KR20190112175A - 항―ｎｇｆ 조성물 및 그의 용도 - Google Patents

항―ｎｇｆ 조성물 및 그의 용도 Download PDF

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Publication number
KR20190112175A
KR20190112175A KR1020197027515A KR20197027515A KR20190112175A KR 20190112175 A KR20190112175 A KR 20190112175A KR 1020197027515 A KR1020197027515 A KR 1020197027515A KR 20197027515 A KR20197027515 A KR 20197027515A KR 20190112175 A KR20190112175 A KR 20190112175A
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pain
antibody
seq
ngf
fragment
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Korean (ko)
Inventor
벤자민 에이치. 덧자르
브라이언 알. 코바체비치
다니엘레 엠. 미첼
에단 더블유. 오자라
페이 판
제프리 티.엘. 스미스
패트리샤 다이안 맥닐
젠스 빌그렌
에리카 에이. 스튜어트
코린 씨. 아카트슈카
베티 유-칭 창
존 에이. 래섬
레온 에프. 가르시아-마르티네즈
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앨더바이오 홀딩스 엘엘씨
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1021—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against cytokines, e.g. growth factors, VEGF, TNF, lymphokines or interferons
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
KR1020197027515A 2010-12-01 2011-12-01 항―ｎｇｆ 조성물 및 그의 용도 Ceased KR20190112175A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41883210P 2010-12-01 2010-12-01
US61/418,832 2010-12-01
PCT/US2011/062963 WO2012075340A2 (en) 2010-12-01 2011-12-01 Anti-ngf compositions and use thereof

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KR1020137017181A Division KR102025848B1 (ko) 2010-12-01 2011-12-01 항―ｎｇｆ 조성물 및 그의 용도

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KR20190112175A true KR20190112175A (ko) 2019-10-02

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KR1020197027515A Ceased KR20190112175A (ko) 2010-12-01 2011-12-01 항―ｎｇｆ 조성물 및 그의 용도
KR1020137017181A Expired - Fee Related KR102025848B1 (ko) 2010-12-01 2011-12-01 항―ｎｇｆ 조성물 및 그의 용도

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Country Link
US (7) US9783601B2 (https=)
EP (2) EP2646468B1 (https=)
JP (2) JP6190723B2 (https=)
KR (2) KR20190112175A (https=)
CN (1) CN103619879A (https=)
AU (2) AU2011336470B8 (https=)
CA (1) CA2821515A1 (https=)
MX (1) MX359070B (https=)
NZ (1) NZ611076A (https=)
WO (1) WO2012075340A2 (https=)

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US20120148490A1 (en) 2012-06-14
CA2821515A1 (en) 2012-06-07
EP2646468A4 (en) 2014-12-03
AU2011336470A1 (en) 2013-06-20
NZ611076A (en) 2015-09-25
JP2014507116A (ja) 2014-03-27
US8911734B2 (en) 2014-12-16
EP2646468A2 (en) 2013-10-09
US10344083B2 (en) 2019-07-09
US20120164067A1 (en) 2012-06-28
US9359432B2 (en) 2016-06-07
US20120141484A1 (en) 2012-06-07
MX359070B (es) 2018-09-13
US20120141485A1 (en) 2012-06-07
US9783602B2 (en) 2017-10-10
US20170327568A1 (en) 2017-11-16
EP2646468B1 (en) 2018-07-25
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AU2011336470B2 (en) 2017-08-17
US20200062837A1 (en) 2020-02-27
US8728473B2 (en) 2014-05-20
US9783601B2 (en) 2017-10-10
MX2013006125A (es) 2014-08-22
EP3434691A1 (en) 2019-01-30
US20150132304A1 (en) 2015-05-14
WO2012075340A2 (en) 2012-06-07
KR20140014102A (ko) 2014-02-05
JP2017079779A (ja) 2017-05-18
WO2012075340A3 (en) 2012-11-01
JP6190723B2 (ja) 2017-08-30
CN103619879A (zh) 2014-03-05
AU2017208339A1 (en) 2017-08-17
AU2011336470B8 (en) 2017-09-14

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