JPS54130587A - Carbostyryl derivative - Google Patents
Carbostyryl derivativeInfo
- Publication number
- JPS54130587A JPS54130587A JP3778378A JP3778378A JPS54130587A JP S54130587 A JPS54130587 A JP S54130587A JP 3778378 A JP3778378 A JP 3778378A JP 3778378 A JP3778378 A JP 3778378A JP S54130587 A JPS54130587 A JP S54130587A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- halogen
- carbostyryl
- lower alkyl
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
- C07D215/28—Alcohols; Ethers thereof with halogen atoms or nitro radicals in positions 5, 6 or 7
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (32)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3778378A JPS54130587A (en) | 1978-03-30 | 1978-03-30 | Carbostyryl derivative |
DE2912105A DE2912105C2 (de) | 1978-03-30 | 1979-03-27 | Neue carbostyrilderivate, verfahren zu deren herstellung und diese enthaltende mittel |
CA000324227A CA1117110A (en) | 1978-03-30 | 1979-03-27 | Carbostyril derivatives and process for preparation thereof |
DE2953723A DE2953723C2 (de) | 1978-03-30 | 1979-03-27 | Neue carbostyrilderivate, verfahren zu deren herstellung und diese enthaltende mittel |
US06/024,602 US4734416A (en) | 1978-03-30 | 1979-03-28 | Pharmaceutically useful carbostyril derivatives |
FI791034A FI70704C (fi) | 1978-03-30 | 1979-03-28 | Foerfarande foer framstaellning av ett karbostyrilderivat med antihistamineffekt och inverkan pao centrala nervsystemet |
AU45480/79A AU515531B2 (en) | 1978-03-30 | 1979-03-28 | Novel carbostyril derivatives |
BE0/194281A BE875174A (fr) | 1978-03-30 | 1979-03-29 | Nouveaux derives de carbostyrile, leur procede de preparation et leurs applications en therapeutique |
NO791049A NO151321C (no) | 1978-03-30 | 1979-03-29 | Analogifremgangsmaate for fremstilling av terapeutisk aktive karbostyrilderivater |
SE7902794A SE434945B (sv) | 1978-03-30 | 1979-03-29 | Karbostyrilderivat |
CH295379A CH641455A5 (de) | 1978-03-30 | 1979-03-29 | Carbostyril-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen. |
FR7907863A FR2421174A1 (fr) | 1978-03-30 | 1979-03-29 | Nouveaux derives de carbostyrile, leur procede de preparation et leurs applications en therapeutique |
AT0235179A AT376432B (de) | 1978-03-30 | 1979-03-29 | Verfahren zum herstellen von neuen carbostyrilderivaten und von deren saeureadditions-salzen |
DK128679A DK158225C (da) | 1978-03-30 | 1979-03-29 | Analogifremgangsmaade til fremstilling af carbostyrilderivater |
SU792745704A SU1140687A3 (ru) | 1978-03-30 | 1979-03-29 | Способ получени карбостирильных производных или их фармацевтически приемлемых солей с кислотами |
ZA791516A ZA791516B (en) | 1978-03-30 | 1979-03-30 | Novel carbostyril derivatives and process for preparation thereof |
MX797848U MX5862E (es) | 1978-03-30 | 1979-03-30 | Procedimiento para la produccion de derivados de carboestirilo |
ES479134A ES479134A1 (es) | 1978-03-30 | 1979-03-30 | Un procedimiento para la preparacion de un derivado de car- boestirilo. |
GB7911155A GB2017701B (en) | 1978-03-30 | 1979-03-30 | Carbostyril derivatives |
IT67674/79A IT1119284B (it) | 1978-03-30 | 1979-03-30 | Derivati carbostirilici e procedimento per la loro preparazione |
PT69422A PT69422A (en) | 1978-03-30 | 1979-03-30 | Novel carbostyril derivatives and process for preparation thereof |
