JP5290254B2 - 所定の冷却プロフィールをもたらす複数の制御可能冷却要素を有する冷却装置 - Google Patents
所定の冷却プロフィールをもたらす複数の制御可能冷却要素を有する冷却装置 Download PDFInfo
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- JP5290254B2 JP5290254B2 JP2010213871A JP2010213871A JP5290254B2 JP 5290254 B2 JP5290254 B2 JP 5290254B2 JP 2010213871 A JP2010213871 A JP 2010213871A JP 2010213871 A JP2010213871 A JP 2010213871A JP 5290254 B2 JP5290254 B2 JP 5290254B2
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Description
本発明の開示は、皮下の脂質豊富細胞を冷却するための装置、システム、及び方法を説明する。用語「皮下組織」は、真皮の下に重なる組織を意味し、アディポサイト(脂肪細胞)及び皮下脂肪を含む。以下に示す詳細のいくつかは、開示した実施形態を当業者が作って用いることを可能にするのに十分な方法で以下の実施形態を説明するために提供されることが認められるであろう。しかし、以下に説明する詳細及び利点のいくつかは、本発明のある一定の実施形態を実施するのに必要でない場合がある。更に、本発明は、特許請求の範囲内であるが図1−11に関して詳細に説明されていない他の実施形態を含むことができる。
図1は、本発明の実施形態による被験者101の皮下の脂質豊富細胞から熱を除去するためのシステム100の等角投影図である。システム100は、被験者101の皮下の脂質豊富細胞から熱を除去するための被験者101の腹部102又は別の適切な部位に設けられた冷却装置104を含むことができる。冷却装置104の様々な実施形態は、図2−11を参照して以下でより詳細に説明する。
図2A、2B、及び2Cは、システム100の用途に適切な本発明の実施形態による冷却装置104の等角投影図である。この実施形態では、冷却装置104は、制御システムハウジング202及び冷却要素ハウジング204a−gを含む。制御システムハウジング202は、カラー310に滑り込むことができ及び/又は冷却要素ハウジングに取り付けることができるスリーブ308(図3)を含む。冷却要素ハウジング204a−gは、取付手段206によって熱交換要素(図示せず)に接続される。取付手段は、当業技術で公知のネジ又はピンのようなあらゆる機械取付装置とすることができる。複数の冷却要素ハウジング204a−gは、多数の同じ形態を有することができる。従って、第1の冷却要素ハウジング204aの特徴は、「a」を付けた参照記号で以下に説明され、対応する第2の冷却要素ハウジング204bの特徴は、「b」を付けた同じ参照記号によって示される等々である。冷却要素ハウジング204aは、ポリマー材料、金属、セラミック、木材、及び/又は他の適切な材料から構成することができる。図2A−Cに示す冷却要素ハウジング204aの実施例は、ほぼ矩形であるが、それは、あらゆる他の望ましい形状を有することができる。
図10は、皮膚の真皮内の横方向冷却パターンの例示的断面図である。冷却パターンは、その冷却パターンが脂質豊富細胞を含むターゲット真皮層に影響を与えるような時に、冷却パターンが均一な冷却層を形成し、フレームのセグメント間のあらゆる間隙が軽減されるように、皮膚の表皮及び真皮を通って冷却要素302a−fから放射する。この冷却パターンの1つの期待される利点は、治療中に真皮層の冷却が均一であることである。図10は、被験者の身体のほぼ平面部分に付加された冷却装置104を開示している。冷却装置の冷却要素302a−fは、被験者の皮膚の輪郭に適合するように互いに対して移動可能である(図2B、C、及びDに示すように)。
ΔE=ρ・V・C・ΔT
