ES2080327T3 - Derivados de acido quinolona-carboxilico. - Google Patents

Derivados de acido quinolona-carboxilico.

Info

Publication number
ES2080327T3
ES2080327T3 ES91913068T ES91913068T ES2080327T3 ES 2080327 T3 ES2080327 T3 ES 2080327T3 ES 91913068 T ES91913068 T ES 91913068T ES 91913068 T ES91913068 T ES 91913068T ES 2080327 T3 ES2080327 T3 ES 2080327T3
Authority
ES
Spain
Prior art keywords
represents hydrogen
lower alkyl
hydrogen
quinolone
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91913068T
Other languages
English (en)
Inventor
Fujiko Konno
Akihiro Shibata
Hideaki Matsuda
Takemitsu Asaoka
Ryuichi Kawahara
Naokata Taido
Tadayuki Kuraishi
Sunao Takeda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SSP Co Ltd
Original Assignee
SSP Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SSP Co Ltd filed Critical SSP Co Ltd
Application granted granted Critical
Publication of ES2080327T3 publication Critical patent/ES2080327T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

UN DERIVADO DEL ACIDO QUINOLECAOXILICO, REPRESENTADO POR LA FORMULA GENERAL (1), SUS SALES Y UN AGENTE ANTIBACTERIANO QUE LO CONTIENE COMO INGREDIENTE ACTIVO, DONDE R ELEVADO 1 REPRESENTA HIDROGENO, ALQUILO, ARALQUILO O UN RESIDUO DE ESTER QUE ES HIDROLIZABLE "IN VIVO"; R (AL CUADRADO) REPRESENTA HIDROGENO O AMINO QUE PUEDE SER SUSTITUIDO CON UNO O DOS GRUPOS ALQUILO BAJO; X REPRESENTA HIDROGENO O HALOGENO; Y REPRESENTA CH SUB 2, O , S, SO, O NR ELEVADO 3, DONDE R ELEVADO 3 REPRESENTA HIDROGENO O ALQUILO BAJO, Y Z REPRESENTA UN ATOMO DE OXIGENO O DOS ATOMOS DE HIDROGENO. ESTE COMPUESTO DESARROLLA UNA POTENTE ACTIVIDAD ANTIBACTERIANA, PARTICULARMENTE CONTRA BACTERIAS GRAM-POSITIVAS, DE TAL MANERA QUE ES UTIL EN LA PREVENCION Y TRATAMIENTO CLINICO DE DIVERSAS ENFERMEDADES INFECCIOSAS.
ES91913068T 1990-07-19 1991-07-17 Derivados de acido quinolona-carboxilico. Expired - Lifetime ES2080327T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP19133990 1990-07-19
JP7977491 1991-04-12

Publications (1)

Publication Number Publication Date
ES2080327T3 true ES2080327T3 (es) 1996-02-01

Family

ID=26420770

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91913068T Expired - Lifetime ES2080327T3 (es) 1990-07-19 1991-07-17 Derivados de acido quinolona-carboxilico.

Country Status (12)

