JP5856980B2 - (R)−2−(7−(4−シクロペンチル−3−(トリフルオロメチル)ベンジルオキシ)−1,2,3,4−テトラヒドロシクロペンタ[b]インドール−3−イル)酢酸およびその塩の調製のためのプロセス - Google Patents
(R)−2−(7−(4−シクロペンチル−3−(トリフルオロメチル)ベンジルオキシ)−1,2,3,4−テトラヒドロシクロペンタ[b]インドール−3−イル)酢酸およびその塩の調製のためのプロセス Download PDFInfo
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- JP5856980B2 JP5856980B2 JP2012551175A JP2012551175A JP5856980B2 JP 5856980 B2 JP5856980 B2 JP 5856980B2 JP 2012551175 A JP2012551175 A JP 2012551175A JP 2012551175 A JP2012551175 A JP 2012551175A JP 5856980 B2 JP5856980 B2 JP 5856980B2
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- trifluoromethyl
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- benzyloxy
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- 0 *CC(CC1)c2c1c(cc(cc1)OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)c1[n]2 Chemical compound *CC(CC1)c2c1c(cc(cc1)OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)c1[n]2 0.000 description 3
- VVQFLWDFZUIVDL-ZHACJKMWSA-N CCOC(/C=C1/C(N2CCOCC2)=CCC1)=O Chemical compound CCOC(/C=C1/C(N2CCOCC2)=CCC1)=O VVQFLWDFZUIVDL-ZHACJKMWSA-N 0.000 description 1
- MOIBBQFSBRXTDL-UHFFFAOYSA-N CCOC(CC(CC1)c2c1c(cc(cc1)OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)c1[nH]2)=O Chemical compound CCOC(CC(CC1)c2c1c(cc(cc1)OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)c1[nH]2)=O MOIBBQFSBRXTDL-UHFFFAOYSA-N 0.000 description 1
- MVGWUTBTXDYMND-QGZVFWFLSA-N OC(C[C@@H](CC1)c2c1c1cc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)ccc1[nH]2)=O Chemical compound OC(C[C@@H](CC1)c2c1c1cc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)ccc1[nH]2)=O MVGWUTBTXDYMND-QGZVFWFLSA-N 0.000 description 1
- JKEHZGXRXDVGJN-UHFFFAOYSA-N [NH-][NH+](c1ccccc1C1CCCC1)[IH]#CC(F)(F)F Chemical compound [NH-][NH+](c1ccccc1C1CCCC1)[IH]#CC(F)(F)F JKEHZGXRXDVGJN-UHFFFAOYSA-N 0.000 description 1
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- C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
- C07C17/272—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by addition reactions
- C07C17/278—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by addition reactions of only halogenated hydrocarbons
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- C07D209/82—Carbazoles; Hydrogenated carbazoles
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- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33683510P | 2010-01-27 | 2010-01-27 | |
| US61/336,835 | 2010-01-27 | ||
| PCT/US2011/000153 WO2011094008A1 (en) | 2010-01-27 | 2011-01-27 | Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015103394A Division JP2015154782A (ja) | 2010-01-27 | 2015-05-21 | (R)−2−(7−(4−シクロペンチル−3−(トリフルオロメチル)ベンジルオキシ)−1,2,3,4−テトラヒドロシクロペンタ[b]インドール−3−イル)酢酸およびその塩の調製のためのプロセス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013518106A JP2013518106A (ja) | 2013-05-20 |
| JP2013518106A5 JP2013518106A5 (https=) | 2014-02-20 |
| JP5856980B2 true JP5856980B2 (ja) | 2016-02-10 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012551175A Active JP5856980B2 (ja) | 2010-01-27 | 2011-01-27 | (R)−2−(7−(4−シクロペンチル−3−(トリフルオロメチル)ベンジルオキシ)−1,2,3,4−テトラヒドロシクロペンタ[b]インドール−3−イル)酢酸およびその塩の調製のためのプロセス |
| JP2015103394A Withdrawn JP2015154782A (ja) | 2010-01-27 | 2015-05-21 | (R)−2−(7−(4−シクロペンチル−3−(トリフルオロメチル)ベンジルオキシ)−1,2,3,4−テトラヒドロシクロペンタ[b]インドール−3−イル)酢酸およびその塩の調製のためのプロセス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015103394A Withdrawn JP2015154782A (ja) | 2010-01-27 | 2015-05-21 | (R)−2−(7−(4−シクロペンチル−3−(トリフルオロメチル)ベンジルオキシ)−1,2,3,4−テトラヒドロシクロペンタ[b]インドール−3−イル)酢酸およびその塩の調製のためのプロセス |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US8853419B2 (https=) |
| EP (3) | EP3378854B1 (https=) |
| JP (2) | JP5856980B2 (https=) |
| CN (2) | CN103221391B (https=) |
| CA (1) | CA2786994C (https=) |
| ES (1) | ES2937386T3 (https=) |
| SG (3) | SG10201906876PA (https=) |
| WO (1) | WO2011094008A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015154782A (ja) * | 2010-01-27 | 2015-08-27 | アリーナ ファーマシューティカルズ, インコーポレイテッド | (R)−2−(7−(4−シクロペンチル−3−(トリフルオロメチル)ベンジルオキシ)−1,2,3,4−テトラヒドロシクロペンタ[b]インドール−3−イル)酢酸およびその塩の調製のためのプロセス |
