|
US2631173A
(en)
|
1949-01-04 |
1953-03-10 |
Phillips Petroleum Co |
Production of cyclooctadiene
|
|
US3687808A
(en)
|
1969-08-14 |
1972-08-29 |
Univ Leland Stanford Junior |
Synthetic polynucleotides
|
|
IL54795A
(en)
|
1978-05-26 |
1980-10-26 |
Yeda Res & Dev |
Analgesic compositions comprising substituted bicyclic and spiroaliphatic amines and certain novel compounds of these types
|
|
US4364934A
(en)
|
1979-12-04 |
1982-12-21 |
Ortho Pharmaceutical Corporation |
Monoclonal antibody to a human early thymocyte antigen and methods for preparing same
|
|
US4469863A
(en)
|
1980-11-12 |
1984-09-04 |
Ts O Paul O P |
Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
|
|
US5023243A
(en)
|
1981-10-23 |
1991-06-11 |
Molecular Biosystems, Inc. |
Oligonucleotide therapeutic agent and method of making same
|
|
US4476301A
(en)
|
1982-04-29 |
1984-10-09 |
Centre National De La Recherche Scientifique |
Oligonucleotides, a process for preparing the same and their application as mediators of the action of interferon
|
|
US5550111A
(en)
|
1984-07-11 |
1996-08-27 |
Temple University-Of The Commonwealth System Of Higher Education |
Dual action 2',5'-oligoadenylate antiviral derivatives and uses thereof
|
|
US5034506A
(en)
|
1985-03-15 |
1991-07-23 |
Anti-Gene Development Group |
Uncharged morpholino-based polymers having achiral intersubunit linkages
|
|
DE3788914T2
(de)
|
1986-09-08 |
1994-08-25 |
Ajinomoto Kk |
Verbindungen zur Spaltung von RNS an eine spezifische Position, Oligomere, verwendet bei der Herstellung dieser Verbindungen und Ausgangsprodukte für die Synthese dieser Oligomere.
|
|
WO1988007089A1
(en)
|
1987-03-18 |
1988-09-22 |
Medical Research Council |
Altered antibodies
|
|
US5264423A
(en)
|
1987-03-25 |
1993-11-23 |
The United States Of America As Represented By The Department Of Health And Human Services |
Inhibitors for replication of retroviruses and for the expression of oncogene products
|
|
US5276019A
(en)
|
1987-03-25 |
1994-01-04 |
The United States Of America As Represented By The Department Of Health And Human Services |
Inhibitors for replication of retroviruses and for the expression of oncogene products
|
|
US5677425A
(en)
|
1987-09-04 |
1997-10-14 |
Celltech Therapeutics Limited |
Recombinant antibody
|
|
US5188897A
(en)
|
1987-10-22 |
1993-02-23 |
Temple University Of The Commonwealth System Of Higher Education |
Encapsulated 2',5'-phosphorothioate oligoadenylates
|
|
US4924624A
(en)
|
1987-10-22 |
1990-05-15 |
Temple University-Of The Commonwealth System Of Higher Education |
2,',5'-phosphorothioate oligoadenylates and plant antiviral uses thereof
|
|
US5403711A
(en)
|
1987-11-30 |
1995-04-04 |
University Of Iowa Research Foundation |
Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved
|
|
ATE151467T1
(de)
|
1987-11-30 |
1997-04-15 |
Univ Iowa Res Found |
Durch modifikationen an der 3'-terminalen phosphodiesterbindung stabilisierte dna moleküle, ihre verwendung als nukleinsäuresonden sowie als therapeutische mittel zur hemmung der expression spezifischer zielgene
|
|
DE68916959T2
(de)
|
1988-03-02 |
1995-01-19 |
Uab Research Foundation |
Reversibel mechanisch-chemisch arbeitende maschinen, die aus bioelastomeren bestehen, die zu regelbaren inversen temperaturübergängen fähig sind, zur umwandlung von chemischer in mechanische arbeit.
|
|
WO1989009221A1
(en)
|
1988-03-25 |
1989-10-05 |
University Of Virginia Alumni Patents Foundation |
Oligonucleotide n-alkylphosphoramidates
|
|
US5278302A
(en)
|
1988-05-26 |
1994-01-11 |
University Patents, Inc. |
Polynucleotide phosphorodithioates
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
US5256775A
(en)
|
1989-06-05 |
1993-10-26 |
Gilead Sciences, Inc. |
Exonuclease-resistant oligonucleotides
|
|
WO1991004753A1
(en)
|
1989-10-02 |
1991-04-18 |
Cetus Corporation |
Conjugates of antisense oligonucleotides and therapeutic uses thereof
|
|
US5399676A
(en)
|
1989-10-23 |
1995-03-21 |
Gilead Sciences |
Oligonucleotides with inverted polarity
|
|
US5177198A
(en)
|
1989-11-30 |
1993-01-05 |
University Of N.C. At Chapel Hill |
Process for preparing oligoribonucleoside and oligodeoxyribonucleoside boranophosphates
|
|
US5623065A
(en)
|
1990-08-13 |
1997-04-22 |
Isis Pharmaceuticals, Inc. |
Gapped 2' modified oligonucleotides
|
|
US5587361A
(en)
|
1991-10-15 |
1996-12-24 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having phosphorothioate linkages of high chiral purity
|
|
US5149797A
(en)
|
1990-02-15 |
1992-09-22 |
The Worcester Foundation For Experimental Biology |
Method of site-specific alteration of rna and production of encoded polypeptides
|
|
US5220007A
(en)
|
1990-02-15 |
1993-06-15 |
The Worcester Foundation For Experimental Biology |
Method of site-specific alteration of RNA and production of encoded polypeptides
|
|
US5321131A
(en)
|
1990-03-08 |
1994-06-14 |
Hybridon, Inc. |
Site-specific functionalization of oligodeoxynucleotides for non-radioactive labelling
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
WO1991018913A1
(en)
|
1990-06-07 |
1991-12-12 |
City Of Hope |
Ribozyme mediated reversal of transformation by cleavage of the hras oncogene rna
|
|
US5270163A
(en)
|
1990-06-11 |
1993-12-14 |
University Research Corporation |
Methods for identifying nucleic acid ligands
|
|
EP0786469B1
(en)
|
1990-06-11 |
2006-03-01 |
Gilead Sciences, Inc. |
Methods of use of nucleic acid ligands
|
|
US5683867A
(en)
|
1990-06-11 |
1997-11-04 |
Nexstar Pharmaceuticals, Inc. |
Systematic evolution of ligands by exponential enrichment: blended SELEX
|
|
US5864026A
(en)
|
1990-06-11 |
1999-01-26 |
Nexstar Pharmaceuticals, Inc. |
Systematic evolution of ligands by exponential enrichment: tissue selex
|
|
US5650275A
(en)
|
1990-06-11 |
1997-07-22 |
Nexstar Pharmacueticals Inc |
Target detection method using spectroscopically detectable nucleic acid ligands
