CR20110250A - Antagonistas de los receptores de la melacortina - Google Patents

Antagonistas de los receptores de la melacortina

Info

Publication number
CR20110250A
CR20110250A CR20110250A CR20110250A CR20110250A CR 20110250 A CR20110250 A CR 20110250A CR 20110250 A CR20110250 A CR 20110250A CR 20110250 A CR20110250 A CR 20110250A CR 20110250 A CR20110250 A CR 20110250A
Authority
CR
Costa Rica
Prior art keywords
melacortine
antagonists
receptors
respect
receptor
Prior art date
Application number
CR20110250A
Other languages
English (en)
Inventor
Koo Lee
Sang Dae Lee
Sang Pil Moon
In Ae Ahn
Sung Pil Choi
Hyun Ho Lee
Dong Sup Shim
Soo Yong Chung
Hyun Min Lee
Original Assignee
Lg Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lg Life Sciences Ltd filed Critical Lg Life Sciences Ltd
Publication of CR20110250A publication Critical patent/CR20110250A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La presente invención se refiere a un compuesto que tiene una buena actividad antagonista cocn respecto al receptor de la melanocortina, o a una sal farmacéuticamente aceptable o un isómero del mismo, y a una composición agonista con respecto al receptor de la melacortina que comprende el mismo como un inngrediente activo.
CR20110250A 2008-11-12 2011-05-12 Antagonistas de los receptores de la melacortina CR20110250A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR20080112403 2008-11-12

Publications (1)

Publication Number Publication Date
CR20110250A true CR20110250A (es) 2011-08-26

Family

ID=42165801

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20110250A CR20110250A (es) 2008-11-12 2011-05-12 Antagonistas de los receptores de la melacortina

Country Status (26)

