PL1932522T3 - Środek terapeutyczny do leczenia choroby wątroby zawierający jako składnik czynny pochodną 2-amino-1,3-propanodiolu - Google Patents

Środek terapeutyczny do leczenia choroby wątroby zawierający jako składnik czynny pochodną 2-amino-1,3-propanodiolu

Info

Publication number
PL1932522T3
PL1932522T3 PL06811299T PL06811299T PL1932522T3 PL 1932522 T3 PL1932522 T3 PL 1932522T3 PL 06811299 T PL06811299 T PL 06811299T PL 06811299 T PL06811299 T PL 06811299T PL 1932522 T3 PL1932522 T3 PL 1932522T3
Authority
PL
Poland
Prior art keywords
amino
active ingredient
therapeutic agent
liver disease
disease containing
Prior art date
Application number
PL06811299T
Other languages
English (en)
Inventor
Takashi Kaneko
Eiji Kobayashi
Tokutarou Yasue
Original Assignee
Kyorin Seiyaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Seiyaku Kk filed Critical Kyorin Seiyaku Kk
Publication of PL1932522T3 publication Critical patent/PL1932522T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PL06811299T 2005-10-07 2006-10-05 Środek terapeutyczny do leczenia choroby wątroby zawierający jako składnik czynny pochodną 2-amino-1,3-propanodiolu PL1932522T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2005295478 2005-10-07
EP06811299A EP1932522B1 (en) 2005-10-07 2006-10-05 Therapeutic agent for liver disease containing 2-amino-1,3-propanediol derivative as active ingredient
PCT/JP2006/319961 WO2007043433A1 (ja) 2005-10-07 2006-10-05 2-アミノ-1,3-プロパンジオール誘導体を有効成分とする肝臓疾患治療剤および肝臓疾患治療方法

Publications (1)

Publication Number Publication Date
PL1932522T3 true PL1932522T3 (pl) 2012-09-28

Family

ID=37942676

Family Applications (1)

Application Number Title Priority Date Filing Date
PL06811299T PL1932522T3 (pl) 2005-10-07 2006-10-05 Środek terapeutyczny do leczenia choroby wątroby zawierający jako składnik czynny pochodną 2-amino-1,3-propanodiolu

Country Status (16)