|
|
US5567588A
(en)
|
1990-06-11 |
1996-10-22 |
University Research Corporation |
Systematic evolution of ligands by exponential enrichment: Solution SELEX
|
|
US5789157A
(en)
|
1990-06-11 |
1998-08-04 |
Nexstar Pharmaceuticals, Inc. |
Systematic evolution of ligands by exponential enrichment: tissue selex
|
|
US6365730B1
(en)
|
1990-06-19 |
2002-04-02 |
Gene Shears Pty. Limited |
DNA-Armed ribozymes and minizymes
|
|
EP0585287B1
(en)
|
1990-07-10 |
1999-10-13 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
|
WO1992001806A1
(en)
|
1990-07-16 |
1992-02-06 |
The Public Health Research Institute Of The City Of New York, Inc. |
Selection of ribozymes that efficiently cleave target rna
|
|
US5177196A
(en)
|
1990-08-16 |
1993-01-05 |
Microprobe Corporation |
Oligo (α-arabinofuranosyl nucleotides) and α-arabinofuranosyl precursors thereof
|
|
JP3257675B2
(ja)
|
1990-10-12 |
2002-02-18 |
マックス−プランク−ゲゼルシャフト ツール フェルデルング デル ビッセンシャフテン エー．ファウ． |
修飾リボザイム
|
|
JPH06504628A
(ja)
|
1990-12-20 |
1994-05-26 |
エクソン・ケミカル・パテンツ・インク |
リソグラフィー及び腐食防止コーティング用途向けのｕｖ／ｅｂ硬化性ブチルコポリマー
|
|
EP0575485A1
(en)
|
1991-03-01 |
1993-12-29 |
Dyax Corp. |
Process for the development of binding mini-proteins
|
|
DK0580737T3
(da)
|
1991-04-10 |
2004-11-01 |
Scripps Research Inst |
Heterodimere receptorbiblioteker ved anvendelse af phagemider
|
|
US7015315B1
(en)
|
1991-12-24 |
2006-03-21 |
Isis Pharmaceuticals, Inc. |
Gapped oligonucleotides
|
|
US5539082A
(en)
|
1993-04-26 |
1996-07-23 |
Nielsen; Peter E. |
Peptide nucleic acids
|
|
US5719262A
(en)
|
1993-11-22 |
1998-02-17 |
Buchardt, Deceased; Ole |
Peptide nucleic acids having amino acid side chains
|
|
US5714331A
(en)
|
1991-05-24 |
1998-02-03 |
Buchardt, Deceased; Ole |
Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
|
|
IE922437A1
(en)
|
1991-07-25 |
1993-01-27 |
Idec Pharma Corp |
Recombinant antibodies for human therapy
|
|
US5571799A
(en)
|
1991-08-12 |
1996-11-05 |
Basco, Ltd. |
(2'-5') oligoadenylate analogues useful as inhibitors of host-v5.-graft response
|
|
US5700922A
(en)
|
1991-12-24 |
1997-12-23 |
Isis Pharmaceuticals, Inc. |
PNA-DNA-PNA chimeric macromolecules
|
|
GB9206422D0
(en)
|
1992-03-24 |
1992-05-06 |
Bolt Sarah L |
Antibody preparation
|
|
US6100099A
(en)
|
1994-09-06 |
2000-08-08 |
Abbott Laboratories |
Test strip having a diagonal array of capture spots
|
|
WO1993022332A2
(en)
|
1992-04-24 |
1993-11-11 |
Board Of Regents, The University Of Texas System |
Recombinant production of immunoglobulin-like domains in prokaryotic cells
|
|
US5652355A
(en)
|
1992-07-23 |
1997-07-29 |
Worcester Foundation For Experimental Biology |
Hybrid oligonucleotide phosphorothioates
|
|
US5436143A
(en)
|
1992-12-23 |
1995-07-25 |
Hyman; Edward D. |
Method for enzymatic synthesis of oligonucleotides
|
|
US5476925A
(en)
|
1993-02-01 |
1995-12-19 |
Northwestern University |
Oligodeoxyribonucleotides including 3'-aminonucleoside-phosphoramidate linkages and terminal 3'-amino groups
|
|
GB9304618D0
(en)
|
1993-03-06 |
1993-04-21 |
Ciba Geigy Ag |
Chemical compounds
|
|
US6214345B1
(en)
|
1993-05-14 |
2001-04-10 |
Bristol-Myers Squibb Co. |
Lysosomal enzyme-cleavable antitumor drug conjugates
|
|
AU691811B2
(en)
|
1993-06-16 |
1998-05-28 |
Celltech Therapeutics Limited |
Antibodies
|
|
EP0733059B1
(en)
|
1993-12-09 |
2000-09-13 |
Thomas Jefferson University |
Compounds and methods for site-directed mutations in eukaryotic cells
|
|
US5625050A
(en)
|
1994-03-31 |
1997-04-29 |
Amgen Inc. |
Modified oligonucleotides and intermediates useful in nucleic acid therapeutics
|
|
US5650502A
(en)
|
1994-11-09 |
1997-07-22 |
Hybridon, Inc. |
Ribozyme analogs having rigid non-nucleotidic linkers
|
|
US6121022A
(en)
|
1995-04-14 |
2000-09-19 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
US5693773A
(en)
|
1995-06-07 |
1997-12-02 |
Hybridon Incorporated |
Triplex-forming antisense oligonucleotides having abasic linkers targeting nucleic acids comprising mixed sequences of purines and pyrimidines
|
|
US5652356A
(en)
|
1995-08-17 |
1997-07-29 |
Hybridon, Inc. |
Inverted chimeric and hybrid oligonucleotides
|
|
JP4046354B2
(ja)
|
1996-03-18 |
2008-02-13 |
ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム |
増大した半減期を有する免疫グロブリン様ドメイン
|
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
|
US6255455B1
(en)
|
1996-10-11 |
2001-07-03 |
The Trustees Of The University Of Pennsylvania |
Rh(D)-binding proteins and magnetically activated cell sorting method for production thereof
|
|
WO1998023289A1
(en)
|
1996-11-27 |
1998-06-04 |
The General Hospital Corporation |
MODULATION OF IgG BINDING TO FcRn
|
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
US6242246B1
(en)
|
1997-12-15 |
2001-06-05 |
Somalogic, Inc. |
Nucleic acid ligand diagnostic Biochip
|
|
US5989823A
(en)
|
1998-09-18 |
1999-11-23 |
Nexstar Pharmaceuticals, Inc. |
Homogeneous detection of a target through nucleic acid ligand-ligand beacon interaction
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
GB9809951D0
(en)
|
1998-05-08 |
1998-07-08 |
Univ Cambridge Tech |
Binding molecules
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
HU230769B1
(hu)
|
1999-01-15 |
2018-03-28 |
Genentech Inc. |
Módosított effektor-funkciójú polipeptid-változatok
|
|
CZ296576B6
(cs)
|
1999-02-12 |
2006-04-12 |
Sankyo Company Limited |
Nukleosidový analog a oligonukleotidový analog a farmaceutický prostredek, sonda a primer s jeho obsahem
|
|
US6136603A
(en)
|
1999-03-26 |
2000-10-24 |
Isis Pharmaceuticals Inc. |
Antisense modulation of interleukin-5 signal transduction
|
|
US6569630B1
(en)
|
1999-07-02 |
2003-05-27 |
Conceptual Mindworks, Inc. |
Methods and compositions for aptamers against anthrax
|
|
ES2236178T3
(es)
|
2000-02-22 |
2005-07-16 |
Banyu Pharmaceutical Co., Ltd. |
Nuevos compuestos de imidazolina.
