JP3370324B2 - ヒトインターロイキン−６受容体に対する再構成ヒト抗体 - Google Patents

ヒトインターロイキン−６受容体に対する再構成ヒト抗体

Info

Publication number
JP3370324B2
JP3370324B2 JP50889892A JP50889892A JP3370324B2 JP 3370324 B2 JP3370324 B2 JP 3370324B2 JP 50889892 A JP50889892 A JP 50889892A JP 50889892 A JP50889892 A JP 50889892A JP 3370324 B2 JP3370324 B2 JP 3370324B2
Authority
JP
Japan
Prior art keywords
chain
region
human
antibody
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP50889892A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO1992019759A1 (ja
Inventor
政幸 土屋
功 佐藤
マーガレット ベンディッグ，メアリー
タレン ジョーンズ，スティーブン
ウィリアム サルダナ，ホセ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26370596&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP3370324(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from JP3095476A external-priority patent/JPH05236966A/ja
Priority claimed from JP4032084A external-priority patent/JPH05227970A/ja
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of JPWO1992019759A1 publication Critical patent/JPWO1992019759A1/ja
Application granted granted Critical
Publication of JP3370324B2 publication Critical patent/JP3370324B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP50889892A 1991-04-25 1992-04-24 ヒトインターロイキン−６受容体に対する再構成ヒト抗体 Expired - Lifetime JP3370324B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP3095476A JPH05236966A (ja) 1991-04-25 1991-04-25 ヒトインターロイキン−６レセプターに対するマウスモノクローナル抗体の可変領域をコードするｄｎａ
JP3-95476 1991-04-25
JP4-32084 1992-02-19
JP4032084A JPH05227970A (ja) 1992-02-19 1992-02-19 ヒトインターロイキン−６受容体に対する再構成ヒト抗体
PCT/JP1992/000544 WO1992019759A1 (fr) 1991-04-25 1992-04-24 Anticorps humains reconstitues diriges contre un recepteur de l'interleukine 6 humaine

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP33828699A Division JP3176598B2 (ja) 1991-04-25 1999-11-29 ヒトインターロイキン−６受容体に対するキメラ抗体

Publications (2)

Publication Number Publication Date
JPWO1992019759A1 JPWO1992019759A1 (ja) 1993-05-13
JP3370324B2 true JP3370324B2 (ja) 2003-01-27

Family

ID=26370596

Family Applications (6)

Application Number Title Priority Date Filing Date
JP50889892A Expired - Lifetime JP3370324B2 (ja) 1991-04-25 1992-04-24 ヒトインターロイキン−６受容体に対する再構成ヒト抗体
JP33828699A Expired - Lifetime JP3176598B2 (ja) 1991-04-25 1999-11-29 ヒトインターロイキン−６受容体に対するキメラ抗体
JP2000229748A Expired - Lifetime JP3913965B2 (ja) 1991-04-25 2000-07-28 ヒトインターロイキン−６受容体に対するキメラ抗体
JP2003347675A Expired - Lifetime JP3616087B2 (ja) 1991-04-25 2003-10-06 ヒトインターロイキン−６受容体に対するキメラ抗体
JP2006338832A Withdrawn JP2007082560A (ja) 1991-04-25 2006-12-15 ヒトインターロイキン−６受容体に対するキメラ抗体
JP2007255248A Pending JP2008073049A (ja) 1991-04-25 2007-09-28 ヒトインターロイキン−６受容体に対する抗体を産生するハイブリドーマ

Family Applications After (5)

Application Number Title Priority Date Filing Date
JP33828699A Expired - Lifetime JP3176598B2 (ja) 1991-04-25 1999-11-29 ヒトインターロイキン−６受容体に対するキメラ抗体
JP2000229748A Expired - Lifetime JP3913965B2 (ja) 1991-04-25 2000-07-28 ヒトインターロイキン−６受容体に対するキメラ抗体
JP2003347675A Expired - Lifetime JP3616087B2 (ja) 1991-04-25 2003-10-06 ヒトインターロイキン−６受容体に対するキメラ抗体
JP2006338832A Withdrawn JP2007082560A (ja) 1991-04-25 2006-12-15 ヒトインターロイキン−６受容体に対するキメラ抗体
JP2007255248A Pending JP2008073049A (ja) 1991-04-25 2007-09-28 ヒトインターロイキン−６受容体に対する抗体を産生するハイブリドーマ

Country Status (16)

Country Link
US (3) US5795965A (cg-RX-API-DMAC10.html)
EP (1) EP0628639B1 (cg-RX-API-DMAC10.html)
JP (6) JP3370324B2 (cg-RX-API-DMAC10.html)
KR (1) KR100249937B1 (cg-RX-API-DMAC10.html)
AT (1) ATE181575T1 (cg-RX-API-DMAC10.html)
AU (2) AU668349B2 (cg-RX-API-DMAC10.html)
DE (2) DE69229482T2 (cg-RX-API-DMAC10.html)
DK (1) DK0628639T3 (cg-RX-API-DMAC10.html)
ES (1) ES2134212T3 (cg-RX-API-DMAC10.html)
GR (1) GR3031174T3 (cg-RX-API-DMAC10.html)
HU (1) HU218140B (cg-RX-API-DMAC10.html)
LU (1) LU91556I2 (cg-RX-API-DMAC10.html)
NL (1) NL300383I2 (cg-RX-API-DMAC10.html)
RU (1) RU2139351C1 (cg-RX-API-DMAC10.html)
TW (1) TW205553B (cg-RX-API-DMAC10.html)
WO (1) WO1992019759A1 (cg-RX-API-DMAC10.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021211006A1 (en) 2020-04-13 2021-10-21 Federal State Budgetary Institution Center Of Biomedical Technologies Of Federal Medical And Biological Agency Inhaled hexapeptide for treating interleukin-6 related respiratory diseases
WO2022005321A1 (en) 2020-06-29 2022-01-06 Federal State Budgetary Institution Scientific center of biomedical technologies of Federal Medical and Biological Agency Inhaled tocilizumab for treating interleukin-6 related respiratory diseases

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WO1995029690A1 (en) * 1994-04-29 1995-11-09 The Trustees Of The University Of Pennsylvania Biologically active peptides and methods of identifying the same
US8017121B2 (en) 1994-06-30 2011-09-13 Chugai Seiyaku Kabushika Kaisha Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component
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UA76934C2 (en) * 1996-10-04 2006-10-16 Chugai Pharmaceutical Co Ltd Reconstructed human anti-hm 1.24 antibody, coding dna, vector, host cell, method for production of reconstructed human antibody, pharmaceutical composition and drug for treating myeloma containing reconstructed human anti-hm 1.24 antibody
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