JPS5746986A - Pyrido(1,2,3-de)(1,4)benzoxazine derivative - Google Patents

Pyrido(1,2,3-de)(1,4)benzoxazine derivative

Info

Publication number
JPS5746986A
JPS5746986A JP55121540A JP12154080A JPS5746986A JP S5746986 A JPS5746986 A JP S5746986A JP 55121540 A JP55121540 A JP 55121540A JP 12154080 A JP12154080 A JP 12154080A JP S5746986 A JPS5746986 A JP S5746986A
Authority
JP
Japan
Prior art keywords
formula
compound expressed
pyrido
salt
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP55121540A
Other languages
English (en)
Other versions
JPS6111955B2 (ja
Inventor
Isao Hayakawa
Tokiyuki Hiramitsu
Yoshiaki Tanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=14813767&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPS5746986(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Priority to JP55121540A priority Critical patent/JPS5746986A/ja
Priority to PH26040A priority patent/PH18276A/en
Priority to ZA815604A priority patent/ZA815604B/xx
Priority to IL63613A priority patent/IL63613A/xx
Priority to DE8181106747T priority patent/DE3167216D1/de
Priority to AT81106747T priority patent/ATE10282T1/de
Priority to EP81106747A priority patent/EP0047005B1/en
Priority to KR1019810003207A priority patent/KR840002141B1/ko
Priority to NO812956A priority patent/NO158507C/no
Priority to ES505116A priority patent/ES505116A0/es
Priority to YU2109/81A priority patent/YU42422B/xx
Priority to FI812693A priority patent/FI71155C/fi
Priority to NZ198224A priority patent/NZ198224A/en
Priority to SI8112109A priority patent/SI8112109A8/sl
Priority to CA000385046A priority patent/CA1167840A/en
Priority to DK388981A priority patent/DK158267C/da
Priority to AU74878/81A priority patent/AU529263B2/en
Priority to US06/298,816 priority patent/US4382892A/en
Priority to GR65931A priority patent/GR74637B/el
Priority to IN985/CAL/81A priority patent/IN155680B/en
Publication of JPS5746986A publication Critical patent/JPS5746986A/ja
Publication of JPS6111955B2 publication Critical patent/JPS6111955B2/ja
Priority to HK821/86A priority patent/HK82186A/xx
Priority to MY712/86A priority patent/MY8600712A/xx
Priority to DK204488A priority patent/DK204488D0/da
Priority to YU74788A priority patent/YU47193B/sh
Priority to HRP-747/88A priority patent/HRP930087A2/xx
Priority to BA970190A priority patent/BA97190B1/bs
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP55121540A 1980-09-02 1980-09-02 Pyrido(1,2,3-de)(1,4)benzoxazine derivative Granted JPS5746986A (en)

Priority Applications (26)

Application Number Priority Date Filing Date Title
JP55121540A JPS5746986A (en) 1980-09-02 1980-09-02 Pyrido(1,2,3-de)(1,4)benzoxazine derivative
PH26040A PH18276A (en) 1980-09-02 1981-08-12 Benzoxazine derivatives and process of preparation
ZA815604A ZA815604B (en) 1980-09-02 1981-08-13 Benzoxazine derivatives
IL63613A IL63613A (en) 1980-09-02 1981-08-19 Dihydrohalo oxo-pyrido(1,2,3-de)(1,4)benzoxazine carboxylic acid derivatives,their preparation and pharmaceutical compositions containing them
DE8181106747T DE3167216D1 (de) 1980-09-02 1981-08-28 Benzoxazine derivatives
AT81106747T ATE10282T1 (de) 1980-09-02 1981-08-28 Benzoxazin-derivate.
EP81106747A EP0047005B1 (en) 1980-09-02 1981-08-28 Benzoxazine derivatives
KR1019810003207A KR840002141B1 (ko) 1980-09-02 1981-08-31 벤즈옥사진 유도체의 제조방법
SI8112109A SI8112109A8 (sl) 1980-09-02 1981-09-01 Postopek za pripravo spojine 9-halo-7-okso-2,3-dihidro-7h-pirido/1,2,3-de/ /1,4/benzoksazin-6-karboksilne kisline
NZ198224A NZ198224A (en) 1980-09-02 1981-09-01 9-halo-7-oxo-2,3-dihydro-7h-pyrido(1,2,3,-de)(1,4)benzoxazine-6-carboxylic acid derivatives
ES505116A ES505116A0 (es) 1980-09-02 1981-09-01 Un procedimiento para la preparacion del acido 9-halo-7-oxo-2,3-dihidro-7m-pirido-1,2,3-de-1,4 benzoxazin 6-carboxilico.
YU2109/81A YU42422B (en) 1980-09-02 1981-09-01 Process for preparing the compounds 9-halo-7-oxo-2,3-dihydro-7h-pyrido(1,2,3-de)(1,4)benzoxazine-6-carboxylic acid
FI812693A FI71155C (fi) 1980-09-02 1981-09-01 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 9-halogen-7-oxo-2,3-dihydro-7h-pyrido/1,2,3-de/ /1,4/bensoxazin-6-karboxylsyraderivat
NO812956A NO158507C (no) 1980-09-02 1981-09-01 Analogifremgangsmaate for fremstilling av terapeutisk aktive 9-halogen-7-okso-2,3-dihydro-7h-pyrido (1,2,3-de)(1,4)-benzoksazin-6-karboksylsyreforbindelser.
IN985/CAL/81A IN155680B (ja) 1980-09-02 1981-09-02
GR65931A GR74637B (ja) 1980-09-02 1981-09-02
CA000385046A CA1167840A (en) 1980-09-02 1981-09-02 Benzoxazine derivatives
DK388981A DK158267C (da) 1980-09-02 1981-09-02 Analogifremgangsmaade til fremstilling af 9-halogen-7-oxo-2,3-dihydro-7h-pyrido(1,2,3-de)(1,4)benzoxazin-6-carboxylsyrederivater
AU74878/81A AU529263B2 (en) 1980-09-02 1981-09-02 Pyrid(1,2,3-de)(1,4)benzoxazine derivatives
US06/298,816 US4382892A (en) 1980-09-02 1981-09-02 Benzoxazine derivatives
HK821/86A HK82186A (en) 1980-09-02 1986-10-30 Benzoxazine derivatives
MY712/86A MY8600712A (en) 1980-09-02 1986-12-30 Benzoxaline derivatives
YU74788A YU47193B (sh) 1980-09-02 1988-04-14 7,8-difluoro-3-metil-2,3-dihidro-4h-1,4-benzoksazin i postupak za njegovo dobijanje
DK204488A DK204488D0 (da) 1980-09-02 1988-04-14 Fremgangsmaade til fremstilling af 7,8-difluor-3-methyl-2,3-dihydro-4h-1,4-benzoxazin
HRP-747/88A HRP930087A2 (en) 1980-09-02 1993-02-01 Process for the preparation of 7,8-difluoro-3-methyl-2,3-dihydro-4h-1,4-benoxazine
BA970190A BA97190B1 (bs) 1980-09-02 1997-08-19 Postupak za dobijanje jedinjenja 9-halo-7-okso-2,3-dihidro-7H-pirido(1,2,3-DE)(1,4) benzoksazin-6-karboksilne kiseline

