PE20130190A1 - Heteroaril-ciclohexil-tetraazabenzo[e] azulenos como antagonistas de los receptores de vasopresina v1a - Google Patents
Heteroaril-ciclohexil-tetraazabenzo[e] azulenos como antagonistas de los receptores de vasopresina v1aInfo
- Publication number
- PE20130190A1 PE20130190A1 PE2012002055A PE2012002055A PE20130190A1 PE 20130190 A1 PE20130190 A1 PE 20130190A1 PE 2012002055 A PE2012002055 A PE 2012002055A PE 2012002055 A PE2012002055 A PE 2012002055A PE 20130190 A1 PE20130190 A1 PE 20130190A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- halogen
- vasoppressin
- blueens
- cyclohexil
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE: R1 ES i) H, ii) ALQUILO C1-6 SIN SUSTITUIR O SUSTITUIDO POR 1 A 5 SUSTITUYENTES SELECCIONADOS DE OH, HALOGENO, CIANO Y ALCOXI C1-6, iii) S(O)2-ALQUILO C1-6, iv) C(O)-ALQUILO C1-6, v) C(O)-ALQUILO C1-6, ENTRE OTROS; R2 ES HALOGENO; R3 ES UN ANILLO HETEROARILO DE 6 ESLABONES, SIN SUSTITUIR O SUSTITUIDO POR 1-5 SUSTITUYENTES SELECCIONADOS DE ALCOXI C1-6, HALOGENO-ALQUILO C1-6, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: TRANS-8-CLORO-1-(4-PIRIDIN-2-IL-CICLOHEXIL)-4H,6H-2,3,5,10b-TETRAAZA-BENZO[E]AZULENO-5-CARBOXILATO DE TERT-BUTILO; TRANS-8-CLORO-1-(4-PIRIMIDIN-2-IL-CICLOHEXIL)-5,6-DIHIDRO-4H-2,3,5,10b-TETRAAZA-BENZO[E]AZULENO; ENTRE OTROS. REFERIDO ADEMAS A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE OBTENCION. DICHO COMPUESTO ES ANTAGONISTA DEL RECEPTOR DE LA VASOPRESINA V1A, SIENDO UTIL PARA TRATAMIENTO DE CIRROSIS HEPATICA, FALLO CARDIACO CRONICO, SINDROME NEFROTICO
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10160643 | 2010-04-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20130190A1 true PE20130190A1 (es) | 2013-02-21 |
Family
ID=43919925
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2016000352A PE20160589A1 (es) | 2010-04-21 | 2011-04-18 | Heteroaril-ciclohexil-tetraazabenzo[e]azulenos como antagonistas de los receptores de vasopresina v1a |
PE2012002055A PE20130190A1 (es) | 2010-04-21 | 2011-04-18 | Heteroaril-ciclohexil-tetraazabenzo[e] azulenos como antagonistas de los receptores de vasopresina v1a |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2016000352A PE20160589A1 (es) | 2010-04-21 | 2011-04-18 | Heteroaril-ciclohexil-tetraazabenzo[e]azulenos como antagonistas de los receptores de vasopresina v1a |
Country Status (35)
Country | Link |
---|---|
US (1) | US8492376B2 (es) |
EP (1) | EP2560975B1 (es) |
JP (1) | JP5579923B2 (es) |
KR (1) | KR101506776B1 (es) |
CN (1) | CN102858776B (es) |
AR (1) | AR080927A1 (es) |
AU (1) | AU2011244407B2 (es) |
BR (1) | BR112012026890A2 (es) |
CA (1) | CA2795526A1 (es) |
CL (1) | CL2012002905A1 (es) |
CO (1) | CO6640209A2 (es) |
CR (1) | CR20120513A (es) |
CY (1) | CY1116661T1 (es) |
DK (1) | DK2560975T3 (es) |
EA (1) | EA021418B1 (es) |
EC (1) | ECSP12012210A (es) |
ES (1) | ES2542953T3 (es) |
HK (1) | HK1176609A1 (es) |
HR (1) | HRP20150929T1 (es) |
HU (1) | HUE026538T2 (es) |
IL (1) | IL222403A (es) |
MA (1) | MA34174B1 (es) |
MX (1) | MX2012012046A (es) |
MY (1) | MY160457A (es) |
NZ (1) | NZ602627A (es) |
PE (2) | PE20160589A1 (es) |
PL (1) | PL2560975T3 (es) |
PT (1) | PT2560975E (es) |
RS (1) | RS54121B1 (es) |
SG (1) | SG184534A1 (es) |
SI (1) | SI2560975T1 (es) |
TW (1) | TWI419890B (es) |
UA (1) | UA109543C2 (es) |
WO (1) | WO2011131596A1 (es) |
ZA (1) | ZA201207689B (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI2356123T1 (sl) * | 2008-11-13 | 2013-01-31 | F. Hoffmann-La Roche Ag | Piro-5,6-dihidro-4h-2,3,5,10b-tetraaza-benzo(e)azuleni |
SG171742A1 (en) * | 2008-11-18 | 2011-07-28 | Hoffmann La Roche | Alkylcyclohexylethers of dihydrotetraazabenzoazulenes |
EP2370441B1 (en) | 2008-11-28 | 2013-09-11 | F. Hoffmann-La Roche AG | Arylcyclohexylethers of dihydrotetraazabenzoazulenes for use as vasopressin v1a receptor antagonists |
