HK1203938A1 - Novel 2h-indazoles as ep2 receptor antagonists ep2 2h- - Google Patents
Novel 2h-indazoles as ep2 receptor antagonists ep2 2h-Info
- Publication number
- HK1203938A1 HK1203938A1 HK15104364.3A HK15104364A HK1203938A1 HK 1203938 A1 HK1203938 A1 HK 1203938A1 HK 15104364 A HK15104364 A HK 15104364A HK 1203938 A1 HK1203938 A1 HK 1203938A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- indazoles
- novel
- receptor antagonists
- antagonists
- receptor
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C—CHEMISTRY; METALLURGY
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- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
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- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Psychology (AREA)
- Gynecology & Obstetrics (AREA)
- Transplantation (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102011087170 | 2011-11-28 | ||
DE102012206715 | 2012-04-24 | ||
PCT/EP2012/073556 WO2013079425A1 (en) | 2011-11-28 | 2012-11-26 | Novel 2h-indazoles as ep2 receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1203938A1 true HK1203938A1 (en) | 2015-11-06 |
Family
ID=47278803
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK15104364.3A HK1203938A1 (en) | 2011-11-28 | 2015-05-07 | Novel 2h-indazoles as ep2 receptor antagonists ep2 2h- |
Country Status (25)
Country | Link |
---|---|
US (1) | US9062041B2 (xx) |
EP (1) | EP2785707B1 (xx) |
JP (1) | JP6192654B2 (xx) |
KR (1) | KR20140103984A (xx) |
CN (1) | CN104144922B (xx) |
AR (1) | AR089011A1 (xx) |
AU (1) | AU2012344015A1 (xx) |
BR (1) | BR112014012459A2 (xx) |
CA (1) | CA2856769A1 (xx) |
CL (1) | CL2014001392A1 (xx) |
CO (1) | CO6970595A2 (xx) |
CR (1) | CR20140257A (xx) |
DO (1) | DOP2014000114A (xx) |
EA (1) | EA201400623A1 (xx) |
EC (1) | ECSP14002542A (xx) |
ES (1) | ES2665510T3 (xx) |
HK (1) | HK1203938A1 (xx) |
IL (1) | IL232503A (xx) |
IN (1) | IN2014CN03854A (xx) |
MX (1) | MX2014006433A (xx) |
PE (1) | PE20141579A1 (xx) |
PH (1) | PH12014501195A1 (xx) |
SG (1) | SG11201402269RA (xx) |
TW (1) | TW201326154A (xx) |
WO (1) | WO2013079425A1 (xx) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2755944B1 (en) | 2011-09-16 | 2017-06-14 | Sanofi | Biarylderivatives,their preparation and their therapeutic application |
TW201326154A (zh) | 2011-11-28 | 2013-07-01 | 拜耳知識產權公司 | 作為ep2受體拮抗劑之新穎2h-吲唑 |
WO2014187744A1 (de) * | 2013-05-23 | 2014-11-27 | Bayer Pharma Aktiengesellschaft | Pharmazeutische zusammensetzung und deren verwendung sowie anwendungsregime dieser pharmazeutischen zusammensetzung zur bedarfsweisen („on-demand") kontrazeption |
WO2014187793A1 (de) * | 2013-05-23 | 2014-11-27 | Bayer Pharma Aktiengesellschaft | Verwendung einer pharmazeutischen zusammensetzung zur notfallkontrazeption |
EP3151820A4 (en) | 2014-06-06 | 2017-11-22 | Flexus Biosciences, Inc. | Immunoregulatory agents |
UY36390A (es) | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen |
EA201790806A1 (ru) | 2014-11-05 | 2017-11-30 | Флексус Байосайенсиз, Инк. | Иммунорегулирующие средства |
AR102537A1 (es) | 2014-11-05 | 2017-03-08 | Flexus Biosciences Inc | Agentes inmunomoduladores |
JP2022506850A (ja) | 2018-11-08 | 2022-01-17 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド | 化学化合物 |
WO2022138792A1 (ja) * | 2020-12-24 | 2022-06-30 | 小野薬品工業株式会社 | Ep2拮抗活性を有する化合物の塩、溶媒和物および結晶 |
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US5861419A (en) | 1996-07-18 | 1999-01-19 | Merck Frosst Canad, Inc. | Substituted pyridines as selective cyclooxygenase-2 inhibitors |
EE03680B1 (et) | 1996-07-18 | 2002-04-15 | Merck Frosst Canada & Co. / Merck Frosst Canada &Cie. | Asendatud püridiinid, nende kasutamine ja farmatseutilised kompositsioonid |
