CO6362006A2 - Agonistas de los receptores de la melanocortina - Google Patents

Agonistas de los receptores de la melanocortina

Info

Publication number
CO6362006A2
CO6362006A2 CO11057597A CO11057597A CO6362006A2 CO 6362006 A2 CO6362006 A2 CO 6362006A2 CO 11057597 A CO11057597 A CO 11057597A CO 11057597 A CO11057597 A CO 11057597A CO 6362006 A2 CO6362006 A2 CO 6362006A2
Authority
CO
Colombia
Prior art keywords
agelists
respect
melanocortine
receptors
melanocortin receptor
Prior art date
Application number
CO11057597A
Other languages
English (en)
Inventor
Koo Lee
Sang-Bin Lee
Soo Yong Chung
Dong Sup Shim
Hyun Ho Lee
Sungmee Choi
In Ae Ahn
Sang Pil Moon
Original Assignee
Lg Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lg Life Sciences Ltd filed Critical Lg Life Sciences Ltd
Publication of CO6362006A2 publication Critical patent/CO6362006A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

La presente invención se refiere a un compuesto que tiene una buena actividad agonista con respecto al receptor de la melanocortina, o una sal farmacéuticamente aceptable o un isómero del mismo, y a una composición agonista con respecto al receptor de la melanocortina que comprende el mismo como un ingrediente activo.
CO11057597A 2008-11-12 2011-05-11 Agonistas de los receptores de la melanocortina CO6362006A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR20080112403 2008-11-12

Publications (1)

Publication Number Publication Date
CO6362006A2 true CO6362006A2 (es) 2012-01-20

Family

ID=42165801

Family Applications (1)

Application Number Title Priority Date Filing Date
CO11057597A CO6362006A2 (es) 2008-11-12 2011-05-11 Agonistas de los receptores de la melanocortina

Country Status (26)

Country Link
US (4) US8039622B2 (es)
EP (1) EP2350060B1 (es)
JP (1) JP5399506B2 (es)
KR (1) KR101141976B1 (es)
CN (1) CN102282141B (es)
AR (1) AR074109A1 (es)
AU (1) AU2009314827B2 (es)
BR (1) BRPI0921063B8 (es)
CA (1) CA2742248C (es)
CL (1) CL2011001073A1 (es)
CO (1) CO6362006A2 (es)
CR (1) CR20110250A (es)
EA (1) EA019146B1 (es)
EC (1) ECSP11011026A (es)
GE (1) GEP20135850B (es)
IL (1) IL212468A0 (es)
MA (1) MA32774B1 (es)
MX (1) MX2011004583A (es)
NZ (1) NZ592512A (es)
PE (1) PE20110684A1 (es)
TN (1) TN2011000222A1 (es)
TW (1) TWI389903B (es)
UA (1) UA99555C2 (es)
UY (1) UY32238A (es)
WO (1) WO2010056022A2 (es)
ZA (1) ZA201103154B (es)