US8420633B2 (en) | 2010-03-31 | 2013-04-16 | Hoffmann-La Roche Inc. | Aryl-cyclohexyl-tetraazabenzo[e]azulenes |
US8461151B2 (en) | 2010-04-13 | 2013-06-11 | Hoffmann-La Roche Inc. | Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes |
US8492376B2 (en) | 2010-04-21 | 2013-07-23 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes |
US8513238B2 (en) | 2010-05-10 | 2013-08-20 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes |
MX2016006558A (es) | 2013-12-05 | 2016-08-03 | Hoffmann La Roche | Sistesis de trans-8-cloro-5-metil-1-[4-(piridin-2-iloxi)-ciclohexi l]-5,6-dihidro-4h-2,3,5,10b-tetraaza-benzo[e]azuleno y formas cristalinas del mismo. |
WO2017191117A1 (en) | 2016-05-03 | 2017-11-09 | Bayer Pharma Aktiengesellschaft | V1a receptor antagonists for use in the treatment of renal diseases |
CA3079133A1 (en) * | 2017-12-08 | 2019-06-13 | F. Hoffmann-La Roche Ag | Pharmaceutical formulation |
TW201938171A (zh) * | 2017-12-15 | 2019-10-01 | 匈牙利商羅特格登公司 | 作為血管升壓素V1a受體拮抗劑之三環化合物 |
HU231206B1 (hu) * | 2017-12-15 | 2021-10-28 | Richter Gedeon Nyrt. | Triazolobenzazepinek |
US20230084719A1 (en) * | 2018-12-12 | 2023-03-16 | Blackthorn Therapeutics, Inc. | 1-(2,6-diazaspiro[3.3]heptan-6-yl)-5,6-dihydro-4h-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine derivatives and related compounds as vasopressin antagonists for the treatment of neuro-psychological disorders |
JP2023534721A (ja) * | 2020-07-23 | 2023-08-10 | エフ. ホフマン-ラ ロシュ アーゲー | バソプレシン受容体v1aアンタゴニストとしてのヘテロアリール-メチル置換トリアゾール |
JP2023534713A (ja) * | 2020-07-23 | 2023-08-10 | エフ. ホフマン-ラ ロシュ アーゲー | バソプレシン受容体v1aアンタゴニストとしてのシクロヘキシル置換トリアゾール |
CN114644635B (zh) * | 2020-12-21 | 2023-02-03 | 上海济煜医药科技有限公司 | 三氮唑类三并环衍生物及其制备方法和应用 |
CN116836111A (zh) * | 2023-09-01 | 2023-10-03 | 峰成医药科技(天津)有限公司 | 一种氟代吡啶的连续化合成方法 |
Family Cites Families (25)
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AU619555B2 (en) * | 1988-04-27 | 1992-01-30 | Schering Corporation | Certain paf antagonist antihistamine combinations and methods |
US5185331A (en) * | 1991-05-14 | 1993-02-09 | Merck & Co., Inc. | Triazolobenzodiazepines |
CA2120939A1 (en) * | 1991-10-11 | 1993-04-15 | Tetsuya Tahara | Therapeutic agent for osteoporosis and diazepine compound |
US5516774A (en) * | 1993-07-29 | 1996-05-14 | American Cyanamid Company | Tricyclic diazepine vasopressin antagonists and oxytocin antagonists |
US5521173A (en) | 1995-01-17 | 1996-05-28 | American Home Products Corporation | Tricyclic benzazepine vasopressin antagonists |
HU229074B1 (en) | 1999-01-19 | 2013-07-29 | Ortho Mcneil Pharm Inc | Tricyclic benzodiazepines as vasopressin receptor antagonists |
US7022699B2 (en) | 2001-04-12 | 2006-04-04 | Wyeth | Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators |
GB0303852D0 (en) * | 2003-02-19 | 2003-03-26 | Pfizer Ltd | Triazole compounds useful in therapy |
PT1597260E (pt) * | 2003-02-19 | 2007-01-31 | Pfizer | Composto de triazole úteis em terapia |
GB0400700D0 (en) | 2004-01-13 | 2004-02-18 | Pfizer Ltd | Compounds useful in therapy |
KR100840852B1 (ko) | 2004-05-25 | 2008-06-23 | 화이자 프로덕츠 인크. | 테트라아자벤조[e]아줄렌 유도체 및 이의 유사체 |
AP2006003768A0 (en) | 2004-05-25 | 2006-10-31 | Pfizer Prod Inc | TetraazabenzoÄeÜazulene derivatives and analogs tehereof |
GB0412874D0 (en) * | 2004-06-09 | 2004-07-14 | Pfizer Ltd | Novel pharmaceuticals |
EP1632494A1 (en) | 2004-08-24 | 2006-03-08 | Ferring B.V. | Vasopressin v1a antagonists |
MX2007002248A (es) | 2004-08-25 | 2008-10-02 | Pfizer | Triazolobenzodiazepinas y su uso como antagonistas de vasopresina. |
US7221269B2 (en) * | 2004-10-29 | 2007-05-22 | Kimberly-Clark Worldwide, Inc. | Self-adjusting portals with movable data tag readers for improved reading of data tags |