Country Link
US (1) US8048928B2 (pl)
EP (1) EP1932522B1 (pl)
JP (1) JP5116476B2 (pl)
KR (1) KR101297302B1 (pl)
CN (1) CN101277687B (pl)
AU (1) AU2006300485B2 (pl)
BR (1) BRPI0617077A2 (pl)
CA (1) CA2624909C (pl)
CY (1) CY1112911T1 (pl)
DK (1) DK1932522T3 (pl)
ES (1) ES2385580T3 (pl)
PL (1) PL1932522T3 (pl)
PT (1) PT1932522E (pl)
RU (1) RU2421214C2 (pl)
SI (1) SI1932522T1 (pl)
WO (1) WO2007043433A1 (pl)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101884781B (zh) 2004-07-16 2012-07-18 杏林制药株式会社 用于对器官或组织的移植的排异反应或骨髓移植的移植物抗宿主反应预防或治疗的药物组合物
KR101181090B1 (ko) 2004-10-12 2012-09-07 교린 세이야꾸 가부시키 가이샤 2-아미노-2-[2-[4-(3-벤질옥시페닐티오)-2-클로로페닐]에틸]-1,3-프로판디올 염산염 또는 그 수화물의 제조방법 및 그 제조 중간체
CA2624909C (en) 2005-10-07 2013-10-01 Kyorin Pharmaceutical Co., Ltd. Therapeutic agent for treating liver disease containing 2-amino-1,3-propanediol derivative as active ingredient, and method for treating liver disease
TWI389683B (zh) 2006-02-06 2013-03-21 Kyorin Seiyaku Kk A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient
MX2009001457A (es) 2006-08-08 2009-02-19 Kyorin Seiyaku Kk Derivados de aminoalcohol e inmunosupresores que contienen lo mismo como ingrediente activo.
WO2008018427A1 (fr) 2006-08-08 2008-02-14 Kyorin Pharmaceutical Co., Ltd. Dérivé d'ester de l'acide aminophosphorique et modulateur du récepteur s1p contenant ledit dérivé en tant que principe actif
US20100093745A1 (en) * 2007-02-13 2010-04-15 Kazuhiko Kuriyama Therapeutic agent or prophylactic agent for demyelinating disease comprising amino alcohol derivative as active ingredient
TW200946105A (en) 2008-02-07 2009-11-16 Kyorin Seiyaku Kk Therapeutic agent or preventive agent for inflammatory bowel disease containing amino alcohol derivative as active ingredient
WO2009119395A1 (ja) 2008-03-24 2009-10-01 杏林製薬株式会社 2-アミノ-2-[2-[4-(3-ベンジルオキシフェニルチオ)-2-クロロフェニル]エチル]-1,3-プロパンジオール塩酸塩の結晶化方法
WO2009142195A1 (ja) * 2008-05-20 2009-11-26 杏林製薬株式会社 寛解導入維持剤
JP5856980B2 (ja) 2010-01-27 2016-02-10 アリーナ ファーマシューティカルズ, インコーポレイテッド (R)−2−(7−(4−シクロペンチル−3−(トリフルオロメチル)ベンジルオキシ)−1,2,3,4−テトラヒドロシクロペンタ[b]インドール−3−イル)酢酸およびその塩の調製のためのプロセス
US8526213B2 (en) 2010-11-01 2013-09-03 Micron Technology, Inc. Memory cells, methods of programming memory cells, and methods of forming memory cells
CA3002551A1 (en) 2015-06-22 2016-12-29 Arena Pharmaceuticals, Inc. Crystalline l-arginine salt of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid(com pound 1)for use in s1p1 receptor-associated disorders
EP3582814B1 (en) 2017-02-16 2024-05-01 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of inflammatory bowel disease with extra-intestinal manifestations
CN110520124A (zh) * 2017-02-16 2019-11-29 艾尼纳制药公司 用于治疗原发性胆汁性胆管炎的化合物和方法
KR20210040954A (ko) 2018-07-27 2021-04-14 프리오테라 리미티드 조혈 줄기세포 이식을 받은 환자에 있어서의 혈액 악성 종양의 재발 억제제