HN2001000224A (es) * | 2000-10-19 | 2002-06-13 | Pfizer | Compuestos de imidazol condensado con arilo o heteroarilo como agentes anti - inflamatorios y analgesicos. |
CA2457468A1 (en) | 2001-08-09 | 2003-02-27 | Ono Pharmaceutical Co., Ltd. | Carboxylic acid derivatives and pharmaceutical agent comprising the same as active ingredient |
WO2003030911A1 (en) | 2001-10-08 | 2003-04-17 | Medical Research Council | Use of prostaglandin e synthase inhibitors, or ep2 or ep4 receptor antagonists, in the treatment of a pathological condition of the uterus |
EP1439837B1 (en) | 2001-10-23 | 2008-04-09 | Laboratoires Serono SA | Pyrazolidinone compounds as ligands of the prostaglandin ep2 and/or ep4 receptors |
ATE371454T1 (de) | 2001-10-31 | 2007-09-15 | Medical Res Council | Antagonisten der prostaglandin ep2 und/oder ep4 rezeptoren zur behandlung von menorrhagie |
IL162602A0 (en) | 2001-12-20 | 2005-11-20 | Applied Research Systems | Pyrrolidine derivatives as prostaglandin modulators |
AP2004003094A0 (en) | 2002-01-31 | 2004-09-30 | Pfizer Prod Inc | Metabolities of (3-{[4-tert-butyl-benzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic acid |
NZ535024A (en) | 2002-03-05 | 2006-10-27 | Ono Pharmaceutical Co | 8-azaprostaglandin derivative compound and agent comprising the compound as active ingredient |
US20060128810A1 (en) | 2002-10-10 | 2006-06-15 | Kyoto University | Remedies for allergic diseases |
DK1866292T3 (da) | 2005-03-31 | 2011-05-09 | Auckland Uniservices Ltd | Tricykliske 1,2,4-triazinoxider og sammensætninger deraf til terapeutisk anvendelse i cancerbehandlinger |
PL1816121T3 (pl) | 2005-11-21 | 2008-08-29 | Bayer Schering Pharma Ag | Pochodne 9-chloro-15-deoksyprostaglandyny, sposób ich wytwarzania oraz ich zastosowanie jako leków |
DE102005062741A1 (de) | 2005-12-22 | 2007-06-28 | Bayer Schering Pharma Ag | Fluorene und Carbazole als Liganden des EP2 Rezeptors |
WO2007091107A1 (en) | 2006-02-10 | 2007-08-16 | Summit Corporation Plc | Treatment of duchenne muscular dystrophy |
EP1884906A1 (de) | 2006-07-31 | 2008-02-06 | Siemens Building Technologies Fire & Security Products GmbH & Co. oHG | Levelsynchronisation bei Funk-Kommunikationsnetzwerken |
EP1903037A1 (de) | 2006-09-07 | 2008-03-26 | Bayer Schering Pharma Aktiengesellschaft | 1-(Het)aryl-3-[hetaryl-piperidin-4-yl]-thioharnstoffe als Modulatoren des EP2-Rezeptors |
EP1900731A1 (de) | 2006-09-07 | 2008-03-19 | Bayer Schering Pharma Aktiengesellschaft | N-(1-Phthalazin-1-yl-piperidin-4-yl)-amide als EP2-Rezeptor Modulatoren |
EP1903038A1 (de) | 2006-09-07 | 2008-03-26 | Bayer Schering Pharma Aktiengesellschaft | N-(1-Hetaryl-piperidin-4-yl)-(het)arylamide als EP2-Rezeptor Modulatoren |
JP2010511721A (ja) | 2006-12-05 | 2010-04-15 | ナショナル チャオ トン ユニバーシティ | インダゾール化合物 |
KR20100009582A (ko) | 2007-05-10 | 2010-01-27 | 화이자 리미티드 | 아제티딘 유도체 및 프로스타글란딘 e2 길항제로서 그의 용도 |
EP2003118A1 (de) | 2007-06-13 | 2008-12-17 | Bayer Schering Pharma Aktiengesellschaft | Zimtsäurederivate als Modulatoren des EP2-Rezeptors |
EP2002834A1 (de) | 2007-06-13 | 2008-12-17 | Bayer Schering Pharma Aktiengesellschaft | Aryl/Hetarylamide als Modulatoren des EP2-Rezeptors |
EP2003119A1 (de) | 2007-06-13 | 2008-12-17 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Acetamide als Modulatoren des EP2-Rezeptors |
EP2014663A1 (de) | 2007-07-12 | 2009-01-14 | Bayer Schering Pharma AG | Thienopyrimidylamine als Modulatoren des EP2-Rezeptors |
EP2014662A1 (de) | 2007-07-12 | 2009-01-14 | Bayer Schering Pharma Aktiengesellschaft | Indolylalkylthienopyrimidylamine als Modulatoren des EP2-Rezeptors |
EP2222665A1 (en) * | 2007-11-15 | 2010-09-01 | Pfizer Limited | Azetidines as ep2 antagonists |
JP5375824B2 (ja) * | 2008-05-14 | 2013-12-25 | アステラス製薬株式会社 | アミド化合物 |
