JP7490631B2 - Ａ２ａ／ａ２ｂ阻害剤としての縮合ピラジン誘導体 - Google Patents

Ａ２ａ／ａ２ｂ阻害剤としての縮合ピラジン誘導体 Download PDF

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JP7490631B2
JP7490631B2 JP2021500095A JP2021500095A JP7490631B2 JP 7490631 B2 JP7490631 B2 JP 7490631B2 JP 2021500095 A JP2021500095 A JP 2021500095A JP 2021500095 A JP2021500095 A JP 2021500095A JP 7490631 B2 JP7490631 B2 JP 7490631B2
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alkyl
independently selected
cycloalkyl
membered heterocycloalkyl
membered heteroaryl
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JP2021529804A (ja
JP2021529804A5 (https=
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ジア・ホアン
ワン・シャオジャオ
ピーター・ニールス・カールセン
ガン・ペイ
リィ・ヨン
チィ・チャオ
ウー・リアンシン
ウェンチン・ヤオ
ユー・ジヨン
ウェンユー・ジュー
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Incyte Corp
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Incyte Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2021500095A 2018-07-05 2019-07-03 Ａ２ａ／ａ２ｂ阻害剤としての縮合ピラジン誘導体 Active JP7490631B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023186994A JP7700196B2 (ja) 2018-07-05 2023-10-31 Ａ２ａ／ａ２ｂ阻害剤としての縮合ピラジン誘導体

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862694138P 2018-07-05 2018-07-05
US62/694,138 2018-07-05
US201862755845P 2018-11-05 2018-11-05
US62/755,845 2018-11-05
PCT/US2019/040496 WO2020010197A1 (en) 2018-07-05 2019-07-03 Fused pyrazine derivatives as a2a / a2b inhibitors

Related Child Applications (1)

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JP2023186994A Division JP7700196B2 (ja) 2018-07-05 2023-10-31 Ａ２ａ／ａ２ｂ阻害剤としての縮合ピラジン誘導体

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JP2021529804A JP2021529804A (ja) 2021-11-04
JP2021529804A5 JP2021529804A5 (https=) 2023-11-09
JP7490631B2 true JP7490631B2 (ja) 2024-05-27

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JP2023186994A Active JP7700196B2 (ja) 2018-07-05 2023-10-31 Ａ２ａ／ａ２ｂ阻害剤としての縮合ピラジン誘導体

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US (3) US11161850B2 (https=)
EP (1) EP3818063A1 (https=)
JP (2) JP7490631B2 (https=)
KR (1) KR20210049090A (https=)
CN (2) CN113166153B (https=)
AU (1) AU2019297361B2 (https=)
BR (1) BR112021000075A2 (https=)
CA (1) CA3105721A1 (https=)
CL (1) CL2021000004A1 (https=)
CO (1) CO2021001251A2 (https=)
CR (2) CR20210071A (https=)
EC (1) ECSP21007838A (https=)
GE (4) GEAP202315761A (https=)
IL (2) IL300821B2 (https=)
JO (1) JOP20200342A1 (https=)
MA (1) MA53097A (https=)
MX (3) MX2021000116A (https=)
PE (1) PE20211807A1 (https=)
PH (1) PH12021550019A1 (https=)
SA (1) SA521420965B1 (https=)
SG (1) SG11202013216RA (https=)
TW (2) TWI851441B (https=)
UA (1) UA128332C2 (https=)
WO (1) WO2020010197A1 (https=)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
JP2023509456A (ja) * 2020-01-03 2023-03-08 インサイト・コーポレイション Ａ２ａ／ａ２ｂ及びｐｄ－１／ｐｄ－ｌ１阻害剤を含む併用療法

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US12414952B2 (en) 2018-11-20 2025-09-16 Merck Sharp & Dohme Llc Substituted amino triazolopyrimidine and amino triazolopyrazine adenosine receptor antagonists, pharmaceutical compositions and their use
TWI829857B (zh) 2019-01-29 2024-01-21 美商英塞特公司 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
TW202135823A (zh) 2020-01-03 2021-10-01 美商英塞特公司 Ｃｄ７３抑制劑及ａ２ａ／ａ２ｂ腺苷受體抑制劑組合療法
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KR102621694B1 (ko) * 2022-09-15 2024-01-08 주식회사 스탠다임 아데노신 a2a 수용체 길항제 및 이의 용도
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