Family Cites Families (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2126658T3 (es) 1992-10-21 1999-04-01 Yoshitomi Pharmaceutical Compuesto de 2-amino-1,3-propanodiol e inmunosupresor.
US5948820A (en) 1994-08-22 1999-09-07 Yoshitomi Pharmaceutical Industries, Ltd. Benzene compound and pharmaceutical use thereof
US5447922A (en) 1994-08-24 1995-09-05 Bristol-Myers Squibb Company α-phosphonosulfinic squalene synthetase inhibitors
CN1137086C (zh) 1997-04-04 2004-02-04 三菱制药株式会社 2-氨基丙烷-1,3-二醇化合物、其作为医药的用途及其合成中间体
JPH1180026A (ja) * 1997-09-02 1999-03-23 Yoshitomi Pharmaceut Ind Ltd 新規免疫抑制剤、その使用方法およびその同定方法
ES2284256T3 (es) 1998-07-02 2007-11-01 Kyowa Hakko Kogyo Co., Ltd. Medicamentos para la diabetes.
AU767241B2 (en) * 1998-09-14 2003-11-06 Qiang Xu Immunosuppressive agents
JP2000154151A (ja) * 1998-09-14 2000-06-06 Kyo Jo 免疫抑制剤
US20020143034A1 (en) 1998-12-30 2002-10-03 Fujisawa Pharmaceutical Co. Ltd. Aminoalcohol derivatives and their use as beta 3 adrenergic agonists
AU2001264313A1 (en) 2000-06-20 2002-01-02 Japan Tobacco Inc. Pyrazolopyridine compounds and use thereof as drugs
IL153594A0 (en) 2000-07-13 2003-07-06 Sankyo Co Amino alcohol derivatives and pharmaceutical compositions containing the same
JP2002053575A (ja) 2000-08-09 2002-02-19 Sankyo Co Ltd アミノアルコ−ル類
JP2004507552A (ja) 2000-08-31 2004-03-11 メルク エンド カムパニー インコーポレーテッド 免疫調節剤としてのリン酸誘導体
WO2002064616A2 (en) 2001-01-30 2002-08-22 University Of Virgina Patent Foundation Agonists and antagonists of sphingosine-1-phosphate receptors
WO2002062389A1 (fr) 2001-02-08 2002-08-15 Ono Pharmaceutical Co., Ltd. Remedes pour des maladies urinaires contenant des agents de regulation du recepteur de lpa
JP4318921B2 (ja) 2001-02-22 2009-08-26 ノバルティス アクチエンゲゼルシャフト 移植片の機能発現遅延の処置のための医薬の製造のためのリンパ球ホーミング促進剤の使用
KR20030093279A (ko) 2001-03-26 2003-12-06 노파르티스 아게 2-아미노-프로판올 유도체
JP2002316985A (ja) 2001-04-20 2002-10-31 Sankyo Co Ltd ベンゾチオフェン誘導体
ES2316613T3 (es) 2001-05-10 2009-04-16 Ono Pharmaceutical Co., Ltd. Derivados de acido crboxilico y composiciones farmaceuticas que contienen los mismos como ingrediente activo.
JP2004534772A (ja) 2001-05-24 2004-11-18 藤沢薬品工業株式会社 アミノアルコール誘導体
US20040235794A1 (en) 2001-09-04 2004-11-25 Shinji Nakade Remedies for respiratory diseases comprising sphingosine-1-phosphate receptor controller
ES2292809T3 (es) 2001-09-27 2008-03-16 Kyorin Pharmaceutical Co., Ltd. Derivado de sulfuro de diarilo, sal de adicion del mismo, y agente inmunosupresor.
CA2460640C (en) 2001-09-27 2011-03-29 Kyorin Pharmaceutical Co., Ltd. Diaryl ether derivatives, salts thereof and immunosuppressive agents using the same
JP4035759B2 (ja) 2001-11-06 2008-01-23 独立行政法人産業技術総合研究所 アミノアルコールリン酸化合物、製造方法、及びその利用方法
WO2003059880A1 (fr) 2002-01-11 2003-07-24 Sankyo Company, Limited Derive d'amino-alcool ou derive d'acide phosphonique et composition medicamenteuse les contenant
JP2003267936A (ja) 2002-01-11 2003-09-25 Sankyo Co Ltd ベンゼン環化合物
EP1470137B1 (en) 2002-01-18 2009-09-02 Merck & Co., Inc. Edg receptor agonists