|
|
US6784291B2
(en)
|
2000-05-04 |
2004-08-31 |
Avi Biopharma, Inc. |
Splice-region antisense composition and method
|
|
EP1191097A1
(en)
|
2000-09-21 |
2002-03-27 |
Leids Universitair Medisch Centrum |
Induction of exon skipping in eukaryotic cells
|
|
US7658921B2
(en)
|
2000-12-12 |
2010-02-09 |
Medimmune, Llc |
Molecules with extended half-lives, compositions and uses thereof
|
|
PT1355919E
(pt)
|
2000-12-12 |
2011-03-02 |
Medimmune Llc |
Moléculas com semivida longa, composições que as contêm e suas utilizações
|
|
US20040063654A1
(en)
|
2001-11-02 |
2004-04-01 |
Davis Mark E. |
Methods and compositions for therapeutic use of RNA interference
|
|
US7241444B2
(en)
|
2002-01-18 |
2007-07-10 |
Pierre Fabre Medicament |
Anti-IGF-IR antibodies and uses thereof
|
|
US7575886B2
(en)
|
2002-03-11 |
2009-08-18 |
Momenta Pharmaceuticals, Inc. |
Analysis of sulfated polysaccharides
|
|
US7399586B2
(en)
|
2002-05-23 |
2008-07-15 |
Ceptyr, Inc. |
Modulation of biological signal transduction by RNA interference
|
|
US7250496B2
(en)
|
2002-11-14 |
2007-07-31 |
Rosetta Genomics Ltd. |
Bioinformatically detectable group of novel regulatory genes and uses thereof
|
|
EP2305812A3
(en)
|
2002-11-14 |
2012-06-06 |
Dharmacon, Inc. |
Fuctional and hyperfunctional sirna
|
|
US9045518B2
(en)
|
2002-11-18 |
2015-06-02 |
Santaris Pharma A/S |
Amino-LNA, thio-LNA and alpha-L-oxy-LN
|
|
JP4777777B2
(ja)
|
2002-11-25 |
2011-09-21 |
雅文 松尾 |
ｍＲＮＡ前駆体のスプライシングを修飾するＥＮＡ核酸医薬
|
|
ATE496893T1
(de)
|
2002-12-20 |
2011-02-15 |
X Ceptor Therapeutics Inc |
Isochinolinonderivate und deren verwendung als medikamente
|
|
PT1592793E
(pt)
|
2003-02-10 |
2009-09-30 |
Santaris Pharma As |
Compostos oligoméricos para a modulação da expressão de survivina
|
|
CA2524255C
(en)
|
2003-03-21 |
2014-02-11 |
Academisch Ziekenhuis Leiden |
Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure
|
|
WO2004094647A2
(en)
|
2003-04-18 |
2004-11-04 |
Cytovia, Inc. |
Methods of treating diseases responsive to induction of apoptosis and screening assays
|
|
MXPA06000619A
(es)
|
2003-07-15 |
2006-04-11 |
Hybridon Inc |
Estimulacion sinergistica del sistema inmune usando oligonucleotidos inmunoestimuladores y/o compuestos inmunomeros en conjunto con citocinas y/o agentes quimioterapeuticos o terapia de radiacion.
|
|
GB0407315D0
(en)
|
2003-07-15 |
2004-05-05 |
Cambridge Antibody Tech |
Human antibody molecules
|
|
US7683036B2
(en)
|
2003-07-31 |
2010-03-23 |
Regulus Therapeutics Inc. |
Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
|
|
US7442372B2
(en)
|
2003-08-29 |
2008-10-28 |
Biomarin Pharmaceutical Inc. |
Delivery of therapeutic compounds to the brain and other tissues
|
|
US20050053981A1
(en)
|
2003-09-09 |
2005-03-10 |
Swayze Eric E. |
Gapped oligomeric compounds having linked bicyclic sugar moieties at the termini
|
|
GB0324854D0
(en)
|
2003-10-24 |
2003-11-26 |
Expresson Biosystems Ltd |
App/ena antisense
|
|
CN1922313B
(zh)
|
2004-02-10 |
2011-10-26 |
生物马林医药公司 |
酸性α-糖苷酶及其片段
|
|
WO2005087217A1
(en)
|
2004-03-05 |
2005-09-22 |
The General Hospital Corporation |
Compositions and methods for modulating interaction between polypeptides
|
|
WO2005113571A2
(en)
|
2004-05-13 |
2005-12-01 |
The University Of North Carolina At Chapel Hill |
Methods for the delivery of oligomeric compounds
|
|
CA2566519C
(en)
|
2004-05-14 |
2020-04-21 |
Rosetta Genomics Ltd. |
Micrornas and uses thereof
|
|
AR049390A1
(es)
|
2004-06-09 |
2006-07-26 |
Wyeth Corp |
Anticuerpos contra la interleuquina-13 humana y usos de los mismos
|
|
USRE48960E1
(en)
|
2004-06-28 |
2022-03-08 |
The University Of Western Australia |
Antisense oligonucleotides for inducing exon skipping and methods of use thereof
|
|
ATE498685T1
(de)
|
2004-06-28 |
2011-03-15 |
Univ Western Australia |
Antisense-oligonukleotide zur induktion von exon- skipping sowie verfahren zur verwendung davon
|
|
WO2006022688A1
(en)
|
2004-08-06 |
2006-03-02 |
Applera Corporation |
Diagnosis of pancreatic cancer by using pancreatic targets
|
|
FR2874384B1
(fr)
|
2004-08-17 |
2010-07-30 |
Genethon |
Vecteur viral adeno-associe pour realiser du saut d'exons dans un gene codant une proteine a domaines dispensables
|
|
DK1812031T3
(en)
|
2004-11-01 |
2015-09-14 |
Univ California |
Compositions and methods for the modification of biomolecules
|
|
US8431558B2
(en)
|
2004-11-01 |
2013-04-30 |
The Regents Of The University Of California |
Compositions and methods for modification of biomolecules
|
|
US20120122801A1
(en)
|
2005-01-05 |
2012-05-17 |
Prosensa B.V. |
Mannose-6-phosphate receptor mediated gene transfer into muscle cells
