JPS57149286A - 8-aminopyrido(1,2,3-de)(1,4)banzoxazine derivative - Google Patents

8-aminopyrido(1,2,3-de)(1,4)banzoxazine derivative

Info

Publication number
JPS57149286A
JPS57149286A JP3630081A JP3630081A JPS57149286A JP S57149286 A JPS57149286 A JP S57149286A JP 3630081 A JP3630081 A JP 3630081A JP 3630081 A JP3630081 A JP 3630081A JP S57149286 A JPS57149286 A JP S57149286A
Authority
JP
Japan
Prior art keywords
compound
amino
methyl
formula
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3630081A
Other languages
Japanese (ja)
Other versions
JPH0116837B2 (en
Inventor
Isao Hayakawa
Yoshiaki Tanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Priority to JP3630081A priority Critical patent/JPS57149286A/en
Publication of JPS57149286A publication Critical patent/JPS57149286A/en
Publication of JPH0116837B2 publication Critical patent/JPH0116837B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:A compound of formulaI[R<3> is H, lower alkyl; R<10> is mono- or disubstituted or cyclic amine, where these substituents may contain hetero atoms or may be substituted with hydroxyl, lower alkyl, lower alkoxy or amino; X is halogen]and its salts. EXAMPLE:8-Amino-9-fluoro-3-methyl-10- ( 4-methyl-1-piperazinyl ) -7-oxo-2, 3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid. USE:Antibacterial: it is effective against gram-positive and -negative bacteria including Pseudomonas areuginosa. PREPARATION:A compound of formula II in a polar solvent such as dimethyl sulfoxide or sulfolane is heated with an amine of R<10>H at room temperature to 200 deg.C, preferably 70-150 deg.C for 30min to 48hr to give the compound of formula I.
JP3630081A 1981-03-13 1981-03-13 8-aminopyrido(1,2,3-de)(1,4)banzoxazine derivative Granted JPS57149286A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3630081A JPS57149286A (en) 1981-03-13 1981-03-13 8-aminopyrido(1,2,3-de)(1,4)banzoxazine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3630081A JPS57149286A (en) 1981-03-13 1981-03-13 8-aminopyrido(1,2,3-de)(1,4)banzoxazine derivative

Publications (2)

Publication Number Publication Date
JPS57149286A true JPS57149286A (en) 1982-09-14
JPH0116837B2 JPH0116837B2 (en) 1989-03-27

Family

ID=12465958

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3630081A Granted JPS57149286A (en) 1981-03-13 1981-03-13 8-aminopyrido(1,2,3-de)(1,4)banzoxazine derivative

Country Status (1)

Country Link
JP (1) JPS57149286A (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4473568A (en) * 1983-03-01 1984-09-25 Warner Lambert Company Antibacterial thiazolidine or thiomorpholine substituted quinolines
US4571396A (en) * 1984-04-16 1986-02-18 Warner-Lambert Company Antibacterial agents
JPS6143186A (en) * 1984-07-20 1986-03-01 ワーナー‐ランバート・コンパニー Antibacterial-ii
EP0206076A2 (en) * 1985-06-22 1986-12-30 Bayer Ag 1,8-Bridged 4-quinolone-3-carboxylic acids, process for their preparation as well as medicaments containing them, and their use for the preparation of medicaments
JPS62145088A (en) * 1985-12-10 1987-06-29 バイエル・アクチエンゲゼルシヤフト Enantiomerically pure 1, 8-crosslinked 4-quinolone-3- carboxylic acid
US5097032A (en) * 1984-07-20 1992-03-17 Warner-Lambert Company Antibacterial agents - II
EP0550019A2 (en) * 1991-12-31 1993-07-07 Korea Research Institute Of Chemical Technology Novel quinolone carboxylic acid derivatives and processes for preparing same
EP0550016A1 (en) * 1991-12-31 1993-07-07 Korea Research Institute Of Chemical Technology Novel quinolone carboxylic acid derivatives and processes for preparing same

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4473568A (en) * 1983-03-01 1984-09-25 Warner Lambert Company Antibacterial thiazolidine or thiomorpholine substituted quinolines
US4571396A (en) * 1984-04-16 1986-02-18 Warner-Lambert Company Antibacterial agents
JPS6143186A (en) * 1984-07-20 1986-03-01 ワーナー‐ランバート・コンパニー Antibacterial-ii
US5097032A (en) * 1984-07-20 1992-03-17 Warner-Lambert Company Antibacterial agents - II
EP0206076A2 (en) * 1985-06-22 1986-12-30 Bayer Ag 1,8-Bridged 4-quinolone-3-carboxylic acids, process for their preparation as well as medicaments containing them, and their use for the preparation of medicaments
US4847375A (en) * 1985-06-22 1989-07-11 Bayer Aktiengesellschaft Antibacterial 1,8-bridged 4-quinoline-3-carboxylic acids
JPS62145088A (en) * 1985-12-10 1987-06-29 バイエル・アクチエンゲゼルシヤフト Enantiomerically pure 1, 8-crosslinked 4-quinolone-3- carboxylic acid
EP0550019A2 (en) * 1991-12-31 1993-07-07 Korea Research Institute Of Chemical Technology Novel quinolone carboxylic acid derivatives and processes for preparing same
EP0550016A1 (en) * 1991-12-31 1993-07-07 Korea Research Institute Of Chemical Technology Novel quinolone carboxylic acid derivatives and processes for preparing same
EP0550019A3 (en) * 1991-12-31 1993-09-01 Korea Research Institute Of Chemical Technology Novel quinolone carboxylic acid derivatives and processes for preparing same

Also Published As

Publication number Publication date
JPH0116837B2 (en) 1989-03-27

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