PE20141579A1 - Nuevos 2h-indazoles como antagonistas del receptor ep2 - Google Patents

Nuevos 2h-indazoles como antagonistas del receptor ep2

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Publication number
PE20141579A1
PE20141579A1 PE2014000760A PE2014000760A PE20141579A1 PE 20141579 A1 PE20141579 A1 PE 20141579A1 PE 2014000760 A PE2014000760 A PE 2014000760A PE 2014000760 A PE2014000760 A PE 2014000760A PE 20141579 A1 PE20141579 A1 PE 20141579A1
Authority
PE
Peru
Prior art keywords
methyl
alkyl
residue
members
indazoles
Prior art date
Application number
PE2014000760A
Other languages
English (en)
Inventor
Nico Brauer
Anne Mengel
Ulrike Rohn
Andrea Rotgeri
Bernd Buchmann
Bernhard Lindenthal
Laak Antonius Ter
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47278803&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20141579(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of PE20141579A1 publication Critical patent/PE20141579A1/es

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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract

SE REFIERE A COMPUESTOS DE FORMULA (I), EN DONDE: R1 ES H, ALQILO C1-C2 O ALQUIL C1-C2-XILO; R2 ES H O METILO; R4 ES H, ALQUILO C1-C4, CICLOALQUILO C3-C4 O CH2-CICLOALQUILO C3-C4; X JUNTO CON R4 FORMAN UN RESIDUO DE HETEROCICLILO DE 4-6 MIEMBROS POR MEDIO DE UNA LIGACION DE CARBONO DE ANILLO; m ES 1 O 2; n ES 1 O 2; Ar ES UN RESIDUO DE ARILO DE 6-10 MIEMBROS O RESIDUO DE HETARILO DE 5 A 10 MIEMBROS; R3 ES HALOGENO, CN, SF5, ALQUILO C1-C4, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 2-{[1-(4-CIANO-2-FLUOROBENZOIL)PIPERIDIN-4-IL]METIL}-N-(2-METOXIETIL)-4-METIL-2H-INDAZOL-5-CARBOXAMIDA; N-(2-METOXIETIL)-4-METIL-2-{[1-(4-MORFOLINOBENZOIL)PIPERIDIN-4-IL]METIL}-2H-INDAZOL-5-CARBOXAMIDA; ENTRE OTROS. SE REFIERE TAMBIEN A UN METODO PARA LA PREPARACION DE DICHOS COMPUESTOS
PE2014000760A 2011-11-28 2012-11-26 Nuevos 2h-indazoles como antagonistas del receptor ep2 PE20141579A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102011087170 2011-11-28
DE102012206715 2012-04-24

Publications (1)

Publication Number Publication Date
PE20141579A1 true PE20141579A1 (es) 2014-11-15

Family

ID=47278803

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2014000760A PE20141579A1 (es) 2011-11-28 2012-11-26 Nuevos 2h-indazoles como antagonistas del receptor ep2

Country Status (25)

Country Link
US (1) US9062041B2 (es)
EP (1) EP2785707B1 (es)
JP (1) JP6192654B2 (es)
KR (1) KR20140103984A (es)
CN (1) CN104144922B (es)
AR (1) AR089011A1 (es)
AU (1) AU2012344015A1 (es)
BR (1) BR112014012459A2 (es)
CA (1) CA2856769A1 (es)
CL (1) CL2014001392A1 (es)
CO (1) CO6970595A2 (es)
CR (1) CR20140257A (es)
DO (1) DOP2014000114A (es)
EA (1) EA201400623A1 (es)
EC (1) ECSP14002542A (es)
ES (1) ES2665510T3 (es)
HK (1) HK1203938A1 (es)
IL (1) IL232503A (es)
IN (1) IN2014CN03854A (es)
MX (1) MX2014006433A (es)
PE (1) PE20141579A1 (es)
PH (1) PH12014501195A1 (es)
SG (1) SG11201402269RA (es)
TW (1) TW201326154A (es)
WO (1) WO2013079425A1 (es)

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UY36391A (es) 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido1), sus métodos de síntesis y composiciones farmacèuticas que las contienen
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CL2014001392A1 (es) 2014-10-03
IL232503A (en) 2015-08-31
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US20140336172A1 (en) 2014-11-13
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