|
|
US20060252107A1
(en)
|
2005-02-22 |
2006-11-09 |
Acucela, Inc. |
Compositions and methods for diagnosing and treating retinal diseases
|
|
US7736647B2
(en)
|
2005-06-15 |
2010-06-15 |
Monoclonal Antibodies Therapeutics |
Anti-CD71 monoclonal antibodies and uses thereof for treating malignant tumor cells
|
|
EP1940861A4
(en)
|
2005-10-06 |
2009-09-09 |
Univ Delaware |
GUANIDINE RICH POLYNUCLEOTIDES FOR THE TREATMENT OF HUNTINGTON'S DISEASE
|
|
JP2007104971A
(ja)
|
2005-10-14 |
2007-04-26 |
New Industry Research Organization |
ミオスタチンのスプライシング制御アンチセンスオリゴヌクレオチド
|
|
JP5342881B2
(ja)
|
2006-01-27 |
2013-11-13 |
アイシス ファーマシューティカルズ， インコーポレーテッド |
６−修飾された二環式核酸類似体
|
|
US7569686B1
(en)
|
2006-01-27 |
2009-08-04 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for synthesis of bicyclic nucleic acid analogs
|
|
WO2007089612A2
(en)
|
2006-01-30 |
2007-08-09 |
President And Fellows Of Harvard College |
Methods and compositions for treating and preventing bacterial infections
|
|
DK1988823T3
(en)
|
2006-02-09 |
2018-12-03 |
Genzyme Corp |
SLOW INTRAVENTRICULAR ADMINISTRATION
|
|
EP2623986B1
(en)
|
2006-02-10 |
2017-06-14 |
Life Technologies Corporation |
Labeling and detection of post translationally modified proteins
|
|
CA2648132C
(en)
|
2006-04-03 |
2019-05-28 |
Santaris Pharma A/S |
Pharmaceutical composition comprising anti-mirna antisense oligonucleotides
|
|
US8859752B2
(en)
|
2006-04-18 |
2014-10-14 |
The Trustees Of The University Of Pennsylvania |
SIRNA-based therapy of Fibrodyplasia Ossificans Progressiva (FOP)
|
|
EP2023940B1
(en)
|
2006-05-05 |
2011-06-22 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating expression of sglt2
|
|
EP1857548A1
(en)
|
2006-05-19 |
2007-11-21 |
Academisch Ziekenhuis Leiden |
Means and method for inducing exon-skipping
|
|
US20080081791A1
(en)
|
2006-07-06 |
2008-04-03 |
Weida Huang |
Methods of using combinations of siRNAs for treating a disease or a disorder, and for enhancing siRNA efficacy in RNAi
|
|
AU2007282224B2
(en)
|
2006-08-11 |
2013-08-29 |
Vico Therapeutics B.V. |
Methods and means for treating DNA repeat instability associated genetic disorders
|
|
ES2603379T3
(es)
|
2006-10-09 |
2017-02-27 |
Roche Innovation Center Copenhagen A/S |
Compuestos antagonistas de ARN para la modulación de PCSK9
|
|
WO2008049085A1
(en)
|
2006-10-18 |
2008-04-24 |
Isis Pharmaceuticals, Inc. |
Antisense compounds
|
|
CA2693178C
(en)
|
2006-11-29 |
2018-12-04 |
Nationwide Children's Hospital, Inc. |
Myostatin inhibition for enhancing muscle and/or improving muscle function
|
|
SI2457920T1
(en)
|
2007-01-18 |
2018-02-28 |
Genzyme Corporation |
Oligosaccharides containing the amino acid group and their conjugates
|
|
US8318438B2
(en)
|
2007-03-01 |
2012-11-27 |
The United States Of America As Represented By The Secretary Of The Air Force |
Aptamer-based assays
|
|
EP2149605B1
(en)
|
2007-03-22 |
2013-07-03 |
Santaris Pharma A/S |
Short RNA antagonist compounds for the modulation of target mRNA
|
|
WO2008113832A2
(en)
|
2007-03-22 |
2008-09-25 |
Santaris Pharma A/S |
SHORT RNA ANTAGONIST COMPOUNDS FOR THE MODULATION OF TARGET mRNA
|
|
ES2776406T3
(es)
|
2007-07-12 |
2020-07-30 |
Gitr Inc |
Terapias de combinación que emplean moléculas de enlazamiento a GITR
|
|
AU2008317566B2
(en)
|
2007-10-26 |
2014-05-01 |
Academisch Ziekenhuis Leiden |
Means and methods for counteracting muscle disorders
|
|
USRE48468E1
(en)
|
2007-10-26 |
2021-03-16 |
Biomarin Technologies B.V. |
Means and methods for counteracting muscle disorders
|
|
WO2009075815A1
(en)
|
2007-12-07 |
2009-06-18 |
Duke University |
Immunomodulating gene therapy
|
|
WO2009090182A1
(en)
|
2008-01-14 |
2009-07-23 |
Santaris Pharma A/S |
C4'-substituted - dna nucleotide gapmer oligonucleotides
|
|
EP2268811A1
(en)
|
2008-03-07 |
2011-01-05 |
Santaris Pharma A/S |
Pharmaceutical compositions for treatment of microrna related diseases
|
|
US8846639B2
(en)
|
2008-04-04 |
2014-09-30 |
Isis Pharmaceutical, Inc. |
Oligomeric compounds comprising bicyclic nucleosides and having reduced toxicity
|
|
EP2119783A1
(en)
|
2008-05-14 |
2009-11-18 |
Prosensa Technologies B.V. |
Method for efficient exon (44) skipping in Duchenne Muscular Dystrophy and associated means
|
|
US20110130346A1
(en)
|
2008-05-30 |
2011-06-02 |
Isis Innovation Limited |
Peptide conjugates for delvery of biologically active compounds
|
|
ES2535461T3
(es)
|
2008-07-08 |
2015-05-11 |
Duke University |
Método de tratamiento de la enfermedad por almacenamiento de glucógeno
|
|
US8084601B2
(en)
|
2008-09-11 |
2011-12-27 |