Country Link
US (4) US8288386B2 (es)
EP (1) EP2350060B1 (es)
JP (1) JP5399506B2 (es)
KR (1) KR101141976B1 (es)
CN (1) CN102282141B (es)
AR (1) AR074109A1 (es)
AU (1) AU2009314827B2 (es)
BR (1) BRPI0921063B8 (es)
CA (1) CA2742248C (es)
CL (1) CL2011001073A1 (es)
CO (1) CO6362006A2 (es)
CR (1) CR20110250A (es)
EA (1) EA019146B1 (es)
EC (1) ECSP11011026A (es)
GE (1) GEP20135850B (es)
IL (1) IL212468A0 (es)
MA (1) MA32774B1 (es)
MX (1) MX2011004583A (es)
NZ (1) NZ592512A (es)
PE (1) PE20110684A1 (es)
TN (1) TN2011000222A1 (es)
TW (1) TWI389903B (es)
UA (1) UA99555C2 (es)
UY (1) UY32238A (es)
WO (1) WO2010056022A2 (es)
ZA (1) ZA201103154B (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA99555C2 (en) * 2008-11-12 2012-08-27 Элджи Лайф Саенсез Лтд. Melanocortin receptor agonists
WO2012100342A1 (en) 2011-01-27 2012-08-02 Université de Montréal Pyrazolopyridine and pyrazolopyrimidine derivatives as melanocortin-4 receptor modulators
PT3539551T (pt) 2011-12-29 2021-11-04 Rhythm Pharmaceuticals Inc Método de tratamento de distúrbios associados ao recetor de melanocortina-4 em portadores heterozigóticos
JP6235560B2 (ja) 2012-04-25 2017-11-22 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ （３，４−ジクロロ−フェニル）−（（ｓ）−３−プロピル−ピロリジン−３−イル）−メタノン塩酸塩及び製造方法
CN103420981A (zh) * 2012-05-21 2013-12-04 中国医学科学院药物研究所 含有取代吡咯烷基的硫代吗啉类化合物
SG10202101510XA (en) 2015-09-30 2021-03-30 Rhythm Pharmaceuticals Inc Method of treating melanocortin-4 receptor pathway-associated disorders
WO2019195756A1 (en) 2018-04-06 2019-10-10 Rhythm Pharmaceuticals, Inc. Compositions for treating kidney disease
JP7467510B2 (ja) * 2019-11-07 2024-04-15 エルジー・ケム・リミテッド メラノコルチン－４受容体アゴニスト
PE20240124A1 (es) 2020-10-29 2024-01-22 Lg Chemical Ltd Forma cristalina ii del compuesto agonista de receptor de melanocortina y metodo de preparacion para la misma
EP4219475A4 (en) 2020-10-29 2024-03-13 Lg Chem, Ltd. CRYSTAL FORM IV OF A MELANOCORTIN RECEPTOR AGONIST COMPOUND AND PROCESS FOR PRODUCTION THEREOF
PE20240048A1 (es) 2020-10-29 2024-01-09 Lg Chemical Ltd Forma cristalina i del compuesto agonista de receptor de melanocortina y metodo de preparacion para la misma
US20230382895A1 (en) * 2020-10-29 2023-11-30 Lg Chem, Ltd. Crystalline form iii of melanocortin receptor agonist compound and preparation method therefor
WO2022092908A1 (ko) 2020-10-29 2022-05-05 주식회사 엘지화학 무정형의 멜라노코르틴-4 수용체 작용제
JP2024501829A (ja) 2020-12-22 2024-01-16 エルジー・ケム・リミテッド メラノコルチン受容体アゴニスト化合物の結晶形ｉｉｉおよびその製造方法
EP4249482A4 (en) 2020-12-22 2024-05-15 Lg Chem, Ltd. AMORPHOUS MELANOCORTIN RECEPTOR AGONIST AND PREPARATION METHOD THEREFOR
KR20220090456A (ko) 2020-12-22 2022-06-29 주식회사 엘지화학 멜라노코르틴 수용체 작용제 화합물의 결정형 i 및 이의 제조방법
US20240051944A1 (en) 2020-12-22 2024-02-15 Lg Chem, Ltd. Crystalline form ii of melanocortin receptor agonist compound and preparation method therefor
MX2023007429A (es) * 2020-12-22 2023-07-03 Lg Chemical Ltd Uso como agonista selectivo de receptor de melanocortina-4.
CA3203998A1 (en) * 2021-01-21 2022-07-28 Hee Dong Park Use of melanocortin-4 receptor agonist
TWI826938B (zh) 2021-02-26 2023-12-21 南韓商Ｌｇ化學股份有限公司 黑皮質素-4受體促效劑
JP2024518055A (ja) 2021-05-06 2024-04-24 エルジー・ケム・リミテッド メラノコルチン受容体アゴニスト化合物の結晶形ｖおよびその製造方法
WO2022235105A1 (ko) 2021-05-06 2022-11-10 주식회사 엘지화학 멜라노코르틴 수용체 작용제 화합물의 결정형 ⅶ 및 이의 제조방법
BR112023022432A2 (pt) 2021-05-07 2024-01-09 Lg Chemical Ltd Formas cristalinas iv de sais de ácidos orgânicos de composto agonista do receptor de melanocortina, seus metódos de preparação, seus usos, e composições farmacêuticas compreendendo as mesmas
CN117255787A (zh) 2021-05-07 2023-12-19 株式会社Lg 化学 黑皮质素受体激动剂化合物的硫酸盐晶体及其制备方法
WO2022235107A1 (ko) 2021-05-07 2022-11-10 주식회사 엘지화학 멜라노코르틴 수용체 작용제 화합물과 바닐린의 공결정 및 이의 제조방법

