ATE218581T1 - Cyclosporinderivat, dessen herstellung und pharmazeutische zusammensetzung - Google Patents

Cyclosporinderivat, dessen herstellung und pharmazeutische zusammensetzung

Info

Publication number
ATE218581T1
ATE218581T1 AT97952997T AT97952997T ATE218581T1 AT E218581 T1 ATE218581 T1 AT E218581T1 AT 97952997 T AT97952997 T AT 97952997T AT 97952997 T AT97952997 T AT 97952997T AT E218581 T1 ATE218581 T1 AT E218581T1
Authority
AT
Austria
Prior art keywords
production
pharmaceutical composition
cyclosporine derivative
cyclosporine
derivative
Prior art date
Application number
AT97952997T
Other languages
English (en)
Inventor
Jean-Claude Barriere
Georges Bashiardes
Jean-Christophe Carry
Michel Evers
Bruno Filoche
Serge Mignani
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Application granted granted Critical
Publication of ATE218581T1 publication Critical patent/ATE218581T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT97952997T 1996-12-24 1997-12-23 Cyclosporinderivat, dessen herstellung und pharmazeutische zusammensetzung ATE218581T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9615954A FR2757520B1 (fr) 1996-12-24 1996-12-24 Derive de cyclosporine, sa preparation et les compositions pharmaceutiques qui le contiennent
PCT/FR1997/002404 WO1998028328A1 (fr) 1996-12-24 1997-12-23 Derive de cyclosporine, sa preparation et les compositions pharmaceutiques qui le contiennent

Publications (1)

Publication Number Publication Date
ATE218581T1 true ATE218581T1 (de) 2002-06-15

Family

ID=9499087

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97952997T ATE218581T1 (de) 1996-12-24 1997-12-23 Cyclosporinderivat, dessen herstellung und pharmazeutische zusammensetzung

Country Status (11)

Country Link
US (1) US5948755A (de)
EP (1) EP0951473B1 (de)
JP (1) JP4104666B2 (de)
AT (1) ATE218581T1 (de)
AU (1) AU5669198A (de)
DE (1) DE69713151D1 (de)
DK (1) DK0951473T3 (de)
ES (1) ES2178036T3 (de)
FR (1) FR2757520B1 (de)
PT (1) PT951473E (de)
WO (1) WO1998028328A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030220234A1 (en) 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
AU760168B2 (en) * 1998-06-12 2003-05-08 Scynexis, Inc. Novel cyclosporins
PT1091975E (pt) 1998-07-01 2006-05-31 Debiopharm Sa Nova ciclosporina com um perfil de actividade melhorado
US6254860B1 (en) * 1999-04-13 2001-07-03 Allergan Sales, Inc. Ocular treatment using cyclosporin-A derivatives
BRPI0213658A8 (pt) 2001-10-19 2016-12-06 F Hoffmann La Roche Ltd Método para preparar uma mistura isomérica predeterminada ou não dos análogos de ciclosporina a modificados no resíduo de 1-aminoácido, métodopara produzir uma mistura enriquecida com e-isômero ou com z-isômero de análogos de ciclosporina a modificados no resíduo de 1-aminoácido, mistura de (e) e (z)-isômeros, composição, método para a síntese estereoseletiva do z-isômero de isatx247, método para a preparação de aldeído do ciclosporina a
JP2005506990A (ja) * 2001-10-19 2005-03-10 アイソテクニカ インコーポレーテッド 新規のシクロスポリン類似体のマイクロエマルションプレコンセントレート
KR100512019B1 (ko) * 2002-07-25 2005-09-02 신득용 사이클로스포린 ａ 또는 이의 유도체를 이용한 세포의노화를 억제하는 방법 및 배양배지
EP1603512A2 (de) 2003-03-17 2005-12-14 Albany Molecular Research, Inc. Neue cyclosporine
GB0320638D0 (en) 2003-09-03 2003-10-01 Novartis Ag Organic compounds
US7439254B2 (en) * 2003-12-08 2008-10-21 Cytokinetics, Inc. Compounds, compositions, and methods
JP2008514701A (ja) 2004-09-29 2008-05-08 エーエムアール テクノロジー インコーポレイテッド シクロスポリンアルキン類似体およびそれらの薬学的使用
US7511013B2 (en) 2004-09-29 2009-03-31 Amr Technology, Inc. Cyclosporin analogues and their pharmaceutical uses
US7196161B2 (en) 2004-10-01 2007-03-27 Scynexis Inc. 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
BRPI0516737A (pt) * 2004-10-01 2008-04-29 Scynexis Inc método para tratamento ou prevenção da infecção pelo vìrus da hepatite c, usos de um derivado de ciclosporina e de 3-[(r) -2- (n,n-dimetilamino) etiltio-sar] -4- (gama-hidroximetileucina) ciclosporina, ou um sal farmaceuticamente aceitável deste, sal farmaceuticamente aceitável do derivado de ciclosporina, e, hidrato
KR101191833B1 (ko) 2004-10-01 2012-10-16 데비오팜 에스 에이 씨형 간염 감염의 치료용［디-멜라］3-［에트발］4-시클로스포린의 이용 및 상기［디-멜라］3-［에트발］4-시클로스포린으로 구성되는 약학 조성물
US7361636B2 (en) 2004-10-06 2008-04-22 Amr Technology, Inc. Cyclosporin alkynes and their utility as pharmaceutical agents
US8329658B2 (en) * 2005-09-30 2012-12-11 Scynexis, Inc. Arylalkyl and heteroarylalkyl derivatives of cyclosporine A for the treatment and prevention of viral infection
EP1933859A2 (de) 2005-09-30 2008-06-25 Scynexis, Inc. Verfahren und pharmazeutische zusammensetzungen zur behandlung und prävention von hepatitis-c-infektionen
US7696166B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US8188052B2 (en) 2006-05-19 2012-05-29 Scynexis, Inc. Method for the treatment and prevention of ocular disorders
JP2009539292A (ja) * 2006-06-02 2009-11-12 ぺリション、クロード、アニー 活性電子の管理
WO2008069917A2 (en) 2006-11-20 2008-06-12 Scynexis, Inc. Novel cyclic peptides
US20080255038A1 (en) * 2007-04-11 2008-10-16 Samuel Earl Hopkins Pharmaceutical compositions
EP2195009B1 (de) 2007-09-26 2014-07-30 Oregon Health and Science University Zyklische undekapeptide und derivate als therapien für multiple sklerose
CA2724523A1 (en) * 2008-06-06 2010-01-07 Scynexis, Inc. Novel macrocyclic peptides
WO2009148615A1 (en) * 2008-06-06 2009-12-10 Scynexis, Inc. Cyclosporin analogs and their use in the treatment of hcv infections
CN102149402B (zh) * 2008-07-10 2014-07-09 阿勒根公司 用于治疗眼睛和皮肤的疾病和病症的环孢菌素衍生物
US8536114B2 (en) * 2008-12-31 2013-09-17 Scynexis, Inc. Macrocycles
EP2435065A1 (de) * 2009-05-27 2012-04-04 Allergan, Inc. Cyclosporinderivate zur behandlung von entzündungserkrankungen und -leiden
KR101149529B1 (ko) 2009-09-11 2012-05-25 한국화학연구원 인덴온 유도체 및 이를 포함하는 약학적 조성물
JP2013516424A (ja) 2009-12-30 2013-05-13 サイネクシス，インコーポレーテッド シクロスポリン類似体
MY165152A (en) 2010-12-15 2018-02-28 Contravir Pharmaceuticals Inc Cyclosporine analogue molecules modified at amino acid 1 and 3
US9395551B2 (en) 2013-04-24 2016-07-19 Kamakura Koki Co., Ltd. Optical image stabilizer
US20180296588A1 (en) * 2017-04-14 2018-10-18 Contravir Pharmaceuticals, Inc. Combination therapy for treating viral infections