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55121540A JPS5746986A (en) 1980-09-02 1980-09-02 Pyrido(1,2,3-de)(1,4)benzoxazine derivative

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP13447084A Division JPS6034968A (ja) 1984-06-29 1984-06-29 ピリド〔１，２，３−ｄｅ〕〔１，４〕ベンゾオキサジン誘導体

Publications (2)

Publication Number Publication Date
JPS5746986A true JPS5746986A (en) 1982-03-17
JPS6111955B2 JPS6111955B2 (ja) 1986-04-05

Family

ID=14813767

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55121540A Granted JPS5746986A (en) 1980-09-02 1980-09-02 Pyrido(1,2,3-de)(1,4)benzoxazine derivative

Country Status (21)

Country Link
US (1) US4382892A (ja)
EP (1) EP0047005B1 (ja)
JP (1) JPS5746986A (ja)
KR (1) KR840002141B1 (ja)
AT (1) ATE10282T1 (ja)
AU (1) AU529263B2 (ja)
CA (1) CA1167840A (ja)
DE (1) DE3167216D1 (ja)
DK (2) DK158267C (ja)
ES (1) ES505116A0 (ja)
FI (1) FI71155C (ja)
GR (1) GR74637B (ja)
HK (1) HK82186A (ja)
IL (1) IL63613A (ja)
IN (1) IN155680B (ja)
MY (1) MY8600712A (ja)
NO (1) NO158507C (ja)
NZ (1) NZ198224A (ja)
PH (1) PH18276A (ja)
YU (2) YU42422B (ja)
ZA (1) ZA815604B (ja)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58210092A (ja) * 1982-05-31 1983-12-07 Dai Ichi Seiyaku Co Ltd ピリドベンズオキサジン誘導体およびその製造法
JPS59116217A (ja) * 1982-12-22 1984-07-05 Dai Ichi Seiyaku Co Ltd マイコプラズマ感染症用薬
JPS59105303U (ja) * 1982-12-28 1984-07-16 埼玉機器株式会社 切削加工用刃物
JPS6020840A (ja) * 1983-07-14 1985-02-02 Toshiba Mach Co Ltd 工作機械の油温制御装置
JPS61180771A (ja) * 1985-01-05 1986-08-13 バイエル・アクチエンゲゼルシヤフト 安定な抗バクテリア剤水溶液
WO1987003587A1 (en) 1985-12-09 1987-06-18 Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. Process for the preparation of quinoline carboxylic acids
JPS62145088A (ja) * 1985-12-10 1987-06-29 バイエル・アクチエンゲゼルシヤフト 鏡像異性体的に純粋な１，８−橋かけされた４−キノロン−３−カルボン酸
JPS62252790A (ja) * 1985-06-20 1987-11-04 Dai Ichi Seiyaku Co Ltd ピリドベンゾオキサジン誘導体
JPS63154621A (ja) * 1986-12-18 1988-06-27 Dai Ichi Seiyaku Co Ltd 外用剤
JPH01308281A (ja) * 1987-08-31 1989-12-12 Dainippon Pharmaceut Co Ltd 三環式化合物、そのエステルおよびその塩
US5175160A (en) * 1988-08-09 1992-12-29 Daiichi Pharmaceutical Co., Ltd. Antimicrobial agent for animals
US5910498A (en) * 1994-10-20 1999-06-08 Wakunaga Seiyaku Kabushiki Kaisha Pyridonecarboxylic acid derivatives or salts thereof and antibacterial agents comprising the same as active ingredient
US6211375B1 (en) 1996-04-19 2001-04-03 Wakunaga Pharmaceutical Co., Ltd. Pyridonecarboxylic acid derivatives or salts thereof and antibacterial agents containing the same as the active ingredient
US6586420B1 (en) 1999-09-02 2003-07-01 Wakunaga Pharmaceutical Co., Ltd. Quinolinecarboxylic acid derivative or its salt
EP2275141A1 (en) 1999-03-17 2011-01-19 Daiichi Pharmaceutical Co., Ltd. Tastemasked pharmaceutical compositions

