AT376432B - Verfahren zum herstellen von neuen carbostyrilderivaten und von deren saeureadditions-salzen - Google Patents
Verfahren zum herstellen von neuen carbostyrilderivaten und von deren saeureadditions-salzenInfo
- Publication number
- AT376432B AT376432B AT0235179A AT235179A AT376432B AT 376432 B AT376432 B AT 376432B AT 0235179 A AT0235179 A AT 0235179A AT 235179 A AT235179 A AT 235179A AT 376432 B AT376432 B AT 376432B
- Authority
- AT
- Austria
- Prior art keywords
- acid addition
- addition salts
- producing new
- carbostyrile
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
- C07D215/28—Alcohols; Ethers thereof with halogen atoms or nitro radicals in positions 5, 6 or 7
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Anesthesiology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT391583A AT376433B (de) | 1978-03-30 | 1983-11-07 | Verfahren zum herstellen von neuen carbostyrilderivaten und von deren saeureadditionssalzen |
AT391783A AT376435B (de) | 1978-03-30 | 1983-11-07 | Verfahren zum herstellen von neuen carbostyrilderivaten und von deren saeureadditionssalzen |
AT391683A AT376434B (de) | 1978-03-30 | 1983-11-07 | Verfahren zum herstellen von neuen carbostyrilderivaten und von deren saeureadditionssalzen |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3778378A JPS54130587A (en) | 1978-03-30 | 1978-03-30 | Carbostyryl derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
ATA235179A ATA235179A (de) | 1984-04-15 |
AT376432B true AT376432B (de) | 1984-11-26 |
Family
ID=12507080
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT0235179A AT376432B (de) | 1978-03-30 | 1979-03-29 | Verfahren zum herstellen von neuen carbostyrilderivaten und von deren saeureadditions-salzen |
Country Status (21)
Country | Link |
---|---|
US (2) | US4734416A (de) |
JP (1) | JPS54130587A (de) |
AT (1) | AT376432B (de) |
AU (1) | AU515531B2 (de) |
BE (1) | BE875174A (de) |
CA (1) | CA1117110A (de) |
CH (2) | CH641455A5 (de) |
DE (2) | DE2953723C2 (de) |
DK (1) | DK158225C (de) |
ES (4) | ES479134A1 (de) |
FI (1) | FI70704C (de) |
FR (1) | FR2421174A1 (de) |
GB (1) | GB2017701B (de) |
IT (1) | IT1119284B (de) |
MX (1) | MX5862E (de) |
NL (1) | NL183189C (de) |
NO (1) | NO151321C (de) |
PT (1) | PT69422A (de) |
SE (1) | SE434945B (de) |
SU (2) | SU1140687A3 (de) |
ZA (1) | ZA791516B (de) |
Families Citing this family (88)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2827566A1 (de) * | 1978-06-23 | 1980-01-10 | Boehringer Mannheim Gmbh | 1,2-dihydro-chinolin-2-on-derivate und verfahren zu ihrer herstellung |
DE3034237A1 (de) * | 1979-09-18 | 1981-04-16 | Otsuka Pharmaceutical Co. Ltd., Tokyo | Carbostyrilderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende, antihistaminisch wirkende mittel |
PH17194A (en) | 1980-03-06 | 1984-06-19 | Otsuka Pharma Co Ltd | Novel carbostyril derivatives,and pharmaceutical composition containing the same |
JPS57193461A (en) * | 1981-05-22 | 1982-11-27 | Otsuka Pharmaceut Co Ltd | Benzazepine derivative |
CN85108214A (zh) * | 1984-11-22 | 1986-08-20 | 赫彻斯特股份公司 | 新的取代的苯基哌嗪衍生物及其药物的制造方法 |
JPS6129331A (ja) * | 1985-03-13 | 1986-02-10 | アラ−ガン・ハンフリ− | 検眼装置 |
DK588486A (da) * | 1985-12-09 | 1987-06-10 | Otsuka Pharma Co Ltd | Anvendelse af en forbindelse til behandling af hypoxi |
