WO1999023070A8 - N-acetylserotonin derivatives and uses thereof - Google Patents

N-acetylserotonin derivatives and uses thereof

Info

Publication number
WO1999023070A8
WO1999023070A8 PCT/US1998/023206 US9823206W WO9923070A8 WO 1999023070 A8 WO1999023070 A8 WO 1999023070A8 US 9823206 W US9823206 W US 9823206W WO 9923070 A8 WO9923070 A8 WO 9923070A8
Authority
WO
WIPO (PCT)
Prior art keywords
acetylserotonin
derivatives
compounds
treatment
nas
Prior art date
Application number
PCT/US1998/023206
Other languages
French (fr)
Other versions
WO1999023070A1 (en
Inventor
Gregory F Oxenkrug
Pura J Requintina
Sergei O Bachurin
Andrey Zakharovic Afanasiev
Original Assignee
St Elizabeths Medical Ct
Gregory F Oxenkrug
Pura J Requintina
Sergei O Bachurin
Andrey Zakharovic Afanasiev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by St Elizabeths Medical Ct, Gregory F Oxenkrug, Pura J Requintina, Sergei O Bachurin, Andrey Zakharovic Afanasiev filed Critical St Elizabeths Medical Ct
Priority to AU16988/99A priority Critical patent/AU1698899A/en
Publication of WO1999023070A1 publication Critical patent/WO1999023070A1/en
Publication of WO1999023070A8 publication Critical patent/WO1999023070A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to pharmaceutically active compounds, including derivatives of N-acetylserotonin (NAS), and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly useful for the treatment of hypertension.
PCT/US1998/023206 1997-11-04 1998-11-02 N-acetylserotonin derivatives and uses thereof WO1999023070A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU16988/99A AU1698899A (en) 1997-11-04 1998-11-02 N-acetylserotonin derivatives and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6457597P 1997-11-04 1997-11-04
US60/064,575 1997-11-04

Publications (2)

Publication Number Publication Date
WO1999023070A1 WO1999023070A1 (en) 1999-05-14
WO1999023070A8 true WO1999023070A8 (en) 1999-07-01

Family

ID=22056900

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/023206 WO1999023070A1 (en) 1997-11-04 1998-11-02 N-acetylserotonin derivatives and uses thereof

Country Status (2)

Country Link
AU (1) AU1698899A (en)
WO (1) WO1999023070A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6562858B2 (en) 1999-05-17 2003-05-13 St. Elizabeth's Medical Center Of Boston, Inc. Method for treating depression
US6239162B1 (en) 1999-05-17 2001-05-29 St. Elizabeth's Medical Center Method for treating depression
ES2172415B2 (en) * 2000-07-28 2003-11-16 Univ Madrid Complutense TREATMENT OF GLAUCOMA AND OCULAR HYPERTENSION THROUGH A MELATONINE ANALOG.
US20070088073A1 (en) * 2005-10-19 2007-04-19 Allergan, Inc. Method for treating pain
US7902251B2 (en) * 2005-10-19 2011-03-08 Allergan, Inc. Method for treating pain
CN108602775B (en) 2016-01-14 2022-04-29 贝思以色列女会吏医学中心公司 Mast cell modulators and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1255199B (en) * 1992-07-01 1995-10-20 Franco Fraschini SYNTHESIZED DRUG ANALOG OF MELATONIN PARTICULARLY EFFECTIVE IN THE PATHOLOGIES THAT INTERFER WITH CIRCADIAN RHYTHMS
WO1998044796A1 (en) * 1997-04-04 1998-10-15 St. Elizabeth's Medical Center Of Boston, Inc. Method for treating hypertension
AU6880498A (en) * 1997-04-04 1998-10-30 St. Elizabeth's Medical Center Of Boston, Inc. Method for treating depression, obsessive compulsive disorder or anxiety

Also Published As

Publication number Publication date
AU1698899A (en) 1999-05-24
WO1999023070A1 (en) 1999-05-14

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