PE20130190A1 - Heteroaril-ciclohexil-tetraazabenzo[e] azulenos como antagonistas de los receptores de vasopresina v1a - Google Patents

Heteroaril-ciclohexil-tetraazabenzo[e] azulenos como antagonistas de los receptores de vasopresina v1a

Info

Publication number
PE20130190A1
PE20130190A1 PE2012002055A PE2012002055A PE20130190A1 PE 20130190 A1 PE20130190 A1 PE 20130190A1 PE 2012002055 A PE2012002055 A PE 2012002055A PE 2012002055 A PE2012002055 A PE 2012002055A PE 20130190 A1 PE20130190 A1 PE 20130190A1
Authority
PE
Peru
Prior art keywords
alkyl
halogen
vasoppressin
blueens
cyclohexil
Prior art date
Application number
PE2012002055A
Other languages
English (en)
Inventor
Cosimo Dolente
Patrick Schnider
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20130190A1 publication Critical patent/PE20130190A1/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/55131,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/55171,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/10Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE: R1 ES i) H, ii) ALQUILO C1-6 SIN SUSTITUIR O SUSTITUIDO POR 1 A 5 SUSTITUYENTES SELECCIONADOS DE OH, HALOGENO, CIANO Y ALCOXI C1-6, iii) S(O)2-ALQUILO C1-6, iv) C(O)-ALQUILO C1-6, v) C(O)-ALQUILO C1-6, ENTRE OTROS; R2 ES HALOGENO; R3 ES UN ANILLO HETEROARILO DE 6 ESLABONES, SIN SUSTITUIR O SUSTITUIDO POR 1-5 SUSTITUYENTES SELECCIONADOS DE ALCOXI C1-6, HALOGENO-ALQUILO C1-6, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: TRANS-8-CLORO-1-(4-PIRIDIN-2-IL-CICLOHEXIL)-4H,6H-2,3,5,10b-TETRAAZA-BENZO[E]AZULENO-5-CARBOXILATO DE TERT-BUTILO; TRANS-8-CLORO-1-(4-PIRIMIDIN-2-IL-CICLOHEXIL)-5,6-DIHIDRO-4H-2,3,5,10b-TETRAAZA-BENZO[E]AZULENO; ENTRE OTROS. REFERIDO ADEMAS A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE OBTENCION. DICHO COMPUESTO ES ANTAGONISTA DEL RECEPTOR DE LA VASOPRESINA V1A, SIENDO UTIL PARA TRATAMIENTO DE CIRROSIS HEPATICA, FALLO CARDIACO CRONICO, SINDROME NEFROTICO
PE2012002055A 2010-04-21 2011-04-18 Heteroaril-ciclohexil-tetraazabenzo[e] azulenos como antagonistas de los receptores de vasopresina v1a PE20130190A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10160643 2010-04-21

Publications (1)

Publication Number Publication Date
PE20130190A1 true PE20130190A1 (es) 2013-02-21

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Family Applications (2)

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PE2016000352A PE20160589A1 (es) 2010-04-21 2011-04-18 Heteroaril-ciclohexil-tetraazabenzo[e]azulenos como antagonistas de los receptores de vasopresina v1a
PE2012002055A PE20130190A1 (es) 2010-04-21 2011-04-18 Heteroaril-ciclohexil-tetraazabenzo[e] azulenos como antagonistas de los receptores de vasopresina v1a

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PE2016000352A PE20160589A1 (es) 2010-04-21 2011-04-18 Heteroaril-ciclohexil-tetraazabenzo[e]azulenos como antagonistas de los receptores de vasopresina v1a

Country Status (35)