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6534503B1 (en) 1998-04-28 2003-03-18 Lion Bioscience Ag Melanocortin receptor-3 ligands to treat sexual dysfunction
WO2000074679A1 (en) 1999-06-04 2000-12-14 Merck & Co., Inc. Substituted piperidines as melanocortin-4 receptor agonists
GB0002059D0 (en) 2000-01-28 2000-03-22 Melacure Therapeutics Ab Novel aromatic amines
CA2403686C (en) 2000-03-23 2010-01-26 Merck & Co., Inc. Substituted piperidines as melanocortin receptor agonists
JP2003527444A (ja) 2000-03-23 2003-09-16 メルク エンド カムパニー インコーポレーテッド メラノコルチン受容体アゴニストとして作用するスピロピペリジン誘導体
GB0019359D0 (en) * 2000-08-07 2000-09-27 Melacure Therapeutics Ab Novel guanidines
WO2002015909A1 (en) 2000-08-23 2002-02-28 Merck & Co., Inc. Substituted piperidines as melanocortin receptor agonists
DZ3415A1 (fr) 2000-08-31 2002-03-07 Chiron Corp Guanidinobenzamides comme mc4-r agonistes.
ES2247298T3 (es) 2001-01-23 2006-03-01 Eli Lilly And Company Derivados de piperazina y piperidina como agonistas del receptor de melanocortina.
EP1368339A1 (en) 2001-01-23 2003-12-10 Eli Lilly & Company Substituted piperidines/piperazines as melanocortin receptor agonists
CA2432988A1 (en) 2001-01-23 2002-08-01 Cristina Garcia-Paredes Melanocortin receptor agonists
WO2002067869A2 (en) 2001-02-28 2002-09-06 Merck & Co., Inc. Acylated piperidine derivatives as melanocortin-4 receptor agonists
IL157253A0 (en) 2001-02-28 2004-02-19 Merck & Co Inc Acylated piperidine derivatives as melanocortin-4 receptor agonists
CA2439149C (en) 2001-02-28 2012-04-24 Merck & Co., Inc. Acylated piperidine derivatives as melanocortin-4 receptor agonists
ES2278016T3 (es) 2001-04-09 2007-08-01 Novartis Vaccines And Diagnostics, Inc. Compuestos guanidino como agonistas del receptor de melanocortina 4 (mc4-r).
US6911447B2 (en) 2001-04-25 2005-06-28 The Procter & Gamble Company Melanocortin receptor ligands
US7115607B2 (en) 2001-07-25 2006-10-03 Amgen Inc. Substituted piperazinyl amides and methods of use
US6977264B2 (en) 2001-07-25 2005-12-20 Amgen Inc. Substituted piperidines and methods of use
AR043434A1 (es) 2003-03-03 2005-07-27 Merck & Co Inc Derivados de piperizacina acilados como agonistas del receptor de melanocortina-4. composiciones farmaceuticas y usos
CA2519939A1 (en) 2003-03-26 2004-10-14 Merck & Co., Inc. Bicyclic piperidine derivatives as melanocortin-4 receptor agonists
US20050192286A1 (en) 2003-10-22 2005-09-01 Neurocrine Biosciences, Inc. Ligands of melanocortin receptors and compositions and methods related thereto
US7989634B2 (en) * 2003-11-12 2011-08-02 Lg Life Sciences Ltd. Melanocortin receptor agonists
GB0402492D0 (en) 2004-02-04 2004-03-10 Pfizer Ltd Pharmaceutically active compounds
WO2006019787A2 (en) 2004-07-16 2006-02-23 Merck & Co., Inc. Acylated piperidine derivatives as melanocortin-4 receptor agonists
EP1773338B1 (en) 2004-07-19 2010-01-06 Merck & Co., Inc. Acylated piperidine derivatives as melanocortin-4 receptor agonists
DE102005000666B3 (de) 2005-01-04 2006-10-05 Sanofi-Aventis Deutschland Gmbh Sulfonylpyrrolidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US20080234280A1 (en) 2005-08-01 2008-09-25 Mcmurray Gordon Use of Mc4 Receptor Agonist Compounds
JP2009503050A (ja) 2005-08-04 2009-01-29 ファイザー・リミテッド ピペリジノイル−ピロリジンおよびピペリジノイル−ピペリジン化合物
BRPI0616463A2 (pt) 2005-09-29 2011-06-21 Merck & Co Inc composto, composição farmacêutica, e, uso de um composto
CA2624031A1 (en) 2005-09-30 2007-04-12 Merck & Co., Inc. Acylated piperidine derivatives as melanocortin-4 receptor agonists
EP1940401B1 (en) * 2005-10-18 2012-07-11 Merck Sharp & Dohme Corp. Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
JP2007131570A (ja) 2005-11-09 2007-05-31 Mitsubishi Pharma Corp 新規なアミノピロリジン誘導体
MX2008010899A (es) 2006-02-23 2008-11-27 Pfizer Ltd Piperidinoilpirrolidinas agonistas del receptor de melanocortina tipo 4.
WO2007096186A1 (en) 2006-02-23 2007-08-30 Santhera Pharmaceuticals (Schweiz) Ag Substituted phenylpiperidine derivatives as melanocortin-4 receptor modulators
CN101466669B (zh) 2006-06-09 2011-11-30 阿克申制药公司 苯基吡咯氨基胍衍生物
TWI332501B (en) 2006-07-14 2010-11-01 Lg Life Sciences Ltd Melanocortin receptor agonists
AU2007300529A1 (en) 2006-09-27 2008-04-03 Merck Sharp & Dohme Corp. Acylated piperidine derivatives as melanocortin-4 receptor modulators
UA99555C2 (en) * 2008-11-12 2012-08-27 Элджи Лайф Саенсез Лтд. Melanocortin receptor agonists

