JPS5566580A - Coumarin derivative, its preparation and antiallergic agent containing the same as effective component - Google Patents

Coumarin derivative, its preparation and antiallergic agent containing the same as effective component

Info

Publication number
JPS5566580A
JPS5566580A JP13923178A JP13923178A JPS5566580A JP S5566580 A JPS5566580 A JP S5566580A JP 13923178 A JP13923178 A JP 13923178A JP 13923178 A JP13923178 A JP 13923178A JP S5566580 A JPS5566580 A JP S5566580A
Authority
JP
Japan
Prior art keywords
formula
compound
preparation
antiallergic agent
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP13923178A
Other languages
Japanese (ja)
Other versions
JPS6136754B2 (en
Inventor
Kiyoshi Kuriyama
Jun Nakano
Kiyonoshin Ichikawa
Kiyoshi Ito
Yuji Suzuki
Katsuro Ishizuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kaken Pharmaceutical Co Ltd
Original Assignee
Kaken Pharmaceutical Co Ltd
Kakenyaku Kako KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaken Pharmaceutical Co Ltd, Kakenyaku Kako KK filed Critical Kaken Pharmaceutical Co Ltd
Priority to JP13923178A priority Critical patent/JPS5566580A/en
Publication of JPS5566580A publication Critical patent/JPS5566580A/en
Publication of JPS6136754B2 publication Critical patent/JPS6136754B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:Coumarin derivatives of formula I (R is H, alkyl, halogen; n is 1, 2; two Rs arbitrarily adjacent to each other may form a condensed ring along with binding carbon atoms). EXAMPLE:6-Isopropyl-3-(1H-tetrazol-5-yl)coumarin. USE:Antiallergic agent; they depress histamines from mast cells caused by immune reactions and the liberation of SRS-A and are used as remedy and preventive for allergic asthma, dermatitis, rhinitis and enterogastritis. PREPARATION:A compound of formula II is made to react with hydrogen azide or its salt to give the compound of formula I. The reaction is conducted in a solvent of benzene or so, at room temperature-130 deg.C. The compounds of formula II are partially novel and, for example, obtained by reaction of a compound of formula III with a cyanomalonic ester.
JP13923178A 1978-11-11 1978-11-11 Coumarin derivative, its preparation and antiallergic agent containing the same as effective component Granted JPS5566580A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13923178A JPS5566580A (en) 1978-11-11 1978-11-11 Coumarin derivative, its preparation and antiallergic agent containing the same as effective component

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13923178A JPS5566580A (en) 1978-11-11 1978-11-11 Coumarin derivative, its preparation and antiallergic agent containing the same as effective component

Publications (2)

Publication Number Publication Date
JPS5566580A true JPS5566580A (en) 1980-05-20
JPS6136754B2 JPS6136754B2 (en) 1986-08-20

Family

ID=15240527

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13923178A Granted JPS5566580A (en) 1978-11-11 1978-11-11 Coumarin derivative, its preparation and antiallergic agent containing the same as effective component

Country Status (1)

Country Link
JP (1) JPS5566580A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014152213A3 (en) * 2013-03-15 2014-11-13 Discoverybiomed, Inc. Coumarin derivatives and methods of use in treating cystic fibrosis, chronic obstructive pulmonary disease, and misfolded protein disorders
WO2014152278A3 (en) * 2013-03-15 2014-11-13 Discoverybiomed, Inc. Coumarin derivatives and methods of use in treating hyperproliferative diseases
US9221840B2 (en) 2011-05-17 2015-12-29 Discoverybiomed Inc. Treating protein folding disorders with small molecule CFTR correctors
US9546176B2 (en) 2012-11-20 2017-01-17 Discoverybiomed, Inc. Small molecule bicyclic and tricyclic CFTR correctors
US9676779B2 (en) 2012-11-20 2017-06-13 Discoverybiomed, Inc. Small molecule CFTR correctors
CN108069929A (en) * 2016-11-18 2018-05-25 中国科学院大连化学物理研究所 3- substituted cumarins analog derivative and the agonist of application and GPR35 receptors

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9221840B2 (en) 2011-05-17 2015-12-29 Discoverybiomed Inc. Treating protein folding disorders with small molecule CFTR correctors
US9546176B2 (en) 2012-11-20 2017-01-17 Discoverybiomed, Inc. Small molecule bicyclic and tricyclic CFTR correctors
US9676779B2 (en) 2012-11-20 2017-06-13 Discoverybiomed, Inc. Small molecule CFTR correctors
WO2014152213A3 (en) * 2013-03-15 2014-11-13 Discoverybiomed, Inc. Coumarin derivatives and methods of use in treating cystic fibrosis, chronic obstructive pulmonary disease, and misfolded protein disorders
WO2014152278A3 (en) * 2013-03-15 2014-11-13 Discoverybiomed, Inc. Coumarin derivatives and methods of use in treating hyperproliferative diseases
US9815825B2 (en) 2013-03-15 2017-11-14 Discoverybiomed, Inc. Coumarin derivatives and methods of use in treating cystic fibrosis, chronic obstructive pulmonary disease, and misfolded protein disorders
US10369145B2 (en) 2013-03-15 2019-08-06 Discoverybiomed, Inc. Coumarin derivatives and methods of use in treating hyperproliferative diseases
CN108069929A (en) * 2016-11-18 2018-05-25 中国科学院大连化学物理研究所 3- substituted cumarins analog derivative and the agonist of application and GPR35 receptors

Also Published As

Publication number Publication date
JPS6136754B2 (en) 1986-08-20

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