BR9807456A - Peptìdios antipatogênicos sintéticos e composições que compreendem os mesmos - Google Patents

Peptìdios antipatogênicos sintéticos e composições que compreendem os mesmos

Info

Publication number
BR9807456A
BR9807456A BR9807456-3A BR9807456A BR9807456A BR 9807456 A BR9807456 A BR 9807456A BR 9807456 A BR9807456 A BR 9807456A BR 9807456 A BR9807456 A BR 9807456A
Authority
BR
Brazil
Prior art keywords
amino acid
peptides
cytolytic
cells
hemolytic
Prior art date
Application number
BR9807456-3A
Other languages
English (en)
Inventor
Yechiel Shai
Iraelense
Ziv Oren
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/IL1997/000066 external-priority patent/WO1997031019A2/en
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Publication of BR9807456A publication Critical patent/BR9807456A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C07K14/43572—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from bees
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/461—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from fish
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Insects & Arthropods (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Patente de Invenção:<B>"PEPTìDIOS ANTIPATOGêNICOS SINTéTICOS E COMPOSIçõES QUE COMPREEDEM OS MESMOS"<D>. Agentes citóliticos não-hemolíticos selecionados a partir de peptídios, complexos de peptídios enfeixados, misturas de peptídios ou copolímeros aleatórios de peptídios tem uma atividade citolítica seletiva, manifestada em que eles têm uma atividade citolítica sobre células patogênicas, sendo células que não ocorrem de forma natural no interior do corpo, e que consistem de organismos patogênicos microbianos e células malignas; e não são hemolíticos, não tendo efeito citolítico sobre as células vermelhas do sangue. Os peptídios podem ser derivados cíclicos de peptídios naturais, tais como a pardaxina e a melitina e fragmentos dos mesmos nos quais os resíduos de aminoácido L são substituídos por resíduos de aminoácido D correspondentes, ou são diastereómeros de peptídios lineares compostos por proporções variáveis de pelo menos um aminoácido carregado de forma positiva e pelo menos um aminoácido hidrófobo, e nos quais, pelo menos um dos resíduos de aminoácido é um aminoácido D. As composições farmacêuticas compostas pelos agentes citolíticos não-hemolíticos podem ser usadas para o tratamento de diversas doenças ocasionadas por patógenos, incluindo as infeções antibacterianas, fúngicas, virais, de micoplasma e por protozoários e para o tratamento do câncer.
BR9807456-3A 1997-02-20 1998-02-19 Peptìdios antipatogênicos sintéticos e composições que compreendem os mesmos BR9807456A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/IL1997/000066 WO1997031019A2 (en) 1996-02-22 1997-02-20 Antipathogenic peptides and compositions comprising them
PCT/IL1998/000081 WO1998037090A1 (en) 1997-02-20 1998-02-19 Antipathogenic synthetic peptides and compositions comprising them

Publications (1)

Publication Number Publication Date
BR9807456A true BR9807456A (pt) 2000-04-25

Family

ID=11061982

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9807456-3A BR9807456A (pt) 1997-02-20 1998-02-19 Peptìdios antipatogênicos sintéticos e composições que compreendem os mesmos

Country Status (10)