US20040058894A1 (en) 2002-01-18 2004-03-25 Doherty George A. Selective S1P1/Edg1 receptor agonists
JP4709488B2 (ja) 2002-01-18 2011-06-22 メルク・シャープ・エンド・ドーム・コーポレイション Edg受容体作動薬としてのN−(ベンジル)アミノアルキルカルボン酸化合物、ホスフィン酸化合物、ホスホン酸化合物およびテトラゾール類
EP1482896A4 (en) 2002-03-01 2005-11-23 Merck & Co Inc AMINOALKYLPHOSPHONATES AND ASSOCIATED COMPOUNDS AS EDG RECEPTOR AGONISTS
AU2003217764A1 (en) 2002-03-01 2003-09-16 Merck & Co., Inc. Aminoalkylphosphonates and related compounds as edg receptor agonists
CA2488117A1 (en) 2002-06-17 2003-12-24 Merck & Co., Inc. 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylates and 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)pyrrolidine-3-carboxylates as edg receptor agonists
ES2464157T3 (es) 2002-06-26 2014-05-30 Ono Pharmaceutical Co., Ltd. Remedios para enfermedades causadas por contracción o dilatación vascular
CA2533587A1 (en) 2002-07-30 2004-02-05 University Of Virginia Patent Foundation Compounds active in sphingosine 1-phosphate signaling
BR0314113A (pt) 2002-09-13 2005-07-12 Novartis Ag Derivados de amino propanol
BR0314455A (pt) 2002-09-19 2005-07-26 Kyorin Seiyaku Kk Derivados de aminoálcool, seus sais e agentes imunosupressores
BR0314760A (pt) 2002-09-24 2005-07-26 Novartis Ag Compostos orgânicos
TW200408393A (en) 2002-10-03 2004-06-01 Ono Pharmaceutical Co Antagonist of lysophosphatidine acid receptor
JP4140698B2 (ja) 2002-10-18 2008-08-27 第一三共株式会社 リン酸又はホスホン酸誘導体
CA2509218C (en) 2002-12-20 2010-09-07 Merck & Co., Inc. 1-(amino)indanes and (1,2-dihydro-3-amino)-benzofurans, benzothiophenes and indoles as edg receptor agonists
CA2515638A1 (en) 2003-02-11 2004-08-26 Shifeng Pan Novel bicyclic compounds and compositions
EP1602660B1 (en) 2003-02-18 2011-04-06 Kyorin Pharmaceutical Co., Ltd. Aminophosphonic acid derivatives, addition salts thereof and s1p receptor modulators
JP2004307441A (ja) 2003-04-10 2004-11-04 Kyorin Pharmaceut Co Ltd ベンゼン誘導体とその付加塩及び免疫抑制剤
JP2004307442A (ja) 2003-04-10 2004-11-04 Kyorin Pharmaceut Co Ltd ヘテロ環誘導体とその付加塩及び免疫抑制剤
JP2004307439A (ja) 2003-04-10 2004-11-04 Kyorin Pharmaceut Co Ltd アミノジオール誘導体とその付加塩及び免疫抑制剤
JP2004307440A (ja) 2003-04-10 2004-11-04 Kyorin Pharmaceut Co Ltd 2−アミノ‐1,3‐プロパンジオール誘導体とその付加塩
CA2523582A1 (en) 2003-04-30 2004-11-11 Novartis Ag Amino-propanol derivatives as sphingosine-1-phosphate receptor modulator
EP1622866B1 (en) 2003-04-30 2012-07-25 Novartis AG Aminopropanol derivatives as sphingosine-1-phosphate receptor modulators
JP2006528980A (ja) 2003-05-15 2006-12-28 メルク エンド カムパニー インコーポレーテッド S1p受容体作働薬としての3−(2−アミノ−1−アザシクロ)−5−アリール−1,2,4−オキサジアゾール類
CN1787817B (zh) 2003-05-19 2011-09-07 Irm责任有限公司 免疫抑制剂化合物及组合物
GB0313612D0 (en) 2003-06-12 2003-07-16 Novartis Ag Organic compounds
JP2005047899A (ja) 2003-07-11 2005-02-24 Sankyo Co Ltd アミノアルコール化合物
WO2005014525A2 (en) 2003-08-12 2005-02-17 Mitsubishi Pharma Corporation Bi-aryl compound having immunosuppressive activity
WO2005014603A1 (en) 2003-08-12 2005-02-17 Mitsubishi Pharma Corporation Phosphinane compounds with immunomodulating activity