NLAANVRAGE7902514,A NL183189C (nl) | 1978-03-30 | 1979-03-30 | Farmaceutisch preparaat dat een met een (piperazine-1-yl)alkoxygroep gesubstitueerd carbostyrilderivaat bevat, alsmede een dergelijk carbostyrilderivaat. |
ES486990A ES486990A1 (es) | 1978-03-30 | 1979-12-17 | Un procedimiento para la preparacion de un derivado de car- boestirilo |
ES486991A ES486991A1 (es) | 1978-03-30 | 1979-12-17 | Un procedimiento para la preparacion de un derivado de car- boestirilo |
ES486992A ES486992A1 (es) | 1978-03-30 | 1979-12-17 | Un procedimiento para la preparacion de un derivado de car- boestirilo |
SU813328599A SU1232144A3 (ru) | 1978-03-30 | 1981-09-08 | Способ получени карбостирильных производных |
CH190082A CH641350A5 (de) | 1978-03-30 | 1982-03-26 | Pharmazeutische zusammensetzung zur verwendung als antihistaminicum, auf der basis eines carbostyrilderivates. |
AT391783A AT376435B (de) | 1978-03-30 | 1983-11-07 | Verfahren zum herstellen von neuen carbostyrilderivaten und von deren saeureadditionssalzen |
AT391583A AT376433B (de) | 1978-03-30 | 1983-11-07 | Verfahren zum herstellen von neuen carbostyrilderivaten und von deren saeureadditionssalzen |
AT391683A AT376434B (de) | 1978-03-30 | 1983-11-07 | Verfahren zum herstellen von neuen carbostyrilderivaten und von deren saeureadditionssalzen |
JP61295668A JPS62149664A (ja) | 1978-03-30 | 1986-12-10 | カルボスチリル誘導体の製造法 |
US07/025,193 US4824840A (en) | 1978-03-30 | 1987-03-12 | Carbostyril derivatives and pharmaceutical preparations containing same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3778378A JPS54130587A (en) | 1978-03-30 | 1978-03-30 | Carbostyryl derivative |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP61295668A Division JPS62149664A (ja) | 1978-03-30 | 1986-12-10 | カルボスチリル誘導体の製造法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS54130587A true JPS54130587A (en) | 1979-10-09 |
JPS6223750B2 JPS6223750B2 (ja) | 1987-05-25 |
Family
ID=12507080
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3778378A Granted JPS54130587A (en) | 1978-03-30 | 1978-03-30 | Carbostyryl derivative |
Country Status (21)
Country | Link |
---|---|
US (2) | US4734416A (ja) |
JP (1) | JPS54130587A (ja) |
AT (1) | AT376432B (ja) |
AU (1) | AU515531B2 (ja) |
BE (1) | BE875174A (ja) |
CA (1) | CA1117110A (ja) |
CH (2) | CH641455A5 (ja) |
DE (2) | DE2912105C2 (ja) |
DK (1) | DK158225C (ja) |
ES (4) | ES479134A1 (ja) |
FI (1) | FI70704C (ja) |
FR (1) | FR2421174A1 (ja) |
GB (1) | GB2017701B (ja) |
IT (1) | IT1119284B (ja) |
MX (1) | MX5862E (ja) |
NL (1) | NL183189C (ja) |
NO (1) | NO151321C (ja) |
PT (1) | PT69422A (ja) |
SE (1) | SE434945B (ja) |
SU (2) | SU1140687A3 (ja) |
ZA (1) | ZA791516B (ja) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS552693A (en) * | 1978-06-23 | 1980-01-10 | Boehringer Mannheim Gmbh | 1*22dihydrooquinolinee22one derivative*its manufacture and allurgic affection therapeutic drug containing it |
JPS57193461A (en) * | 1981-05-22 | 1982-11-27 | Otsuka Pharmaceut Co Ltd | Benzazepine derivative |
JPS6129331A (ja) * | 1985-03-13 | 1986-02-10 | アラ−ガン・ハンフリ− | 検眼装置 |
JPH02191256A (ja) * | 1988-10-31 | 1990-07-27 | Otsuka Pharmaceut Co Ltd | カルボスチリル誘導体及び該誘導体を含有する精神分裂病治療剤 |