DK167187A (da) * | 1986-04-02 | 1987-10-03 | Otsuka Pharma Co Ltd | Carbostyrilderivater og salte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddel indeholdende disse |
KR940000785B1 (ko) * | 1986-04-02 | 1994-01-31 | 오오쓰까세이야꾸 가부시끼가이샤 | 카르보스티릴 유도체 및 그의 염의 제조 방법 |
JPH0696555B2 (ja) * | 1986-07-31 | 1994-11-30 | 大塚製薬株式会社 | カルボスチリル誘導体 |
US4886809A (en) * | 1986-07-31 | 1989-12-12 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives and salts thereof |
US4803203A (en) * | 1986-11-05 | 1989-02-07 | Warner-Lambert Company | Phenyl and heterocyclic piperazinyl alkoxy-benzheterocyclic compounds as antipsychotic agents |
JPS63141967A (ja) * | 1986-11-21 | 1988-06-14 | エイ・エッチ・ロビンス・カンパニー・インコーポレーテッド | 抗アレルギー薬として有用な1−アリールオキシー4−[(4−アリール)−1−ピペラジニル]−2−ブタノール |
FR2637591B1 (fr) * | 1988-10-11 | 1992-10-23 | Synthelabo | Derives de quinoleinone, leur preparation et leur application en therapeutique |
US5006528A (en) * | 1988-10-31 | 1991-04-09 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives |
JP2608788B2 (ja) * | 1988-10-31 | 1997-05-14 | 大塚製薬 株式会社 | 精神分裂病治療剤 |
JP2900130B2 (ja) * | 1995-03-16 | 1999-06-02 | 大塚製薬株式会社 | カルボスチリル誘導体及び該誘導体を含有する精神分裂病治療剤 |
AR032641A1 (es) * | 2001-01-29 | 2003-11-19 | Otsuka Pharma Co Ltd | Agonista de subtipo de receptor 5-ht 1a. |
US7053092B2 (en) | 2001-01-29 | 2006-05-30 | Otsuka Pharmaceutical Co., Ltd. | 5-HT1a receptor subtype agonist |
MY129350A (en) * | 2001-04-25 | 2007-03-30 | Bristol Myers Squibb Co | Aripiprazole oral solution |
AR033485A1 (es) | 2001-09-25 | 2003-12-26 | Otsuka Pharma Co Ltd | Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma |
US8703772B2 (en) | 2001-09-25 | 2014-04-22 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
MY138669A (en) | 2001-09-25 | 2009-07-31 | Otsuka Pharma Co Ltd | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
AU2003291757A1 (en) * | 2002-11-08 | 2004-06-03 | Bristol-Myers Squibb Company | Formulations of low solubility bioactive agents and processes for making the same |
BRPI0305500B1 (pt) * | 2003-01-09 | 2018-01-23 | Otsuka Pharmaceutical Co., Ltd. | Processo para preparar aripiprazol |
WO2004064752A2 (en) * | 2003-01-22 | 2004-08-05 | Alkermes Controlled Therapeutics, Inc. | Method of preparing sustained release microparticles |
CN1809545A (zh) * | 2003-06-20 | 2006-07-26 | 艾尼纳制药公司 | N-苯基-哌嗪衍生物和预防或者治疗5HT2c受体相关疾病的方法 |
US20050032781A1 (en) * | 2003-08-06 | 2005-02-10 | Elliot Ehrich | Methods for administering active agents to CYP 2D6 sensitive patients |
US6987111B2 (en) | 2003-08-06 | 2006-01-17 | Alkermes Controlled Therapeutics, Ii | Aripiprazole, olanzapine and haloperidol pamoate salts |
ES2315721T5 (es) * | 2003-10-23 | 2012-08-24 | Otsuka Pharmaceutical Co., Ltd. | Formulación de aripiprazol inyectable estéril de liberación controlada y procedimiento |
GB0326148D0 (en) | 2003-11-10 | 2003-12-17 | Lilly Co Eli | Morpholine derivatives |
US7714129B2 (en) * | 2003-12-16 | 2010-05-11 | Teva Pharmaceutical Industries Ltd. | Methods of preparing anhydrous aripiprazole form II |
TW200529850A (en) * | 2003-12-16 | 2005-09-16 | Teva Pharma | Methods of preparing aripiprazole crystalline forms |
DE202005020539U1 (de) * | 2004-02-05 | 2006-09-28 | Teva Pharmaceutical Industries Ltd. | Aripiprazol |
