PE20120578A1 - Agonistas y antagonistas del receptor de s1p5, y metodos de uso de los mismos - Google Patents

Agonistas y antagonistas del receptor de s1p5, y metodos de uso de los mismos

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Publication number
PE20120578A1
PE20120578A1 PE2011001458A PE2011001458A PE20120578A1 PE 20120578 A1 PE20120578 A1 PE 20120578A1 PE 2011001458 A PE2011001458 A PE 2011001458A PE 2011001458 A PE2011001458 A PE 2011001458A PE 20120578 A1 PE20120578 A1 PE 20120578A1
Authority
PE
Peru
Prior art keywords
substituted
antagonists
methods
same
receptor agonists
Prior art date
Application number
PE2011001458A
Other languages
English (en)
Inventor
Christopher M Harris
Adrian D Hobson
Noel S Wilson
Original Assignee
Abbott Lab
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Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of PE20120578A1 publication Critical patent/PE20120578A1/es

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE: EL ANILLO 1 ES SELECCIONADO DE BENZOFURANILO SUSTITUIDO O NO, BENZIMIDAZOLILO SUSTITUIDO O NO, BENZOTIAZOLILO SUSTITUIDO O NO, BENZOTIENILO, SUSTITUIDO O NO, ENTRE OTROS; L SE SELECCIONA ENTRE N(Ra)-, -O- Y C(Ra)2; X SE SELECCIONA ENTRE N SI L ES C(Ra)2, O ES CRa SI L SE SELECCIONA ENTRE N Y O; R2 Y R2a SON H, ALQUILO, ALQUENILO, ALCOXIALQUILO, CICLOALQUILO OPCIONALMENTE SUSTITUIDOS, ENTRE OTROS. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES AGONISTA O ANTAGONISTA DE LOS RECEPTORES INDIVIDUALES DE LA FAMILIA DE RECEPTORES DE SIP UTIL EN EL TRATAMIENTO DE TRANSTORNOS NEURODEGENERATIVOS O DOLOR NEUROPATICO
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