JP6450191B2 - ペプチドミメティック大環状化合物 - Google Patents

ペプチドミメティック大環状化合物 Download PDF

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Publication number
JP6450191B2
JP6450191B2 JP2014557790A JP2014557790A JP6450191B2 JP 6450191 B2 JP6450191 B2 JP 6450191B2 JP 2014557790 A JP2014557790 A JP 2014557790A JP 2014557790 A JP2014557790 A JP 2014557790A JP 6450191 B2 JP6450191 B2 JP 6450191B2
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Prior art keywords
peptidomimetic macrocycle
amino acid
pharmaceutically acceptable
xaa
acceptable salt
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Japanese (ja)
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JP2015509940A5 (enExample
JP2015509940A (ja
Inventor
ゲラヴァイス，ヴァンサン
エルキン，カール
ナッシュ，ヒュー・エム
ソーヤー，トミ・ケイ
グレイヴズ，ブラッドフォード・ジェイ
フェイファン，エリック
Original Assignee
エイルロン セラピューティクス，インコーポレイテッド
エイルロン セラピューティクス，インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4746—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used p53
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/03—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2014557790A 2012-02-15 2013-02-14 ペプチドミメティック大環状化合物 Active JP6450191B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261599328P 2012-02-15 2012-02-15
US61/599,328 2012-02-15
US201261656962P 2012-06-07 2012-06-07
US61/656,962 2012-06-07
US201261723770P 2012-11-07 2012-11-07
US61/723,770 2012-11-07
PCT/US2013/026238 WO2013123266A1 (en) 2012-02-15 2013-02-14 Peptidomimetic macrocycles

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2018041095A Division JP6694459B2 (ja) 2012-02-15 2018-03-07 ペプチドミメティック大環状化合物

Publications (3)

Publication Number Publication Date
JP2015509940A JP2015509940A (ja) 2015-04-02
JP2015509940A5 JP2015509940A5 (enExample) 2016-04-07
JP6450191B2 true JP6450191B2 (ja) 2019-01-09

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Family Applications (3)

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JP2014557790A Active JP6450191B2 (ja) 2012-02-15 2013-02-14 ペプチドミメティック大環状化合物
JP2018041095A Expired - Fee Related JP6694459B2 (ja) 2012-02-15 2018-03-07 ペプチドミメティック大環状化合物
JP2020041519A Pending JP2020109106A (ja) 2012-02-15 2020-03-11 ペプチドミメティック大環状化合物

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JP2020041519A Pending JP2020109106A (ja) 2012-02-15 2020-03-11 ペプチドミメティック大環状化合物

Country Status (19)

Country Link
US (6) US8927500B2 (enExample)
EP (2) EP3769776A1 (enExample)
JP (3) JP6450191B2 (enExample)
KR (1) KR102112373B1 (enExample)
CN (4) CN107216380A (enExample)
AR (1) AR089993A1 (enExample)
AU (2) AU2013221432B2 (enExample)
BR (1) BR112014020103A2 (enExample)
CA (1) CA2862038C (enExample)
ES (1) ES2817877T3 (enExample)
IL (1) IL233710B (enExample)
MX (1) MX362492B (enExample)
NZ (1) NZ627528A (enExample)
PH (1) PH12014501844A1 (enExample)
RU (2) RU2642299C2 (enExample)
SG (2) SG10201606775YA (enExample)
TW (1) TWI654207B (enExample)
WO (1) WO2013123266A1 (enExample)
ZA (1) ZA201405691B (enExample)

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