US7507823B2 (en) * | 2004-05-06 | 2009-03-24 | Bristol-Myers Squibb Company | Process of making aripiprazole particles |
CA2565996A1 (en) * | 2004-05-11 | 2005-11-17 | Pfizer Products Inc. | Combination of atypical antipsychotics and 5-ht1b receptor antagonists |
TW200616608A (en) * | 2004-07-09 | 2006-06-01 | Forest Laboratories | Memantine as adjunctive treatment to atypical antipsychotics in schizophrenia patients |
US20060024362A1 (en) | 2004-07-29 | 2006-02-02 | Pawan Seth | Composition comprising a benzimidazole and process for its manufacture |
CN101111481A (zh) * | 2004-11-18 | 2008-01-23 | 斯索恩有限公司 | 制备结晶阿立哌唑的方法 |
WO2006053780A1 (en) * | 2004-11-18 | 2006-05-26 | Synthon B.V. | Crystalline aripiprazole solvates |
EP1844792A4 (de) * | 2004-12-14 | 2008-05-21 | Shionogi & Co | Therapeutisches mittel gegen obstipation |
EP1686126A1 (de) * | 2005-01-27 | 2006-08-02 | Sandoz AG | Aripiprazol-Salze |
SI1844036T1 (sl) * | 2005-01-27 | 2015-12-31 | Sandoz Ag | Postopek za pripravo aripiprazola |
WO2006097344A1 (en) * | 2005-03-17 | 2006-09-21 | Synthon B.V. | Pharmaceutical tablets of crystalline type ii aripiprazole |
TWI320783B (en) | 2005-04-14 | 2010-02-21 | Otsuka Pharma Co Ltd | Heterocyclic compound |
GT200600161A (es) * | 2005-04-22 | 2007-03-14 | Nuevas combinaciones terapeuticas para el tratamiento o la prevencion de los trastornos psicoticos | |
WO2007035348A2 (en) | 2005-09-15 | 2007-03-29 | Elan Pharma International, Limited | Nanoparticulate aripiprazole formulations |
WO2007075871A2 (en) * | 2005-12-22 | 2007-07-05 | Teva Pharmaceutical Industries Ltd. | Processes for reducing particle size of aripiprazole |
EP1988899A4 (de) * | 2006-02-03 | 2009-12-30 | Reddys Lab Ltd Dr | Aripiprazol-co-kristalle |
US20060223820A1 (en) * | 2006-03-21 | 2006-10-05 | Chemagis Ltd. | Crystalline aripiprazole salts and processes for preparation and purification thereof |
US7799790B2 (en) * | 2006-07-20 | 2010-09-21 | Helm Ag | Amorphous aripiprazole and process for the preparation thereof |
EP1880714A1 (de) * | 2006-07-20 | 2008-01-23 | Helm AG | Amorphes Aripiprazol und Verfahren zu dessen Herstellung |
WO2008047340A1 (en) * | 2006-10-19 | 2008-04-24 | Mor Research Applications Ltd. | Combined therapies of antipsychotic drugs and tetracyclines in the treatment of psychiatric disorders |
ES2401603T3 (es) * | 2006-10-24 | 2013-04-23 | Cambrex Charles City, Inc. | Procedimiento para preparar aripiprazol anhidro de tipo l |
EP1930396B1 (de) * | 2006-12-04 | 2011-07-06 | Merck Patent GmbH | Furochromanderivate |
BRPI0811844A2 (pt) | 2007-05-21 | 2014-11-18 | Reviva Pharmaceuticals Inc | Composto, e, método para tratar um paciente |
LT2170279T (lt) * | 2007-07-31 | 2018-03-12 | Otsuka Pharmaceutical Co., Ltd. | Aripiprazolo suspensijos ir liofilizuotos kompozicijos gamybos būdai |
ES2353444T3 (es) | 2008-01-23 | 2011-03-02 | Helm Ag | Aripiprazol amorfo y procedimiento para su preparación. |
DE102008022221A1 (de) | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitoren der humanen Aldosteronsynthase CYP11B2 |
MX2010012186A (es) * | 2008-05-09 | 2011-02-22 | Univ Emory | Antagonistas del receptor nmda para el tratamiento de transtornos neuropsiquitricos. |