JPH07304741A (ja) * | 1995-03-16 | 1995-11-21 | Otsuka Pharmaceut Co Ltd | カルボスチリル誘導体及び該誘導体を含有する精神分裂病治療剤 |
JP2004517937A (ja) * | 2001-01-29 | 2004-06-17 | 大塚製薬株式会社 | 5−ht1a受容体サブタイプ作動薬 |
US7910589B2 (en) | 2001-09-25 | 2011-03-22 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
JP2011520815A (ja) * | 2008-05-09 | 2011-07-21 | エモリー・ユニバーシテイ | 精神神経障害治療のためのnmda受容体拮抗薬 |
US8030312B2 (en) | 2001-01-29 | 2011-10-04 | Otsuka Pharmaceutical Co., Ltd. | 5-HT1A receptor subtype agonist |
US8703772B2 (en) | 2001-09-25 | 2014-04-22 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
Families Citing this family (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3034237A1 (de) * | 1979-09-18 | 1981-04-16 | Otsuka Pharmaceutical Co. Ltd., Tokyo | Carbostyrilderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende, antihistaminisch wirkende mittel |
PH17194A (en) * | 1980-03-06 | 1984-06-19 | Otsuka Pharma Co Ltd | Novel carbostyril derivatives,and pharmaceutical composition containing the same |
DE3442570A1 (de) * | 1984-11-22 | 1986-05-22 | Hoechst Ag, 6230 Frankfurt | Neue substituierte phenylpiperazinderivate, verfahren zu deren herstellung und die verwendung substituierter phenylpiperazinderivate als aggressionshemmer fuer tiere |
DK588486A (da) * | 1985-12-09 | 1987-06-10 | Otsuka Pharma Co Ltd | Anvendelse af en forbindelse til behandling af hypoxi |
KR940000785B1 (ko) * | 1986-04-02 | 1994-01-31 | 오오쓰까세이야꾸 가부시끼가이샤 | 카르보스티릴 유도체 및 그의 염의 제조 방법 |
DK167187A (da) * | 1986-04-02 | 1987-10-03 | Otsuka Pharma Co Ltd | Carbostyrilderivater og salte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddel indeholdende disse |
JPH0696555B2 (ja) * | 1986-07-31 | 1994-11-30 | 大塚製薬株式会社 | カルボスチリル誘導体 |
DE3784401T2 (de) * | 1986-07-31 | 1993-08-12 | Otsuka Pharma Co Ltd | Karbostyril-derivate und ihre salze, verfahren zu ihrer herstellung und diese enthaltende kardiotonische zusammensetzung. |
US4803203A (en) * | 1986-11-05 | 1989-02-07 | Warner-Lambert Company | Phenyl and heterocyclic piperazinyl alkoxy-benzheterocyclic compounds as antipsychotic agents |
EP0269383A3 (en) * | 1986-11-21 | 1990-05-02 | A.H. Robins Company, Incorporated | 1-Aryloxy-4-[(4-aryl)-1-piperazinyl]-2-butanols useful as antiallergy agents |
FR2637591B1 (fr) * | 1988-10-11 | 1992-10-23 | Synthelabo | Derives de quinoleinone, leur preparation et leur application en therapeutique |
US5006528A (en) * | 1988-10-31 | 1991-04-09 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives |
MY129350A (en) * | 2001-04-25 | 2007-03-30 | Bristol Myers Squibb Co | Aripiprazole oral solution |
PE20030445A1 (es) | 2001-09-25 | 2003-07-26 | Otsuka Pharma Co Ltd | Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma |
US20040185110A1 (en) * | 2002-11-08 | 2004-09-23 | Ronald Harland | Formulations of low solubility bioactive agents and processes for making the same |
EP1480953B2 (en) * | 2003-01-09 | 2010-08-18 | Otsuka Pharmaceutical Co., Ltd. | Process for preparing aripiprazole |
WO2004064752A2 (en) * | 2003-01-22 | 2004-08-05 | Alkermes Controlled Therapeutics, Inc. | Method of preparing sustained release microparticles |
EA200600071A1 (ru) * | 2003-06-20 | 2006-08-25 | Арена Фармасьютикалз, Инк. | Производные n-фенилпиперазина и способы профилактики или лечения заболеваний, связанных с 5ht-рецептором |
