JPS6223750B2 - - Google Patents

Info

Publication number
JPS6223750B2
JPS6223750B2 JP53037783A JP3778378A JPS6223750B2 JP S6223750 B2 JPS6223750 B2 JP S6223750B2 JP 53037783 A JP53037783 A JP 53037783A JP 3778378 A JP3778378 A JP 3778378A JP S6223750 B2 JPS6223750 B2 JP S6223750B2
Authority
JP
Japan
Prior art keywords
dihydrocarbostyryl
propoxy
phenylpiperazinyl
general formula
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP53037783A
Other languages
English (en)
Japanese (ja)
Other versions
JPS54130587A (en
Inventor
Kazuhisa Sakano
Takafumi Fujioka
Yasuo Ooshiro
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP3778378A priority Critical patent/JPS54130587A/ja
Priority to DE2953723A priority patent/DE2953723C2/de
Priority to DE2912105A priority patent/DE2912105C2/de
Priority to CA000324227A priority patent/CA1117110A/en
Priority to US06/024,602 priority patent/US4734416A/en
Priority to FI791034A priority patent/FI70704C/fi
Priority to AU45480/79A priority patent/AU515531B2/en
Priority to FR7907863A priority patent/FR2421174A1/fr
Priority to BE0/194281A priority patent/BE875174A/xx
Priority to SE7902794A priority patent/SE434945B/sv
Priority to CH295379A priority patent/CH641455A5/de
Priority to SU792745704A priority patent/SU1140687A3/ru
Priority to NO791049A priority patent/NO151321C/no
Priority to AT0235179A priority patent/AT376432B/de
Priority to DK128679A priority patent/DK158225C/da
Priority to NLAANVRAGE7902514,A priority patent/NL183189C/xx
Priority to PT69422A priority patent/PT69422A/pt
Priority to ES479134A priority patent/ES479134A1/es
Priority to GB7911155A priority patent/GB2017701B/en
Priority to IT67674/79A priority patent/IT1119284B/it
Priority to MX797848U priority patent/MX5862E/es
Priority to ZA791516A priority patent/ZA791516B/xx
Publication of JPS54130587A publication Critical patent/JPS54130587A/ja
Priority to ES486990A priority patent/ES486990A1/es
Priority to ES486992A priority patent/ES486992A1/es
Priority to ES486991A priority patent/ES486991A1/es
Priority to SU813328599A priority patent/SU1232144A3/ru
Priority to CH190082A priority patent/CH641350A5/de
Priority to AT391683A priority patent/AT376434B/de
Priority to AT391783A priority patent/AT376435B/de
Priority to AT391583A priority patent/AT376433B/de
Priority to JP61295668A priority patent/JPS62149664A/ja
Priority to US07/025,193 priority patent/US4824840A/en
Publication of JPS6223750B2 publication Critical patent/JPS6223750B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C07D215/28—Alcohols; Ethers thereof with halogen atoms or nitro radicals in positions 5, 6 or 7

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP3778378A 1978-03-30 1978-03-30 Carbostyryl derivative Granted JPS54130587A (en)

Priority Applications (32)