EP2321011A1 (de) * | 2008-06-25 | 2011-05-18 | Pfizer Inc. | Diaryl-verbindungen und ihre verwendungen |
US8431576B2 (en) | 2009-06-25 | 2013-04-30 | Alkermes Pharma Ireland Limited | Heterocyclic compounds for the treatment of neurological and psychological disorders |
MY162348A (en) | 2009-09-11 | 2017-06-15 | Otsuka Pharma Co Ltd | Therapeutic agent for chronic pain |
WO2011030213A1 (en) | 2009-09-14 | 2011-03-17 | Jubilant Organosys Limited | Improved process for the preparation of 7.(4-bromobutoxy) 3,4-dihydrocarbostyril, a precursor of aripiprazole |
US8541404B2 (en) | 2009-11-09 | 2013-09-24 | Elexopharm Gmbh | Inhibitors of the human aldosterone synthase CYP11B2 |
US9145372B2 (en) | 2010-11-15 | 2015-09-29 | Agenebio, Inc. | Pyridazine derivatives, compositions and methods for treating cognitive impairment |
IL296695A (en) | 2011-03-18 | 2022-11-01 | Alkermes Pharma Ireland Ltd | Pharmaceutical preparations containing sorbitan esters |
WO2012131451A1 (en) | 2011-03-30 | 2012-10-04 | Jubilant Life Sciences Limited | Process for producing aripiprazole in anhydrous type i crystals |
TW201309651A (zh) | 2011-06-29 | 2013-03-01 | Otsuka Pharma Co Ltd | 阿立哌唑(aripiprazole)無水物B形結晶微粒子之製造方法 |
JP6333802B2 (ja) | 2012-03-19 | 2018-05-30 | アルカームス ファーマ アイルランド リミテッド | ベンジルアルコールを含む医薬組成物 |
CA2867123C (en) | 2012-03-19 | 2021-02-16 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising water-insoluble antipsychotic agents and glycerol esters |
WO2013142198A1 (en) | 2012-03-19 | 2013-09-26 | Alkermes Pharma Ireland Limited | Pharmaaceutical compositions comprising fatty acid esters |
AU2013259551B2 (en) * | 2012-05-09 | 2017-11-02 | Sunovion Pharmaceuticals Inc. | Heteroaryl compounds and methods of use thereof |
KR101571670B1 (ko) | 2012-08-08 | 2015-11-25 | 주식회사 씨엠지제약 | 아리피프라졸을 포함하는 경구용 속용 필름 제제 |
CN104822660A (zh) * | 2012-08-21 | 2015-08-05 | 詹森药业有限公司 | 阿立哌唑半抗原及其在免疫测定中的应用 |
NZ730571A (en) | 2012-09-19 | 2018-12-21 | Alkermes Pharma Ireland Ltd | Pharmaceutical compositions having improved storage stability |
WO2014078568A1 (en) | 2012-11-14 | 2014-05-22 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
US10525057B2 (en) | 2013-09-24 | 2020-01-07 | Otsuka Pharmaceutical Co., Ltd. | Method of providing aripiprazole to patients having impaired CYP2D6 or CYP3A4 enzyme function |
CA3123897C (en) | 2013-12-20 | 2024-02-06 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
EP3119399A4 (de) | 2014-03-20 | 2017-09-27 | Alkermes Pharma Ireland Limited | Aripiprazolformulierungen mit erhöhten injektionsgeschwindigkeiten |
KR20160139704A (ko) | 2015-05-28 | 2016-12-07 | 주식회사 씨엠지제약 | 아리피프라졸을 포함하는 경구용 속용 필름 제제, 및 이의 제조방법 |
CA2990004C (en) | 2015-06-19 | 2024-04-23 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
US11505555B2 (en) | 2016-12-19 | 2022-11-22 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
US20180170941A1 (en) | 2016-12-19 | 2018-06-21 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
US11273158B2 (en) | 2018-03-05 | 2022-03-15 | Alkermes Pharma Ireland Limited | Aripiprazole dosing strategy |
JP2021528427A (ja) | 2018-06-19 | 2021-10-21 | エージンバイオ, インコーポレイテッド | 認知障害を処置するためのベンゾジアゼピン誘導体、組成物および方法 |
WO2024039886A1 (en) | 2022-08-19 | 2024-02-22 | Agenebio, Inc. | Benzazepine derivatives, compositions, and methods for treating cognitive impairment |