Royal Holloway And Bedford New College Royal Holloway, University Of London |
Oligomers
|
|
CN112574988A
(zh)
|
2008-10-24 |
2021-03-30 |
萨雷普塔治疗公司 |
用于dmd的多外显子跳跃组合物
|
|
JP5786109B2
(ja)
|
2008-10-27 |
2015-09-30 |
プロセンサ テクノロジーズ ベー．フェー． |
Ｄｕｃｈｅｎｎｅ型筋ジストロフィーｍＲＮＡ前駆体のエクソン４５の効率的なスキッピングのための方法及び手段
|
|
CA3040973A1
(en)
|
2008-12-16 |
2010-07-01 |
Genzyme Corporation |
Oligosaccharide-protein conjugates
|
|
US8466340B2
(en)
|
2009-02-18 |
2013-06-18 |
Amicus Therapeutics, Inc. |
Mouse model for pompe disease and methods of use thereof
|
|
CA2759899A1
(en)
|
2009-04-24 |
2010-10-28 |
Prosensa Technologies B.V. |
Oligonucleotide comprising an inosine for treating dmd
|
|
ES2618572T3
(es)
*
|
2009-05-08 |
2017-06-21 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con la familia de la distrofina mediante inhibición de un transcrito antisentido natural para la familia de dmd
|
|
EP2475376B1
(en)
|
2009-06-17 |
2016-03-30 |
BioMarin Pharmaceutical Inc. |
Formulations for lysosomal enzymes
|
|
FR2947269B1
(fr)
|
2009-06-29 |
2013-01-18 |
Sanofi Aventis |
Nouveaux composes anticancereux
|
|
WO2011036640A2
(en)
|
2009-09-24 |
2011-03-31 |
Cellectis |
Meganuclease reagents of uses thereof for treating genetic diseases caused by frame shift/non sense mutations
|
|
EP2490699A1
(en)
|
2009-10-20 |
2012-08-29 |
Santaris Pharma A/S |
Oral delivery of therapeutically effective lna oligonucleotides
|
|
LT2499249T
(lt)
|
2009-11-12 |
2018-12-27 |
The University Of Western Australia |
Priešprasmės molekulės ir patologijų gydymo būdai
|
|
WO2011078797A2
(en)
|
2009-12-22 |
2011-06-30 |
Singapore Health Services Pte. Ltd |
Antisense oligonucleotides and uses threreof
|
|
WO2011130164A2
(en)
|
2010-04-13 |
2011-10-20 |
The Regents Of The University Of California |
Unconjugated anti-tfr antibodies and compositions thereof for the treatment of cancer
|
|
DK2528625T3
(da)
|
2010-04-15 |
2013-10-14 |
Spirogen Sarl |
Pyrrolobenzodiazepiner og konjugater deraf
|
|
DK2563753T6
(en)
|
2010-04-27 |
2016-04-04 |
Synaffix Bv |
Fused cyclooctynforbindelser and their use in metal-free click-reactions
|
|
KR20200133284A
(ko)
|
2010-05-28 |
2020-11-26 |
사렙타 쎄러퓨틱스, 인코퍼레이티드 |
변형된 서브유니트간 결합 및/또는 말단 그룹을 갖는 올리고뉴클레오타이드 유사체
|
|
IT1400425B1
(it)
|
2010-06-08 |
2013-05-31 |
Amsterdam Molecular Therapeutics Bv |
Modified snrnas for use in therapy.
|
|
WO2012007896A1
(en)
|
2010-07-12 |
2012-01-19 |
Covx Technologies Ireland, Ltd. |
Multifunctional antibody conjugates
|
|
WO2012012467A2
(en)
|
2010-07-19 |
2012-01-26 |
Isis Pharmaceuticals, Inc. |
Modulation of nuclear-retained rna
|
|
WO2012024535A2
(en)
|
2010-08-18 |
2012-02-23 |
Fred Hutchinson Cancer Research Center |
Methods for determining the presence or risk of developing facioscapulohumeral dystrophy (fshd)
|
|
TWI541024B
(zh)
|
2010-09-01 |
2016-07-11 |
日本新藥股份有限公司 |
反義核酸
|
|
US20120225034A1
(en)
|
2010-09-02 |
2012-09-06 |
Universite De Mons |
Agents useful in treating facioscapulohumeral muscular dystrophy
|
|
AR084020A1
(es)
|
2010-11-30 |
2013-04-17 |
Genentech Inc |
Anticuerpos para el receptor de la barrera hematoencefalica de baja afinidad y sus usos
|
|
EP2672977A1
(en)
|
2011-02-08 |
2013-12-18 |
The Charlotte-Mecklenburg Hospital Authority d/b/a Carolina Healthcare System |
Antisense oligonucleotides
|
|
US10017764B2
(en)
|
2011-02-08 |
2018-07-10 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleotides and uses thereof
|
|
JP2014513946A
(ja)
|
2011-04-22 |
2014-06-19 |
プロセンサ テクノロジーズ ビー．ブイ． |
筋強直性ジストロフィー１型（ｄｍ１）などのヒト遺伝性疾患の治療、遅延及び／又は予防のための新規の化合物
|
|
JP2014523884A
(ja)
|
2011-06-24 |
2014-09-18 |
セントローズ， エルエルシー |
細胞外標的化薬物複合体
|
|
AU2012286994B2
(en)
|
2011-07-25 |
2017-08-10 |
Nationwide Children's Hospital, Inc. |
Recombinant virus products and methods for inhibition of expression of DUX4
|
|
US20140242093A1
(en)
|
2011-07-29 |
2014-08-28 |
Fred Hutchinson Cancer Research Center |
Methods and compositions for modulating the innate immune response and/or myogenesis in a mammalian subject
|
|
WO2013036748A1
(en)
|
2011-09-09 |
2013-03-14 |
Berry, Lana, L. |
Bicyclo[6.1.0]non-4-yne reagents for chemical modification of oligonucleotides
|
|
HK1200484A1
(zh)
|
2011-09-14 |
2015-08-07 |
Translate Bio Ma, Inc. |
多聚寡核苷酸化合物
|
|
CA2858347C
(en)
|
2011-12-05 |
2020-07-07 |
New York University |
V1v2 immunogens
|
|
US9725716B2
(en)
|
2011-12-06 |
2017-08-08 |
Ohio State Innovation Foundation and Research Institute at Nationwide Children's Hospital |
Non-ionic, low osmolar contrast agents for delivery of antisense oligonucleotides and treatment of disease
|
|