ATE449069T1 (de) 2003-08-28 2009-12-15 Novartis Pharma Gmbh Aminopropanolderivate
CN1874991A (zh) 2003-08-29 2006-12-06 小野药品工业株式会社 能够结合s1p受体的化合物及其药物用途
EP1670463A2 (en) 2003-10-01 2006-06-21 Merck & Co., Inc. 3,5-aryl, heteroaryl or cycloalkyl substituted-1,2,4-oxadiazoles as s1p receptor agonists
GB0324210D0 (en) 2003-10-15 2003-11-19 Novartis Ag Organic compounds
WO2005041899A2 (en) 2003-11-03 2005-05-12 University Of Virginia Patent Foundation Orally available sphingosine 1-phosphate receptor agonists and antagonists
CA2547198A1 (en) 2003-12-17 2005-06-30 Merck & Co., Inc. (3,4-disubstituted)propanoic carboxylates as s1p (edg) receptor agonists
TW200526548A (en) 2003-12-25 2005-08-16 Sankyo Co Ether derivatives
GB0401332D0 (en) 2004-01-21 2004-02-25 Novartis Ag Organic compounds
CA2557536C (en) 2004-02-24 2010-07-13 Sankyo Company Limited Amino alcohol compound
TW200538433A (en) 2004-02-24 2005-12-01 Irm Llc Immunosuppressant compounds and compositiions
US7718704B2 (en) 2004-02-24 2010-05-18 Irm Llc Immunosuppressant compounds and compositions
JP2005247691A (ja) 2004-03-01 2005-09-15 Toa Eiyo Ltd S1p3受容体拮抗薬
GB0405289D0 (en) 2004-03-09 2004-04-21 Novartis Ag Organic compounds
GB0411929D0 (en) 2004-05-27 2004-06-30 Novartis Ag Organic compounds
EP1760071A4 (en) 2004-06-23 2008-03-05 Ono Pharmaceutical Co COMPOUND WITH S1P RECEPTOR BINDING ABILITY AND USE THEREOF
CN101884781B (zh) 2004-07-16 2012-07-18 杏林制药株式会社 用于对器官或组织的移植的排异反应或骨髓移植的移植物抗宿主反应预防或治疗的药物组合物
TW200611687A (en) 2004-07-29 2006-04-16 Sankyo Co Pharmaceutical compositions used for immunosuppressant
KR20070058455A (ko) 2004-08-13 2007-06-08 프래시스 파마슈티컬즈 인코포레이티드 스핑고신-1-포스페이트(s1p) 수용체 활성을 조절하기위한 방법 및 조성물
KR101181090B1 (ko) 2004-10-12 2012-09-07 교린 세이야꾸 가부시키 가이샤 2-아미노-2-[2-[4-(3-벤질옥시페닐티오)-2-클로로페닐]에틸]-1,3-프로판디올 염산염 또는 그 수화물의 제조방법 및 그 제조 중간체
JPWO2006041015A1 (ja) 2004-10-12 2008-05-15 杏林製薬株式会社 アミノアルコール誘導体とその付加塩及び免疫抑制剤
US7888527B2 (en) 2004-12-06 2011-02-15 University Of Virginia Patent Foundation Aryl amide sphingosine 1-phosphate analogs
TW200702326A (en) 2005-05-31 2007-01-16 Mitsubishi Pharma Corp 2-aminobutanol compound and its pharmaceutical use
TWI418350B (zh) 2005-06-24 2013-12-11 Sankyo Co 含有ppar調節劑之醫藥組成物的用途
DK1926483T3 (da) 2005-09-09 2011-03-14 Novartis Ag Behandling af autoimmune sygdomme
CA2624909C (en) 2005-10-07 2013-10-01 Kyorin Pharmaceutical Co., Ltd. Therapeutic agent for treating liver disease containing 2-amino-1,3-propanediol derivative as active ingredient, and method for treating liver disease
WO2007043568A1 (ja) 2005-10-12 2007-04-19 Toa Eiyo Ltd. S1p3受容体拮抗剤
TWI389683B (zh) 2006-02-06 2013-03-21 Kyorin Seiyaku Kk A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient
AU2007279311A1 (en) 2006-07-25 2008-01-31 Alcon Research, Ltd. Antagonists of endothelial differentiation gene subfamily 3 (Edg-3, S1P3) receptors for prevention and treatment of ocular disorders
US7877152B2 (en) 2006-07-31 2011-01-25 JusJas LLC Bipolar stimulation/recording device with widely spaced electrodes