ここで、ΔEは内部エネルギの変化であり、ρは材料密度であり、Vは材料容積であり、C°は材料の熱容量であり、ΔTは温度変化である。上述の問題において、アルミニウムの容積は、V=1インチ×1.5インチ×0.4インチ、又は、.06インチ3(9.8×10-7m3)である。アルミニウムの典型的な等級に対して、C°=875J/kg*℃及びρ=2770kg/m3である。これらの定数を用いて方程式を解くと、以下の通りである。
ΔE=2770kg/m3*9.8×10-7m3*875J/kg*℃*30℃=71.3J
71.3J/(10J/秒)=7.13秒
多くの皮膚冷却装置は、熱電気冷却器又は他の冷却源と皮膚の間のアルミニウム又は他の伝導材料の比較的厚い部分に依存している。冷却装置が、皮膚組織のような比較的絶縁性の材料に付加されると、アルミニウムプレートは、皮膚の表面にわたって等温になり、一定の温度プロフィールを維持する。この設計の欠点は、装置が最初に冷却する時又は熱循環中にアルミニウムプレートによって与えられた熱質量が大きな冷却力を必要とすることである。このいずれか又は両方により、冷却装置から必要な冷却時間の増加又は力の増大を生じる。
ある一定の実施形態では、望ましい温度が達成された状態で、領域の温度は、所定の期間にわたって維持することができる。冷却サイクルは、皮膚から熱交換面420a−gを分離することによって終了することができる。ある一定の期間の後に、必要に応じて冷却装置104は、脂質豊富細胞が脂質豊富細胞の望ましい減少を発現するのに十分な量の影響を受けるまで、上述の皮膚と同じ部分に再付加することができる。代替的な実施形態では、冷却装置104は、異なる皮下のターゲット領域の脂質豊富細胞に選択的に影響を与えるように、上述とは異なる皮膚の部分に付加することができる。
作動中に、熱交換面420の間の角度は、冷却要素302a−gを回転又は移動させることによって選択される。冷却要素(320a−g)の間の角度は、多くの場合に熱交換面320a−gを被験者101の様々な身体の輪郭及び/又は望ましい固定配置に適合させるように選択される。図2Aに示す実施形態では、熱交換面320a−gの間の角度は、ほぼ180°とすることができ、すなわち、熱交換面320a−gは、冷却装置を治療領域に付加するためにほぼ同一平面上にある。図2Bに示す実施形態では、角度は、冷却装置を被験者の身体の周囲で曲げることができるように、180°よりも小さくすることができる。図2Cに示す実施形態では、冷却装置は、被験者の身体に適合するように更に曲げられる。他の実施形態では、角度は、当業者によって認められるように被験者の身体に適合するあらゆる角度とすることができる。
図11は、処理ユニット114の用途に適切な例示的ソフトウエアモジュール940を示す機能図である。各構成要素は、C++プログラム言語のような従来のプログラム言語のソースコードとして書かれたコンピュータプログラム、手順、又は処理とすることができ、プロセッサ942のCPUによる実行のために呈示することができる。ソースコード並びにオブジェクト及びバイトコードの様々な実施は、コンピュータ可読記憶媒体上に記憶されるか、又は搬送波内の伝送媒体上に組み込むことができる。プロセッサ942のモジュールは、入力モジュール944、データベースモジュール946、処理モジュール948、出力モジュール950、及び任意的に表示モジュール951を含むことができる。別の実施形態では、ソフトウエアモジュール940は、分散コンピューティング手法におけるネットワークサーバのCPUによる実行のために呈示することができる。
101 被験者
104 冷却装置
Claims (22)
- 皮膚を有する被験者の皮下の脂質豊富細胞から熱を除去するための冷却装置であって、
要素を互いに対して回転させるために互いにヒンジで動く複数の冷却要素であって、該冷却要素は、皮膚インタフェース表面を有し且つ前記脂質豊富細胞は実質的に影響をうけるが非脂質豊富細胞は実質的に影響を受けないようにして熱を除去するように構成されている前記冷却要素、及び
前記冷却要素が前記脂肪豊富細胞から熱を除去できるようにして前記冷却装置を被験者上に取外し可能に保持する保持装置を含む
ことを特徴とする装置。 - 前記冷却要素の間の角度は、約0°から約45°まで回転することができることを特徴とする請求項1に記載の冷却装置。
- 被験者に適合するように構成された弓形形状を形成することを特徴とする請求項1に記載の冷却装置。