Country Link
US (2) US5385900A (es)
EP (1) EP0493608B1 (es)
JP (2) JP2613139B2 (es)
KR (1) KR100195070B1 (es)
AT (1) ATE128707T1 (es)
CA (1) CA2065846C (es)
DE (1) DE69113604T2 (es)
DK (1) DK0493608T3 (es)
ES (1) ES2080327T3 (es)
GR (1) GR3017651T3 (es)
HK (1) HK125296A (es)
WO (1) WO1992001676A1 (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2102196A1 (en) * 1992-05-26 1993-11-27 Terumitsu Kaihoh 5-aminoquinolone carboxylic acid derivative and antibacterial agent containing the same as active ingredient
FR2706459B1 (fr) * 1993-06-17 1995-08-04 Bouchara Sa Nouveaux dérivés quinoloniques, leur procédé d'obtention et les compositions pharmaceutiques qui en contiennent.
CN1038326C (zh) * 1993-07-20 1998-05-13 爱斯制药株式会社 5－氨基喹诺酮羧酸衍生物及其含有该衍生物作为活性成分的抗菌剂
US6699492B2 (en) * 1999-03-31 2004-03-02 Insite Vision Incorporated Quinolone carboxylic acid compositions and related methods of treatment
US6685958B2 (en) * 2001-04-25 2004-02-03 Insite Vision Incorporated Quinolone carboxylic acid compositions and related methods of treatment
US6818654B2 (en) * 2002-03-12 2004-11-16 Abbott Laboratories Antibacterial compounds
US7576216B2 (en) 2004-07-30 2009-08-18 Abbott Laboratories Preparation of pyridonecarboxylic acid antibacterials
ES2506143T3 (es) * 2004-07-30 2014-10-13 Abbvie Inc. Preparación de sustancias antibacterianas de ácido piridonacarboxílico
JP5284777B2 (ja) * 2005-04-11 2013-09-11 アボット・ラボラトリーズ 難溶性薬剤の改善された溶解プロファイルを有する医薬組成物
BRPI0717513A2 (pt) 2006-10-06 2013-11-19 Bausch & Lomb Processo para preparar um composto, enantiômero isolado de uma fluoroquinolona, uso do enantiômero isolado, e, composição oftálmica
US8252783B2 (en) 2007-01-24 2012-08-28 Bausch & Lomb Incorporated Quinolone carboxylic acids, derivatives thereof, and methods of making and using same
US7632944B2 (en) * 2007-01-24 2009-12-15 Bausch & Lomb Incorporated Quinolone carboxylic acids, derivatives thereof, and methods of making and using same
US20080200442A1 (en) * 2007-02-16 2008-08-21 Srini Venkatesh Compositions and Methods for Treating, Reducing, Ameliorating, or Preventing Infections of the Ear or Upper Respiratory Tract
CA2679626C (en) * 2007-03-21 2012-10-23 Bausch & Lomb Incorporated Fluoroquinolones for treating, reducing, ameliorating, or preventing infections caused by antibacterial-drug resistant bacteria
US8173640B1 (en) 2007-05-18 2012-05-08 Bausch & Lomb Incorporated Compositions and methods for treating, reducing, ameliorating, or preventing infections
CA2686833A1 (en) * 2007-06-11 2008-12-18 Bausch & Lomb Incorporated Compositions and methods for modulating inflammation using fluoroquinolones
US20090042936A1 (en) * 2007-08-10 2009-02-12 Ward Keith W Compositions and Methods for Treating or Controlling Anterior-Segment Inflammation
US20090054406A1 (en) * 2007-08-21 2009-02-26 Ward Keith W Compositions and Methods for Modulating Endophthalmitis Using Fluoroquinolones
US20110166126A1 (en) * 2007-08-21 2011-07-07 Ward Keith W Compositions and Methods for Modulating Endophthalmitis Using Fluoroquinolones
US20090082337A1 (en) * 2007-09-21 2009-03-26 Srini Venkastesh Compositions Comprising Quinolone and Methods for Treating or Controlling Infections
MX2010004373A (es) * 2007-11-01 2010-05-05 Bausch & Lomb Materiales miscibles en agua no acuosos como vehiculos para suministro de farmacos.
ES2402321T3 (es) * 2007-11-05 2013-04-30 Bausch & Lomb Incorporated Materiales inmiscibles en agua como vehículos para el suministro de fármacos
US20090239836A1 (en) * 2008-03-24 2009-09-24 Mary Lee Ciolkowski Multifunctional Ophthalmic Compositions
US8415342B2 (en) 2008-10-29 2013-04-09 Bausch & Lomb Incorporated Besifloxacin ophthalmic composition for the treatment or control of infection
US8481526B2 (en) * 2009-03-25 2013-07-09 Bausch & Lomb Incorporated Fluoroquinolone carboxylic acid molecular crystals
US20110077270A1 (en) * 2009-04-21 2011-03-31 Pfeffer Bruce A Compositions and Methods for Treating Ocular Inflammation with Lower Risk of Increased Intraocular Pressure
US8518935B2 (en) * 2009-12-11 2013-08-27 Bausch & Lomb Incorporated Amorphous besifloxacin solid
US20110319502A1 (en) 2010-06-25 2011-12-29 Coffey Martin J Compositions and Methods for Enhancing Reduction of Spore-Forming Microorganisms
TWI606044B (zh) * 2011-08-31 2017-11-21 大塚製藥股份有限公司 喹啉酮化合物
CN102659761B (zh) * 2012-04-27 2017-10-10 常州市亚邦医药研究所有限公司 盐酸贝西沙星的制备方法
WO2013169458A1 (en) 2012-05-11 2013-11-14 Bausch & Lomb Incorporated Pharmaceutical compositions and methods for treating, controlling, ameliorating, or reversing conditions of dry eye
CN103044397A (zh) * 2013-01-06 2013-04-17 安徽赛诺医药化工有限公司 一种合成贝西沙星的新方法
CN104592197A (zh) * 2015-01-07 2015-05-06 广州仁恒医药科技有限公司 一种盐酸贝西沙星的制备方法
CN104592196A (zh) * 2015-01-07 2015-05-06 广州仁恒医药科技有限公司 一种盐酸贝西沙星的制备方法
WO2016120813A1 (en) 2015-01-28 2016-08-04 Mankind Research Centre Fluoroquinolone carboxylic acid compounds and use thereof for the preparation of besifloxacin hydrochloride