Application Number Priority Date Filing Date Title
JP3778378A JPS54130587A (en) 1978-03-30 1978-03-30 Carbostyryl derivative
DE2953723A DE2953723C2 (de) 1978-03-30 1979-03-27 Neue carbostyrilderivate, verfahren zu deren herstellung und diese enthaltende mittel
DE2912105A DE2912105C2 (de) 1978-03-30 1979-03-27 Neue carbostyrilderivate, verfahren zu deren herstellung und diese enthaltende mittel
CA000324227A CA1117110A (en) 1978-03-30 1979-03-27 Carbostyril derivatives and process for preparation thereof
US06/024,602 US4734416A (en) 1978-03-30 1979-03-28 Pharmaceutically useful carbostyril derivatives
FI791034A FI70704C (fi) 1978-03-30 1979-03-28 Foerfarande foer framstaellning av ett karbostyrilderivat med antihistamineffekt och inverkan pao centrala nervsystemet
AU45480/79A AU515531B2 (en) 1978-03-30 1979-03-28 Novel carbostyril derivatives
FR7907863A FR2421174A1 (fr) 1978-03-30 1979-03-29 Nouveaux derives de carbostyrile, leur procede de preparation et leurs applications en therapeutique
BE0/194281A BE875174A (fr) 1978-03-30 1979-03-29 Nouveaux derives de carbostyrile, leur procede de preparation et leurs applications en therapeutique
SE7902794A SE434945B (sv) 1978-03-30 1979-03-29 Karbostyrilderivat
CH295379A CH641455A5 (de) 1978-03-30 1979-03-29 Carbostyril-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
SU792745704A SU1140687A3 (ru) 1978-03-30 1979-03-29 Способ получени карбостирильных производных или их фармацевтически приемлемых солей с кислотами
NO791049A NO151321C (no) 1978-03-30 1979-03-29 Analogifremgangsmaate for fremstilling av terapeutisk aktive karbostyrilderivater
AT0235179A AT376432B (de) 1978-03-30 1979-03-29 Verfahren zum herstellen von neuen carbostyrilderivaten und von deren saeureadditions-salzen
DK128679A DK158225C (da) 1978-03-30 1979-03-29 Analogifremgangsmaade til fremstilling af carbostyrilderivater
ES479134A ES479134A1 (es) 1978-03-30 1979-03-30 Un procedimiento para la preparacion de un derivado de car- boestirilo.
PT69422A PT69422A (en) 1978-03-30 1979-03-30 Novel carbostyril derivatives and process for preparation thereof
NLAANVRAGE7902514,A NL183189C (nl) 1978-03-30 1979-03-30 Farmaceutisch preparaat dat een met een (piperazine-1-yl)alkoxygroep gesubstitueerd carbostyrilderivaat bevat, alsmede een dergelijk carbostyrilderivaat.
GB7911155A GB2017701B (en) 1978-03-30 1979-03-30 Carbostyril derivatives
IT67674/79A IT1119284B (it) 1978-03-30 1979-03-30 Derivati carbostirilici e procedimento per la loro preparazione
MX797848U MX5862E (es) 1978-03-30 1979-03-30 Procedimiento para la produccion de derivados de carboestirilo
ZA791516A ZA791516B (en) 1978-03-30 1979-03-30 Novel carbostyril derivatives and process for preparation thereof
ES486991A ES486991A1 (es) 1978-03-30 1979-12-17 Un procedimiento para la preparacion de un derivado de car- boestirilo
ES486992A ES486992A1 (es) 1978-03-30 1979-12-17 Un procedimiento para la preparacion de un derivado de car- boestirilo
ES486990A ES486990A1 (es) 1978-03-30 1979-12-17 Un procedimiento para la preparacion de un derivado de car- boestirilo
SU813328599A SU1232144A3 (ru) 1978-03-30 1981-09-08 Способ получени карбостирильных производных
CH190082A CH641350A5 (de) 1978-03-30 1982-03-26 Pharmazeutische zusammensetzung zur verwendung als antihistaminicum, auf der basis eines carbostyrilderivates.
AT391683A AT376434B (de) 1978-03-30 1983-11-07 Verfahren zum herstellen von neuen carbostyrilderivaten und von deren saeureadditionssalzen
AT391783A AT376435B (de) 1978-03-30 1983-11-07 Verfahren zum herstellen von neuen carbostyrilderivaten und von deren saeureadditionssalzen
AT391583A AT376433B (de) 1978-03-30 1983-11-07 Verfahren zum herstellen von neuen carbostyrilderivaten und von deren saeureadditionssalzen
JP61295668A JPS62149664A (ja) 1978-03-30 1986-12-10 カルボスチリル誘導体の製造法
US07/025,193 US4824840A (en) 1978-03-30 1987-03-12 Carbostyril derivatives and pharmaceutical preparations containing same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3778378A JPS54130587A (en) 1978-03-30 1978-03-30 Carbostyryl derivative