WO2010008777A2 (en) | 2008-06-23 | 2010-01-21 | Ligand Pharmaceuticals Inc. | Fused azabicyclic pyridines |
AP2011005728A0 (en) | 2008-11-10 | 2011-06-30 | Pfizer Ltd | Pyrrolidines. |
JP2012512877A (ja) * | 2008-12-18 | 2012-06-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | セロトニン5−ht2b受容体阻害剤 |
TW201107315A (en) * | 2009-07-27 | 2011-03-01 | Kissei Pharmaceutical | Indole derivatives, or the pharmaceutically acceptable salts |
DE102009049662A1 (de) * | 2009-10-13 | 2011-04-14 | Bayer Schering Pharma Aktiengesellschaft | 2,5-Disubstituierte 2H-Indazole als EP2-Rezeptor-Antagonisten |
TW201326154A (zh) | 2011-11-28 | 2013-07-01 | 拜耳知識產權公司 | 作為ep2受體拮抗劑之新穎2h-吲唑 |
-
2012
- 2012-11-16 TW TW101142970A patent/TW201326154A/zh unknown
- 2012-11-26 US US14/361,213 patent/US9062041B2/en not_active Expired - Fee Related
- 2012-11-26 MX MX2014006433A patent/MX2014006433A/es not_active Application Discontinuation
- 2012-11-26 KR KR1020147017230A patent/KR20140103984A/ko not_active Application Discontinuation
- 2012-11-26 CA CA2856769A patent/CA2856769A1/en not_active Abandoned
- 2012-11-26 AU AU2012344015A patent/AU2012344015A1/en not_active Abandoned
- 2012-11-26 WO PCT/EP2012/073556 patent/WO2013079425A1/en active Application Filing
- 2012-11-26 IN IN3854CHN2014 patent/IN2014CN03854A/en unknown
- 2012-11-26 PE PE2014000760A patent/PE20141579A1/es not_active Application Discontinuation
- 2012-11-26 ES ES12794931.1T patent/ES2665510T3/es active Active
- 2012-11-26 JP JP2014542872A patent/JP6192654B2/ja not_active Expired - Fee Related
- 2012-11-26 BR BR112014012459A patent/BR112014012459A2/pt active Search and Examination
- 2012-11-26 CN CN201280067965.1A patent/CN104144922B/zh not_active Expired - Fee Related
- 2012-11-26 EA EA201400623A patent/EA201400623A1/ru unknown
- 2012-11-26 EP EP12794931.1A patent/EP2785707B1/en not_active Not-in-force
- 2012-11-26 SG SG11201402269RA patent/SG11201402269RA/en unknown
- 2012-11-28 AR ARP120104465A patent/AR089011A1/es active Pending
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2014
- 2014-05-08 IL IL232503A patent/IL232503A/en not_active IP Right Cessation
- 2014-05-27 PH PH12014501195A patent/PH12014501195A1/en unknown
- 2014-05-27 CL CL2014001392A patent/CL2014001392A1/es unknown
- 2014-05-28 DO DO2014000114A patent/DOP2014000114A/es unknown
- 2014-05-28 EC ECIEPI20142542A patent/ECSP14002542A/es unknown
- 2014-05-28 CR CR20140257A patent/CR20140257A/es unknown
- 2014-05-28 CO CO14115091A patent/CO6970595A2/es unknown
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- 2015-05-07 HK HK15104364.3A patent/HK1203938A1/xx not_active IP Right Cessation
Also Published As
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IL232503A (en) | 2015-08-31 |
CA2856769A1 (en) | 2013-06-06 |
ES2665510T3 (es) | 2018-04-26 |
EP2785707A1 (en) | 2014-10-08 |
AR089011A1 (es) | 2014-07-23 |
DOP2014000114A (es) | 2014-07-15 |
CN104144922A (zh) | 2014-11-12 |
PH12014501195A1 (en) | 2014-09-01 |
CR20140257A (es) | 2014-07-15 |
WO2013079425A1 (en) | 2013-06-06 |
EP2785707B1 (en) | 2018-01-24 |
MX2014006433A (es) | 2014-07-11 |
IL232503A0 (en) | 2014-07-01 |
AU2012344015A1 (en) | 2014-05-29 |
KR20140103984A (ko) | 2014-08-27 |
SG11201402269RA (en) | 2014-09-26 |
PE20141579A1 (es) | 2014-11-15 |
CO6970595A2 (es) | 2014-06-13 |
JP2014533713A (ja) | 2014-12-15 |
TW201326154A (zh) | 2013-07-01 |
JP6192654B2 (ja) | 2017-09-06 |
NZ624722A (en) | 2016-08-26 |
IN2014CN03854A (xx) | 2015-09-04 |
CL2014001392A1 (es) | 2014-10-03 |
ECSP14002542A (es) | 2015-12-31 |
US20140336172A1 (en) | 2014-11-13 |
US9062041B2 (en) | 2015-06-23 |
BR112014012459A2 (pt) | 2017-06-06 |
CN104144922B (zh) | 2016-08-31 |
EA201400623A1 (ru) | 2014-11-28 |
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