US20080188478A1 (en) | 2005-04-26 | 2008-08-07 | Pfizer Inc. | Compounds Useful In Therapy |
CA2608718A1 (en) | 2005-05-18 | 2006-11-23 | Pfizer Limited | 1, 2, 4-triazole derivatives as vasopressin antagonists |
KR101129791B1 (ko) | 2007-01-12 | 2012-03-23 | 에프. 호프만-라 로슈 아게 | 스파이로피페리딘 글리신아마이드 유도체 |
AP2010005364A0 (en) * | 2008-01-24 | 2010-08-31 | Panacea Biotec Ltd | Novel heterocyclic compounds. |
SG171742A1 (en) | 2008-11-18 | 2011-07-28 | Hoffmann La Roche | Alkylcyclohexylethers of dihydrotetraazabenzoazulenes |
US8420633B2 (en) | 2010-03-31 | 2013-04-16 | Hoffmann-La Roche Inc. | Aryl-cyclohexyl-tetraazabenzo[e]azulenes |
US8461151B2 (en) | 2010-04-13 | 2013-06-11 | Hoffmann-La Roche Inc. | Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes |
US8492376B2 (en) | 2010-04-21 | 2013-07-23 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes |
US8513238B2 (en) | 2010-05-10 | 2013-08-20 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes |
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2011
- 2011-04-14 US US13/086,422 patent/US8492376B2/en active Active
- 2011-04-18 MX MX2012012046A patent/MX2012012046A/es active IP Right Grant
- 2011-04-18 TW TW100113411A patent/TWI419890B/zh not_active IP Right Cessation
- 2011-04-18 UA UAA201213290A patent/UA109543C2/uk unknown
- 2011-04-18 SG SG2012075156A patent/SG184534A1/en unknown
- 2011-04-18 NZ NZ602627A patent/NZ602627A/xx not_active IP Right Cessation
- 2011-04-18 PT PT117145649T patent/PT2560975E/pt unknown
- 2011-04-18 RS RS20150473A patent/RS54121B1/en unknown
- 2011-04-18 EA EA201291092A patent/EA021418B1/ru not_active IP Right Cessation
- 2011-04-18 AU AU2011244407A patent/AU2011244407B2/en not_active Ceased
- 2011-04-18 EP EP11714564.9A patent/EP2560975B1/en not_active Not-in-force
- 2011-04-18 PL PL11714564T patent/PL2560975T3/pl unknown
- 2011-04-18 BR BR112012026890A patent/BR112012026890A2/pt not_active IP Right Cessation
- 2011-04-18 HU HUE11714564A patent/HUE026538T2/en unknown
- 2011-04-18 JP JP2013505426A patent/JP5579923B2/ja not_active Expired - Fee Related
- 2011-04-18 CA CA2795526A patent/CA2795526A1/en not_active Abandoned
- 2011-04-18 DK DK11714564.9T patent/DK2560975T3/en active
- 2011-04-18 CN CN201180019877.XA patent/CN102858776B/zh active Active
- 2011-04-18 KR KR1020127030366A patent/KR101506776B1/ko not_active IP Right Cessation
- 2011-04-18 MY MYPI2012004627A patent/MY160457A/en unknown
- 2011-04-18 PE PE2016000352A patent/PE20160589A1/es not_active Application Discontinuation
- 2011-04-18 ES ES11714564.9T patent/ES2542953T3/es active Active
- 2011-04-18 MA MA35328A patent/MA34174B1/fr unknown
- 2011-04-18 PE PE2012002055A patent/PE20130190A1/es not_active Application Discontinuation
- 2011-04-18 WO PCT/EP2011/056071 patent/WO2011131596A1/en active Application Filing
- 2011-04-18 SI SI201130543T patent/SI2560975T1/sl unknown
- 2011-04-19 AR ARP110101333A patent/AR080927A1/es unknown
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2012
- 2012-09-24 CO CO12165814A patent/CO6640209A2/es not_active Application Discontinuation
- 2012-10-02 EC ECSP12012210 patent/ECSP12012210A/es unknown
- 2012-10-10 CR CR20120513A patent/CR20120513A/es unknown
- 2012-10-11 IL IL222403A patent/IL222403A/en active IP Right Grant
- 2012-10-12 ZA ZA2012/07689A patent/ZA201207689B/en unknown
- 2012-10-18 CL CL2012002905A patent/CL2012002905A1/es unknown
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2013
- 2013-03-22 HK HK13103560.9A patent/HK1176609A1/zh not_active IP Right Cessation
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2015
- 2015-08-27 CY CY20151100757T patent/CY1116661T1/el unknown
- 2015-09-04 HR HRP20150929TT patent/HRP20150929T1/hr unknown
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