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP61295668A Division JPS62149664A (ja) 1978-03-30 1986-12-10 カルボスチリル誘導体の製造法

Publications (2)

Publication Number Publication Date
JPS54130587A JPS54130587A (en) 1979-10-09
JPS6223750B2 true JPS6223750B2 (show.php) 1987-05-25

Family

ID=12507080

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3778378A Granted JPS54130587A (en) 1978-03-30 1978-03-30 Carbostyryl derivative

Country Status (21)

Country Link
US (2) US4734416A (show.php)
JP (1) JPS54130587A (show.php)
AT (1) AT376432B (show.php)
AU (1) AU515531B2 (show.php)
BE (1) BE875174A (show.php)
CA (1) CA1117110A (show.php)
CH (2) CH641455A5 (show.php)
DE (2) DE2912105C2 (show.php)
DK (1) DK158225C (show.php)
ES (4) ES479134A1 (show.php)
FI (1) FI70704C (show.php)
FR (1) FR2421174A1 (show.php)
GB (1) GB2017701B (show.php)
IT (1) IT1119284B (show.php)
MX (1) MX5862E (show.php)
NL (1) NL183189C (show.php)
NO (1) NO151321C (show.php)
PT (1) PT69422A (show.php)
SE (1) SE434945B (show.php)
SU (2) SU1140687A3 (show.php)
ZA (1) ZA791516B (show.php)