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CA2825098C (en) 2011-01-27 2020-03-10 Universite De Montreal Pyrazolopyridine and pyrazolopyrimidine derivatives as melanocortin-4 receptor modulators
PT2797615T (pt) 2011-12-29 2019-07-11 Rhythm Pharmaceuticals Inc Método de tratamento de distúrbios associados ao recetor de melanocortina-4 em portadores heterozigóticos
JP6235560B2 (ja) 2012-04-25 2017-11-22 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ （３，４−ジクロロ−フェニル）−（（ｓ）−３−プロピル−ピロリジン−３−イル）−メタノン塩酸塩及び製造方法
CN103420981A (zh) * 2012-05-21 2013-12-04 中国医学科学院药物研究所 含有取代吡咯烷基的硫代吗啉类化合物
JP6940853B2 (ja) 2015-09-30 2021-09-29 リズム ファーマシューティカルズ， インコーポレイテッド メラノコルチン４受容体経路関連障害を治療する方法
AU2019249255A1 (en) 2018-04-06 2020-11-05 Alastair GARFIELD Compositions for treating kidney disease
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AU2021370072B2 (en) * 2020-10-29 2024-02-08 Lg Chem, Ltd. Crystalline form iii of melanocortin receptor agonist compound and method for preparing same
JP2023548161A (ja) 2020-10-29 2023-11-15 エルジー・ケム・リミテッド メラノコルチン受容体アゴニスト化合物の結晶形ｉｖおよびその製造方法
IL302425A (en) 2020-10-29 2023-06-01 Lg Chemical Ltd An amorphous form of a melanocortin receptor agonist and a method for its preparation
JP2023548327A (ja) 2020-10-29 2023-11-16 エルジー・ケム・リミテッド メラノコルチン受容体アゴニスト化合物の結晶形ｉおよびその製造方法
KR20220090458A (ko) 2020-12-22 2022-06-29 주식회사 엘지화학 멜라노코르틴 수용체 작용제 화합물의 결정형 ⅲ 및 이의 제조방법
KR20220090457A (ko) 2020-12-22 2022-06-29 주식회사 엘지화학 멜라노코르틴 수용체 작용제 화합물의 결정형 ⅱ 및 이의 제조방법
CN116669742A (zh) 2020-12-22 2023-08-29 株式会社Lg化学 无定形黑皮质素受体激动剂及其制备方法
CN116782877A (zh) * 2020-12-22 2023-09-19 株式会社Lg化学 作为黑皮质素-4受体的选择性激动剂的用途
KR20220090456A (ko) 2020-12-22 2022-06-29 주식회사 엘지화학 멜라노코르틴 수용체 작용제 화합물의 결정형 i 및 이의 제조방법
TWI804170B (zh) * 2021-01-21 2023-06-01 南韓商Ｌｇ化學股份有限公司 黑皮質素-4受體促效劑的用途
EP4299572A1 (en) 2021-02-26 2024-01-03 Lg Chem, Ltd. Melanocortin-4 receptor agonist
CA3217168A1 (en) 2021-05-06 2022-11-10 Lg Chem, Ltd. Crystalline form v of melanocortin receptor agonist compound, and method for preparing same
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WO2022235106A1 (ko) 2021-05-07 2022-11-10 주식회사 엘지화학 멜라노코르틴 수용체 작용제 화합물의 유기산 염의 결정형 ⅳ 및 이의 제조방법
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Also Published As

Publication number Publication date
US8288386B2 (en) 2012-10-16
CR20110250A (es) 2011-08-26
US8236955B2 (en) 2012-08-07
CN102282141A (zh) 2011-12-14
US8039622B2 (en) 2011-10-18
UY32238A (es) 2010-01-05
TWI389903B (zh) 2013-03-21
US20110245500A1 (en) 2011-10-06
TW201022246A (en) 2010-06-16
WO2010056022A2 (en) 2010-05-20
CA2742248C (en) 2014-01-14
PE20110684A1 (es) 2011-09-28
IL212468A0 (en) 2011-06-30
US20100120783A1 (en) 2010-05-13
BRPI0921063B8 (pt) 2021-05-25
GEP20135850B (en) 2013-06-10
KR20100053458A (ko) 2010-05-20
EP2350060A2 (en) 2011-08-03
ECSP11011026A (es) 2011-06-30
CN102282141B (zh) 2014-09-10
BRPI0921063B1 (pt) 2021-03-16
KR101141976B1 (ko) 2012-05-07
MX2011004583A (es) 2011-06-01
AU2009314827B2 (en) 2012-04-05
NZ592512A (en) 2012-12-21
UA99555C2 (en) 2012-08-27
US20110224219A1 (en) 2011-09-15
CA2742248A1 (en) 2010-05-20
JP5399506B2 (ja) 2014-01-29
EA201170676A1 (ru) 2011-12-30
AR074109A1 (es) 2010-12-22
EP2350060A4 (en) 2012-07-25
US8183243B2 (en) 2012-05-22
CL2011001073A1 (es) 2011-10-07
TN2011000222A1 (en) 2012-12-17
JP2012508730A (ja) 2012-04-12
EA019146B1 (ru) 2014-01-30
WO2010056022A3 (en) 2010-09-10
EP2350060B1 (en) 2013-09-18
ZA201103154B (en) 2012-01-25
MA32774B1 (fr) 2011-11-01
AU2009314827A1 (en) 2010-05-20
BRPI0921063A2 (pt) 2015-08-25
US20110237795A1 (en) 2011-09-29

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