Country Link
US (1) US7001983B1 (pt)
EP (1) EP0977774A1 (pt)
JP (1) JP2001512475A (pt)
CN (1) CN1252808A (pt)
AU (1) AU6005698A (pt)
BR (1) BR9807456A (pt)
CA (1) CA2281204A1 (pt)
EA (1) EA199900752A1 (pt)
IL (1) IL131368A0 (pt)
WO (1) WO1998037090A1 (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6818213B1 (en) 1998-07-13 2004-11-16 Board Of Regents, The University Of Texas System Cancer treatment compositions comprising therapeutic conjugates that bind to aminophospholipids
IL140700A0 (en) * 1998-07-13 2002-02-10 Univ Texas Cancer treatment methods using therapeutic conjugates that bind to aminophospholipids
IL139720A0 (en) * 2000-11-16 2002-02-10 Yeda Res & Dev Diastereomeric peptides and pharmaceutical compositions comprising them
US7671011B2 (en) 2003-06-19 2010-03-02 Yeda Research & Development Co. Ltd. Antimicrobial and anticancer lipopeptides
CA2544223C (en) 2003-11-05 2017-03-07 Dana-Farber Cancer Institute, Inc. Stabilized alpha helical peptides and uses thereof
EP1973556A2 (en) * 2005-12-27 2008-10-01 Yeda Research And Development Co., Ltd. Histidine-containing diastereomeric peptides and uses thereof
KR100811745B1 (ko) 2006-07-07 2008-03-11 조선대학교산학협력단 세포투과성 펩타이드 Ｐｅｐ １으로부터 설계된 신규한항균 펩타이드 Ｐｅｐ 1 Ｋ 및 그의 용도
CA2939778C (en) 2007-01-31 2019-01-29 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
CN101730708B (zh) 2007-03-28 2013-09-18 哈佛大学校长及研究员协会 缝合多肽
WO2009151788A2 (en) * 2008-04-22 2009-12-17 The Washington University Universal anchor peptide for nanoparticles
EP2168590A1 (en) * 2008-09-24 2010-03-31 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Antimicrobial peptides
AU2010204648B2 (en) 2009-01-14 2016-09-01 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
IT1395137B1 (it) * 2009-08-05 2012-09-05 Spider Biotech S R L Nuovi peptidi antipatogeni
CA2774973A1 (en) 2009-09-22 2011-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
SI2603600T1 (sl) 2010-08-13 2019-04-30 Aileron Therapeutics, Inc. Peptidomimetični makrocikli
GB201115910D0 (en) * 2011-09-14 2011-10-26 Univ Manchester Peptides
WO2013059525A1 (en) 2011-10-18 2013-04-25 Aileron Therapeutics, Inc. Peptidomimetic macrocyles
SG11201404648PA (en) 2012-02-15 2014-09-26 Aileron Therapeutics Inc Peptidomimetic macrocycles
CN108912211A (zh) 2012-02-15 2018-11-30 爱勒让治疗公司 三唑交联的和硫醚交联的拟肽大环化合物
EP2914256B1 (en) 2012-11-01 2019-07-31 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
EP3062889A2 (en) 2013-11-01 2016-09-07 Spherium Biomed S.L. Inclusion bodies for transdermal delivery of therapeutic and cosmetic agents
BR112017005736A2 (pt) 2014-09-24 2017-12-12 Aileron Therapeutics Inc macrociclos peptidomiméticos e formulações dos mesmos
EP3197478A4 (en) 2014-09-24 2018-05-30 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US10253067B2 (en) 2015-03-20 2019-04-09 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1
US11174288B2 (en) 2016-12-06 2021-11-16 Northeastern University Heparin-binding cationic peptide self-assembling peptide amphiphiles useful against drug-resistant bacteria

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01104006A (ja) * 1986-08-07 1989-04-21 Medice Chem Pharm Fab Puetter Gmbh & Co Kg 医薬製剤
US5792831A (en) * 1990-02-08 1998-08-11 Magainin Pharmaceuticals Inc. Analogues of magainin peptides containing D-amino acids
AU5081193A (en) * 1992-08-31 1994-03-29 Magainin Pharmaceuticals, Inc. Treatment of gynecological malignancies with biologically active peptides
AU4957196A (en) * 1995-07-06 1997-02-05 Mogam Biotechnology Research Institute Novel antibiotic peptides
IL117223A0 (en) * 1996-02-22 1996-06-18 Yeda Res & Dev Antipathogenic polypeptides and compositions comprising them

Also Published As

Publication number Publication date
JP2001512475A (ja) 2001-08-21
EA199900752A1 (ru) 2000-06-26
CA2281204A1 (en) 1998-08-27
IL131368A0 (en) 2001-01-28
AU6005698A (en) 1998-09-09
CN1252808A (zh) 2000-05-10
WO1998037090A1 (en) 1998-08-27
US7001983B1 (en) 2006-02-21
EP0977774A1 (en) 2000-02-09

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Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]