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0194972B1 (de) * 1985-03-11 1992-07-29 Sandoz Ag Cyclosporine
US4814323A (en) * 1986-03-25 1989-03-21 Andrieu J M Process for the treatment and the prevention of AIDS and other disorders induced by the LAV/HTLV III virus
SK278808B6 (sk) * 1990-11-02 1998-03-04 Novartis Ag Cyklosporíny, ich použitie pri príprave liečiva na
NZ315324A (en) * 1995-07-17 1999-10-28 Chem Ag C Cyclosporin derivatives with anti-hiv effect

Also Published As

Publication number Publication date
FR2757520B1 (fr) 1999-01-29
EP0951473A1 (de) 1999-10-27
AU5669198A (en) 1998-07-17
ES2178036T3 (es) 2002-12-16
PT951473E (pt) 2002-11-29
JP4104666B2 (ja) 2008-06-18
DE69713151D1 (de) 2002-07-11
EP0951473B1 (de) 2002-06-05
WO1998028328A1 (fr) 1998-07-02
JP2001507016A (ja) 2001-05-29
FR2757520A1 (fr) 1998-06-26
US5948755A (en) 1999-09-07
DK0951473T3 (da) 2002-09-16

Similar Documents

Publication Publication Date Title
ATE218581T1 (de) Cyclosporinderivat, dessen herstellung und pharmazeutische zusammensetzung
DE69713148D1 (de) Cyclosporinderivate, deren herstellung und pharmazeutische zusammensetzungen
DE69713152D1 (de) Cyclosporinderivate, deren herstellung und pharmazeutische zusammensetzungen
ATE290015T1 (de) Cyclosporinderivate, deren herstellung und pharmazeutische zubereitungen
SE9504661D0 (sv) New compounds
TW262461B (de)
NO971889L (no) Forbindelser og sammensetninger for levering av aktive midler
DE60038183D1 (de) Verbindungen und zusammensetzungen zur abgabe aktiver wirkstoffe
FI964681A0 (fi) Ihmisperäiset Lactobacillus-kannat, niitä sisältävät valmisteet ja niiden käytöt
ATE272628T1 (de) Substituierte gamma-phenyl-delta-lactone und deren analoge, und ihre verwendungen
TR199900661T2 (xx) Cilt enfeksiyonlar�n�n tedavisi amac�yla 1-hidroksi-2-piridonlar�n kullan�m�
TR200402070T4 (tr) Siklobüten-dion türevleri ve bunların damar sertliği tedavisinde kullanımı
SE0004101D0 (sv) New use
CA2340734A1 (en) Optically active pyridyl-4h-1,2,4-oxadiazine derivative and its use in the treatment of vascular diseases
SE9504662D0 (sv) New compounds
AU4568400A (en) Sphingomyelinase inhibitor
FI932654A0 (fi) Hydroxamsyraderivat, som hindrar lipoxigenas
NZ504614A (en) Echinocandin derivatives and application as anti-fungal agents
MX9605312A (es) Dipsipeptidos ciclicos antifungales.
IL139317A0 (en) Benzimdazole and benzoxazole derivatives and pharmaceutical compositions contining the same
MX9708385A (es) Derivados novedosos de tetraciclina, composiciones que los contienen, y el uso de las mismas.