US20050032781A1 (en) * | 2003-08-06 | 2005-02-10 | Elliot Ehrich | Methods for administering active agents to CYP 2D6 sensitive patients |
US6987111B2 (en) | 2003-08-06 | 2006-01-17 | Alkermes Controlled Therapeutics, Ii | Aripiprazole, olanzapine and haloperidol pamoate salts |
ATE411797T2 (de) | 2003-10-23 | 2008-11-15 | Otsuka Pharma Co Ltd | Sterile injizierbare aripiprazol-formulierung mit kontrollierter freisetzung und verfahren |
GB0326148D0 (en) | 2003-11-10 | 2003-12-17 | Lilly Co Eli | Morpholine derivatives |
PT1613598E (pt) * | 2003-12-16 | 2012-01-13 | Teva Pharma | Métodos para preparar formas cristalinas de aripiprazol |
US7714129B2 (en) * | 2003-12-16 | 2010-05-11 | Teva Pharmaceutical Industries Ltd. | Methods of preparing anhydrous aripiprazole form II |
WO2005077904A1 (en) * | 2004-02-05 | 2005-08-25 | Teva Pharmaceutical Industries, Ltd. | Process for preparing aripiprazole |
US7507823B2 (en) * | 2004-05-06 | 2009-03-24 | Bristol-Myers Squibb Company | Process of making aripiprazole particles |
MXPA06013163A (es) * | 2004-05-11 | 2007-02-13 | Pfizer Prod Inc | Combinacion de antipsicoticos atipicos y antagonistas del receptor 5-ht1b. |
TW200616608A (en) * | 2004-07-09 | 2006-06-01 | Forest Laboratories | Memantine as adjunctive treatment to atypical antipsychotics in schizophrenia patients |
US20060024362A1 (en) * | 2004-07-29 | 2006-02-02 | Pawan Seth | Composition comprising a benzimidazole and process for its manufacture |
EP1812397A1 (en) * | 2004-11-18 | 2007-08-01 | Synthon B.V. | Process of making crystalline aripiprazole |
CN101087760B (zh) * | 2004-11-18 | 2011-09-28 | 斯索恩有限公司 | 结晶的阿立哌唑溶剂化物 |
JPWO2006064780A1 (ja) * | 2004-12-14 | 2008-06-12 | 塩野義製薬株式会社 | 便秘治療剤 |
PL1844036T3 (pl) * | 2005-01-27 | 2016-02-29 | Sandoz Ag | Sposób otrzymywania arypiprazolu |
EP1686126A1 (en) * | 2005-01-27 | 2006-08-02 | Sandoz AG | Salts of aripiprazole |
ES2526415T3 (es) * | 2005-03-17 | 2015-01-12 | Synthon B.V. | Comprimidos farmacéuticos de aripiprazol cristalino de tipo II |
TWI320783B (en) | 2005-04-14 | 2010-02-21 | Otsuka Pharma Co Ltd | Heterocyclic compound |
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JP2009508859A (ja) | 2005-09-15 | 2009-03-05 | エラン ファーマ インターナショナル リミテッド | ナノ粒子アリピプラゾール製剤 |
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WO2008047340A1 (en) * | 2006-10-19 | 2008-04-24 | Mor Research Applications Ltd. | Combined therapies of antipsychotic drugs and tetracyclines in the treatment of psychiatric disorders |
US8039621B2 (en) * | 2006-10-24 | 2011-10-18 | Cambrex Charles City, Inc. | Process for preparing anhydrous Aripirazole type I |
EP1930396B1 (de) * | 2006-12-04 | 2011-07-06 | Merck Patent GmbH | Furochromanderivate |
EP2162135A4 (en) | 2007-05-21 | 2012-02-22 | Reviva Pharmaceuticals Inc | COMPOSITIONS, SYNTHESIS AND METHOD FOR THE APPLICATION OF ATTAINED CHINOLINONE-BASED ANTIPSYCHOTICS |
MY152789A (en) * | 2007-07-31 | 2014-11-28 | Otsuka Pharma Co Ltd | Methods for producing aripiprazole suspension and freeze-dried formulation |
ES2353444T3 (es) | 2008-01-23 | 2011-03-02 | Helm Ag | Aripiprazol amorfo y procedimiento para su preparación. |