Families Citing this family (142)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH22140A (en) 1982-06-29 1988-06-01 Daiichi Seiyaku Co Tricyclic compounds
JPS591489A (ja) * 1982-06-29 1984-01-06 Dai Ichi Seiyaku Co Ltd ピリドベンゾオキサジン誘導体
US5281612A (en) * 1982-09-09 1994-01-25 Warner-Lambert Company Naphthyridine antibacterial agents
US4665079A (en) * 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
IE55898B1 (en) * 1982-09-09 1991-02-14 Warner Lambert Co Antibacterial agents
US4473568A (en) * 1983-03-01 1984-09-25 Warner Lambert Company Antibacterial thiazolidine or thiomorpholine substituted quinolines
US4730000A (en) * 1984-04-09 1988-03-08 Abbott Laboratories Quinoline antibacterial compounds
DE3333719A1 (de) * 1983-09-17 1985-04-04 Bayer Ag Loesungen milchsaurer salze von piperazinylchinolon- und piperazinyl-azachinoloncarbonsaeuren
US4551456A (en) * 1983-11-14 1985-11-05 Merck & Co., Inc. Ophthalmic use of norfloxacin and related antibiotics
US4774246A (en) * 1984-01-26 1988-09-27 Abbott Laboratories Quinoline antibacterial compounds
US4571396A (en) * 1984-04-16 1986-02-18 Warner-Lambert Company Antibacterial agents
US4540694A (en) * 1984-04-26 1985-09-10 Abbott Laboratories 1-Pyridine substituted quino-benoxazines and antibacterial use
US4529725A (en) * 1984-04-26 1985-07-16 Abbott Laboratories 1-Pyridine substituted quino-benzothiazine
US4528285A (en) * 1984-04-26 1985-07-09 Abbott Laboratories Methylenedioxy quino-benzothiazine derivatives
US4542133A (en) * 1984-04-26 1985-09-17 Abbott Laboratories Methylenedioxy quino-benoxazine derivatives and antibacterial use
DE3580183D1 (de) * 1984-04-26 1990-11-29 Abbott Lab Antibakterielle chinobenzoxazin-verbindungen.
US4533663A (en) * 1984-04-26 1985-08-06 Abbott Laboratories Quino-benzothiazine antibacterial compounds
US4607032A (en) * 1984-04-26 1986-08-19 Abbott Laboratories Quino-benoxazine antibacterial compounds
US4550104A (en) * 1984-07-20 1985-10-29 Warner-Lambert Company Antibacterial thiazolo-quinolines and thiazolo-naphthyridines
US4822801A (en) * 1984-07-20 1989-04-18 Warner-Lambert Company 4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial agents
US4550103A (en) * 1984-07-20 1985-10-29 Warner-Lambert Company Antibacterial 1-oxo-benzoquinolizine-2-carboxylic acids
US5097032A (en) * 1984-07-20 1992-03-17 Warner-Lambert Company Antibacterial agents - II
EP0184384B1 (en) * 1984-12-06 1989-08-02 Pfizer Inc. Substituted dihydroquinolone carboxylic acids, anti-bacterial compositions containing them
DE3517709A1 (de) * 1985-01-05 1986-07-10 Bayer Ag Basische zubereitungen von chinoloncarbonsaeuren
CA1253154A (en) * 1985-05-24 1989-04-25 Atsushi Takagi Benzo¬ij|quinolizine-2-carboxylic acid derivatives
DK170473B1 (da) * 1985-06-20 1995-09-11 Daiichi Seiyaku Co S(-)-pyridobenzoxazinforbindelser
AU585995B2 (en) * 1985-06-20 1989-06-29 Daiichi Pharmaceutical Co., Ltd. Optically active pyridobenzoxazine derivatives and intermediates thereof
DE3522406A1 (de) * 1985-06-22 1987-01-02 Bayer Ag Verfahren zur herstellung von 1,8-verbrueckten 4-chinolon-3-carbonsaeuren
DE3522405A1 (de) * 1985-06-22 1987-01-02 Bayer Ag 1,8-verbrueckte 4-chinolon-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende arzneimittel und ihre verwendung zur herstellung von arzneimitteln
DE3608745A1 (de) * 1985-07-24 1987-01-29 Bayer Ag Bakterizide zubereitungen zur anwendung auf dem gebiet der veterinaermedizin
IN166416B (ja) * 1985-09-18 1990-05-05 Pfizer
US5237060A (en) * 1985-12-10 1993-08-17 Bayer Aktiengesellschaft Process of preparing enantiomerically pure 1,8-bridged 4-quinolone-3-carboxylic acids
US4687770A (en) * 1985-12-23 1987-08-18 Abbott Laboratories Isoxazolo-pyrido-benzoxazine and isothiazolo-pyrido-benzoxazine derivatives
US4689325A (en) * 1985-12-23 1987-08-25 Abbott Laboratories Isoxazolo-pyrido-phenoxazine and isothiazolo-pyrido-phenoxazine derivatives
US4692454A (en) * 1986-02-03 1987-09-08 Warner-Lambert Company Opthalmic use of quinolone antibiotics
US5153204A (en) * 1986-03-01 1992-10-06 Bayer Aktiengesellschaft 7-(1-Pyrrolidinyl)-quinolonecarboxylic acid derivatives
DE3606698A1 (de) * 1986-03-01 1987-09-03 Bayer Ag 7-(1-pyrrolidinyl)-chinoloncarbonsaeure -derivate
DE3623757A1 (de) * 1986-07-15 1988-01-21 Bayer Ag Neue 1,8-verbrueckte 4-chinoloncarbonsaeuren und diese enthaltende arzneimittel