Also Published As

Publication number Publication date
EP1932522A4 (en) 2010-07-07
KR101297302B1 (ko) 2013-08-19
CN101277687A (zh) 2008-10-01
BRPI0617077A2 (pt) 2015-01-06
PT1932522E (pt) 2012-06-26
CA2624909A1 (en) 2007-04-19
RU2008115613A (ru) 2009-11-20
CA2624909C (en) 2013-10-01
CN101277687B (zh) 2012-07-18
DK1932522T3 (da) 2012-07-02
EP1932522B1 (en) 2012-05-23
ES2385580T3 (es) 2012-07-26
WO2007043433A1 (ja) 2007-04-19
JP5116476B2 (ja) 2013-01-09
JPWO2007043433A1 (ja) 2009-04-16
KR20080064962A (ko) 2008-07-10
US8048928B2 (en) 2011-11-01
AU2006300485A1 (en) 2007-04-19
AU2006300485B2 (en) 2011-08-25
EP1932522A1 (en) 2008-06-18
CY1112911T1 (el) 2016-04-13
SI1932522T1 (sl) 2012-08-31
US20090253802A1 (en) 2009-10-08
RU2421214C2 (ru) 2011-06-20

Similar Documents

Publication Publication Date Title
PL1932522T3 (pl) Środek terapeutyczny do leczenia choroby wątroby zawierający jako składnik czynny pochodną 2-amino-1,3-propanodiolu
IL192150A0 (en) Therapeutic agent for inflammatory bowel disease containing as active ingredient 2-amino-1,3-propanediol derivative, or method for treating inflammatory bowel disease
HK1124534A1 (en) Therapeutic agent for heart disease
AP2441A (en) Low-faoming aqueous formulations used for crop protection
IL191907A0 (en) Azepinoindole derivatives as pharmaceutical agents
HK1103393A1 (en) Cyclohexane derivative, prodrug thereof and salt thereof, and therapeutic agent containing the same for diabetes
EP1981547A4 (en) STABLE THERAPEUTIC FORMULATIONS
IL179566A0 (en) Concentrated aqueous formulations for crop protection
EP2093237A4 (en) ANTICANCER AGENT COMPRISING ANTI-HB-EGF ANTIBODY AS ACTIVE INGREDIENT
ZA200709999B (en) Fungicidal active ingredient combination
EP1776112A4 (en) HETEROCYCLIC COMPOUNDS AS PHARMACEUTICAL AGENTS
ZA200805453B (en) Indanyl-and tetrahydronaphthyl-amino-azoline compounds for combating animal pests
IL201418A0 (en) Therapeutic agent for glaucoma containing adenosine derivative as active ingredient
HUE031355T2 (hu) Vízben nem oldódó aktív szerves vegyületek kompozíciói
ZA200800698B (en) Pyrazole derivatives as therapeutic agents
ZA200805452B (en) Indanyl-and Tetrahydronaphtyl-amino-thiourea compounds for combating animal pests
PL1773307T3 (pl) Preparaty 2-amino-1,3-propanodioli i ich analogów
ZA200804757B (en) Fungicidal active ingredient combination
ZA200804952B (en) Fungicidal active substance combination
EP1884237A4 (en) NEUROCYTE PROTECTIVE AGENT COMPRISING AN AMIDINO DERIVATIVE AS AN ACTIVE SUBSTANCE
EP1967208A4 (en) THERAPEUTIC AGENT FOR SKIN OR AGENT PROMOTING REGENERATION OF SKIN CONTAINING GHRELINE, AND DERIVATIVES THEREOF OR SUBSTANCE CAPABLE OF ACTING AS ACTIVE INGREDIENT ON GHS-R1a
EP1806137A4 (en) THERAPEUTIC AGENT FOR THE TREATMENT OF GLOMERULAR DISEASE
EP1967201A4 (en) THERAPEUTIC AGENT FOR SKIN OR SKIN REGENERATING AGENT CONTAINING DESACYL-GHRELINE OR A DERIVATIVE THEREOF AS ACTIVE INGREDIENT
ZA200700755B (en) Novel cyclohexane derivative, prodrug thereof and salt thereof, and therapeutic agent containing the same for diabetes
PL1876175T3 (pl) Środek terapeutyczny do leczenia chorób rogówki