PL2560975T3 - Heteroarylo-cykloheksylo-tetraazabenzo[e]azuleny jako antagoniści receptora v1a wazopresyny - Google Patents

Heteroarylo-cykloheksylo-tetraazabenzo[e]azuleny jako antagoniści receptora v1a wazopresyny

Info

Publication number
PL2560975T3
PL2560975T3 PL11714564T PL11714564T PL2560975T3 PL 2560975 T3 PL2560975 T3 PL 2560975T3 PL 11714564 T PL11714564 T PL 11714564T PL 11714564 T PL11714564 T PL 11714564T PL 2560975 T3 PL2560975 T3 PL 2560975T3
Authority
PL
Poland
Prior art keywords
tetraazabenzo
azulenes
vasopressin
heteroaryl
cyclohexyl
Prior art date
Application number
PL11714564T
Other languages
English (en)
Inventor
Cosimo Dolente
Patrick Schnider
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PL2560975T3 publication Critical patent/PL2560975T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
PL11714564T 2010-04-21 2011-04-18 Heteroarylo-cykloheksylo-tetraazabenzo[e]azuleny jako antagoniści receptora v1a wazopresyny PL2560975T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10160643 2010-04-21
PCT/EP2011/056071 WO2011131596A1 (en) 2010-04-21 2011-04-18 Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes as vasopressin v1a receptor antagonists
EP11714564.9A EP2560975B1 (en) 2010-04-21 2011-04-18 Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes as vasopressin v1a receptor antagonists

Publications (1)

Publication Number Publication Date
PL2560975T3 true PL2560975T3 (pl) 2015-11-30

Family

ID=43919925

Family Applications (1)

Application Number Title Priority Date Filing Date
PL11714564T PL2560975T3 (pl) 2010-04-21 2011-04-18 Heteroarylo-cykloheksylo-tetraazabenzo[e]azuleny jako antagoniści receptora v1a wazopresyny

Country Status (35)