US4864023A (en) * 1986-09-12 1989-09-05 Hoffmann-La Roche Inc. Pyrido(3,2,1-IJ)-1,3,4-benzoxadiazine derivatives
ES2059335T3 (es) * 1986-09-12 1994-11-16 Hoffmann La Roche Derivados de pirido(3,2,1-ij)-1,3,4-benzoxadiazina, procedimiento para su obtencion, preparados farmaceuticos correspondientes y productos intermedios utilizables en el procedimiento.
ATE110061T1 (de) * 1986-12-25 1994-09-15 Daiichi Seiyaku Co Optisch aktive 2,3-dihydrobenzoxazinderivate und verfahren zu deren herstellung.
DE3881939T2 (de) * 1987-02-26 1993-09-30 Rohto Pharma Verwendung von Ofloxacin zur lokalen Behandlung oder Prophylaxe von Beschwerden der Wurzelhaut der Zähne.
JPH01199979A (ja) * 1987-04-07 1989-08-11 Kanebo Ltd 新規キノリンカルボン酸誘導体および該化合物を有効成分とする抗菌剤
NO883398L (no) * 1987-08-03 1989-02-06 Daiichi Seiyaku Co Fremgangsmaate for fremstilling av benzoksazin-derivater.
US4839355A (en) * 1987-09-09 1989-06-13 Sterling Drug Inc. Tricyclic-pyridinylquinoline compounds, their preparation and use
US4889857A (en) * 1987-10-12 1989-12-26 Yoshitomi Pharmaceutical Industries, Ltd. Quinolonecarboxylic acid compounds and pharmaceutical use thereof
WO1989005643A1 (en) * 1987-12-18 1989-06-29 Pfizer Inc. Heterocyclic-substituted quinoline-carboxylic acids
FI95567C (fi) * 1987-12-25 1996-02-26 Daiichi Seiyaku Co Propoksibentseenijohdannaisia ja menetelmä niiden valmistamiseksi
FR2634483B2 (fr) * 1987-12-29 1994-03-04 Esteve Labor Dr Derives des acides 7-(1-azetidinyl)-1,4-dihydro-4-oxoquinoleine-3-carboxyliques, leur preparation et leur application en tant que medicaments
FR2625200A1 (en) * 1987-12-29 1989-06-30 Esteve Labor Dr 7-(1-Azetidinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid derivatives, their preparation and their application as medicaments
US5173484A (en) * 1988-02-05 1992-12-22 Bayer Aktiengesellschaft Quinolone- and naphthyridone carboxylic acid derivatives, process for their production, antibacterial compositions and feed additives containing them
JPH01258620A (ja) * 1988-04-08 1989-10-16 Dai Ichi Seiyaku Co Ltd 耳疾患用局所製剤
JP2844079B2 (ja) * 1988-05-23 1999-01-06 塩野義製薬株式会社 ピリドンカルボン酸系抗菌剤
KR910003630B1 (ko) * 1988-06-17 1991-06-07 한국과학기술원 벤조일 아세틱 에스테르 유도체 및 그 제조방법
MY104139A (en) * 1988-08-09 1994-02-28 Daiichi Seiyaku Co Antimicrobial agent for animals
JPH02157282A (ja) * 1988-12-12 1990-06-18 Wakunaga Pharmaceut Co Ltd 新規ピリドベンゾオキサジン誘導体
FR2654728B2 (fr) * 1989-03-16 1994-09-23 Esteve Labor Dr Derives d'acides pyridone carboxyliques azetidinyl substitues, leur preparation et leur application en tant que medicament.
FR2649106A2 (fr) * 1989-06-29 1991-01-04 Esteve Labor Dr Derives d'acides pyridone carboxyliques azetidinyl substitues, leur preparation et leur application en tant que medicament
FR2644455B1 (fr) * 1989-03-16 1994-09-23 Esteve Labor Dr Derives d'acides pyridone carboxyliques azetidinyl substitues, leur preparation et leur application en tant que medicaments
NO177302C (no) * 1989-03-16 1995-08-23 Esteve Labor Dr Analogifremgangsmåte til fremstilling av terapeutisk aktive substituerte azetidinylkinolon(naftyridon)karboksylsyrederivater
US5214051A (en) * 1989-08-01 1993-05-25 Pfizer Inc. Thiazolyl and oxazolyl[5,4-c]piperidyl-substituted quinolone-carboxylic acid and related analogs thereof having antibacterial properties are disclosed
US5385913A (en) * 1989-10-06 1995-01-31 Pfizer Inc. 1,4-dihydro-4-oxo-3-quinoline derivatives as selectively toxic mammalian antibacterial agents
FR2655545B1 (fr) * 1989-12-11 1994-06-10 Rhone Poulenc Sante Nouvelle application therapeutique des derives des fluoroquinolones.
TW208013B (ja) * 1990-03-01 1993-06-21 Daiichi Co Ltd
US5166203A (en) * 1990-08-30 1992-11-24 Kanebo, Ltd. Quinolinecarboxylic acid derivatives, antibacterial agent containing the same
US5308843A (en) * 1990-09-11 1994-05-03 Sterling Drug Inc. Method of inhibiting mammalian topoisomerase II and malignant cell growth in mammals, with substituted (S)-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4 ]-benzoxazine(and-benzothiazine)-6-carboxylic acids
FR2676445B1 (fr) * 1991-05-16 1995-02-03 Esteve Labor Dr Derives de pyridone amino acide azetidinyl substitues, leur preparation et leur application en tant que medicaments.
