ATE230749T1 - Glucocorticoid selektive entzündungshemmende mittel - Google Patents

Glucocorticoid selektive entzündungshemmende mittel

Info

Publication number
ATE230749T1
ATE230749T1 AT99906996T AT99906996T ATE230749T1 AT E230749 T1 ATE230749 T1 AT E230749T1 AT 99906996 T AT99906996 T AT 99906996T AT 99906996 T AT99906996 T AT 99906996T AT E230749 T1 ATE230749 T1 AT E230749T1
Authority
AT
Austria
Prior art keywords
glucocorticoid
inflammatory agents
selective anti
mammal
compounds
Prior art date
Application number
AT99906996T
Other languages
English (en)
Inventor
Michael J Coughlan
Steven W Elmore
Michael E Kort
Philip R Kym
Jimmie L Moore
John K Pratt
Alan X Wang
James P Edwards
Todd K Jones
Original Assignee
Abbott Lab
Ligand Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab, Ligand Pharm Inc filed Critical Abbott Lab
Application granted granted Critical
Publication of ATE230749T1 publication Critical patent/ATE230749T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
AT99906996T 1998-02-13 1999-02-12 Glucocorticoid selektive entzündungshemmende mittel ATE230749T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2394798A 1998-02-13 1998-02-13
US24783199A 1999-02-10 1999-02-10
PCT/US1999/003127 WO1999041256A1 (en) 1998-02-13 1999-02-12 Glucocorticoid-selective anti-inflammatory agents

Publications (1)

Publication Number Publication Date
ATE230749T1 true ATE230749T1 (de) 2003-01-15

Family

ID=26697833

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99906996T ATE230749T1 (de) 1998-02-13 1999-02-12 Glucocorticoid selektive entzündungshemmende mittel

Country Status (21)

