JP6543268B2 - 嚢胞性線維症膜コンダクタンス調節因子が媒介する疾患を処置するための医薬組成物 - Google Patents

嚢胞性線維症膜コンダクタンス調節因子が媒介する疾患を処置するための医薬組成物 Download PDF

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JP6543268B2
JP6543268B2 JP2016561619A JP2016561619A JP6543268B2 JP 6543268 B2 JP6543268 B2 JP 6543268B2 JP 2016561619 A JP2016561619 A JP 2016561619A JP 2016561619 A JP2016561619 A JP 2016561619A JP 6543268 B2 JP6543268 B2 JP 6543268B2
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pharmaceutical composition
compound
weight
agent
solid dispersion
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JP2017511344A5 (enExample
JP2017511344A (ja
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ブライアン ディーン フェニックス，
ブライアン ディーン フェニックス，
ローレント ジーン−クロード バグノル，
ローレント ジーン−クロード バグノル，
ジェフリー グレン ブロジャー，
ジェフリー グレン ブロジャー，
サチン チャンドラン，
サチン チャンドラン，
エレニ ドコウ，
エレニ ドコウ，
ロリ アン フェリス，
ロリ アン フェリス，
ドラグティン ネジック，
ドラグティン ネジック，
ケイティー リン マッカーティ，
ケイティー リン マッカーティ，
アレス メデク，
アレス メデク，
サラ エー． ワゲナー，
サラ エー． ワゲナー，
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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JP2016561619A 2014-04-15 2015-04-14 嚢胞性線維症膜コンダクタンス調節因子が媒介する疾患を処置するための医薬組成物 Active JP6543268B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461979848P 2014-04-15 2014-04-15
US61/979,848 2014-04-15
US201462059287P 2014-10-03 2014-10-03
US62/059,287 2014-10-03
PCT/US2015/025722 WO2015160787A1 (en) 2014-04-15 2015-04-14 Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases

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JP2017511344A JP2017511344A (ja) 2017-04-20
JP2017511344A5 JP2017511344A5 (enExample) 2018-05-31
JP6543268B2 true JP6543268B2 (ja) 2019-07-10

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US7645789B2 (en) 2006-04-07 2010-01-12 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
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HRP20140103T1 (hr) 2007-11-16 2014-05-09 Vertex Pharmaceuticals Inc. Izokinolinski modulatori transportera atp-vežuä†e kazete
PL2231606T3 (pl) 2007-12-07 2013-07-31 Vertex Pharma Sposoby wytwarzania kwasów cykloalkilokarboksyamidopirydynobenzoesowych
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JP5523352B2 (ja) 2008-02-28 2014-06-18 バーテックス ファーマシューティカルズ インコーポレイテッド Ｃｆｔｒ修飾因子としてのへテロアリール誘導体
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RS62767B1 (sr) 2010-04-07 2022-01-31 Vertex Pharma Farmaceutski sastavi 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-il) ciklopropankarboksamido)-3-metilpiriodin-2-il)benzojeve kiseline i njihova primena
CN105130948A (zh) 2010-04-22 2015-12-09 弗特克斯药品有限公司 制备环烷基甲酰胺基-吲哚化合物的方法
MX355183B (es) 2012-01-25 2018-04-09 Vertex Pharma Formulaciones de acido 3- (6- (1- (2.2- difluorobenzo [d] [1,3] dioxol-5-il) ciclopropancarboxamido) -3- metilpiridin-2-il) benzoico.
JP2015511583A (ja) 2012-02-27 2015-04-20 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ 薬学的組成物およびその投与
CA2878057A1 (en) 2012-07-16 2014-01-23 Rossitza Gueorguieva Alargova Pharmaceutical compositions of (r)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration thereof
HRP20210516T2 (hr) 2013-11-12 2021-10-01 Vertex Pharmaceuticals Incorporated Postupak proizvodnje farmaceutskih pripravaka za liječenje bolesti koje su posredovane putem cftr
JP6543268B2 (ja) 2014-04-15 2019-07-10 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ 嚢胞性線維症膜コンダクタンス調節因子が媒介する疾患を処置するための医薬組成物
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