DE4120646A1 (de) * 1991-06-22 1992-12-24 Bayer Ag 7-isoindolinyl-chinolon- und naphthyridoncarbonsaeure-derivate
DE4121214A1 (de) * 1991-06-27 1993-01-14 Bayer Ag 7-azaisoindolinyl-chinolon- und -naphthyridoncarbonsaeure-derivate
DE69224071T2 (de) * 1991-09-17 1998-05-07 Alcon Lab Inc Chinolan-antibiotika und polystyrolsulfonat enthaltende zusammensetzungen
US5521310A (en) * 1992-10-07 1996-05-28 Derivados Del Etilo, S.A. Process to obtain benzoxazines to be used for the synthesis of ofloxazine, levofloxazine and derivatives
WO1994025464A1 (en) * 1993-04-24 1994-11-10 Korea Research Institute Of Chemical Technology Novel quinolone carboxylic acid derivatives and process for preparing the same
US5532239A (en) * 1993-08-02 1996-07-02 Assistance Publique - Hopitaux De Paris Therapeutic application of fluoroquinolone derivatives
KR950018003A (ko) * 1993-12-09 1995-07-22 스미스클라인 비참 피엘씨 신규한 퀴놀론 유도체 및 그의 제조 방법
DE4424369A1 (de) * 1994-07-11 1996-01-18 Bayer Ag Pyrido[3,2,1.i,j][3,1]benzoxazinderivate
US5644056A (en) * 1995-06-07 1997-07-01 Hoechst Celanese Corporation Method of preparing 7,8-difluoro-2,3-dihydro-3-methyl-4H-1, 4-benzoxazine
KR100309871B1 (ko) 1999-02-24 2001-10-29 윤종용 (-)피리도벤즈옥사진 카르복실산 유도체의 제조방법
US6166012A (en) * 1999-07-30 2000-12-26 Allergan Sales, Inc. Antibiotic compositions and method for using same
US6552020B1 (en) 1999-07-30 2003-04-22 Allergan, Inc. Compositions including antibiotics and methods for using same
SE9904108D0 (sv) 1999-11-15 1999-11-15 New Pharma Research Ab Nya föreningar
US6608078B2 (en) 2000-05-08 2003-08-19 Wockhardt Limited Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment
JP2004503593A (ja) 2000-07-14 2004-02-05 アラーガン、インコーポレイテッド 増大した溶解度を持つ治療活性成分を含む組成物
US7098219B2 (en) 2000-08-01 2006-08-29 Wockhart Limited Inhibitors of cellular efflux pumps of microbes
WO2003079972A2 (en) 2002-02-22 2003-10-02 New River Parmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
ATE319710T1 (de) 2000-12-21 2006-03-15 Pharmacia & Upjohn Co Llc Antimikrobielle chinolonderivate und ihre verwendung zur behandlung bakterieller infektionen
US6964966B2 (en) 2001-04-25 2005-11-15 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
US6878713B2 (en) * 2001-04-25 2005-04-12 Wockhardt Limited Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
IL161164A0 (en) 2001-10-03 2004-08-31 Teva Pharma Preparation of levofloxacin and forms thereof
US7425628B2 (en) * 2001-10-03 2008-09-16 Teva Pharmaceutical Industries Ltd. Methods for the purification of levofloxacin
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
CA2470495A1 (en) * 2001-12-24 2003-07-17 Teva Pharmaceutical Industries Ltd. Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder or granular material, and process and tooling for producing it
US6664267B1 (en) 2002-05-28 2003-12-16 Wockhardt Limited Crystalline fluoroquinolone arginine salt form
DE10312346A1 (de) * 2003-03-20 2004-09-30 Bayer Healthcare Ag Kontrolliertes Freisetzungssystem
US20040191332A1 (en) * 2003-03-27 2004-09-30 Allergan, Inc. Preserved ophthalmic compositions
US7439268B2 (en) * 2003-07-18 2008-10-21 Idexx Laboratories Compositions containing prodrugs of florfenicol and methods of use
WO2005014046A2 (en) * 2003-08-07 2005-02-17 Allergan, Inc. Compositions for delivery of therapeutics into the eyes and methods for making and using the same
US20050049210A1 (en) * 2003-08-27 2005-03-03 Idexx Laboratories, Inc. Methods for the controlled delivery of pharmacologically active compounds
EP1660495B1 (en) 2003-09-04 2007-07-11 Wockhardt Limited Benzoquinolizine-2-carboxylic acid arginine salt tetrahydrate
WO2005026145A2 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Quinolone antibacterial agents
DE10351448A1 (de) 2003-11-04 2005-06-09 Bayer Healthcare Ag Geschmackstoffhaltige Arzneimittelformulierungen mit verbesserten pharmazeutischen Eigenschaften
CN100412075C (zh) * 2004-06-22 2008-08-20 浙江医药股份有限公司新昌制药厂 左旋氧氟沙星和氧氟沙星的制备方法
DE102005055385A1 (de) * 2004-12-09 2006-06-14 Bayer Healthcare Ag Arzneimittel zur hygienischen Applikation im Ohr
US8546423B2 (en) 2005-05-18 2013-10-01 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US7498307B2 (en) * 2005-06-17 2009-03-03 Michael Alan Sturgess Combinations of DnaK inhibitors with known antibacterial agents