- 前記冷却要素は、前記インタフェース部材と熱的に連通した流体チャンバ、及び該流体チャンバと流体連通した複数の流体ポートを更に含み、前記流体ポートは、前記流体チャンバを通る流体循環を可能にするように構成されており、
前記流体チャンバと連通した流体は、該流体を冷やす装置を通って循環され、または、
前記流体チャンバは、蛇行形状であり、または
前記冷却要素は、流体的に直列に接続されていることを特徴とする請求項1に記載の冷却装置。 - 冷却装置と被験者の皮膚との間の熱伝導率を増大させるために、冷却装置と被験者の皮膚との間のインタフェースに付加された熱伝導性カプリング剤を更に含むことを特徴とする請求項1に記載の冷却装置。
- 前記複数の冷却要素の各々は、対応するインタフェース部材と熱的に連通した第1の側面、及び対応する熱電気熱交換器と熱的に連通した該第1の側面の反対側の第2の側面を有し、
前記冷却要素は、ターゲット領域の温度を、該領域の脂質豊富細胞は影響を受けるが、前記熱交換面に近接した非脂質豊富細胞が大きく影響を受けないように低下させるように構成されている、
ことを特徴とする請求項1に記載の冷却装置。 - 前記インタフェース部材の少なくとも1つに近接した感知素子を更に含むことを特徴とする請求項1に記載の冷却装置。
- 対応するインタフェース部材の温度を検出するための前記インタフェース部材の少なくとも1つに近接した第1の温度感知素子と、
被験者の皮膚の温度を検出するための前記インタフェース部材の少なくとも1つに近接した第2の温度感知素子と、
を更に含むことを特徴とする請求項1に記載の冷却装置。 - 前記ヒンジは、リビングヒンジであることを特徴とする請求項1に記載の冷却装置。
- 皮下の脂質豊富細胞から熱を除去するためのシステムであって、
互いに対して移動可能であり、かつ回転可能なセグメント化されたフレーム上に収容された複数の熱電気冷却装置及び対応する複数の熱交換要素と熱的に連結され、かつ被験者の表皮下のターゲット領域の温度を低下させて、該領域の脂質豊富細胞の温度を、該脂質豊富細胞は実質的に影響を受けるが、表皮の非脂質豊富細胞が実質的に影響を受けないように低下させるように構成された複数の回転可能な冷却要素と、
前記冷却装置によって発生した熱を消散させるために該冷却装置と流体的に連結した流体チャンバと、
を含むことを特徴とするシステム。 - 前記流体チャンバと熱的に連通し、前記冷却装置に冷却液を供給するように構成された冷却ユニットを更に含み、
前記冷却装置が前記冷却ユニットと流体連通するように該冷却ユニットと該冷却装置の間に流体ラインを更に含み、
前記冷却装置が、熱交換面の少なくとも1つに近接した感知素子を更に含む場合に、前記システムが、更に、
前記感知素子と電気通信し、該感知素子からの電気信号を作動パラメータに変換するように構成されたプロセッサと、
前記作動パラメータを記憶するために前記プロセッサと電気的に接続したデータベースと、を含み、前記プロセッサは、前記作動パラメータに基づいて前記領域の温度を制御するための制御モジュールを含み、前記領域の前記温度は、選択された空間温度プロフィールに基づいて制御され、または、
前記プロセッサは、前記作動パラメータに基づいて前記領域の温度を制御するための制御モジュールを含み、前記領域の前記温度は、所定の時間変動プロフィールに基づいて制御される、
ことを特徴とする請求項10に記載のシステム。 - 皮膚を有する被験者の皮下の脂質豊富細胞から熱を除去するための冷却装置であって、該冷却装置が、
熱電気冷却装置から成る複数の冷却要素であって、前記冷却要素の各々が隣接冷却要素に対して移動可能であり且つ前記脂質豊富細胞は実質的に影響をうけるが非脂質豊富細胞は実質的に影響を受けないようにして被験者の皮膚の下のターゲット領域の温度を減少して前記領域の脂質豊富細胞の温度を減少ように構成されている前記冷却要素、及び
前記被験者の周囲を包む可撓性基板を含み、
前記複数の冷却要素の各々が、前記基板が前記被験者の周囲を包む時に、脂質豊富細胞に影響を与えるように前記被験者に接触可能であるようにして、前記複数の冷却要素は、前記基板上に固定的に配置されており、
前記冷却装置が前記被験者の皮膚に適合可能である
ことを特徴とする装置。 - 前記冷却要素は、縁部を有し、
隣接冷却要素の縁部は、互いに実質的に平行のままである、
