ATE272628T1 - Substituierte gamma-phenyl-delta-lactone und deren analoge, und ihre verwendungen - Google Patents

Substituierte gamma-phenyl-delta-lactone und deren analoge, und ihre verwendungen

Info

Publication number
ATE272628T1
ATE272628T1 AT99941351T AT99941351T ATE272628T1 AT E272628 T1 ATE272628 T1 AT E272628T1 AT 99941351 T AT99941351 T AT 99941351T AT 99941351 T AT99941351 T AT 99941351T AT E272628 T1 ATE272628 T1 AT E272628T1
Authority
AT
Austria
Prior art keywords
lactones
phenyl
delta
analogues
substituted gamma
Prior art date
Application number
AT99941351T
Other languages
English (en)
Inventor
Yaping Shen
David L Burgoyne
Ronald W Lauener
Yuanlin Zhou
Patrick J Rebstein
Samuel D M Abraham
Original Assignee
Inflazyme Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inflazyme Pharm Ltd filed Critical Inflazyme Pharm Ltd
Application granted granted Critical
Publication of ATE272628T1 publication Critical patent/ATE272628T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C07D211/76—Oxygen atoms attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
AT99941351T 1998-09-09 1999-09-09 Substituierte gamma-phenyl-delta-lactone und deren analoge, und ihre verwendungen ATE272628T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9963798P 1998-09-09 1998-09-09
US12150799P 1999-02-23 1999-02-23
US14951799P 1999-08-17 1999-08-17
PCT/CA1999/000819 WO2000014083A1 (en) 1998-09-09 1999-09-09 SUBSTITUTED η-PHENYL-Δ-LACTONES AND ANALOGS THEREOF AND USES RELATED THERETO

Publications (1)

Publication Number Publication Date
ATE272628T1 true ATE272628T1 (de) 2004-08-15

Family

ID=27378872

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99941351T ATE272628T1 (de) 1998-09-09 1999-09-09 Substituierte gamma-phenyl-delta-lactone und deren analoge, und ihre verwendungen

Country Status (9)

Country Link
US (1) US6458829B1 (de)
EP (1) EP1112262B1 (de)
JP (1) JP4979157B2 (de)
AT (1) ATE272628T1 (de)
AU (1) AU757052B2 (de)
CA (1) CA2343732C (de)
DE (1) DE69919179T2 (de)
ES (1) ES2226422T3 (de)
WO (1) WO2000014083A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6770658B2 (en) 1998-09-09 2004-08-03 Inflazyme Pharmaceuticals Ltd. Substituted γ-phenyl-Δ-lactams and uses related thereto
US7868015B2 (en) * 2000-08-10 2011-01-11 Cold Spring Harbor Laboratory Phosphodiesesterase 4 inhibitors for the treatment of a cognitive deficit
US20040224316A1 (en) 2000-08-10 2004-11-11 Tully Timothy P. Augmented cognitive training
US9931318B2 (en) * 2003-04-08 2018-04-03 Dart Neuroscience (Cayman) Ltd. Phosphodiesterase 4 inhibitors for cognitive and motor rehabilitation
US8153646B2 (en) 2000-08-10 2012-04-10 Dart Neuroscience (Cayman) Ltd. Phosphodiesterase 4 inhibitors for cognitive and motor rehabilitation
KR100439425B1 (ko) * 2001-03-22 2004-07-05 (주)바이오케어 잔토리졸을 포함하는 조성물 및 그 용도
WO2002094320A1 (fr) * 2001-05-23 2002-11-28 Tanabe Seiyaku Co., Ltd. Compositions therapeutiques permettant de reparer la chondropathie
US7041280B2 (en) 2001-06-29 2006-05-09 Genzyme Corporation Aryl boronate functionalized polymers for treating obesity
US6858592B2 (en) 2001-06-29 2005-02-22 Genzyme Corporation Aryl boronic acids for treating obesity
CA2493544A1 (en) * 2002-07-22 2004-01-29 Chemgenex Pharmaceuticals, Inc. Angiogenesis inhibition by cephalotaxine alkaloids, derivatives, compositions and uses thereof
EP2177626B1 (de) 2002-08-19 2013-12-18 Dart NeuroScience (Cayman) Ltd Abtastverfahren für kognitive Verstärker
ES2213485B1 (es) * 2003-02-13 2005-12-16 Almirall Prodesfarma, S.A. Derivados de la 2-fenilpiran-4-ona.
WO2005095965A1 (en) * 2004-03-03 2005-10-13 Bayer Technology Services Gmbh Analytical platform and method for generating protein expression profiles of cell populations
AU2006213915A1 (en) * 2005-02-10 2006-08-17 Chemgenex Pharmaceuticals, Inc. Medical devices
CA2600822A1 (en) * 2005-03-14 2006-09-21 Nycomed Gmbh Method for preventing cardiovascular diseases
SG172602A1 (en) 2006-05-19 2011-07-28 Helicon Therapeutics Inc Phosphodiesterase 4 inhibitors for cognitive and motor rehabilitation
GB0722769D0 (en) * 2007-11-21 2008-01-02 Biolipox Ab New compounds
CA2680414A1 (en) * 2007-03-12 2008-09-18 Biolipox Ab Piperidinones useful in the treatment of inflammation
WO2008128191A2 (en) * 2007-04-13 2008-10-23 Chemgenex Pharmaceuticals, Inc. Oral cephalotaxine dosage forms
CN102089279A (zh) * 2007-11-21 2011-06-08 解码遗传Ehf公司 用于治疗炎症的联芳基pde4抑制剂
AU2008326309C1 (en) 2007-11-21 2015-03-12 Decode Genetics Ehf Biaryl PDE4 inhibitors for treating pulmonary and cardiovascular disorders
WO2011114103A1 (en) 2010-03-18 2011-09-22 Biolipox Ab Pyrimidinones for use as medicaments
US8883857B2 (en) 2012-12-07 2014-11-11 Baylor College Of Medicine Small molecule xanthine oxidase inhibitors and methods of use
US20150050626A1 (en) * 2013-03-15 2015-02-19 Dart Neuroscience, Llc Systems, Methods, and Software for Improving Cognitive and Motor Abilities