US9155792B2 (en) * 2006-02-13 2015-10-13 Trustees Of Boston University RecA inhibitors with antibiotic activity, compositions and methods of use
US20070197548A1 (en) 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone compositions
US7973022B2 (en) 2006-02-17 2011-07-05 Idexx Laboratories, Inc. Fluoroquinolone carboxylic acid salt compositions
DE102006010643A1 (de) 2006-03-08 2007-09-13 Bayer Healthcare Aktiengesellschaft Arzneimittel enthaltend Fluorchinolone
DE102006010642A1 (de) * 2006-03-08 2007-09-27 Bayer Healthcare Aktiengesellschaft Arzneimittelformulierungen, enthaltend Fluorchinolone
US20100234348A1 (en) * 2006-08-04 2010-09-16 Trustees Of Boston University Compositions and methods for potentiating antibiotic activity
US20100029938A1 (en) * 2006-12-22 2010-02-04 Farmaprojects, S. A. Process for the preparation of an antibacterial quinolone compound
EP1939206A1 (en) * 2006-12-22 2008-07-02 Farmaprojects, S.A. Process for the preparation of an antibacterial quinolone compound
DE102007026550A1 (de) * 2007-06-08 2008-12-11 Bayer Healthcare Ag Extrudate mit verbesserter Geschmacksmaskierung
US7902227B2 (en) * 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
US7550625B2 (en) * 2007-10-19 2009-06-23 Idexx Laboratories Esters of florfenicol
DE102007055341A1 (de) * 2007-11-19 2009-05-20 Bayer Animal Health Gmbh Stabilisierung öliger Suspensionen enthaltend hydrophobe Kieselsäuren
US7842714B2 (en) 2008-03-03 2010-11-30 Allergan, Inc. Ketorolac tromethamine compositions for treating ocular pain
US9192571B2 (en) * 2008-03-03 2015-11-24 Allergan, Inc. Ketorolac tromethamine compositions for treating or preventing ocular pain
NZ592717A (en) 2008-10-07 2013-03-28 Mpex Pharmaceuticals Inc Aerosol fluoroquinolone formulations for improved pharmacokinetics comprising levofloxacin or ofloxacin and a di- or trivalent cation
WO2010042549A1 (en) 2008-10-07 2010-04-15 Mpex Pharmaceuticals, Inc. Inhalation of levofloxacin for reducing lung inflammation
EP2379505A4 (en) 2008-12-05 2012-10-17 Designmedix Inc MODIFIED CHLOROQUINE WITH SINGLE RING UNIT OR CONDENSED RING UNIT
AU2010247141A1 (en) 2009-05-15 2011-12-15 Redx Pharma Plc Redox drug derivatives
ES2739979T3 (es) 2009-09-04 2020-02-05 Horizon Orphan Llc Uso de levofloxacino en aerosol para el tratamiento de la fibrosis quística
WO2011034971A1 (en) * 2009-09-15 2011-03-24 Designmedix, Inc. Modified fluoroquinolone compounds and methods of using the same
CN101747382B (zh) * 2009-12-29 2012-06-27 广东药学院 一种以喹诺酮类化合物为配体的钌多吡啶配合物及其制备方法和应用
EP2555750A2 (en) 2010-04-07 2013-02-13 Allergan, Inc. Combinations of preservative compositions for ophthalmic formulations
JP2013523828A (ja) 2010-04-07 2013-06-17 アラーガン インコーポレイテッド 眼科用組成物のための保存剤の組み合わせ
CN101880288B (zh) * 2010-07-12 2012-02-22 浙江东亚药业有限公司 一种氧氟沙星的合成方法
CN103200930A (zh) 2010-10-12 2013-07-10 拜耳知识产权有限责任公司 非淀粉基软咀嚼品
WO2013157018A1 (en) 2012-04-18 2013-10-24 Indian Institute Of Technology Madras A process for the preparation of the core structure in quinolone and napthyridone class of antibiotics
KR102253847B1 (ko) 2012-12-19 2021-05-21 바이엘 애니멀 헬스 게엠베하 향상된 수용성 및 우수한 저장 안정성을 가지는 정제
CN104098588B (zh) * 2013-04-02 2016-05-25 广州白云山医药集团股份有限公司白云山制药总厂 一类三环喹诺酮衍生物及其制备方法和用途
MD4291C1 (ro) * 2013-12-27 2015-02-28 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Preparat medicamentos pentru tratamentul otitelor
CN104402917A (zh) * 2014-12-02 2015-03-11 千辉药业（安徽）有限责任公司 一种新氧氟沙星中间体的制备方法
CN105037388A (zh) * 2015-08-28 2015-11-11 安徽环球药业股份有限公司 一种安妥沙星的制备方法
CN109251211A (zh) * 2016-12-21 2019-01-22 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） 一类喹诺酮羧酸化合物及其中间体、制备方法以及应用
CN106632444A (zh) * 2016-12-29 2017-05-10 千辉药业（安徽）有限责任公司 一种新氧氟沙星中间体的合成方法
GB201708606D0 (en) * 2017-05-30 2017-07-12 King's College London Antibiotic resistance breakers
ES2962526T3 (es) 2017-06-22 2024-03-19 Cipla Ltd Secretagogos PAR-4 para el tratamiento del cáncer
JOP20180097B1 (ar) * 2018-10-22 2023-03-28 Univ Of Jordan مشتقات 1.8 - نفثاريدين الغلايكوزيلية و طرق تحضيرها و استخدامها في معالجة الالتهابات الميكروبية
WO2020202239A1 (en) * 2019-04-04 2020-10-08 The University Of Jordan Glycosylated 3-substituted fluoroquinolone derivatives, preparation methods thereof, and their use in the treatment of antimicrobial infections
US20210068425A1 (en) * 2019-09-06 2021-03-11 Bayer Healthcare Llc Palatable granular veterinary compositions