Country Link
US (1) US8492376B2 (pl)
EP (1) EP2560975B1 (pl)
JP (1) JP5579923B2 (pl)
KR (1) KR101506776B1 (pl)
CN (1) CN102858776B (pl)
AR (1) AR080927A1 (pl)
AU (1) AU2011244407B2 (pl)
BR (1) BR112012026890A2 (pl)
CA (1) CA2795526A1 (pl)
CL (1) CL2012002905A1 (pl)
CO (1) CO6640209A2 (pl)
CR (1) CR20120513A (pl)
CY (1) CY1116661T1 (pl)
DK (1) DK2560975T3 (pl)
EA (1) EA021418B1 (pl)
EC (1) ECSP12012210A (pl)
ES (1) ES2542953T3 (pl)
HK (1) HK1176609A1 (pl)
HR (1) HRP20150929T1 (pl)
HU (1) HUE026538T2 (pl)
IL (1) IL222403A (pl)
MA (1) MA34174B1 (pl)
MX (1) MX2012012046A (pl)
MY (1) MY160457A (pl)
NZ (1) NZ602627A (pl)
PE (2) PE20160589A1 (pl)
PL (1) PL2560975T3 (pl)
PT (1) PT2560975E (pl)
RS (1) RS54121B1 (pl)
SG (1) SG184534A1 (pl)
SI (1) SI2560975T1 (pl)
TW (1) TWI419890B (pl)
UA (1) UA109543C2 (pl)
WO (1) WO2011131596A1 (pl)
ZA (1) ZA201207689B (pl)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2356123T1 (sl) * 2008-11-13 2013-01-31 F. Hoffmann-La Roche Ag Piro-5,6-dihidro-4h-2,3,5,10b-tetraaza-benzo(e)azuleni
SG171742A1 (en) * 2008-11-18 2011-07-28 Hoffmann La Roche Alkylcyclohexylethers of dihydrotetraazabenzoazulenes
EP2370441B1 (en) 2008-11-28 2013-09-11 F. Hoffmann-La Roche AG Arylcyclohexylethers of dihydrotetraazabenzoazulenes for use as vasopressin v1a receptor antagonists
US8420633B2 (en) 2010-03-31 2013-04-16 Hoffmann-La Roche Inc. Aryl-cyclohexyl-tetraazabenzo[e]azulenes
US8461151B2 (en) 2010-04-13 2013-06-11 Hoffmann-La Roche Inc. Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes
US8492376B2 (en) 2010-04-21 2013-07-23 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8513238B2 (en) 2010-05-10 2013-08-20 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes
MX2016006558A (es) 2013-12-05 2016-08-03 Hoffmann La Roche Sistesis de trans-8-cloro-5-metil-1-[4-(piridin-2-iloxi)-ciclohexi l]-5,6-dihidro-4h-2,3,5,10b-tetraaza-benzo[e]azuleno y formas cristalinas del mismo.
WO2017191117A1 (en) 2016-05-03 2017-11-09 Bayer Pharma Aktiengesellschaft V1a receptor antagonists for use in the treatment of renal diseases
CA3079133A1 (en) * 2017-12-08 2019-06-13 F. Hoffmann-La Roche Ag Pharmaceutical formulation
TW201938171A (zh) * 2017-12-15 2019-10-01 匈牙利商羅特格登公司 作為血管升壓素Ｖ１ａ受體拮抗劑之三環化合物
HU231206B1 (hu) * 2017-12-15 2021-10-28 Richter Gedeon Nyrt. Triazolobenzazepinek
US20230084719A1 (en) * 2018-12-12 2023-03-16 Blackthorn Therapeutics, Inc. 1-(2,6-diazaspiro[3.3]heptan-6-yl)-5,6-dihydro-4h-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine derivatives and related compounds as vasopressin antagonists for the treatment of neuro-psychological disorders
JP2023534721A (ja) * 2020-07-23 2023-08-10 エフ． ホフマン－ラ ロシュ アーゲー バソプレシン受容体ｖ１ａアンタゴニストとしてのヘテロアリール－メチル置換トリアゾール
JP2023534713A (ja) * 2020-07-23 2023-08-10 エフ． ホフマン－ラ ロシュ アーゲー バソプレシン受容体ｖ１ａアンタゴニストとしてのシクロヘキシル置換トリアゾール
CN114644635B (zh) * 2020-12-21 2023-02-03 上海济煜医药科技有限公司 三氮唑类三并环衍生物及其制备方法和应用
CN116836111A (zh) * 2023-09-01 2023-10-03 峰成医药科技(天津)有限公司 一种氟代吡啶的连续化合成方法