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3607885A (en) * 1968-08-15 1971-09-21 Universal Oil Prod Co Preparation of lactones such as substituted delta valerolactones
US3644426A (en) * 1969-08-15 1972-02-22 Universal Oil Prod Co Preparation of delta valero-lactones
US3718743A (en) * 1970-11-19 1973-02-27 Merck & Co Inc 5-phenyl-2-piperidones and 5-phenyl-2-thiopiperidones in compositions and methods for treating pain, fever and inflammation
US3814771A (en) * 1970-11-19 1974-06-04 T Shen 5-phenyl-2-piperidones and 5-phenyl-2-thiopiperidones
JPS51131870A (en) * 1975-01-20 1976-11-16 Yoshitomi Pharmaceut Ind Ltd A process for preparing novel amide compounds
JPS52156859A (en) * 1976-06-18 1977-12-27 Yoshitomi Pharmaceut Ind Ltd Heterocyclic amide derivatives
US4616089A (en) * 1983-08-03 1986-10-07 University Of California Synthetic anti-inflammatory derivatives of manoalide
JP3101053B2 (ja) * 1992-02-07 2000-10-23 株式会社共立 新規化合物及び該化合物を含有するマツノザイセンチュウ殺線虫剤
DE19603477A1 (de) * 1996-01-31 1997-08-07 Klaus Dr Med Reuter Tumormittel
WO1998032721A1 (fr) * 1997-01-22 1998-07-30 Chisso Corporation Composes et composition a cristaux liquides et element graphique a cristaux liquides contenant lesdits composes

Also Published As

Publication number Publication date
AU757052B2 (en) 2003-01-30
EP1112262B1 (de) 2004-08-04
WO2000014083A1 (en) 2000-03-16
CA2343732C (en) 2009-06-16
AU5500999A (en) 2000-03-27
ES2226422T3 (es) 2005-03-16
JP4979157B2 (ja) 2012-07-18
CA2343732A1 (en) 2000-03-16
JP2002524456A (ja) 2002-08-06
DE69919179D1 (de) 2004-09-09
US6458829B1 (en) 2002-10-01
DE69919179T2 (de) 2005-07-28
EP1112262A1 (de) 2001-07-04

Similar Documents

Publication Publication Date Title
ATE272628T1 (de) Substituierte gamma-phenyl-delta-lactone und deren analoge, und ihre verwendungen
DE69501591T2 (de) Lactobazillusstämme menschlichen ursprungs, ihre zusammensetzung und deren verwendung
BG106030A (en) Pharmaceutical composition
BR9916132A (pt) Composições e utilização das mesmas
HK1036931A1 (en) Pharmaceutical compositions containing compounds with activity for the enhancement of absorption of active ingredients.
EE200000468A (et) Ühendid, nende kasutamine ja farmatseutiline kompositsioon
PT902789E (pt) Derivados de androsteno
ATE231872T1 (de) Thiazolopyrimidinderivate
BR0008228A (pt) Composições de n-benzoil estaurosporinaespontaneamente dispersìveis
YU60900A (sh) Novi kristalni oblici antivirusnog benzimidazolskog jedinjenja
ATE204297T1 (de) Peptidanaloge des lh-rh, ihre verwendungen und die sie enthaltenden pharmazeutischen zusammensetzungen
ATE230749T1 (de) Glucocorticoid selektive entzündungshemmende mittel
DE69932510D1 (de) Vaskularisierungsinhibitoren
TR199801861T2 (xx) Farmas�tik olarak yararl� bile�imler.
ATE226947T1 (de) 2-substituierte 1,2,5-thiadiazolidin-3-on-1,1- dioxiden, zusammensetzung und deren verwendung
ES2221950T3 (es) Dihidrobenzofurano y compuestos relacionados utiles como agentes anti-inflamatorios.
DE4493718T1 (de) Abbaubare Succinsäurederivatchelanten, Verwendungen und Zusammensetzungen davon
MX9101958A (es) Inhibidores de acat de urea de aminosulfonilo
IL144199A0 (en) Novel bretylium compositions and kits, and their use in preventing and treating cardiovascular conditions
PT1066304E (pt) Antagonistas macrolidos de lhrh
ATE196914T1 (de) Lh-rh analoge mit starrer konformation, deren verwendungen und pharmazeutische zusammensetzungen
WO1999023070A8 (en) N-acetylserotonin derivatives and uses thereof
SE9902673D0 (sv) New composition
PE61999A1 (es) Compuestos de tetrahidropiridina
ITFI930007A0 (it) Tiodiazepine, loro processidi preparazione e composizioni farmaceuti- che che le contengono.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1112262

Country of ref document: EP