CO6150181A2 - Compuesto 6-(bencilo sustituido con heterociclo)-4-oxoquinolina y su uso como inhibidor de integrasa vih - Google Patents
Compuesto 6-(bencilo sustituido con heterociclo)-4-oxoquinolina y su uso como inhibidor de integrasa vihInfo
- Publication number
- CO6150181A2 CO6150181A2 CO09003378A CO09003378A CO6150181A2 CO 6150181 A2 CO6150181 A2 CO 6150181A2 CO 09003378 A CO09003378 A CO 09003378A CO 09003378 A CO09003378 A CO 09003378A CO 6150181 A2 CO6150181 A2 CO 6150181A2
- Authority
- CO
- Colombia
- Prior art keywords
- cor1rb
- group
- cor2rb
- optionally substituted
- atom
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 125000001424 substituent group Chemical group 0.000 abstract 8
- 125000000623 heterocyclic group Chemical group 0.000 abstract 5
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 150000001721 carbon Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000002911 monocyclic heterocycle group Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000004434 sulfur atom Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 101100150273 Caenorhabditis elegans srb-1 gene Proteins 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
1.- Un compuesto representado por la siguiente fórmula [I] o una de sus sales farmacéuticamente aceptables o uno de sus solvatos:en donde el anillo A es un grupo heterocíclico monocíclico opcionalmente sustituido con 1 a 5 sustituyentes seleccionados del siguiente grupo A, en donde el grupo heterocíclico monocíclico contiene, además de átomo de carbono, al menos un heteroátomo seleccionado de átomo de nitrógeno, átomo de oxígeno y átomo de azufre; el grupo A es un grupo que consiste en átomo de halógeno, grupo alquilo de C1-4, -(CH2)nORa1, -NRa3Ra4, -CORa2 y -CONRa3Ra4, en donde Ra1, Ra2, Ra3 y Ra4 son iguales o diferentes y cada uno es un átomo de hidrógeno o un grupo alquilo de C1-4 y n es 0 o un número entero de 1 a 4; R1 es un átomo de hidrógeno, un grupo alquilo de C1-6 opcionalmente sustituido con 1 a 3 sustituyentes seleccionados del siguiente grupo B, un grupo de anillo de carbonos de C3-10 opcionalmente sustituido con 1 a 5 sustituyentes seleccionados del grupo A antes mencionado o un grupo heterocíclico opcionalmente sustituido con 1 a 5 sustituyentes seleccionados del grupo A antes mencionado, en donde el grupo heterocíclico contiene, además de átomo de carbono, al menos un heteroátomo seleccionado de átomo de nitrógeno, átomo de oxígeno y átomo de azufre; el grupo B es un grupo que consiste en un grupo de anillo de carbonos de C3-10 opcionalmente sustituido con 1 a 5 sustituyentes seleccionados del grupo A antes mencionado, un grupo heterocíclico opcionalmente sustituido con 1 a 5 sustituyentes seleccionados del grupo A antes mencionado, en donde el grupo heterocíclico es como se definió con anterioridad, átomo de halógeno, grupo ciano, -ORb1, SRb1, -NRb2Rb3, -CONRb2Rb3, -SO2NRb2Rb3, -CORb1, -NRb2CORb1, SO2Rb1, -NRb2SO2Rb1, -COORb1, -NRb2COORb1 y -NRb4CO-NRb2Rb3 en donde Rb1, Rb2, Rb3 y Rb4 son iguales o diferentes y cada uno es un átomo de hidrógeno, un grupo alquilo de C1-4, un grupo de anillo de carbonos de C3-10 opcionalmente sustituido con 1 a 5 sustituyentes seleccionados del grupo A antes mencionado o un grupo heterocíclico opcionalmente sustituido con 1 a 5 sustituyentes ...