ことを特徴とする請求項12に記載の冷却装置。 - 前記冷却要素は、少なくとも1つの方向に平面に対して回転可能であることを特徴とする請求項12に記載の冷却装置。
- 前記複数の冷却要素の各々は、少なくとも1つの他の冷却要素に隣接して位置決めされ、該隣接冷却要素にヒンジ式に取り付けられていることを特徴とする請求項12に記載の冷却装置。
- 皮下の脂質豊富細胞から熱を除去するためのシステムであって、
互いに対して移動可能であり、かつ回転可能なセグメント化されたフレーム上に収容された複数の熱電気冷却装置及び対応する複数の熱交換要素と熱的に連結され、かつ被験者の表皮下のターゲット領域の温度を低下させて、該領域の脂質豊富細胞の温度を、該脂質豊富細胞は実質的に影響を受けるが、表皮の非脂質豊富細胞が実質的に影響を受けないように低下させるように構成された複数の回転可能な冷却要素と、
前記冷却装置によって発生した熱を消散させるために該冷却装置と流体的に連結した流体チャンバと、
前記感知素子と電気通信し、該感知素子からの電気信号を作動パラメータに変換するように構成されたプロセッサと、
前記作動パラメータを記憶するために前記プロセッサと電気的に接続したデータベースと、
前記流体チャンバと熱的に連通し、前記冷却装置に冷却液を供給するように構成された冷却ユニットとを含み、
前記冷却装置は、熱交換面の少なくとも1つに近接した圧力感知素子を更に含むシステム。 - 前記冷却装置が前記冷却ユニットと流体連通するように該冷却ユニットと該冷却装置の間に流体ラインを更に含むことを特徴とする請求項16に記載のシステム。
- 前記プロセッサは、前記作動パラメータに基づいて前記領域の温度を制御するための制御モジュールを含み、
前記領域の前記温度は、選択された空間温度プロフィールに基づいて制御される、
ことを特徴とする請求項16に記載のシステム。 - 前記プロセッサは、前記作動パラメータに基づいて前記領域の温度を制御するための制御モジュールを含み、
前記領域の前記温度は、所定の時間変動プロフィールに基づいて制御される、
ことを特徴とする請求項16に記載のシステム。 - 圧力センサを更に含むことを特徴とする請求項1記載の冷却装置。
- 圧力センサを更に含むことを特徴とする請求項10記載の冷却システム。
- 圧力センサを更に含むことを特徴とする請求項12記載の冷却装置。
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AU2007202446A9 (en) | 2008-04-17 |
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WO2008039557A1 (en) | 2008-04-03 |
US20220387211A1 (en) | 2022-12-08 |
CN110013378B (zh) | 2022-05-13 |
US10292859B2 (en) | 2019-05-21 |
US11219549B2 (en) | 2022-01-11 |
CN101309657A (zh) | 2008-11-19 |
CN110013378A (zh) | 2019-07-16 |
JP2011019927A (ja) | 2011-02-03 |
CN103948467A (zh) | 2014-07-30 |
CN101309657B (zh) | 2014-01-22 |
US11179269B2 (en) | 2021-11-23 |
ES2624771T5 (es) | 2020-05-05 |
US20150342780A1 (en) | 2015-12-03 |
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US20240065883A1 (en) | 2024-02-29 |
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ES2624771T3 (es) | 2017-07-17 |
US20190336327A1 (en) | 2019-11-07 |
JP2009501067A (ja) | 2009-01-15 |
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