Families Citing this family (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2827566A1 (de) * 1978-06-23 1980-01-10 Boehringer Mannheim Gmbh 1,2-dihydro-chinolin-2-on-derivate und verfahren zu ihrer herstellung
DE3034237A1 (de) * 1979-09-18 1981-04-16 Otsuka Pharmaceutical Co. Ltd., Tokyo Carbostyrilderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende, antihistaminisch wirkende mittel
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
JPS57193461A (en) * 1981-05-22 1982-11-27 Otsuka Pharmaceut Co Ltd Benzazepine derivative
DE3442570A1 (de) * 1984-11-22 1986-05-22 Hoechst Ag, 6230 Frankfurt Neue substituierte phenylpiperazinderivate, verfahren zu deren herstellung und die verwendung substituierter phenylpiperazinderivate als aggressionshemmer fuer tiere
JPS6129331A (ja) * 1985-03-13 1986-02-10 アラ−ガン・ハンフリ− 検眼装置
DK588486A (da) * 1985-12-09 1987-06-10 Otsuka Pharma Co Ltd Anvendelse af en forbindelse til behandling af hypoxi
DK167187A (da) * 1986-04-02 1987-10-03 Otsuka Pharma Co Ltd Carbostyrilderivater og salte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddel indeholdende disse
KR940000785B1 (ko) * 1986-04-02 1994-01-31 오오쓰까세이야꾸 가부시끼가이샤 카르보스티릴 유도체 및 그의 염의 제조 방법
EP0255134B1 (en) * 1986-07-31 1993-03-03 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof, process for preparing them, and cardiotonic composition containing same
JPH0696555B2 (ja) * 1986-07-31 1994-11-30 大塚製薬株式会社 カルボスチリル誘導体
US4803203A (en) * 1986-11-05 1989-02-07 Warner-Lambert Company Phenyl and heterocyclic piperazinyl alkoxy-benzheterocyclic compounds as antipsychotic agents
JPS63141967A (ja) * 1986-11-21 1988-06-14 エイ・エッチ・ロビンス・カンパニー・インコーポレーテッド 抗アレルギー薬として有用な１−アリールオキシー４−［（４−アリール）−１−ピペラジニル］−２−ブタノール
FR2637591B1 (fr) * 1988-10-11 1992-10-23 Synthelabo Derives de quinoleinone, leur preparation et leur application en therapeutique
US5006528A (en) * 1988-10-31 1991-04-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
JP2608788B2 (ja) * 1988-10-31 1997-05-14 大塚製薬 株式会社 精神分裂病治療剤
JP2900130B2 (ja) * 1995-03-16 1999-06-02 大塚製薬株式会社 カルボスチリル誘導体及び該誘導体を含有する精神分裂病治療剤
AR032641A1 (es) * 2001-01-29 2003-11-19 Otsuka Pharma Co Ltd Agonista de subtipo de receptor 5-ht 1a.
US7053092B2 (en) * 2001-01-29 2006-05-30 Otsuka Pharmaceutical Co., Ltd. 5-HT1a receptor subtype agonist
MY129350A (en) 2001-04-25 2007-03-30 Bristol Myers Squibb Co Aripiprazole oral solution
MY138669A (en) 2001-09-25 2009-07-31 Otsuka Pharma Co Ltd Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
AR033485A1 (es) 2001-09-25 2003-12-26 Otsuka Pharma Co Ltd Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma
US8703772B2 (en) 2001-09-25 2014-04-22 Otsuka Pharmaceutical Co., Ltd. Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
AU2003291757A1 (en) * 2002-11-08 2004-06-03 Bristol-Myers Squibb Company Formulations of low solubility bioactive agents and processes for making the same
EP1480953B2 (en) * 2003-01-09 2010-08-18 Otsuka Pharmaceutical Co., Ltd. Process for preparing aripiprazole
WO2004064752A2 (en) * 2003-01-22 2004-08-05 Alkermes Controlled Therapeutics, Inc. Method of preparing sustained release microparticles
AU2004265243A1 (en) * 2003-06-20 2005-02-24 Arena Pharmaceuticals, Inc. N-phenyl-piperazine derivatives and methods of prophylaxis or treatment of 5HT2c receptor associated diseases
US20050032781A1 (en) * 2003-08-06 2005-02-10 Elliot Ehrich Methods for administering active agents to CYP 2D6 sensitive patients