DE102008022221A1 (de) | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitoren der humanen Aldosteronsynthase CYP11B2 |
JP2011526881A (ja) * | 2008-06-25 | 2011-10-20 | ファイザー・インク | ジアリール化合物およびそれらの使用 |
EP3309151A1 (en) | 2009-06-25 | 2018-04-18 | Alkermes Pharma Ireland Limited | Heterocyclic compounds for the treatment of neurological and psychological disorders |
KR20160147061A (ko) | 2009-09-11 | 2016-12-21 | 오츠카 세이야쿠 가부시키가이샤 | 만성 동통 치료제 |
WO2011030213A1 (en) | 2009-09-14 | 2011-03-17 | Jubilant Organosys Limited | Improved process for the preparation of 7.(4-bromobutoxy) 3,4-dihydrocarbostyril, a precursor of aripiprazole |
US8541404B2 (en) | 2009-11-09 | 2013-09-24 | Elexopharm Gmbh | Inhibitors of the human aldosterone synthase CYP11B2 |
NO3034079T3 (ja) | 2010-11-15 | 2018-06-09 | ||
HRP20240285T1 (hr) * | 2011-03-18 | 2024-05-24 | Alkermes Pharma Ireland Limited | Farmaceutski pripravci koji sadrže sorbitan estere |
WO2012131451A1 (en) | 2011-03-30 | 2012-10-04 | Jubilant Life Sciences Limited | Process for producing aripiprazole in anhydrous type i crystals |
TW201309651A (zh) | 2011-06-29 | 2013-03-01 | Otsuka Pharma Co Ltd | 阿立哌唑(aripiprazole)無水物B形結晶微粒子之製造方法 |
US9999670B2 (en) | 2012-03-19 | 2018-06-19 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising benzyl alcohol |
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1978
- 1978-03-30 JP JP3778378A patent/JPS54130587A/ja active Granted
-
1979
- 1979-03-27 DE DE2912105A patent/DE2912105C2/de not_active Expired
- 1979-03-27 DE DE2953723A patent/DE2953723C2/de not_active Expired
- 1979-03-27 CA CA000324227A patent/CA1117110A/en not_active Expired
- 1979-03-28 FI FI791034A patent/FI70704C/fi not_active IP Right Cessation
- 1979-03-28 AU AU45480/79A patent/AU515531B2/en not_active Expired
- 1979-03-28 US US06/024,602 patent/US4734416A/en not_active Expired - Lifetime
- 1979-03-29 NO NO791049A patent/NO151321C/no unknown
- 1979-03-29 SE SE7902794A patent/SE434945B/sv not_active IP Right Cessation
- 1979-03-29 AT AT0235179A patent/AT376432B/de not_active IP Right Cessation
- 1979-03-29 BE BE0/194281A patent/BE875174A/xx not_active IP Right Cessation
- 1979-03-29 SU SU792745704A patent/SU1140687A3/ru active
- 1979-03-29 FR FR7907863A patent/FR2421174A1/fr active Granted
- 1979-03-29 DK DK128679A patent/DK158225C/da not_active IP Right Cessation
- 1979-03-29 CH CH295379A patent/CH641455A5/de not_active IP Right Cessation
- 1979-03-30 IT IT67674/79A patent/IT1119284B/it active
- 1979-03-30 MX MX797848U patent/MX5862E/es unknown
- 1979-03-30 ZA ZA791516A patent/ZA791516B/xx unknown
- 1979-03-30 PT PT69422A patent/PT69422A/pt unknown
- 1979-03-30 NL NLAANVRAGE7902514,A patent/NL183189C/xx not_active IP Right Cessation
- 1979-03-30 GB GB7911155A patent/GB2017701B/en not_active Expired
- 1979-03-30 ES ES479134A patent/ES479134A1/es not_active Expired
- 1979-12-17 ES ES486990A patent/ES486990A1/es not_active Expired
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1981
- 1981-09-08 SU SU813328599A patent/SU1232144A3/ru active
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1982
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1987
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Cited By (30)