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006174331 | 2006-06-23 | ||
| JP2006220082 | 2006-08-11 | ||
| JP2006274143 | 2006-10-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6150181A2 true CO6150181A2 (es) | 2010-04-20 |
Family
ID=38833517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO09003378A CO6150181A2 (es) | 2006-06-23 | 2009-01-16 | Compuesto 6-(bencilo sustituido con heterociclo)-4-oxoquinolina y su uso como inhibidor de integrasa vih |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7872004B2 (es) |
| EP (2) | EP2368880A1 (es) |
| JP (1) | JP4038231B1 (es) |
| KR (1) | KR101053811B1 (es) |
| AR (1) | AR061583A1 (es) |
| AU (1) | AU2007262010B2 (es) |
| BR (1) | BRPI0713336A2 (es) |
| CA (1) | CA2653830C (es) |
| CL (1) | CL2007001838A1 (es) |
| CO (1) | CO6150181A2 (es) |
| IL (1) | IL195862A0 (es) |
| MX (1) | MX2009000159A (es) |
| MY (1) | MY144773A (es) |
| NO (1) | NO20090322L (es) |
| NZ (1) | NZ573709A (es) |
| PE (1) | PE20080211A1 (es) |
| SA (1) | SA07280343B1 (es) |
| TW (1) | TW200811153A (es) |
| WO (1) | WO2007148780A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4059923A1 (en) * | 2002-11-20 | 2022-09-21 | Japan Tobacco Inc. | 4-oxoquinoline compound and use thereof as hiv integrase inhibitor |
| MX2009002689A (es) * | 2006-09-12 | 2009-03-26 | Gilead Sciences Inc | Proceso e intermediarios para preparar inhibidores de integrasa. |
| AR068403A1 (es) | 2007-09-11 | 2009-11-18 | Gilead Sciences Inc | Proceso e intermediarios para la preparacion de inhibidores de integrasa |
| EP2488521B1 (en) | 2009-10-13 | 2013-12-18 | Elanco Animal Health Ireland Limited | Macrocyclic integrase inhibitors |
| WO2011121105A1 (en) | 2010-04-02 | 2011-10-06 | Tibotec Pharmaceuticals | Macrocyclic integrase inhibitors |
| US9089574B2 (en) | 2011-11-30 | 2015-07-28 | Emory University | Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections |
| US8877931B2 (en) | 2012-08-03 | 2014-11-04 | Gilead Sciences, Inc. | Process and intermediates for preparing integrase inhibitors |
| EP4122537A1 (en) | 2019-03-22 | 2023-01-25 | Gilead Sciences, Inc. | Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use |
| US11697652B2 (en) | 2020-02-24 | 2023-07-11 | Gilead Sciences, Inc. | Tetracyclic compounds and uses thereof |
| WO2022159387A1 (en) | 2021-01-19 | 2022-07-28 | Gilead Sciences, Inc. | Substituted pyridotriazine compounds and uses thereof |
| CN115448866B (zh) * | 2022-10-13 | 2023-11-21 | 中北大学 | 一种1-甲基-2,3,4,5-四硝基吡咯的制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU735186B2 (en) * | 1997-09-15 | 2001-07-05 | Warner Chilcott Company, Llc | Antimicrobial quinolones, their compositions and uses |
| AU2003236827A1 (en) | 2002-07-08 | 2004-01-23 | Coloplast A/S | Conduit device |
| EP4059923A1 (en) * | 2002-11-20 | 2022-09-21 | Japan Tobacco Inc. | 4-oxoquinoline compound and use thereof as hiv integrase inhibitor |
| DE602005023717D1 (de) | 2004-03-10 | 2010-11-04 | Usa | Chinolin-4-one als inhibitoren der retroviralen integrase zur behandlung von hiv, aids und aids-related complex (arc) |