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| US8580841B2 (en) | 2008-07-23 | 2013-11-12 | Arena Pharmaceuticals, Inc. | Substituted 1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid derivatives useful in the treatment of autoimmune and inflammatory disorders |
| HRP20160890T1 (hr) | 2008-08-27 | 2016-09-23 | Arena Pharmaceuticals, Inc. | Derivati supstituirane tricikličke kiseline kao agonisti s1p1-receptora korisni u liječenju autoimunih i upalnih poremećaja |
| CN105503882B (zh) | 2010-03-03 | 2019-07-05 | 艾尼纳制药公司 | 制备s1p1受体调节剂及其晶体形式的方法 |
| CN102659664B (zh) * | 2012-03-28 | 2015-01-21 | 中国计量学院 | 合成分离拉洛皮兰及其类似物的方法 |
| PL3242666T3 (pl) | 2015-01-06 | 2025-02-17 | Arena Pharmaceuticals, Inc. | Związek do zastosowania w leczeniu dolegliwości związanych z receptorem s1p1 |
| BR112017027656B1 (pt) | 2015-06-22 | 2023-12-05 | Arena Pharmaceuticals, Inc. | Hábito cristalino de placa livre de sal de l-arginina de ácido (r)-2-(7-(4- ciclopentil-3-(trifluorometil)benzilóxi)- 1,2,3,4-tetra-hidrociclo-penta[b]indol-3- il)acético, composição farmacêutica que o compreende, seus usos e método de preparação do mesmo |
| CN106349006B (zh) * | 2016-08-26 | 2019-02-05 | 大连奇凯医药科技有限公司 | 3-三氟甲基苯乙腈的制备方法 |
| MX2019009843A (es) | 2017-02-16 | 2020-01-30 | Arena Pharm Inc | Compuestos y metodos para el tratamiento de la enfermedad inflamatoria intestinal con manifestaciones extraintestinales. |
| MX2019009841A (es) * | 2017-02-16 | 2020-01-30 | Arena Pharm Inc | Compuestos y metodos para el tratamiento de la colangitis biliar primaria. |
| US11066422B2 (en) | 2017-07-13 | 2021-07-20 | Toray Fine Chemicals Co., Ltd. | Method of producing cycloalkyl(trifluoromethyl)benzene |
| CA3102136A1 (en) | 2018-06-06 | 2019-12-12 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the s1p1 receptor |
| CN112955431A (zh) * | 2018-09-06 | 2021-06-11 | 艾尼纳制药公司 | 可用于治疗自身免疫性病症和炎性病症的化合物 |
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| CN109529920B (zh) * | 2018-11-12 | 2021-11-02 | 山东科技大学 | 用于轻质烷烃异构化的负载硼化钛催化剂及其制备方法和使用方法 |
| CN109678715B (zh) * | 2018-11-28 | 2019-11-12 | 中国药科大学 | 2-(1-酰氧正戊基)苯甲酸与碱性氨基酸或氨基胍形成的盐、其制备方法及用途 |
| CN118649163A (zh) * | 2018-11-30 | 2024-09-17 | 艾尼纳制药公司 | 治疗与s1p1受体有关的病况的方法 |
| CN113874009A (zh) | 2019-01-08 | 2021-12-31 | 艾尼纳制药公司 | 治疗与s1p1受体有关的病况的方法 |
| CN115038438A (zh) * | 2019-10-01 | 2022-09-09 | 艾尼纳制药公司 | 治疗与s1p1受体相关的病症的方法 |
| JP7749552B2 (ja) | 2019-10-31 | 2025-10-06 | イドルシア・ファーマシューティカルズ・リミテッド | Cxcr7アンタゴニストのs1p1受容体調節剤との合剤 |
| AU2020389144A1 (en) | 2019-11-20 | 2022-06-09 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the S1P1 receptor |
| CN111763148B (zh) * | 2020-06-19 | 2022-10-28 | 广州大学 | 一种含三氟甲基的炔基环戊烯衍生物及其制备方法和应用 |
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| CA3200998A1 (en) * | 2020-11-09 | 2022-05-12 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the s1p1 receptor |
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| KR20240134360A (ko) | 2022-01-13 | 2024-09-09 | 아레나 파마슈티칼스, 인크. | 호르몬 치료와 조합되어 s1p1 수용체-연관된 장애를 치료하는 데 사용하기 위한 에트라시모드 |
| EP4212156A1 (en) | 2022-01-13 | 2023-07-19 | Abivax | Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a s1p receptor modulator |
| WO2023214312A1 (en) | 2022-05-06 | 2023-11-09 | Arena Pharmaceuticals, Inc. | Methods of treating atopic dermatitis with etrasimod |
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| CN119330873B (zh) * | 2024-11-08 | 2025-07-11 | 成都克莱蒙医药科技有限公司 | 一种依曲莫德中间体的制备方法 |
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| CH480410A (de) | 1967-01-09 | 1969-10-31 | Geigy Ag J R | Verfahren zur Herstellung von wasserlöslichen Azopyrimidinfarbstoffen |
| CA961052A (en) | 1967-01-12 | 1975-01-14 | Max Schellenbaum | N-2-ethylhexyl-n'-aryl ureas and preparation containing them |
| US3608087A (en) | 1968-06-21 | 1971-09-21 | Merck & Co Inc | Feed compositions |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015154782A (ja) * | 2010-01-27 | 2015-08-27 | アリーナ ファーマシューティカルズ, インコーポレイテッド | (R)−2−(7−(4−シクロペンチル−3−(トリフルオロメチル)ベンジルオキシ)−1,2,3,4−テトラヒドロシクロペンタ[b]インドール−3−イル)酢酸およびその塩の調製のためのプロセス |
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| JP2013518106A (ja) | 2013-05-20 |
| US20140357690A1 (en) | 2014-12-04 |
| US11674163B2 (en) | 2023-06-13 |
| US20160016904A1 (en) | 2016-01-21 |
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