Country Link
EP (1) EP1053239B1 (de)
JP (1) JP2002503665A (de)
KR (1) KR20010040935A (de)
CN (1) CN1119348C (de)
AT (1) ATE230749T1 (de)
AU (1) AU766441B2 (de)
BG (1) BG64317B1 (de)
BR (1) BR9907788A (de)
CA (1) CA2320943A1 (de)
DE (1) DE69904804T2 (de)
DK (1) DK1053239T3 (de)
ES (1) ES2192035T3 (de)
HK (1) HK1033308A1 (de)
HU (1) HUP0100460A3 (de)
IL (1) IL137508A0 (de)
NO (1) NO20004053L (de)
NZ (1) NZ506013A (de)
PL (1) PL193323B1 (de)
SK (1) SK284689B6 (de)
TR (1) TR200003094T2 (de)
WO (1) WO1999041256A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6506766B1 (en) * 1998-02-13 2003-01-14 Abbott Laboratories Glucocortiocoid-selective antinflammatory agents
US6436986B1 (en) 1999-09-01 2002-08-20 Abbott Laboratories Glucocorticoid receptor antagonists for treatment of diabetes
CO5180649A1 (es) * 1999-09-01 2002-07-30 Abbott Lab Antagonistas de los receptores de los glucocorticoides para el tratamiento de la diabetes para el tratamiento de la diabetes
US6329534B1 (en) 1999-09-01 2001-12-11 Abbott Laboratories Glucocorticoid receptor antagonists for treatment of diabetes
US6593480B2 (en) 1999-09-01 2003-07-15 Abbott Laboratories Glucocorticoid receptor antagonists for treatment of diabetes
EP1201660B1 (de) 2000-10-30 2005-08-31 Pfizer Products Inc. Glucocorticoid Rezeptor Modulatoren
WO2003002548A1 (en) * 2001-06-29 2003-01-09 Abbott Laboratories A process for the preparation of chiral glucocorticoid receptor agents
US6608216B2 (en) 2001-06-29 2003-08-19 Abbott Laboratories Process for the preparation of chiral glucocorticoid receptor agents
US6518430B1 (en) 2001-09-21 2003-02-11 Abbott Laboratories Process for the preparation of 5-(substituted)-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-F]quinolines and derivatives thereof
CA2472746A1 (en) 2002-01-14 2003-07-24 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical formulations containing them and uses thereof
ES2298508T3 (es) 2002-03-26 2008-05-16 Boehringer Ingelheim Pharmaceuticals Inc. Mimeticos de glucocorticoides, metodos para prepararlos, composiciones farmaceuticas y sus usos.
CA2477764A1 (en) 2002-03-26 2003-10-09 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
DE60335869D1 (de) 2002-04-11 2011-03-10 Merck Sharp & Dohme 1h-benzo(f)indazol-5-yl-derivate als selektive glucocorticoid-rezeptor-modulatoren
US7186864B2 (en) 2002-05-29 2007-03-06 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US7074806B2 (en) 2002-06-06 2006-07-11 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
CA2496175A1 (en) 2002-08-21 2004-03-04 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted hihydroquinolines as glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
DE20301728U1 (de) 2002-10-11 2004-03-11 Ligand Pharmaceuticals, Inc., San Diego 5-substituierte 7,9-Difluor-5H-Chromeno(3,4-f) -Chinolin-Verbindungen als selektive Progesteronrezeptormodulator-Verbindungen
HK1055058A2 (en) * 2002-10-11 2003-12-05 Ligand Pharm Inc 5-CYCLOALKENYL 5H-CHROMENO[3,4-f]QUINOLINE DERIVATIVES AS SELECTIVE PROGESTERONE RECEPTOR MODULATOR COMPOUNDS
CA2501833A1 (en) * 2002-10-11 2004-04-22 Ligand Pharmaceuticals Incorporated 5-(1',1'-cycloalkyl/alkenyl)methylidene 1,2-dihydro-5h-chromeno[3,4-f]quinolines as selective progesterone receptor modulator compounds
EP1583745A1 (de) 2003-01-03 2005-10-12 Boehringer Ingelheim Pharmaceuticals Inc. 1-propanol- und 1-propylaminderivate undderen verwendung als glucocorticoidliganden
US20070088042A1 (en) 2004-09-09 2007-04-19 Meissner Robert S Fluorinated 4-azasteroid derivatives as androgen receptor modulators
US7235662B2 (en) 2003-06-11 2007-06-26 Bristol-Myers Squibb Company Modulators of the glucocorticoid receptor and method
US8097606B2 (en) 2003-07-23 2012-01-17 Corcept Therapeutics, Inc. Antiglucocorticoids for the treatment of catatonia
UY28526A1 (es) 2003-09-24 2005-04-29 Boehringer Ingelheim Pharma Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos
US7507843B2 (en) 2003-10-16 2009-03-24 Boehringer Ingelheim Pharmaceuticals, Inc. Stereoselective synthesis of certain trifluoromethyl-substituted alcohols
US7795272B2 (en) 2004-03-13 2010-09-14 Boehringer Ingelheim Pharmaceutical, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
JP2008525525A (ja) 2004-12-27 2008-07-17 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド グルココルチコイドミメティクス、その製法、医薬組成物及び使用
EP1944290B1 (de) * 2005-09-14 2013-12-04 Santen Pharmaceutical Co., Ltd. Neues 1,2-dihydrochinolinderivat mit glucocorticoidrezeptorbindender aktivität
EP2443134A2 (de) 2009-06-16 2012-04-25 Schering Corporation Neue [3,2-c]heteroarylsteroide als glucocorticoidrezeptoragonisten, zusammensetzungen und verwendung
AU2010280323A1 (en) 2009-07-31 2012-03-08 Cadila Healthcare Limited Novel compounds as modulators of glucocorticoid receptors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ300739A (en) * 1994-12-22 2000-05-26 Ligand Pharm Inc Steroid receptor modulator compounds

Also Published As

Publication number Publication date
KR20010040935A (ko) 2001-05-15
AU766441B2 (en) 2003-10-16
NZ506013A (en) 2003-03-28
SK284689B6 (sk) 2005-09-08
HK1033308A1 (en) 2001-08-24
HUP0100460A3 (en) 2003-03-28
CN1119348C (zh) 2003-08-27
TR200003094T2 (tr) 2001-01-22
ES2192035T3 (es) 2003-09-16
EP1053239B1 (de) 2003-01-08
JP2002503665A (ja) 2002-02-05
BG64317B1 (bg) 2004-09-30
DK1053239T3 (da) 2003-04-22
EP1053239A1 (de) 2000-11-22
NO20004053D0 (no) 2000-08-11
AU2677399A (en) 1999-08-30
SK11972000A3 (sk) 2001-08-06
IL137508A0 (en) 2001-07-24
HUP0100460A2 (hu) 2001-09-28
CN1296486A (zh) 2001-05-23
PL193323B1 (pl) 2007-02-28
BG104719A (en) 2001-05-31
NO20004053L (no) 2000-09-11
DE69904804D1 (de) 2003-02-13
WO1999041256A1 (en) 1999-08-19
BR9907788A (pt) 2001-10-30
CA2320943A1 (en) 1999-09-19
PL343018A1 (en) 2001-07-30
DE69904804T2 (de) 2003-11-06

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