US6987111B2 (en) 2003-08-06 2006-01-17 Alkermes Controlled Therapeutics, Ii Aripiprazole, olanzapine and haloperidol pamoate salts
KR100931784B1 (ko) 2003-10-23 2009-12-14 오츠카 세이야쿠 가부시키가이샤 방출조절성 멸균 아리피프라졸 주사제, 그 제조방법
GB0326148D0 (en) 2003-11-10 2003-12-17 Lilly Co Eli Morpholine derivatives
US7504504B2 (en) * 2003-12-16 2009-03-17 Teva Pharmaceutical Industries Ltd. Methods of preparing aripiprazole crystalline forms
US7714129B2 (en) * 2003-12-16 2010-05-11 Teva Pharmaceutical Industries Ltd. Methods of preparing anhydrous aripiprazole form II
DE202005020539U1 (de) * 2004-02-05 2006-09-28 Teva Pharmaceutical Industries Ltd. Aripiprazol
US7507823B2 (en) * 2004-05-06 2009-03-24 Bristol-Myers Squibb Company Process of making aripiprazole particles
MXPA06013163A (es) * 2004-05-11 2007-02-13 Pfizer Prod Inc Combinacion de antipsicoticos atipicos y antagonistas del receptor 5-ht1b.
TW200616608A (en) * 2004-07-09 2006-06-01 Forest Laboratories Memantine as adjunctive treatment to atypical antipsychotics in schizophrenia patients
US20060024362A1 (en) 2004-07-29 2006-02-02 Pawan Seth Composition comprising a benzimidazole and process for its manufacture
WO2006053781A1 (en) * 2004-11-18 2006-05-26 Synthon B.V. Process of making crystalline aripiprazole
CN101087760B (zh) * 2004-11-18 2011-09-28 斯索恩有限公司 结晶的阿立哌唑溶剂化物
WO2006064780A1 (ja) * 2004-12-14 2006-06-22 Shionogi & Co., Ltd. 便秘治療剤
CA2594690C (en) * 2005-01-27 2013-08-27 Sandoz Ag Salts of aripiprazole
EP1686126A1 (en) * 2005-01-27 2006-08-02 Sandoz AG Salts of aripiprazole
ES2526415T3 (es) * 2005-03-17 2015-01-12 Synthon B.V. Comprimidos farmacéuticos de aripiprazol cristalino de tipo II
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
CA2605447A1 (en) * 2005-04-22 2006-11-02 Wyeth Therapeutic combinations for the treatment or prevention of psychotic disorders
EP1933814A2 (en) 2005-09-15 2008-06-25 Elan Pharma International Limited Nanoparticulate aripiprazole formulations
JP2008537540A (ja) * 2005-12-22 2008-09-18 テバ ファーマシューティカル インダストリーズ リミティド アリピプラゾールの粒径を小さくする方法
WO2007092779A2 (en) * 2006-02-03 2007-08-16 Dr. Reddy's Laboratories Ltd. Aripiprazole co-crystals
US20060223820A1 (en) * 2006-03-21 2006-10-05 Chemagis Ltd. Crystalline aripiprazole salts and processes for preparation and purification thereof
US7799790B2 (en) * 2006-07-20 2010-09-21 Helm Ag Amorphous aripiprazole and process for the preparation thereof
EP1880714A1 (en) * 2006-07-20 2008-01-23 Helm AG Amorphous Aripiprazole and Process for the Preparation thereof
WO2008047340A1 (en) * 2006-10-19 2008-04-24 Mor Research Applications Ltd. Combined therapies of antipsychotic drugs and tetracyclines in the treatment of psychiatric disorders
WO2008051541A2 (en) * 2006-10-24 2008-05-02 Cambrex Charles City, Inc. Process for preparing anhydrous aripirazole type i
ATE515554T1 (de) * 2006-12-04 2011-07-15 Merck Patent Gmbh Furochromanderivate
RU2497819C2 (ru) 2007-05-21 2013-11-10 Ривайва Фармасьютикалс, Инк. Композиции, синтез и способы применения атипичных нейролептиков на основе хинолина
LT2170279T (lt) * 2007-07-31 2018-03-12 Otsuka Pharmaceutical Co., Ltd. Aripiprazolo suspensijos ir liofilizuotos kompozicijos gamybos būdai
ATE482691T1 (de) 2008-01-23 2010-10-15 Helm Ag Amorphes aripiprazol und verfahren zu seiner herstellung
DE102008022221A1 (de) 2008-05-06 2009-11-12 Universität des Saarlandes Inhibitoren der humanen Aldosteronsynthase CYP11B2