ES2963237A1 (es) * | 2022-08-25 | 2024-03-25 | Consejo Superior Investigacion | Derivados de quinolina-2(1H)-ona para el tratamiento y prevención de enfermedades neurodegenerativas |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA801037A (en) * | 1968-12-10 | Regnier Gilbert | Procede de preparation de nouveaux derives du piperazino-phenylethanol | |
GB1021522A (en) * | 1963-05-10 | 1966-03-02 | Ici Ltd | 2-quinolone derivatives |
GB1075156A (en) * | 1963-08-27 | 1967-07-12 | Luso Farmaco Inst | Substituted piperazines |
NL131192C (de) * | 1965-06-16 | |||
US3362956A (en) * | 1965-08-19 | 1968-01-09 | Sterling Drug Inc | 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines |
US3706749A (en) * | 1967-03-30 | 1972-12-19 | Mcneilab Inc | N-acyl carbostyrils |
US3703522A (en) * | 1967-03-30 | 1972-11-21 | Mcneilab Inc | Carbostyril derivatives |
US3511841A (en) * | 1967-05-29 | 1970-05-12 | Sterling Drug Inc | 1-((4-,5-,6-,and 7-azaindolyl)-lower-alkyl)- 4-substituted-piperazines |
US3635976A (en) * | 1967-12-20 | 1972-01-18 | Pennwalt Corp | 1 - heterocyclic alkyl-1 2 3 4-tetrahydroquinazolinones and analgesic intermediates thereof |
CH523899A (de) * | 1968-07-05 | 1972-06-15 | Cassella Farbwerke Mainkur Ag | Verfahren zur Herstellung von Derivaten des 2-Oxo-1,2-dihydro-chinolins |
DE1795362A1 (de) * | 1968-09-19 | 1972-01-05 | Boehringer Mannheim Gmbh | Basische AEther und Verfahren zur Herstellung derselben |
DE2123923A1 (de) * | 1971-05-14 | 1972-11-23 | Boehringer Mannheim Gmbh, 6800 Mannheim | 4-eckige Klammer auf omega- (Flavon-7yl-oxy) -alkyl eckige Klammer zu -pigerazin-Derivate und Verfahren zu ihrer Herstellung |
BE884459Q (fr) * | 1971-05-14 | 1981-01-26 | Boehringer Mannheim Gmbh | Derives de la 4-(omega-(coumarine-7-yl-oxy)-alkyl)-piperazine et procede de preparation |
DE2335432A1 (de) * | 1973-07-12 | 1975-01-30 | Boehringer Mannheim Gmbh | 3,4-dihydro-2h-naphthalinon-(1)5-oxy-propyl-piperazin-derivate und verfahren zu ihrer herstellung |
US3910924A (en) * | 1972-04-13 | 1975-10-07 | Otsuka Pharma Co Ltd | 3,4-Dihydrocarbostyril derivatives and a process for preparing the same |
JPS48103590A (de) * | 1972-04-13 | 1973-12-25 | ||
US4256890A (en) * | 1972-09-14 | 1981-03-17 | Otsukapharmaceutical Co., Ltd. | 3,4-Dihydrocarbostyril derivatives and process for producing the same |
NL7314812A (de) * | 1972-11-02 | 1974-05-06 | ||
DE2334009A1 (de) * | 1973-07-04 | 1975-01-23 | Boehringer Mannheim Gmbh | Purin-derivate sowie verfahren zu ihrer herstellung |
US3981864A (en) * | 1973-09-08 | 1976-09-21 | Eisai Co., Ltd. | 1,3-Benzodioxol derivatives |
US4026895A (en) * | 1973-09-08 | 1977-05-31 | Eisai Co., Ltd. | 1,3-Benzodioxol derivatives |
US4117228A (en) * | 1973-09-08 | 1978-09-26 | Eisai Co., Ltd. | 1,3-benzodioxol derivatives |
GB1451900A (en) * | 1973-10-30 | 1976-10-06 | Sandoz Ltd | Quinolin-2-1h-ones |
JPS5089376A (de) * | 1973-12-19 | 1975-07-17 | ||
US4032528A (en) * | 1974-03-25 | 1977-06-28 | Sandoz, Inc. | 1,4-substituted-quinolin-2(1h)-ones as cns agents |
US3983121A (en) * | 1974-07-01 | 1976-09-28 | Council Of Scientific And Industrial Research | 1-Substituted 4-(β-2-quinolylethyl)piperazines and 1,2,3,4-tetrahydroquinolyl-ethyl analogues thereof |
