JP7720697B2 - Ｊａｋ阻害剤を用いる化膿性汗腺炎の治療 - Google Patents

Ｊａｋ阻害剤を用いる化膿性汗腺炎の治療

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Publication number
JP7720697B2
JP7720697B2 JP2020552787A JP2020552787A JP7720697B2 JP 7720697 B2 JP7720697 B2 JP 7720697B2 JP 2020552787 A JP2020552787 A JP 2020552787A JP 2020552787 A JP2020552787 A JP 2020552787A JP 7720697 B2 JP7720697 B2 JP 7720697B2
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Japan
Prior art keywords
compound
pharmaceutically acceptable
pharmaceutical composition
acceptable salt
azetidin
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JP2020552787A
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Japanese (ja)
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JP2021519775A5 (https=
JP2021519775A (ja
Inventor
マイケル・ディ・ハウエル
ポール・スミス
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Incyte Corp
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Incyte Corp
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Publication of JP2021519775A publication Critical patent/JP2021519775A/ja
Publication of JP2021519775A5 publication Critical patent/JP2021519775A5/ja
Priority to JP2023192365A priority Critical patent/JP2024026074A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2020552787A 2018-03-30 2019-03-29 Ｊａｋ阻害剤を用いる化膿性汗腺炎の治療 Active JP7720697B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023192365A JP2024026074A (ja) 2018-03-30 2023-11-10 Ｊａｋ阻害剤を用いる化膿性汗腺炎の治療

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862650600P 2018-03-30 2018-03-30
US62/650,600 2018-03-30
PCT/US2019/024998 WO2019191684A1 (en) 2018-03-30 2019-03-29 Treatment of hidradenitis suppurativa using jak inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023192365A Division JP2024026074A (ja) 2018-03-30 2023-11-10 Ｊａｋ阻害剤を用いる化膿性汗腺炎の治療

Publications (3)

Publication Number Publication Date
JP2021519775A JP2021519775A (ja) 2021-08-12
JP2021519775A5 JP2021519775A5 (https=) 2022-01-27
JP7720697B2 true JP7720697B2 (ja) 2025-08-08

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ID=66429533

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JP2020552787A Active JP7720697B2 (ja) 2018-03-30 2019-03-29 Ｊａｋ阻害剤を用いる化膿性汗腺炎の治療
JP2023192365A Pending JP2024026074A (ja) 2018-03-30 2023-11-10 Ｊａｋ阻害剤を用いる化膿性汗腺炎の治療

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Country Status (34)

Country Link
US (3) US11304949B2 (https=)
EP (2) EP4424328A3 (https=)
JP (2) JP7720697B2 (https=)
CN (3) CN113768927A (https=)
AU (2) AU2019245420B2 (https=)
BR (1) BR112020019814A2 (https=)
CA (1) CA3095487A1 (https=)
CL (1) CL2020002512A1 (https=)
CO (1) CO2020013600A2 (https=)
DK (1) DK3773593T3 (https=)
EA (1) EA202092343A1 (https=)
EC (1) ECSP20069416A (https=)
ES (1) ES2980497T3 (https=)
FI (1) FI3773593T3 (https=)
HR (1) HRP20240741T1 (https=)
HU (1) HUE067471T2 (https=)
IL (3) IL277538B2 (https=)
LT (1) LT3773593T (https=)
MA (1) MA52219B1 (https=)
MD (1) MD3773593T2 (https=)
MX (2) MX2020010322A (https=)
MY (1) MY206999A (https=)
PE (1) PE20210402A1 (https=)
PH (1) PH12020551597A1 (https=)
PL (1) PL3773593T3 (https=)
PT (1) PT3773593T (https=)
RS (1) RS65624B1 (https=)
SG (1) SG11202009441PA (https=)
SI (1) SI3773593T1 (https=)
SM (1) SMT202400306T1 (https=)
TW (2) TWI835786B (https=)
UA (1) UA127925C2 (https=)
WO (1) WO2019191684A1 (https=)
ZA (1) ZA202202361B (https=)

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TWI646099B (zh) * 2012-11-01 2019-01-01 英塞特控股公司 作爲ｊａｋ抑制劑之三環稠合噻吩衍生物
KR102925957B1 (ko) 2018-02-16 2026-02-11 인사이트 코포레이션 사이토카인-관련 장애의 치료를 위한 jak1 경로 억제제
MA52655A (fr) 2018-03-30 2021-02-17 Incyte Corp Biomarqueurs pour maladie cutanée inflammatoire
SMT202400306T1 (it) 2018-03-30 2024-09-16 Incyte Corp Trattamento dell'idrosadenite suppurativa utilizzando inibitori di jak.
CA3097025A1 (en) 2018-04-13 2019-10-17 Incyte Corporation Biomarkers for graft-versus-host disease
CA3117969A1 (en) 2018-10-31 2020-05-07 Incyte Corporation Combination therapy for treatment of hematological diseases
US12312358B2 (en) * 2019-02-15 2025-05-27 Pfizer Inc. Crystalline pyrimidinyl-3,8-diazabicyclo[3.2.1]octanylmethanone compound and use thereof
WO2020181034A1 (en) 2019-03-05 2020-09-10 Incyte Corporation Jak1 pathway inhibitors for the treatment of chronic lung allograft dysfunction
KR20220059519A (ko) * 2019-09-11 2022-05-10 화이자 인코포레이티드 키나제 억제제에 의한 한선염의 치료
WO2021072098A1 (en) 2019-10-10 2021-04-15 Incyte Corporation Biomarkers for graft-versus-host disease
EP4041204A1 (en) 2019-10-10 2022-08-17 Incyte Corporation Biomarkers for graft-versus-host disease
US11992490B2 (en) 2019-10-16 2024-05-28 Incyte Corporation Use of JAK1 inhibitors for the treatment of cutaneous lupus erythematosus and Lichen planus (LP)
CA3204374A1 (en) 2020-12-08 2022-06-16 Incyte Corporation Jak1 pathway inhibitors for the treatment of vitiligo
UA129643C2 (uk) 2021-05-03 2025-06-18 Інсайт Корпорейшн Інгібітори шляху jak1 для лікування вузлуватого свербця
US20230293544A1 (en) * 2022-03-17 2023-09-21 Pfizer Inc. Methods, dosage regimens, and compositions for treating hidradenitis
CN117186078A (zh) * 2023-11-06 2023-12-08 药康众拓(北京)医药科技有限公司 氘代氮杂环丁烷类jak抑制剂药物及用途
WO2025117642A1 (en) * 2023-12-01 2025-06-05 Incyte Corporation Ruxolitinib for treating hidradenitis suppurativa (hs)
CN119385915B (zh) * 2024-08-19 2025-07-22 南昌大学 一种乌帕替尼醇质体水凝胶及其制备方法与应用

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