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JPS552693A (en) * | 1978-06-23 | 1980-01-10 | Boehringer Mannheim Gmbh | 1*22dihydrooquinolinee22one derivative*its manufacture and allurgic affection therapeutic drug containing it |
JPS6331465B2 (ja) * | 1978-06-23 | 1988-06-23 | Boehringer Mannheim Gmbh | |
JPS57193461A (en) * | 1981-05-22 | 1982-11-27 | Otsuka Pharmaceut Co Ltd | Benzazepine derivative |
JPS6129331A (ja) * | 1985-03-13 | 1986-02-10 | アラ−ガン・ハンフリ− | 検眼装置 |
JPH02191256A (ja) * | 1988-10-31 | 1990-07-27 | Otsuka Pharmaceut Co Ltd | カルボスチリル誘導体及び該誘導体を含有する精神分裂病治療剤 |
JPH07304741A (ja) * | 1995-03-16 | 1995-11-21 | Otsuka Pharmaceut Co Ltd | カルボスチリル誘導体及び該誘導体を含有する精神分裂病治療剤 |
US8722680B2 (en) | 2001-01-29 | 2014-05-13 | Otsuka Pharmaceutical Co., Ltd. | Method of treating neurodegenerative diseases |
US8642600B2 (en) | 2001-01-29 | 2014-02-04 | Otsuka Pharmaceutical Co., Ltd. | Method of treating autism |
US9387207B2 (en) | 2001-01-29 | 2016-07-12 | Otsuka Pharmaceutical Co., Ltd. | 5-HT1A receptor subtype agonist |
US9089567B2 (en) | 2001-01-29 | 2015-07-28 | Otsuka Pharmaceutical Co., Ltd. | Method of treating cognitive impairments and schizophrenias |
US8030312B2 (en) | 2001-01-29 | 2011-10-04 | Otsuka Pharmaceutical Co., Ltd. | 5-HT1A receptor subtype agonist |
US9006248B2 (en) | 2001-01-29 | 2015-04-14 | Otsuka Pharmaceutical Co., Ltd. | 5-HT1A receptor subtype agonist |
US8426423B2 (en) | 2001-01-29 | 2013-04-23 | Otsuka Pharmaceutical Co., Ltd. | Method of treating Attention Deficit Hyper-Activity Disorder |
JP2004517937A (ja) * | 2001-01-29 | 2004-06-17 | 大塚製薬株式会社 | 5−ht1a受容体サブタイプ作動薬 |
US8604041B2 (en) | 2001-01-29 | 2013-12-10 | Otsuka Pharmaceutical Co., Ltd. | Method of treating panic disorder |
US8623874B2 (en) | 2001-01-29 | 2014-01-07 | Otsuka Pharmaceutical Co., Ltd. | Method of treating neurodegenerative diseases |
US8680105B2 (en) | 2001-01-29 | 2014-03-25 | Otsuka Pharmaceutical Co., Ltd. | Method of treating down's syndrome |
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US8642760B2 (en) | 2001-09-25 | 2014-02-04 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
US8703773B2 (en) | 2001-09-25 | 2014-04-22 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
US8703772B2 (en) | 2001-09-25 | 2014-04-22 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
US8580796B2 (en) | 2001-09-25 | 2013-11-12 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
US8901130B2 (en) | 2001-09-25 | 2014-12-02 | Ostuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation |
US7910589B2 (en) | 2001-09-25 | 2011-03-22 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
US8993761B2 (en) | 2001-09-25 | 2015-03-31 | Otsuka Pharamceutical Co. Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
US8399469B2 (en) | 2001-09-25 | 2013-03-19 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
US8017615B2 (en) | 2001-09-25 | 2011-09-13 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
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US10150735B2 (en) | 2001-09-25 | 2018-12-11 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
JP2011520815A (ja) * | 2008-05-09 | 2011-07-21 | エモリー・ユニバーシテイ | 精神神経障害治療のためのnmda受容体拮抗薬 |
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