CN117721110A
(zh)
|
2011-12-28 |
2024-03-19 |
日本新药株式会社 |
反义核酸
|
|
TW201333040A
(zh)
|
2012-01-06 |
2013-08-16 |
Bioalliance Cv |
抗－輸鐵蛋白受器之抗體及其使用方法
|
|
CN112251436A
(zh)
|
2012-01-27 |
2021-01-22 |
比奥马林技术公司 |
治疗杜兴型肌营养不良症和贝克型肌营养不良症的具有改善特性的rna调节性寡核苷酸
|
|
WO2013120038A2
(en)
|
2012-02-10 |
2013-08-15 |
Regents Of The University Of Minnesota |
Morpholino targeting dux4 for treating fshd
|
|
PE20190658A1
(es)
|
2012-02-24 |
2019-05-08 |
Abbvie Stemcentrx Llc |
Moduladores y metodos de empleo novedosos
|
|
EP3628326B1
(en)
|
2012-03-15 |
2024-02-28 |
Oxyrane UK Limited |
Methods and materials for treatment of pompe's disease
|
|
US9610362B2
(en)
|
2012-03-16 |
2017-04-04 |
Valerion Therapeutics, Llc |
Antisense conjugates for decreasing expression of DMPK
|
|
SMT201700339T1
(it)
|
2012-04-23 |
2017-09-07 |
Biomarin Tech Bv |
Oligonucleotidi di modulazione dell'rna con caratteristiche migliorate per il trattamento dei disturbi neuromuscolari
|
|
EP2870246B1
(en)
|
2012-07-03 |
2019-09-11 |
BioMarin Technologies B.V. |
Oligonucleotide for the treatment of muscular dystrophy patients
|
|
EP2684892A1
(en)
|
2012-07-13 |
2014-01-15 |
Association Française contre les Myopathies |
Compositions and methods for duchenne muscular dystrophy gene therapy
|
|
ES3047691T3
(en)
|
2012-08-01 |
2025-12-04 |
Ikaika Therapeutics Inc |
Mitigating tissue damage and fibrosis via latent transforming growth factor beta binding protein (ltbp4)
|
|
EP2895200B1
(en)
|
2012-09-14 |
2019-11-06 |
Translate Bio MA, Inc. |
Multimeric oligonucleotide compounds
|
|
KR102240217B1
(ko)
|
2012-09-25 |
2021-04-14 |
젠자임 코포레이션 |
근긴장성 이영양증의 치료용 펩티드-결합 모르폴리노 안티센스 올리고뉴클레오티드
|
|
WO2014059353A2
(en)
|
2012-10-11 |
2014-04-17 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleosides and uses thereof
|
|
FI2911699T4
(fi)
|
2012-10-23 |
2025-12-09 |
Synaffix Bv |
Muokattu vasta-aine, vasta-ainekonjugaatti ja menetelmä niiden valmistamiseksi
|
|
US10131682B2
(en)
|
2012-11-24 |
2018-11-20 |
Hangzhou Dac Biotech Co., Ltd. |
Hydrophilic linkers and their uses for conjugation of drugs to a cell binding molecules
|
|
NZ731587A
(en)
|
2013-03-14 |
2021-07-30 |
Sarepta Therapeutics Inc |
Exon skipping compositions for treating muscular dystrophy
|
|
RS58529B1
(sr)
|
2013-03-14 |
2019-04-30 |
Sarepta Therapeutics Inc |
Sastavi koji preskaču egzon za tretiranje mišićne distrofije
|
|
CA2906812A1
(en)
|
2013-03-15 |
2014-09-18 |
Sarepta Therapeutics, Inc. |
Improved compositions for treating muscular dystrophy
|
|
WO2014189973A2
(en)
|
2013-05-20 |
2014-11-27 |
Genentech, Inc. |
Anti-transferrin receptor antibodies and methods of use
|
|
EP3004062B1
(en)
|
2013-05-24 |
2017-07-19 |
SynAffix B.V. |
Substituted azadibenzocyclooctyne compounds and their use in metal-free click reactions
|
|
EP3004370B1
(en)
|
2013-06-05 |
2024-08-21 |
Duke University |
Rna-guided gene editing and gene regulation
|
|
TW201536329A
(zh)
|
2013-08-09 |
2015-10-01 |
Isis Pharmaceuticals Inc |
用於調節失養性肌強直蛋白質激酶(dmpk)表現之化合物及方法
|
|
EP3033425A4
(en)
|
2013-08-16 |
2017-07-26 |
Rana Therapeutics, Inc. |
Compositions and methods for modulating expression of frataxin
|
|
CA2921457A1
(en)
|
2013-08-16 |
2015-02-19 |
Rana Therapeutics, Inc. |
Heterochromatin forming non-coding rnas
|
|
PE20160209A1
(es)
|
2013-08-28 |
2016-05-09 |
Stemcentrx Inc |
Conjugados anti-dll3 (ligando3 tipo delta) manipulados y metodos de uso
|
|
WO2015042581A1
(en)
|
2013-09-23 |
2015-03-26 |
President And Fellows Of Harvard College |
Allele-specific rna silencing for the treatment of hypertrophic cardiomyopathy
|
|
EP3057618B1
(en)
|
2013-10-14 |
2022-12-14 |
SynAffix B.V. |
Glycoengineered antibody, antibody-conjugate and methods for their preparation
|
|
EP3058083B1
(en)
|
2013-10-14 |
2018-04-11 |
SynAffix B.V. |
Modified glycoprotein, protein-conjugate and process for the preparation thereof
|
|
EP2862928A1
(en)
|
2013-10-18 |
2015-04-22 |
Université de Strasbourg |
Dynamin 2 inhibitor for the treatment of centronuclear myopathies
|
|
US10004814B2
(en)
|
2013-11-11 |
2018-06-26 |
Sirna Therapeutics, Inc. |
Systemic delivery of myostatin short interfering nucleic acids (siNA) conjugated to a lipophilic moiety
|
|
US10344284B2
(en)
|
2013-11-14 |
2019-07-09 |
Lina A. Shehadeh |
Methods and compositions employing an osteopontin aptamer to deliver nucleic acids into smooth muscle, endothelial, cardiac and progenitor/stem cells
|
|
US9994641B2
(en)
|
2013-12-25 |
2018-06-12 |
Jcr Pharmaceuticals Co., Ltd. |
Anti-human transferrin receptor antibody that passes through blood-brain barrier
|
|
ES2917473T3