US3940397A (en) * | 1974-11-13 | 1976-02-24 | E. R. Squibb & Sons, Inc. | 2-[(Substituted-piperazinyl)alkyl]-1H-benz[de]isoquinoline-1,3(2H)-diones |
DE2631317A1 (de) * | 1975-07-23 | 1977-02-17 | Sandoz Ag | Organische verbindungen, ihre verwendung und herstellung |
US3994900A (en) * | 1976-01-23 | 1976-11-30 | E. R. Squibb & Sons, Inc. | 6-(Or 8)-[[(substituted amino)alkyl]oxy(or thio)]-3,4-dihydro-4-phenyl-2(1H)-quinolinones |
ES456325A1 (es) * | 1976-02-27 | 1978-05-01 | Sandoz Ag | Un procedimiento para la preparacion de nuevos derivados delacido 4-hidroxi-2-quinolinon-3-carboxilico. |
US4210753A (en) * | 1976-03-17 | 1980-07-01 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril compounds |
CH619453A5 (de) * | 1976-03-17 | 1980-09-30 | Otsuka Pharma Co Ltd | |
GB1574665A (en) * | 1976-05-08 | 1980-09-10 | Otsuka Pharma Co Ltd | 3,4-dihydrocarbostyril derivatives and process for preparing the same |
US4110449A (en) * | 1977-05-23 | 1978-08-29 | E. R. Squibb & Sons, Inc. | 2-substituted benzisothiazol-3-ones |
US4166116A (en) * | 1977-11-11 | 1979-08-28 | Canadian Patents And Development Limited | Pharmaceutical compositions containing piperazinyl acylhydroxamic acid derivatives to treat inflammation or anaphylactic allergy conditions |
DE2960178D1 (en) * | 1978-06-06 | 1981-04-09 | Hoechst Ag | New substituted phenylpiperazine derivatives, pharmaceutical compositions containing them and process for their preparation |
DE2827566A1 (de) * | 1978-06-23 | 1980-01-10 | Boehringer Mannheim Gmbh | 1,2-dihydro-chinolin-2-on-derivate und verfahren zu ihrer herstellung |
-
1978
- 1978-03-30 JP JP3778378A patent/JPS54130587A/ja active Granted
-
1979
- 1979-03-27 CA CA000324227A patent/CA1117110A/en not_active Expired
- 1979-03-27 DE DE2953723A patent/DE2953723C2/de not_active Expired
- 1979-03-27 DE DE2912105A patent/DE2912105C2/de not_active Expired
- 1979-03-28 FI FI791034A patent/FI70704C/fi not_active IP Right Cessation
- 1979-03-28 US US06/024,602 patent/US4734416A/en not_active Expired - Lifetime
- 1979-03-28 AU AU45480/79A patent/AU515531B2/en not_active Expired
- 1979-03-29 SU SU792745704A patent/SU1140687A3/ru active
- 1979-03-29 DK DK128679A patent/DK158225C/da not_active IP Right Cessation
- 1979-03-29 AT AT0235179A patent/AT376432B/de not_active IP Right Cessation
- 1979-03-29 SE SE7902794A patent/SE434945B/sv not_active IP Right Cessation
- 1979-03-29 FR FR7907863A patent/FR2421174A1/fr active Granted
- 1979-03-29 BE BE0/194281A patent/BE875174A/xx not_active IP Right Cessation
- 1979-03-29 CH CH295379A patent/CH641455A5/de not_active IP Right Cessation
- 1979-03-29 NO NO791049A patent/NO151321C/no unknown
- 1979-03-30 GB GB7911155A patent/GB2017701B/en not_active Expired
- 1979-03-30 MX MX797848U patent/MX5862E/es unknown
- 1979-03-30 ES ES479134A patent/ES479134A1/es not_active Expired
- 1979-03-30 ZA ZA791516A patent/ZA791516B/xx unknown
- 1979-03-30 IT IT67674/79A patent/IT1119284B/it active
- 1979-03-30 NL NLAANVRAGE7902514,A patent/NL183189C/xx not_active IP Right Cessation
- 1979-03-30 PT PT69422A patent/PT69422A/pt unknown
- 1979-12-17 ES ES486992A patent/ES486992A1/es not_active Expired
- 1979-12-17 ES ES486990A patent/ES486990A1/es not_active Expired