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU619555B2 (en) * 1988-04-27 1992-01-30 Schering Corporation Certain paf antagonist antihistamine combinations and methods
US5185331A (en) * 1991-05-14 1993-02-09 Merck & Co., Inc. Triazolobenzodiazepines
CA2120939A1 (en) * 1991-10-11 1993-04-15 Tetsuya Tahara Therapeutic agent for osteoporosis and diazepine compound
US5516774A (en) * 1993-07-29 1996-05-14 American Cyanamid Company Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
US5521173A (en) 1995-01-17 1996-05-28 American Home Products Corporation Tricyclic benzazepine vasopressin antagonists
HU229074B1 (en) 1999-01-19 2013-07-29 Ortho Mcneil Pharm Inc Tricyclic benzodiazepines as vasopressin receptor antagonists
US7022699B2 (en) 2001-04-12 2006-04-04 Wyeth Cyclohexenyl phenyl diazepines vasopressin and oxytocin receptor modulators
GB0303852D0 (en) * 2003-02-19 2003-03-26 Pfizer Ltd Triazole compounds useful in therapy
PT1597260E (pt) * 2003-02-19 2007-01-31 Pfizer Composto de triazole úteis em terapia
GB0400700D0 (en) 2004-01-13 2004-02-18 Pfizer Ltd Compounds useful in therapy
KR100840852B1 (ko) 2004-05-25 2008-06-23 화이자 프로덕츠 인크. 테트라아자벤조[ｅ]아줄렌 유도체 및 이의 유사체
AP2006003768A0 (en) 2004-05-25 2006-10-31 Pfizer Prod Inc TetraazabenzoÄeÜazulene derivatives and analogs tehereof
GB0412874D0 (en) * 2004-06-09 2004-07-14 Pfizer Ltd Novel pharmaceuticals
EP1632494A1 (en) 2004-08-24 2006-03-08 Ferring B.V. Vasopressin v1a antagonists
MX2007002248A (es) 2004-08-25 2008-10-02 Pfizer Triazolobenzodiazepinas y su uso como antagonistas de vasopresina.
US7221269B2 (en) * 2004-10-29 2007-05-22 Kimberly-Clark Worldwide, Inc. Self-adjusting portals with movable data tag readers for improved reading of data tags
US20080188478A1 (en) 2005-04-26 2008-08-07 Pfizer Inc. Compounds Useful In Therapy
CA2608718A1 (en) 2005-05-18 2006-11-23 Pfizer Limited 1, 2, 4-triazole derivatives as vasopressin antagonists
KR101129791B1 (ko) 2007-01-12 2012-03-23 에프. 호프만-라 로슈 아게 스파이로피페리딘 글리신아마이드 유도체
AP2010005364A0 (en) * 2008-01-24 2010-08-31 Panacea Biotec Ltd Novel heterocyclic compounds.
SG171742A1 (en) 2008-11-18 2011-07-28 Hoffmann La Roche Alkylcyclohexylethers of dihydrotetraazabenzoazulenes
US8420633B2 (en) 2010-03-31 2013-04-16 Hoffmann-La Roche Inc. Aryl-cyclohexyl-tetraazabenzo[e]azulenes
US8461151B2 (en) 2010-04-13 2013-06-11 Hoffmann-La Roche Inc. Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes
US8492376B2 (en) 2010-04-21 2013-07-23 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8513238B2 (en) 2010-05-10 2013-08-20 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes

Also Published As

Publication number Publication date
CN102858776A (zh) 2013-01-02
RS54121B1 (en) 2015-12-31
IL222403A (en) 2014-08-31
TW201139444A (en) 2011-11-16
EA021418B1 (ru) 2015-06-30
CO6640209A2 (es) 2013-03-22
SI2560975T1 (sl) 2015-08-31
BR112012026890A2 (pt) 2016-07-19
AU2011244407B2 (en) 2013-06-13
CA2795526A1 (en) 2011-10-27
JP5579923B2 (ja) 2014-08-27
PE20160589A1 (es) 2016-06-11
ZA201207689B (en) 2015-06-24
AR080927A1 (es) 2012-05-16
MX2012012046A (es) 2012-11-22
EP2560975B1 (en) 2015-06-17
CL2012002905A1 (es) 2013-03-22
CR20120513A (es) 2012-11-01
KR101506776B1 (ko) 2015-03-27
TWI419890B (zh) 2013-12-21
MA34174B1 (fr) 2013-04-03
WO2011131596A1 (en) 2011-10-27
CY1116661T1 (el) 2017-03-15
NZ602627A (en) 2013-07-26
HRP20150929T1 (hr) 2015-10-09
UA109543C2 (xx) 2015-09-10
EP2560975A1 (en) 2013-02-27
AU2011244407A1 (en) 2012-10-18
MY160457A (en) 2017-03-15
DK2560975T3 (en) 2015-06-29
ES2542953T3 (es) 2015-08-13
CN102858776B (zh) 2016-01-20
PT2560975E (pt) 2015-08-28
US20110263578A1 (en) 2011-10-27
US8492376B2 (en) 2013-07-23
KR20130008619A (ko) 2013-01-22
SG184534A1 (en) 2012-11-29
JP2013525319A (ja) 2013-06-20
ECSP12012210A (es) 2012-10-30
EA201291092A1 (ru) 2013-04-30
HK1176609A1 (zh) 2013-08-02
HUE026538T2 (en) 2016-06-28
PE20130190A1 (es) 2013-02-21

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