(es)
|
2014-01-16 |
2022-07-08 |
Wave Life Sciences Ltd |
Diseño quiral
|
|
WO2015112016A1
(en)
|
2014-01-24 |
2015-07-30 |
Synaffix B.V. |
Process for the cycloaddition of a halogenated 1,3-dipole compound with a (hetero)cycloalkyne
|
|
CN106660967A
(zh)
|
2014-01-24 |
2017-05-10 |
西纳福克斯股份有限公司 |
(杂)芳基1，3‑偶极化合物与(杂)环炔的环加成方法
|
|
JP2017513921A
(ja)
|
2014-03-03 |
2017-06-01 |
アーチャルジー、スジャータ |
ジストロフィン異常症を治療するためのキメラジストロフィン−ｖｓｖ−ｇタンパク質
|
|
SMT201900169T1
(it)
|
2014-03-12 |
2019-05-10 |
Nippon Shinyaku Co Ltd |
Acido nucleico antisenso
|
|
EP3119909B1
(en)
|
2014-03-18 |
2019-11-13 |
Fred Hutchinson Cancer Research Center |
Dux4-induced gene expression in facioscapulohumeral muscular dystrophy (fshd)
|
|
JP6750148B2
(ja)
|
2014-04-25 |
2020-09-02 |
公益財団法人野口研究所 |
糖鎖切断抗体の製造方法及び均一糖鎖抗体
|
|
EP3135889B1
(en)
|
2014-04-25 |
2021-07-14 |
Yamaha Motor Power Products Kabushiki Kaisha |
Engine
|
|
US20170182189A1
(en)
|
2014-05-23 |
2017-06-29 |
Genzyme Corporation |
Inhibiting or downregulating glycogen synthase by creating premature stop codons using antisense oligonucleotides
|
|
RU2695430C2
(ru)
|
2014-06-17 |
2019-07-23 |
Ниппон Синяку Ко., Лтд. |
Антисмысловые нуклеиновые кислоты
|
|
EP3177633B1
(en)
|
2014-08-04 |
2022-07-20 |
SynAffix B.V. |
Process for the modification of a glycoprotein using a beta-(1,4)-n-acetylgalactosaminyltransferase or a mutant thereof
|
|
CN108064175A
(zh)
|
2014-08-04 |
2018-05-22 |
米拉根医疗股份有限公司 |
Myh7b的抑制剂及其用途
|
|
US10722559B2
(en)
|
2014-08-11 |
2020-07-28 |
Shire Human Genetic Therapies, Inc. |
Mannose-6-phosphate bearing peptides fused to lysosomal enzymes
|
|
US20160075772A1
(en)
|
2014-09-12 |
2016-03-17 |
Regeneron Pharmaceuticals, Inc. |
Treatment of Fibrodysplasia Ossificans Progressiva
|
|
WO2016054231A1
(en)
|
2014-09-30 |
2016-04-07 |
Amicus Therapeutics, Inc. |
Highly potent acid alpha-glucosidase with enhanced carbohydrates
|
|
WO2016053107A1
(en)
|
2014-10-03 |
2016-04-07 |
Synaffix B.V. |
Sulfamide linker, conjugates thereof, and methods of preparation
|
|
WO2016077840A2
(en)
|
2014-11-14 |
2016-05-19 |
Ossianix, Inc. |
TfR SELECTIVE BINDING COMPOUNDS AND RELATED METHODS
|
|
EP3221362B1
(en)
|
2014-11-19 |
2019-07-24 |
F.Hoffmann-La Roche Ag |
Anti-transferrin receptor antibodies and methods of use
|
|
EA036714B1
(ru)
|
2014-11-21 |
2020-12-10 |
Мерк Шарп И Доум Корп. |
Частичные агонисты инсулинового рецептора
|
|
US20190002876A1
(en)
|
2014-12-09 |
2019-01-03 |
The Board Of Regents Of The University Of Texas System |
Compositions and methods for treatment of friedreich's ataxia
|
|
US10538763B2
(en)
|
2015-01-16 |
2020-01-21 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulation of DUX4
|
|
WO2016138534A2
(en)
|
2015-02-27 |
2016-09-01 |
Sarepta Therapeutics, Inc. |
Antisense-induced exon2 inclusion in acid alpha-glucosidase
|
|
CN107810273B
(zh)
|
2015-04-23 |
2022-09-27 |
西纳福克斯股份有限公司 |
用为或衍生自β-(1,4)-N-乙酰半乳糖胺转移酶的糖基转移酶修饰糖蛋白的方法
|
|
BR112017023862A2
(pt)
|
2015-05-04 |
2018-07-17 |
Cytomx Therapeutics Inc |
anticorpos anti-cd71, anticorpos anti-cd71 ativáveis, e métodos de uso destes
|
|
EP3297649B1
(en)
|
2015-05-19 |
2023-10-11 |
Sarepta Therapeutics, Inc. |
Peptide oligonucleotide conjugates
|
|
TWI769982B
(zh)
|
2015-06-24 |
2022-07-11 |
日商Ｊｃｒ製藥股份有限公司 |
通過血腦障壁之抗人類運鐵蛋白受體抗體
|
|
PT3325509T
(pt)
|
2015-07-22 |
2021-03-12 |
Inatherys |
Anticorpos anti-tfr e sua utilização no tratamento de distúrbios proliferativos e inflamatórios
|
|
SI3351633T1
(sl)
|
2015-09-15 |
2020-09-30 |
Nippon Shinyaku Co., Ltd. |
Protismiselna nukleinska kislina
|
|
WO2017049157A1
(en)
|
2015-09-18 |
2017-03-23 |
Duke University |
Methods and compositions for the treatment of steatosis-associated disorders
|
|
EP3353301A1
(en)
|
2015-09-21 |
2018-08-01 |
Association Institut de Myologie |
Antisense oligonucleotides and uses thereof
|
|
US20180265859A1
(en)
|
2015-09-23 |
2018-09-20 |
UNIVERSITé LAVAL |
Modification of the dystrophin gene and uses thereof
|
|
JP7511326B2
(ja)
|
2015-10-09 |
2024-07-05 |
ウェイブ ライフ サイエンシズ リミテッド |
オリゴヌクレオチド組成物およびその方法
|
|
EP3858993A1
(en)
|
2015-10-09 |
2021-08-04 |
Sarepta Therapeutics, Inc. |
Compositions and methods for treating duchenne muscular dystrophy and related disorders
|
|
RU2021102893A
(ru)
|
2015-11-05 |
2021-03-03 |
Бамбу Терапьютикс, Инк. |
Модифицированные гены атаксии фридрейха и векторы для генной терапии
|
|
AU2016365834B2
(en)
|
2015-12-08 |
2023-09-28 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for internalizing enzymes
|
|
FR3044926B1
(fr)
|
2015-12-09 |
2020-01-31 |
Genethon |