- 1979-12-17 ES ES486991A patent/ES486991A1/es not_active Expired
-
1981
- 1981-09-08 SU SU813328599A patent/SU1232144A3/ru active
-
1982
- 1982-03-26 CH CH190082A patent/CH641350A5/de not_active IP Right Cessation
-
1987
- 1987-03-12 US US07/025,193 patent/US4824840A/en not_active Expired - Lifetime
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AT376432B (de) | Verfahren zum herstellen von neuen carbostyrilderivaten und von deren saeureadditions-salzen | |
AT376207B (de) | Verfahren zum herstellen von neuen piperidinderivaten und deren saeureadditionssalzen | |
AT376208B (de) | Verfahren zum herstellen von neuen piperidinderivaten und deren salzen | |
AT371813B (de) | Verfahren zum herstellen von neuen substituierten propanolamin- und morpholinderivaten und von deren isomeren und salzen | |
AT358023B (de) | Verfahren zur herstellung von neuen substi- tuierten 1,1,2-triphenylalken-derivaten und von deren saeureadditionssalzen | |
AT364851B (de) | Verfahren zur herstellung von neuen thienothiazinderivaten und von deren salzen | |
AT371454B (de) | Verfahren zur herstellung von neuen prostanderivaten und von deren salzen | |
AT374188B (de) | Verfahren zur herstellung von neuen a-alkylimidazolderivaten und deren salzen | |
AT366043B (de) | Verfahren zur herstellung von neuen chinazolinderivaten und deren salzen | |
AT374458B (de) | Verfahren zum herstellen von neuen piperidinderivaten und deren salzen | |
ATA419478A (de) | Verfahren zur herstellung von neuen 1,2,3,4,6,7 -hexahydro-11b, alfa-h-benzo-/a/chinolizin- -derivaten und von deren saeureadditionssalzen | |
AT366666B (de) | Verfahren zur herstellung von neuen amidinosulfon- saeurederivaten und von deren salzen | |
AT369731B (de) | Verfahren zur herstellung von neuen 4-pyridon-3-carbonsaeurederivaten und deren salzen | |
AT370095B (de) | Verfahren zum herstellen von neuen 1-aryl-alkyl-imidazolderivaten und deren salzen | |
AT363937B (de) | Verfahren zur herstellung von neuen bispidinderivaten und deren salzen | |
AT371112B (de) | Verfahren zur herstellung von neuen 2-imino-imidazolidin-derivaten und von deren salzen | |
AT368491B (de) | Verfahren zum herstellen von neuen substituierten 1-phenyl-2-aminopropanolen sowie von deren ersternund saeureadditonssalzen | |
AT375358B (de) | Verfahren zum herstellen von neuen piperazinmethaniminderivaten und von deren saeureadditionssalzen | |
AT365183B (de) | Verfahren zur herstellung von neuen 4-amino-2-piperidinochinazolinderivaten und deren salzen | |
AT376434B (de) | Verfahren zum herstellen von neuen carbostyrilderivaten und von deren saeureadditionssalzen | |
ATA391583A (de) | Verfahren zum herstellen von neuen carbostyrilderivaten und von deren saeureadditionssalzen | |
AT372951B (de) | Verfahren zum herstellen von neuen benzimidazolen bzw. benzimidazolidinen und von deren salzen | |
ATA507181A (de) | Verfahren zum herstellen von neuen 1-arylalkyl-imidazolderivaten und deren salzen | |
AT352727B (de) | Verfahren zur herstellung von neuen indol- derivaten und deren salzen | |
ATA144581A (de) | Verfahren zur herstellung von neuen phenylessig- saeure-derivaten und deren salzen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
ELA | Expired due to lapse of time |