EA201791500A1 - Циклопропанкарбоксамидные модуляторы муковисцидозного трансмембранного регулятора проводимости - Google Patents

Циклопропанкарбоксамидные модуляторы муковисцидозного трансмембранного регулятора проводимости

Info

Publication number
EA201791500A1
EA201791500A1 EA201791500A EA201791500A EA201791500A1 EA 201791500 A1 EA201791500 A1 EA 201791500A1 EA 201791500 A EA201791500 A EA 201791500A EA 201791500 A EA201791500 A EA 201791500A EA 201791500 A1 EA201791500 A1 EA 201791500A1
Authority
EA
Eurasian Patent Office
Prior art keywords
modulators
mucoviscidous
cyclopropankarcarboxamid
regulator
transmembrane conductor
Prior art date
Application number
EA201791500A
Other languages
English (en)
Inventor
Чэнчжи Чжан
Джастин Чакма
Original Assignee
Оспекс Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Оспекс Фармасьютикалз, Инк. filed Critical Оспекс Фармасьютикалз, Инк.
Publication of EA201791500A1 publication Critical patent/EA201791500A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

Abstract

Настоящее изобретение относится к новым циклопропанкарбоксамидным модуляторам белков муковисцидозного трансмембранного регулятора проводимости, их фармацевтическим композициям и способам их применения.
EA201791500A 2014-12-31 2015-12-27 Циклопропанкарбоксамидные модуляторы муковисцидозного трансмембранного регулятора проводимости EA201791500A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462098735P 2014-12-31 2014-12-31
PCT/US2015/067544 WO2016109362A1 (en) 2014-12-31 2015-12-27 Cyclopropanecarboxamide modulators of cystic fibrosis transmembrane conductance regulator

Publications (1)

Publication Number Publication Date
EA201791500A1 true EA201791500A1 (ru) 2018-01-31

Family

ID=56284953

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201791500A EA201791500A1 (ru) 2014-12-31 2015-12-27 Циклопропанкарбоксамидные модуляторы муковисцидозного трансмембранного регулятора проводимости

Country Status (10)

Country Link
US (2) US10167278B2 (ru)
EP (1) EP3240539A4 (ru)
AR (1) AR103355A1 (ru)
AU (1) AU2015374342A1 (ru)
BR (1) BR112017014213A2 (ru)
CA (1) CA2970948A1 (ru)
EA (1) EA201791500A1 (ru)
IL (1) IL252818A0 (ru)
TW (1) TW201625597A (ru)
WO (1) WO2016109362A1 (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
CA2797118C (en) 2010-04-22 2021-03-30 Vertex Pharmaceuticals Incorporated Process of producing cycloalkylcarboxamido-indole compounds
KR102447581B1 (ko) 2014-04-15 2022-09-28 버텍스 파마슈티칼스 인코포레이티드 낭포성 섬유증 막전도 조절자 매개 질환 치료용 약제학적 조성물
WO2016160945A1 (en) 2015-03-31 2016-10-06 Concert Pharmaceuticals, Inc. Deuterated vx-661
WO2017180794A1 (en) 2016-04-13 2017-10-19 Skyline Antiinfectives, Inc. Deuterated o-sulfated beta-lactam hydroxamic acids and deuterated n-sulfated beta-lactams
CN109528634A (zh) * 2018-12-19 2019-03-29 江西润泽药业有限公司 复方克林霉素甲硝唑葡萄糖注射液及其制备方法
CN109633040A (zh) * 2019-02-26 2019-04-16 山东博济医药科技有限公司 一种羧甲司坦含量测定方法
CN110227063B (zh) * 2019-06-18 2021-06-15 石药银湖制药有限公司 一种利奈唑胺注射液的制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7645789B2 (en) 2006-04-07 2010-01-12 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
UA104876C2 (ru) 2008-11-06 2014-03-25 Вертекс Фармасьютікалз Інкорпорейтед Модуляторы атф-связывающих кассетных транспортеров
EP2940016A1 (en) 2008-11-06 2015-11-04 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
WO2011050325A1 (en) 2009-10-22 2011-04-28 Vertex Pharmaceuticals Incorporated Compositions for treatment of cystic fibrosis and other chronic diseases
RU2711481C2 (ru) 2010-03-25 2020-01-17 Вертекс Фармасьютикалз Инкорпорейтед ТВЕРДЫЕ ФОРМЫ (R)-1-(2, 2-ДИФТОРБЕНЗО[d][1, 3]ДИОКСОЛ-5-ИЛ)-N-(1-(2, 3-ДИГИДРОКСИПРОПИЛ)-6-ФТОР-2-(1-ГИДРОКСИ-2-МЕТИЛПРОПАН-2-ИЛ)-1H-ИНДОЛ-5-ИЛ)ЦИКЛОПРОПАНКАРБОКСАМИДА
US8802868B2 (en) * 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
CA2797118C (en) 2010-04-22 2021-03-30 Vertex Pharmaceuticals Incorporated Process of producing cycloalkylcarboxamido-indole compounds
CA2796646A1 (en) 2010-04-22 2011-10-27 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions and administrations thereof
US8563593B2 (en) 2010-06-08 2013-10-22 Vertex Pharmaceuticals Incorporated Formulations of (R)-1-(2,2-difluorobenzo[D] [1,3] dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide
US20120046330A1 (en) 2010-08-23 2012-02-23 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of (r)-1-(2,2-difluorobenzo[d] [1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration thereof
HUE047354T2 (hu) * 2011-05-18 2020-04-28 Vertex Pharmaceuticals Europe Ltd Ivacaftor deuterizált származékai
EP2776427B1 (en) 2011-11-08 2017-02-01 Vertex Pharmaceuticals Incorporated Modulators of atp-binding cassette transporters
EP2858645A1 (en) 2012-06-08 2015-04-15 Vertex Pharmaceuticals Incorporated Pharmaceuticl compositions for the treatment of cftr -mediated disorders
EP2872122A1 (en) 2012-07-16 2015-05-20 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of (r)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration thereof
ITMI20122065A1 (it) 2012-12-03 2014-06-04 Univ Padova Uso dei correttori del cftr nel trattamento delle patologie del muscolo striato
WO2016160945A1 (en) 2015-03-31 2016-10-06 Concert Pharmaceuticals, Inc. Deuterated vx-661

Also Published As

Publication number Publication date
TW201625597A (zh) 2016-07-16
AU2015374342A1 (en) 2017-07-20
US20190367492A1 (en) 2019-12-05
US20180265501A1 (en) 2018-09-20
US10689370B2 (en) 2020-06-23
EP3240539A1 (en) 2017-11-08
WO2016109362A1 (en) 2016-07-07
IL252818A0 (en) 2017-08-31
BR112017014213A2 (pt) 2018-04-10
CA2970948A1 (en) 2016-07-07
US10167278B2 (en) 2019-01-01
EP3240539A4 (en) 2018-07-25
AR103355A1 (es) 2017-05-03

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