JP2011520815A (ja) * 2008-05-09 2011-07-21 エモリー・ユニバーシテイ 精神神経障害治療のためのｎｍｄａ受容体拮抗薬
WO2009156889A1 (en) * 2008-06-25 2009-12-30 Pfizer Inc. Diaryl compounds and uses thereof
AU2010266018B2 (en) 2009-06-25 2014-01-09 Alkermes Pharma Ireland Limited Heterocyclic compounds for the treatment of neurological and psychological disorders
SG178938A1 (en) 2009-09-11 2012-04-27 Otsuka Pharma Co Ltd Therapeutic agent for chronic pain
WO2011030213A1 (en) 2009-09-14 2011-03-17 Jubilant Organosys Limited Improved process for the preparation of 7.(4-bromobutoxy) 3,4-dihydrocarbostyril, a precursor of aripiprazole
US8541404B2 (en) 2009-11-09 2013-09-24 Elexopharm Gmbh Inhibitors of the human aldosterone synthase CYP11B2
JP5916746B2 (ja) 2010-11-15 2016-05-11 エージンバイオ， インコーポレイテッド 認知障害を処置するためのピリダジン誘導体、組成物、および方法
MX358344B (es) * 2011-03-18 2018-08-15 Alkermes Pharma Ireland Ltd Composiciones farmaceuticas que comprenden un antipsicotico insoluble en agua y esteres de sorbitan.
WO2012131451A1 (en) 2011-03-30 2012-10-04 Jubilant Life Sciences Limited Process for producing aripiprazole in anhydrous type i crystals
TW201309651A (zh) 2011-06-29 2013-03-01 Otsuka Pharma Co Ltd 阿立哌唑（ａｒｉｐｉｐｒａｚｏｌｅ）無水物Ｂ形結晶微粒子之製造方法
NZ630428A (en) 2012-03-19 2017-02-24 Alkermes Pharma Ireland Ltd Pharmaceutical compositions comprising benzyl alcohol
EP2827868B8 (en) 2012-03-19 2019-12-18 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising fatty acid esters
AU2013235523B9 (en) 2012-03-19 2018-01-04 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising glycerol esters
EP2847193B1 (en) * 2012-05-09 2019-08-07 Sunovion Pharmaceuticals Inc. Heteroaryl compounds and methods of use thereof
KR101571670B1 (ko) 2012-08-08 2015-11-25 주식회사 씨엠지제약 아리피프라졸을 포함하는 경구용 속용 필름 제제
ES2822914T3 (es) * 2012-08-21 2021-05-05 Janssen Pharmaceutica Nv Haptenos de aripiprazol y su uso en inmunoensayos
WO2014080285A2 (en) 2012-09-19 2014-05-30 Alkermes Pharma Ireland Limited Pharmaceutical compositions having improved storage stability
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
US10525057B2 (en) 2013-09-24 2020-01-07 Otsuka Pharmaceutical Co., Ltd. Method of providing aripiprazole to patients having impaired CYP2D6 or CYP3A4 enzyme function
AU2014368961B2 (en) 2013-12-20 2019-10-17 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
CN110368360A (zh) 2014-03-20 2019-10-25 奥克梅斯制药爱尔兰有限公司 具有增加的注射速度的阿立哌唑制剂
KR20160139704A (ko) 2015-05-28 2016-12-07 주식회사 씨엠지제약 아리피프라졸을 포함하는 경구용 속용 필름 제제, 및 이의 제조방법
EP3310785B1 (en) 2015-06-19 2024-11-20 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US11505555B2 (en) 2016-12-19 2022-11-22 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US20180170941A1 (en) 2016-12-19 2018-06-21 Agenebio, Inc. Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
WO2019173230A1 (en) 2018-03-05 2019-09-12 Alkermes Pharma Ireland Limited Aripiprazole dosing strategy
MX2020013927A (es) 2018-06-19 2021-03-02 Agenebio Inc Derivados de benzodiazepina, composiciones y metodos para tratar el deterioro cognitivo.
WO2024039886A1 (en) 2022-08-19 2024-02-22 Agenebio, Inc. Benzazepine derivatives, compositions, and methods for treating cognitive impairment
ES2963237A1 (es) * 2022-08-25 2024-03-25 Consejo Superior Investigacion Derivados de quinolina-2(1H)-ona para el tratamiento y prevención de enfermedades neurodegenerativas