| US7531554B2 (en) | 2004-05-20 | 2009-05-12 | Japan Tobacco Inc. | 4-oxoquinoline compound and use thereof as HIV integrase inhibitor |
| US7745459B2 (en) | 2004-09-21 | 2010-06-29 | Japan Tobacco Inc. | Quinolizinone compound and use thereof as HIV integrase inhibitor |
| WO2006033422A1 (ja) | 2004-09-21 | 2006-03-30 | Japan Tobacco Inc. | キノリジノン化合物、およびそのｈｉｖインテグラーゼ阻害剤としての利用 |
| JP2006174331A (ja) | 2004-12-20 | 2006-06-29 | Fuji Xerox Co Ltd | 画像圧縮装置、画像圧縮方法及びそのプログラム |
| JP2006220082A (ja) | 2005-02-10 | 2006-08-24 | Denso Corp | 燃料噴射装置 |
| JP4572720B2 (ja) | 2005-03-30 | 2010-11-04 | Ｄｉｃ株式会社 | 水分散型アクリル系樹脂の製造方法、並びにそれにより製造される水分散型アクリル粘着剤組成物及び粘着シート |
| DE102006005861A1 (de) | 2006-02-09 | 2007-08-23 | Aicuris Gmbh & Co. Kg | Substituierte Chinolone III |
-
2007
- 2007-06-21 TW TW096122234A patent/TW200811153A/zh unknown
- 2007-06-22 EP EP11168760A patent/EP2368880A1/en not_active Withdrawn
- 2007-06-22 BR BRPI0713336-7A patent/BRPI0713336A2/pt not_active IP Right Cessation
- 2007-06-22 CL CL200701838A patent/CL2007001838A1/es unknown
- 2007-06-22 MX MX2009000159A patent/MX2009000159A/es active IP Right Grant
- 2007-06-22 JP JP2007164676A patent/JP4038231B1/ja not_active Expired - Fee Related
- 2007-06-22 EP EP07845259A patent/EP2033954A4/en not_active Withdrawn
- 2007-06-22 AR ARP070102755A patent/AR061583A1/es not_active Application Discontinuation
- 2007-06-22 NZ NZ573709A patent/NZ573709A/en not_active IP Right Cessation
- 2007-06-22 AU AU2007262010A patent/AU2007262010B2/en not_active Ceased
- 2007-06-22 PE PE2007000805A patent/PE20080211A1/es not_active Application Discontinuation
- 2007-06-22 CA CA2653830A patent/CA2653830C/en not_active Expired - Fee Related
- 2007-06-22 US US11/767,021 patent/US7872004B2/en not_active Expired - Fee Related
- 2007-06-22 WO PCT/JP2007/062579 patent/WO2007148780A1/ja active Application Filing
- 2007-06-22 KR KR1020097001497A patent/KR101053811B1/ko not_active IP Right Cessation
- 2007-06-23 SA SA7280343A patent/SA07280343B1/ar unknown
-
2008
- 2008-12-10 MY MYPI20085006A patent/MY144773A/en unknown
- 2008-12-11 IL IL195862A patent/IL195862A0/en unknown
-
2009
- 2009-01-16 CO CO09003378A patent/CO6150181A2/es unknown
- 2009-01-21 NO NO20090322A patent/NO20090322L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ573709A (en) | 2011-04-29 |
| MX2009000159A (es) | 2009-01-23 |
| CA2653830A1 (en) | 2007-12-27 |
| NO20090322L (no) | 2009-03-20 |
| US7872004B2 (en) | 2011-01-18 |
| AR061583A1 (es) | 2008-09-03 |
| EP2033954A1 (en) | 2009-03-11 |
| SA07280343B1 (ar) | 2011-01-15 |
| PE20080211A1 (es) | 2008-04-23 |
| CA2653830C (en) | 2011-11-22 |
| MY144773A (en) | 2011-10-31 |
| TW200811153A (en) | 2008-03-01 |
| IL195862A0 (en) | 2009-09-01 |
| BRPI0713336A2 (pt) | 2012-11-06 |
| WO2007148780A1 (ja) | 2007-12-27 |
| EP2033954A4 (en) | 2009-08-12 |
| US20080207618A1 (en) | 2008-08-28 |
| AU2007262010A1 (en) | 2007-12-27 |
| AU2007262010B2 (en) | 2011-05-12 |
| CL2007001838A1 (es) | 2008-02-08 |
| EP2368880A1 (en) | 2011-09-28 |
| JP2008110960A (ja) | 2008-05-15 |
| KR20090023731A (ko) | 2009-03-05 |
| KR101053811B1 (ko) | 2011-08-03 |
| JP4038231B1 (ja) | 2008-01-23 |
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