GB1021522A - 2-quinolone derivatives - Google Patents

2-quinolone derivatives

Info

Publication number
GB1021522A
GB1021522A GB1862063A GB1862063A GB1021522A GB 1021522 A GB1021522 A GB 1021522A GB 1862063 A GB1862063 A GB 1862063A GB 1862063 A GB1862063 A GB 1862063A GB 1021522 A GB1021522 A GB 1021522A
Authority
GB
United Kingdom
Prior art keywords
formula
stands
compound
radical
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1862063A
Inventor
Bernard Joseph Mcloughlin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Priority to GB1862063A priority Critical patent/GB1021522A/en
Priority to DK228864A priority patent/DK108973C/en
Priority to CH589164A priority patent/CH452526A/en
Priority to FR1561911D priority patent/FR1561911A/fr
Priority to NL6405107A priority patent/NL6405107A/xx
Priority to BE647697A priority patent/BE647697A/xx
Priority to DEI25807A priority patent/DE1227462B/en
Publication of GB1021522A publication Critical patent/GB1021522A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients

Abstract

The invention comprises compounds of the general formula <FORM:1021522/C2/1> (wherein R1 stands for an alkyl or hydroxyalkyl radical and R2 stands for an alkyl or alkenyl radical) and acid addition salts thereof, pharmaceutical preparations containing them, and their preparation by (a) reacting a compound of the formula <FORM:1021522/C2/2> (wherein X stands for a halogen atom) with R1NH2; (b) reacting a compound of the formula <FORM:1021522/C2/3> or a salt thereof, with a compound (which may be generated in situ) of the formula <FORM:1021522/C2/4> or (c) subjecting a compound of the formula <FORM:1021522/C2/5> (wherein R3 stands for a hydrogenolysable radical) to catalytic hydrogenolysis, optionally followed in each case by acid addition salt formation. The preparation of a number of starting materials of Formulae (II), (III) and (V) is described. The compounds of the invention possess b -adrenergic blocking activity and may be administered in the form of pharmaceutical preparations (e.g. tablets, capsules, solutions, suspensions, syrups, elixirs and dispersible powders) containing them in association with a diluent or carrier.
GB1862063A 1963-05-10 1963-05-10 2-quinolone derivatives Expired GB1021522A (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
GB1862063A GB1021522A (en) 1963-05-10 1963-05-10 2-quinolone derivatives
DK228864A DK108973C (en) 1963-05-10 1964-05-06 Process for the preparation of quinoline compounds or the acid addition salts thereof.
CH589164A CH452526A (en) 1963-05-10 1964-05-06 Process for the preparation of heterocyclic compounds
FR1561911D FR1561911A (en) 1963-05-10 1964-05-08
NL6405107A NL6405107A (en) 1963-05-10 1964-05-08
BE647697A BE647697A (en) 1963-05-10 1964-05-08
DEI25807A DE1227462B (en) 1963-05-10 1964-05-11 Process for the preparation of quinoline derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1862063A GB1021522A (en) 1963-05-10 1963-05-10 2-quinolone derivatives

Publications (1)

Publication Number Publication Date
GB1021522A true GB1021522A (en) 1966-03-02

Family

ID=10115585

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1862063A Expired GB1021522A (en) 1963-05-10 1963-05-10 2-quinolone derivatives

Country Status (7)

Country Link
BE (1) BE647697A (en)
CH (1) CH452526A (en)
DE (1) DE1227462B (en)
DK (1) DK108973C (en)
FR (1) FR1561911A (en)
GB (1) GB1021522A (en)
NL (1) NL6405107A (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK137976A (en) * 1972-04-13 1976-03-29 Otsuka Pharma Co Ltd PROCEDURE FOR PREPARING 2,4-DIHYDROCARBOSTYRIL DERIVATIVES
JPS54130587A (en) * 1978-03-30 1979-10-09 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
JPS56122356A (en) * 1980-02-29 1981-09-25 Otsuka Pharmaceut Co Ltd Carbostyril derivative

Also Published As

Publication number Publication date
DK108973C (en) 1968-03-04
BE647697A (en) 1964-11-09
FR1561911A (en) 1969-04-04
NL6405107A (en) 1964-11-11
DE1227462B (en) 1966-10-27
CH452526A (en) 1968-03-15

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