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA801037A (en) * 1968-12-10 Regnier Gilbert Procede de preparation de nouveaux derives du piperazino-phenylethanol
GB1021522A (en) * 1963-05-10 1966-03-02 Ici Ltd 2-quinolone derivatives
GB1075156A (en) * 1963-08-27 1967-07-12 Luso Farmaco Inst Substituted piperazines
NL131192C (show.php) * 1965-06-16
US3362956A (en) * 1965-08-19 1968-01-09 Sterling Drug Inc 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines
US3706749A (en) * 1967-03-30 1972-12-19 Mcneilab Inc N-acyl carbostyrils
US3703522A (en) * 1967-03-30 1972-11-21 Mcneilab Inc Carbostyril derivatives
US3511841A (en) * 1967-05-29 1970-05-12 Sterling Drug Inc 1-((4-,5-,6-,and 7-azaindolyl)-lower-alkyl)- 4-substituted-piperazines
US3635976A (en) * 1967-12-20 1972-01-18 Pennwalt Corp 1 - heterocyclic alkyl-1 2 3 4-tetrahydroquinazolinones and analgesic intermediates thereof
CH523899A (de) * 1968-07-05 1972-06-15 Cassella Farbwerke Mainkur Ag Verfahren zur Herstellung von Derivaten des 2-Oxo-1,2-dihydro-chinolins
DE1795362A1 (de) * 1968-09-19 1972-01-05 Boehringer Mannheim Gmbh Basische AEther und Verfahren zur Herstellung derselben
BE884459Q (fr) * 1971-05-14 1981-01-26 Boehringer Mannheim Gmbh Derives de la 4-(omega-(coumarine-7-yl-oxy)-alkyl)-piperazine et procede de preparation
DE2123923A1 (de) * 1971-05-14 1972-11-23 Boehringer Mannheim Gmbh, 6800 Mannheim 4-eckige Klammer auf omega- (Flavon-7yl-oxy) -alkyl eckige Klammer zu -pigerazin-Derivate und Verfahren zu ihrer Herstellung
DE2335432A1 (de) * 1973-07-12 1975-01-30 Boehringer Mannheim Gmbh 3,4-dihydro-2h-naphthalinon-(1)5-oxy-propyl-piperazin-derivate und verfahren zu ihrer herstellung
JPS48103590A (show.php) * 1972-04-13 1973-12-25
US3910924A (en) * 1972-04-13 1975-10-07 Otsuka Pharma Co Ltd 3,4-Dihydrocarbostyril derivatives and a process for preparing the same
US4256890A (en) * 1972-09-14 1981-03-17 Otsukapharmaceutical Co., Ltd. 3,4-Dihydrocarbostyril derivatives and process for producing the same
DE2354145A1 (de) * 1972-11-02 1974-05-16 Sandoz Ag Chinazolin-2(lh)-one und verfahren zu ihrer herstellung
DE2334009A1 (de) * 1973-07-04 1975-01-23 Boehringer Mannheim Gmbh Purin-derivate sowie verfahren zu ihrer herstellung
US3981864A (en) * 1973-09-08 1976-09-21 Eisai Co., Ltd. 1,3-Benzodioxol derivatives
US4083853A (en) * 1973-09-08 1978-04-11 Eisai Co., Ltd. 1,3-Benzodioxol derivatives
US4026895A (en) * 1973-09-08 1977-05-31 Eisai Co., Ltd. 1,3-Benzodioxol derivatives
GB1451900A (en) * 1973-10-30 1976-10-06 Sandoz Ltd Quinolin-2-1h-ones
JPS5089376A (show.php) * 1973-12-19 1975-07-17
US4032528A (en) * 1974-03-25 1977-06-28 Sandoz, Inc. 1,4-substituted-quinolin-2(1h)-ones as cns agents
US3983121A (en) * 1974-07-01 1976-09-28 Council Of Scientific And Industrial Research 1-Substituted 4-(β-2-quinolylethyl)piperazines and 1,2,3,4-tetrahydroquinolyl-ethyl analogues thereof
US3940397A (en) * 1974-11-13 1976-02-24 E. R. Squibb & Sons, Inc. 2-[(Substituted-piperazinyl)alkyl]-1H-benz[de]isoquinoline-1,3(2H)-diones
DE2631317A1 (de) * 1975-07-23 1977-02-17 Sandoz Ag Organische verbindungen, ihre verwendung und herstellung
US3994900A (en) * 1976-01-23 1976-11-30 E. R. Squibb & Sons, Inc. 6-(Or 8)-[[(substituted amino)alkyl]oxy(or thio)]-3,4-dihydro-4-phenyl-2(1H)-quinolinones
ES456325A1 (es) * 1976-02-27 1978-05-01 Sandoz Ag Un procedimiento para la preparacion de nuevos derivados delacido 4-hidroxi-2-quinolinon-3-carboxilico.
US4210753A (en) * 1976-03-17 1980-07-01 Otsuka Pharmaceutical Co., Ltd. Carbostyril compounds
CH619453A5 (show.php) * 1976-03-17 1980-09-30 Otsuka Pharma Co Ltd
DE2719562C2 (de) * 1976-05-08 1986-05-07 Otsuka Pharmaceutical Co. Ltd., Tokio/Tokyo 3, 4-Dihydrocarbostyrilderivate, Verfahren zu deren Herstellung und Arzneimittel, welche diese enthalten
US4110449A (en) * 1977-05-23 1978-08-29 E. R. Squibb & Sons, Inc. 2-substituted benzisothiazol-3-ones
US4166116A (en) * 1977-11-11 1979-08-28 Canadian Patents And Development Limited Pharmaceutical compositions containing piperazinyl acylhydroxamic acid derivatives to treat inflammation or anaphylactic allergy conditions
DE2960178D1 (en) * 1978-06-06 1981-04-09 Hoechst Ag New substituted phenylpiperazine derivatives, pharmaceutical compositions containing them and process for their preparation
DE2827566A1 (de) * 1978-06-23 1980-01-10 Boehringer Mannheim Gmbh 1,2-dihydro-chinolin-2-on-derivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
FI791034A7 (fi) 1979-10-01
DK128679A (da) 1979-10-26
FR2421174B1 (show.php) 1982-11-19
CA1117110A (en) 1982-01-26
JPS54130587A (en) 1979-10-09
IT7967674A0 (it) 1979-03-30
DE2953723C2 (de) 1989-01-12
FI70704B (fi) 1986-06-26
ES479134A1 (es) 1980-06-16
NO151321B (no) 1984-12-10
ES486992A1 (es) 1980-10-01
AU515531B2 (en) 1981-04-09
PT69422A (en) 1979-04-01
BE875174A (fr) 1979-10-01
DK158225C (da) 1990-09-17
AU4548079A (en) 1979-10-04
IT1119284B (it) 1986-03-10
NO791049L (no) 1979-10-02
SE7902794L (sv) 1979-10-01
SU1232144A3 (ru) 1986-05-15
ATA235179A (de) 1984-04-15
NO151321C (no) 1985-03-20
US4734416A (en) 1988-03-29
CH641455A5 (de) 1984-02-29
ES486991A1 (es) 1980-10-01
DE2912105A1 (de) 1979-10-11
NL7902514A (nl) 1979-10-02
AT376432B (de) 1984-11-26
ZA791516B (en) 1980-04-30
DE2912105C2 (de) 1985-08-29
CH641350A5 (de) 1984-02-29
GB2017701B (en) 1983-03-16
SE434945B (sv) 1984-08-27
MX5862E (es) 1984-08-13
ES486990A1 (es) 1980-10-01
SU1140687A3 (ru) 1985-02-15
FR2421174A1 (fr) 1979-10-26
FI70704C (fi) 1986-10-06
GB2017701A (en) 1979-10-10
US4824840A (en) 1989-04-25
DK158225B (da) 1990-04-16
NL183189C (nl) 1988-08-16