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3984548A (en) 1974-02-11 1976-10-05 Riker Laboratories, Inc. Substituted pyrido[1,2,3,-de]-1,4-benzoxazines as bactericides
US3883522A (en) 1974-02-11 1975-05-13 Riker Laboratories Inc Substituted pyrido(1,2,3-de)-1,4-benzoxazines
US4133954A (en) * 1976-11-16 1979-01-09 Ciba-Geigy Corporation Pyrrolo- and pyrido-1,4-benzoxazin-3-(2H)-one derivatives as microbicides
JPS5476875A (en) 1977-11-29 1979-06-19 Matsushita Electric Ind Co Ltd Juicer
DE2953974C2 (ja) * 1978-04-12 1992-06-25 Otsuka Pharmaceutical Co., Ltd., Tokio/Tokyo, Jp
JPS54138582A (en) 1978-04-19 1979-10-27 Kyorin Seiyaku Kk Substituted quinolinecarboxylic acid
JPS5845426B2 (ja) * 1978-09-29 1983-10-08 杏林製薬株式会社 置換キノリンカルボン酸誘導体

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0149159B2 (ja) * 1982-05-31 1989-10-23 Daiichi Seiyaku Co
JPS58210092A (ja) * 1982-05-31 1983-12-07 Dai Ichi Seiyaku Co Ltd ピリドベンズオキサジン誘導体およびその製造法
JPS59116217A (ja) * 1982-12-22 1984-07-05 Dai Ichi Seiyaku Co Ltd マイコプラズマ感染症用薬
JPH0235723B2 (ja) * 1982-12-22 1990-08-13 Daiichi Seiyaku Co
JPS59105303U (ja) * 1982-12-28 1984-07-16 埼玉機器株式会社 切削加工用刃物
JPS6020840A (ja) * 1983-07-14 1985-02-02 Toshiba Mach Co Ltd 工作機械の油温制御装置
JPS61180771A (ja) * 1985-01-05 1986-08-13 バイエル・アクチエンゲゼルシヤフト 安定な抗バクテリア剤水溶液
JPH0376306B2 (ja) * 1985-01-05 1991-12-05 Bayer Ag
JPH0327534B2 (ja) * 1985-06-20 1991-04-16 Daiichi Seiyaku Co
JPS62252790A (ja) * 1985-06-20 1987-11-04 Dai Ichi Seiyaku Co Ltd ピリドベンゾオキサジン誘導体
WO1987003587A1 (en) 1985-12-09 1987-06-18 Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. Process for the preparation of quinoline carboxylic acids
JPS62145088A (ja) * 1985-12-10 1987-06-29 バイエル・アクチエンゲゼルシヤフト 鏡像異性体的に純粋な１，８−橋かけされた４−キノロン−３−カルボン酸
JPS63154621A (ja) * 1986-12-18 1988-06-27 Dai Ichi Seiyaku Co Ltd 外用剤
JPH01308281A (ja) * 1987-08-31 1989-12-12 Dainippon Pharmaceut Co Ltd 三環式化合物、そのエステルおよびその塩
US5175160A (en) * 1988-08-09 1992-12-29 Daiichi Pharmaceutical Co., Ltd. Antimicrobial agent for animals
US5910498A (en) * 1994-10-20 1999-06-08 Wakunaga Seiyaku Kabushiki Kaisha Pyridonecarboxylic acid derivatives or salts thereof and antibacterial agents comprising the same as active ingredient
US6211375B1 (en) 1996-04-19 2001-04-03 Wakunaga Pharmaceutical Co., Ltd. Pyridonecarboxylic acid derivatives or salts thereof and antibacterial agents containing the same as the active ingredient
EP2275141A1 (en) 1999-03-17 2011-01-19 Daiichi Pharmaceutical Co., Ltd. Tastemasked pharmaceutical compositions
US6586420B1 (en) 1999-09-02 2003-07-01 Wakunaga Pharmaceutical Co., Ltd. Quinolinecarboxylic acid derivative or its salt