Country Link
US (1) US8492376B2 (es)
EP (1) EP2560975B1 (es)
JP (1) JP5579923B2 (es)
KR (1) KR101506776B1 (es)
CN (1) CN102858776B (es)
AR (1) AR080927A1 (es)
AU (1) AU2011244407B2 (es)
BR (1) BR112012026890A2 (es)
CA (1) CA2795526A1 (es)
CL (1) CL2012002905A1 (es)
CO (1) CO6640209A2 (es)
CR (1) CR20120513A (es)
CY (1) CY1116661T1 (es)
DK (1) DK2560975T3 (es)
EA (1) EA021418B1 (es)
EC (1) ECSP12012210A (es)
ES (1) ES2542953T3 (es)
HK (1) HK1176609A1 (es)
HR (1) HRP20150929T1 (es)
HU (1) HUE026538T2 (es)
IL (1) IL222403A (es)
MA (1) MA34174B1 (es)
MX (1) MX2012012046A (es)
MY (1) MY160457A (es)
NZ (1) NZ602627A (es)
PE (2) PE20160589A1 (es)
PL (1) PL2560975T3 (es)
PT (1) PT2560975E (es)
RS (1) RS54121B1 (es)
SG (1) SG184534A1 (es)
SI (1) SI2560975T1 (es)
TW (1) TWI419890B (es)
UA (1) UA109543C2 (es)
WO (1) WO2011131596A1 (es)
ZA (1) ZA201207689B (es)

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TW201938171A (zh) * 2017-12-15 2019-10-01 匈牙利商羅特格登公司 作為血管升壓素V1a受體拮抗劑之三環化合物
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US20230084719A1 (en) * 2018-12-12 2023-03-16 Blackthorn Therapeutics, Inc. 1-(2,6-diazaspiro[3.3]heptan-6-yl)-5,6-dihydro-4h-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine derivatives and related compounds as vasopressin antagonists for the treatment of neuro-psychological disorders
JP2023534721A (ja) * 2020-07-23 2023-08-10 エフ. ホフマン-ラ ロシュ アーゲー バソプレシン受容体v1aアンタゴニストとしてのヘテロアリール-メチル置換トリアゾール
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Publication number Publication date
CN102858776A (zh) 2013-01-02
RS54121B1 (en) 2015-12-31
IL222403A (en) 2014-08-31
TW201139444A (en) 2011-11-16
EA021418B1 (ru) 2015-06-30
CO6640209A2 (es) 2013-03-22
SI2560975T1 (sl) 2015-08-31
BR112012026890A2 (pt) 2016-07-19
AU2011244407B2 (en) 2013-06-13
CA2795526A1 (en) 2011-10-27
JP5579923B2 (ja) 2014-08-27
PE20160589A1 (es) 2016-06-11
ZA201207689B (en) 2015-06-24
AR080927A1 (es) 2012-05-16
MX2012012046A (es) 2012-11-22
EP2560975B1 (en) 2015-06-17
CL2012002905A1 (es) 2013-03-22
CR20120513A (es) 2012-11-01
KR101506776B1 (ko) 2015-03-27
TWI419890B (zh) 2013-12-21
MA34174B1 (fr) 2013-04-03
WO2011131596A1 (en) 2011-10-27
CY1116661T1 (el) 2017-03-15
NZ602627A (en) 2013-07-26
HRP20150929T1 (hr) 2015-10-09
UA109543C2 (xx) 2015-09-10
EP2560975A1 (en) 2013-02-27
AU2011244407A1 (en) 2012-10-18
MY160457A (en) 2017-03-15
DK2560975T3 (en) 2015-06-29
ES2542953T3 (es) 2015-08-13
CN102858776B (zh) 2016-01-20
PT2560975E (pt) 2015-08-28
US20110263578A1 (en) 2011-10-27
US8492376B2 (en) 2013-07-23
KR20130008619A (ko) 2013-01-22
PL2560975T3 (pl) 2015-11-30
SG184534A1 (en) 2012-11-29
JP2013525319A (ja) 2013-06-20
ECSP12012210A (es) 2012-10-30
EA201291092A1 (ru) 2013-04-30
HK1176609A1 (zh) 2013-08-02
HUE026538T2 (en) 2016-06-28

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