Similar Documents

Publication Publication Date Title
JPS6223750B2 (show.php)
US4567187A (en) Carbostyril derivatives and antihistaminic agents containing the carbostyril derivatives
JP5797090B2 (ja) アリピプラゾールの製造法
JPH02191256A (ja) カルボスチリル誘導体及び該誘導体を含有する精神分裂病治療剤
SE439632B (sv) Karbostyrilderivat, forfarande for framstellning av den och antihistaminmedel
JPH0212204B2 (show.php)
JPS6320226B2 (show.php)
JPH0372068B2 (show.php)
JPS6332069B2 (show.php)
JPS6140674B2 (show.php)
JPS635387B2 (show.php)
JPS628117B2 (show.php)
KR950011748B1 (ko) 술펜아미드 유도체 및 그의 제조방법
CN104080770A (zh) 用于制备罗氟司特的改进方法
JPH10109982A (ja) フラボン誘導体及びこれを含有する医薬
JPS628115B2 (show.php)
JPS6160831B2 (show.php)
JPH0314296B2 (show.php)
JPS6254304B2 (show.php)
JPS6317071B2 (show.php)
JPS63119467A (ja) カルボスチリル誘導体
JPS6353984B2 (show.php)
KR850001796B1 (ko) 카르보스티릴 유도체의 제조방법
JPS628114B2 (show.php)
JPS6320233B2 (show.php)