinas sustituídas con metilmorfolina |
-
2009
- 2009-02-20 CN CN2009801148588A patent/CN102014912A/zh active Pending
- 2009-02-20 WO PCT/GB2009/050167 patent/WO2009104019A1/en active Application Filing
- 2009-02-20 KR KR1020107020929A patent/KR20100135754A/ko not_active Application Discontinuation
- 2009-02-20 US US12/918,650 patent/US20110028471A1/en not_active Abandoned
- 2009-02-20 AU AU2009215375A patent/AU2009215375A1/en not_active Abandoned
- 2009-02-20 CA CA2715181A patent/CA2715181A1/en not_active Abandoned
- 2009-02-20 JP JP2010547258A patent/JP2011512395A/ja active Pending
- 2009-02-20 BR BRPI0908100A patent/BRPI0908100A2/pt not_active IP Right Cessation
- 2009-02-20 RU RU2010138647/15A patent/RU2010138647A/ru unknown
- 2009-02-20 EP EP09713321A patent/EP2262504A1/en not_active Withdrawn
- 2009-02-20 MX MX2010009156A patent/MX2010009156A/es unknown
Also Published As
Publication number | Publication date |
---|---|
AU2009215375A1 (en) | 2009-08-27 |
KR20100135754A (ko) | 2010-12-27 |
JP2011512395A (ja) | 2011-04-21 |
EP2262504A1 (en) | 2010-12-22 |
CN102014912A (zh) | 2011-04-13 |
US20110028471A1 (en) | 2011-02-03 |
WO2009104019A1 (en) | 2009-08-27 |
BRPI0908100A2 (pt) | 2015-10-06 |
CA2715181A1 (en) | 2009-08-27 |
RU2010138647A (ru) | 2012-03-27 |
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