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA85853B (en) * 1984-02-17 1986-09-24 Warner Lambert Co Antibacterial agents
DE3420770A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-(3-oxo-1-piperazinyl)-3-chinoloncarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3420743A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
AU594983B2 (en) * 1985-10-29 1990-03-22 Dainippon Pharmaceutical Co. Ltd. Novel quinoline derivatives and processes for preparation thereof
JPH089597B2 (ja) * 1986-01-21 1996-01-31 杏林製薬株式会社 選択毒性に優れた８‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法
JPS63198664A (ja) * 1986-03-31 1988-08-17 Sankyo Co Ltd キノロンカルボン酸誘導体
JPS63132885A (ja) * 1986-11-25 1988-06-04 Hokuriku Seiyaku Co Ltd キノリン−３−カルボン酸誘導体
DE3641312A1 (de) * 1986-12-03 1988-06-09 Bayer Ag Verfahren zur herstellung von chinolincarbonsaeuren
JPS63196580A (ja) * 1987-02-09 1988-08-15 Hokuriku Seiyaku Co Ltd キノリン−３−カルボン酸誘導体
DE3713672A1 (de) * 1987-04-24 1988-11-17 Bayer Ag Verfahren zur herstellung von parenteral verabreichbaren chinoloncarbonsaeuren
AU618823B2 (en) * 1988-07-20 1992-01-09 Sankyo Company Limited 4-oxoquinoline-3-carboxylic acid derivatives, their preparation and their use
JPH02115181A (ja) * 1988-10-21 1990-04-27 Yoshitomi Pharmaceut Ind Ltd ピリドンカルボン酸化合物
US4945160A (en) * 1988-11-22 1990-07-31 Warner-Lambert Company Preparation of certain 7-substituted quinolones
US5140033A (en) * 1989-04-03 1992-08-18 Bayer Aktiengesellschaft Antibacterial 5-alkylquinolonecarboxylic acids
EP0486687A4 (en) * 1989-07-21 1992-06-17 Iolab Corporation Quinolonecarboxylic acid derivatives

Also Published As

Publication number Publication date
CA2065846A1 (en) 1992-01-20
HK125296A (en) 1996-07-19
JP2805460B2 (ja) 1998-09-30
CA2065846C (en) 2002-07-02
GR3017651T3 (en) 1996-01-31
WO1992001676A1 (en) 1992-02-06
EP0493608A1 (en) 1992-07-08
DE69113604T2 (de) 1996-05-30
ATE128707T1 (de) 1995-10-15
EP0493608B1 (en) 1995-10-04
KR100195070B1 (ko) 1999-06-15
JPH08169880A (ja) 1996-07-02
JPH054968A (ja) 1993-01-14
KR920702348A (ko) 1992-09-03
DE69113604D1 (de) 1995-11-09
US5385900A (en) 1995-01-31
US5447926A (en) 1995-09-05
DK0493608T3 (da) 1996-02-19
EP0493608A4 (en) 1992-08-12
JP2613139B2 (ja) 1997-05-21

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