Also Published As

Publication number Publication date
YU47193B (sh) 1995-01-31
DK388981A (da) 1982-03-03
DE3167216D1 (de) 1984-12-20
NZ198224A (en) 1984-02-03
EP0047005B1 (en) 1984-11-14
EP0047005A1 (en) 1982-03-10
AU7487881A (en) 1982-03-11
NO812956L (no) 1982-03-03
DK204488A (da) 1988-04-14
IL63613A (en) 1984-10-31
AU529263B2 (en) 1983-06-02
US4382892A (en) 1983-05-10
HK82186A (en) 1986-11-07
ES8301977A1 (es) 1983-01-01
FI812693L (fi) 1982-03-03
YU74788A (en) 1989-08-31
MY8600712A (en) 1986-12-31
FI71155C (fi) 1986-11-24
YU210981A (en) 1983-06-30
DK158267B (da) 1990-04-23
NO158507C (no) 1988-09-21
JPS6111955B2 (ja) 1986-04-05
DK158267C (da) 1990-10-15
IL63613A0 (en) 1981-11-30
PH18276A (en) 1985-05-17
CA1167840A (en) 1984-05-22
ZA815604B (en) 1982-08-25
KR830006303A (ko) 1983-09-20
NO158507B (no) 1988-06-13
YU42422B (en) 1988-08-31
ATE10282T1 (de) 1984-11-15
GR74637B (ja) 1984-06-29
ES505116A0 (es) 1983-01-01
IN155680B (ja) 1985-02-23
FI71155B (fi) 1986-08-14
KR840002141B1 (ko) 1984-11-23
DK204488D0 (da) 1988-04-14

Similar Documents

Publication Publication Date Title
JPS5746986A (en) Pyrido(1,2,3-de)(1,4)benzoxazine derivative
ES2080327T3 (es) Derivados de acido quinolona-carboxilico.
DE69123000T2 (de) Neue tricyclische Verbindung oder Salze davon, Verfahren zur Herstellung und antimikrobieller Wirkstoff, der sie enthält
SE8306882D0 (sv) 7-carboxymethoxyphenylacetamido-3-cephem derivatives, processes for the preparation thereof, and antibacterial preparations containing the same
JPS57149286A (en) 8-aminopyrido(1,2,3-de)(1,4)banzoxazine derivative
JPS57203085A (en) 1,8-cyclic substituted quinoline derivative
JPS57176987A (en) Pyrrolo(3,2,1-ij)quinoline-5-carboxylic acid derivative
ES505430A0 (es) Procedimiento para la preparacion de 3-0-desmenlistamicina b.
JPS5788182A (en) Pyrido(1,2,3-de)(1,4)benzoxazinecarboxylic acid derivative
JPS5643288A (en) Cephalosporin derivative and its preparation
JPS5788183A (en) Pyridobenzoxazine derivative
DK206888A (da) Thiadiazolylacetamidcephemderivat
SE8008540L (sv) N-substituerade tiazolylderivat av oxi-imino-substituerade cefalosporiner och forfarande for framstellning derav
DK158736C (da) 1,3-dihydro-6-aminomethyl-7-hydroxy-furo-(3,4-c)-pyridin-derivater samt terapeutisk praeparat indeholdende saadanne forbindelse
MY104139A (en) Antimicrobial agent for animals
JPS5515454A (en) Novel cephalosporin derivative
IE39830L (en) Cephalosporin derivatives
FI915572A0 (fi) Menetelmä terapeuttisesti käyttökelpoisten ja optisesti aktiivisten 10-(3-amino-4,4-dialkyyli-1-pyrrolidinyyli)-9-fluori-2,3-dihydro-3(S)-metyyli-7-okso-7H-pyrido/1,2,3-de//1,4/bentsoksatsiini-6-karboksyylihappojen valmistamiseksi
JPS56142283A (en) Penem-3-carboxylic acid derivative and its preparation
FI921475A (fi) 1,4-dihydro-4-oxo-3-kinolinderivat som selektivt toxiska antibakteriella aemenn hos daeggdjur.
ATE129246T1 (de) Pyrazolo(1,5-a)pyridine, deren herstellung und verwendung.
JPS57176961A (en) Pyridonecarboxylic acid derivative
AU2467388A (en) Quinolinecarboxylic acid derivatives