Also Published As

Publication number Publication date
WO2010056022A2 (en) 2010-05-20
US20100120783A1 (en) 2010-05-13
NZ592512A (en) 2012-12-21
EP2350060A2 (en) 2011-08-03
CA2742248A1 (en) 2010-05-20
US8183243B2 (en) 2012-05-22
BRPI0921063B1 (pt) 2021-03-16
AU2009314827B2 (en) 2012-04-05
KR20100053458A (ko) 2010-05-20
US8288386B2 (en) 2012-10-16
MX2011004583A (es) 2011-06-01
PE20110684A1 (es) 2011-09-28
US8039622B2 (en) 2011-10-18
US20110245500A1 (en) 2011-10-06
CO6362006A2 (es) 2012-01-20
JP5399506B2 (ja) 2014-01-29
CN102282141A (zh) 2011-12-14
CN102282141B (zh) 2014-09-10
IL212468A0 (en) 2011-06-30
CA2742248C (en) 2014-01-14
WO2010056022A3 (en) 2010-09-10
TWI389903B (zh) 2013-03-21
JP2012508730A (ja) 2012-04-12
TW201022246A (en) 2010-06-16
EA201170676A1 (ru) 2011-12-30
BRPI0921063B8 (pt) 2021-05-25
TN2011000222A1 (en) 2012-12-17
US20110224219A1 (en) 2011-09-15
EP2350060B1 (en) 2013-09-18
US20110237795A1 (en) 2011-09-29
CL2011001073A1 (es) 2011-10-07
KR101141976B1 (ko) 2012-05-07
MA32774B1 (fr) 2011-11-01
BRPI0921063A2 (pt) 2015-08-25
EA019146B1 (ru) 2014-01-30
EP2350060A4 (en) 2012-07-25
GEP20135850B (en) 2013-06-10
AR074109A1 (es) 2010-12-22
UY32238A (es) 2010-01-05
AU2009314827A1 (en) 2010-05-20
ZA201103154B (en) 2012-01-25
US8236955B2 (en) 2012-08-07
UA99555C2 (en) 2012-08-27
ECSP11011026A (es) 2011-06-30

Similar Documents

Publication Publication Date Title
CR20110250A (es) Antagonistas de los receptores de la melacortina
UY30829A1 (es) Compuestos agonistas y antagonistas del receptor de esfinfosina-1-fosfato
UY32223A (es) Nuevos compuestos sustituidos con halogenos
CR20110043A (es) Mezclas fungicidas que comprenden 1-metilpirazol-4-ilcarboxanilidas sustituidas
UY32225A (es) Antagonistas de cicloalcano[b]azaindol de los receptores de la prostaglandina d2
CL2012000887A1 (es) Mezcla fungicida sinergica que comprende fluorocitosina y otros compuestos fungicos; composicion fungicida que comprende dicha mezcla y un adyuvante agricolamente aceptable o portador.
CR11264A (es) Compuestos de 5-(4-halo-alcoxi)-fenil)-pirimidin-2-amina y composiciones como inhibidores de cinasa
IN2012DN01241A (es)
EA201001230A1 (ru) Пестицидные смеси
DOP2011000104A (es) Combinacion de una insulina y un agonista de glp-1
CR20120483A (es) Composiciones parasiticidas que comprenden agentes activos múltiples, métodos y usos de los mismos
EA201690033A2 (ru) Морфинановые соединения
HN2008000646A (es) Antagonistas de los receptores 2 de dopamina de rapida disociacion
CO7400870A2 (es) Compuestos derivadios de quinuclidina con actividad antagonista de los receptores muscarínicos y actividad agonista del receptor beta2 adrenérgico
UY32440A (es) Mezclas de plaguicidas
EA201001234A1 (ru) Пестицидные смеси
ECSP10010440A (es) Mezclas de plaguicidas
UY39084A (es) Composiciones herbicidas a base de carbamoíltriazolinona y métodos de uso
EA201071395A1 (ru) Ингибитор толерантности к анальгетику
CL2009000904A1 (es) Compuestos derivados de ciclohexil sulfonamidas que tienen actividad antagonista en el receptor npy y5, composicion farmaceutica y formulacion farmaceutica que los comprende.
EA201001882A1 (ru) Гидроксизамещенные тиенопиримидиноны как антагонисты рецептора-i меланинконцентрирующего гормона
CO6300937A2 (es) Derivados de 3-carboxipropil-aminotetralina y compuestos relacionados como antagonistas de receptores opioides mu
DOP2011000017A (es) Compuestos novedosos activos como antagonistas de receptor muscarinico
PA8814801A1 (es) Triazolopiridazinas como inhibidores de par1, su preparación y su uso como medicamentos
MY160825A (en) Lanthionine derivatives