Outils de therapie genique efficaces pour le saut de l'exon 53 de la dystrophine
|
|
US11135304B2
(en)
|
2015-12-18 |
2021-10-05 |
Eisai R&D Management Co., Ltd. |
C-terminal lysine conjugated immunoglobulins
|
|
WO2017137423A1
(en)
|
2016-02-08 |
2017-08-17 |
Synaffix B.V. |
Improved sulfamide linkers for use in bioconjugates
|
|
IL260983B
(en)
|
2016-02-19 |
2022-07-01 |
Genisphere Llc |
Nucleic acid carriers and methods of medical use
|
|
IL325155A
(en)
|
2016-03-30 |
2026-02-01 |
Amicus Therapeutics Inc |
Formulations containing recombinant acid alpha-glucosidase
|
|
US10227577B2
(en)
|
2016-03-30 |
2019-03-12 |
Amicus Therapeutics, Inc. |
Method for selection of high M6P recombinant proteins
|
|
JP2019513371A
(ja)
|
2016-04-01 |
2019-05-30 |
アビディティー バイオサイエンシーズ エルエルシー |
核酸ポリペプチド組成物とその使用
|
|
BR112018070249A2
(pt)
|
2016-04-02 |
2019-01-29 |
Research Institute At Nationwide Children's Hospital |
sistema promotor de u6 modificada para expressão específica de tecido
|
|
FR3049951A1
(fr)
|
2016-04-12 |
2017-10-13 |
Univ Rabelais Francois |
Nouvelles constructions peptidiques et leur utilisation dans le traitement de la toxoplasmose
|
|
CA3021267A1
(en)
|
2016-04-18 |
2017-10-26 |
Sarepta Therapeutics, Inc. |
Antisense oligomers and methods of using the same for treating diseases associated with the acid alpha-glucosidase gene
|
|
WO2017192679A1
(en)
|
2016-05-04 |
2017-11-09 |
Wave Life Sciences Ltd. |
Methods and compositions of biologically active agents
|
|
EP3463429A4
(en)
|
2016-05-24 |
2020-07-22 |
Merck Sharp & Dohme Corp. |
PARTIAL INSULIN RECEPTOR AGONISTS AND GLP-1 ANALOGUES
|
|
CN109562122A
(zh)
|
2016-06-03 |
2019-04-02 |
波涛生命科学有限公司 |
寡核苷酸、组合物及其方法
|
|
CN109310765A
(zh)
*
|
2016-06-20 |
2019-02-05 |
领先基因生物技术股份有限公司 |
抗体-药物偶联物
|
|
US11427838B2
(en)
|
2016-06-29 |
2022-08-30 |
Vertex Pharmaceuticals Incorporated |
Materials and methods for treatment of myotonic dystrophy type 1 (DM1) and other related disorders
|
|
CA3029772A1
(en)
|
2016-07-05 |
2018-01-11 |
Biomarin Technologies B.V. |
Pre-mrna splice switching or modulating oligonucleotides comprising bicyclic scaffold moieties, with improved characteristics for the treatment of genetic disorders
|
|
US20190330626A1
(en)
|
2016-07-15 |
2019-10-31 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for use in dystrophin transcript
|
|
WO2018017754A1
(en)
|
2016-07-19 |
2018-01-25 |
Duke University |
Therapeutic applications of cpf1-based genome editing
|
|
EP3293259A1
(en)
|
2016-09-12 |
2018-03-14 |
Genethon |
Acid-alpha glucosidase variants and uses thereof
|
|
MX2019002842A
(es)
|
2016-09-12 |
2019-08-29 |
Genethon |
Variantes de alfa-glucosidasa acida y usos de las mismas.
|
|
EP3516062A1
(en)
|
2016-09-21 |
2019-07-31 |
Alnylam Pharmaceuticals, Inc. |
Myostatin irna compositions and methods of use thereof
|
|
IL266690B2
(en)
|
2016-11-16 |
2024-06-01 |
Biomarin Tech Bv |
Substances for targeting various selected organs or tissues
|
|
US10947540B2
(en)
|
2016-11-29 |
2021-03-16 |
Association Institut De Myologie |
Allele-specific silencing therapy for Dynamin 2-related diseases
|
|
CA3044531A1
(en)
|
2016-11-28 |
2018-05-31 |
The Board Of Regents Of The University Of Texas System |
Prevention of muscular dystrophy by crispr/cpf1-mediated gene editing
|
|
JP2020500541A
(ja)
|
2016-12-08 |
2020-01-16 |
ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム |
ヒト化デュシェンヌ型筋ジストロフィー変異を有するｄｍｄレポーターモデル
|
|
SI3554554T1
(sl)
|
2016-12-19 |
2023-02-28 |
Sarepta Therapeutics, Inc. |
Oligomerni konjugati, ki preskakujejo ekson za mišično distrofijo
|
|
TWI761413B
(zh)
|
2016-12-26 |
2022-04-21 |
日商Ｊｃｒ製藥股份有限公司 |
通過血腦障壁之新穎抗人類運鐵蛋白受體抗體
|
|
US10940185B2
(en)
|
2016-12-28 |
2021-03-09 |
Jcr Pharmaceuticals Co., Ltd. |
Lyophilized preparation
|
|
JOP20190166A1
(ar)
|
2017-01-05 |
2019-07-02 |
Univ Texas |
استراتيجية مثلى من أجل تعديلات تخطي إكسون باستخدام crispr/cas9 مع متواليات توجيه ثلاثي
|
|
MX2019008199A
(es)
|
2017-01-06 |
2019-11-25 |
Avidity Biosciences Llc |
Composiciones de acido nucleico polipeptido y metodos de induccion de la omision de exon.
|
|
WO2018140831A2
(en)
|
2017-01-27 |
2018-08-02 |
Silverback Therapeutics, Inc. |
Tumor targeting conjugates and methods of use thereof
|
|
FI3635009T3
(fi)
|
2017-06-07 |
2026-04-07 |
Regeneron Pharma |
Koostumuksia ja menetelmiä entsyymien internalisoimiseksi
|
|
GB201711809D0
(en)
|
2017-07-21 |
2017-09-06 |
Governors Of The Univ Of Alberta |
Antisense oligonucleotide
|
|
CA3099522C
(en)
|
2017-09-19 |
2024-10-08 |
The Governors Of The University Of Alberta |
GAPMERES AND METHODS OF USING THESE FOR THE TREATMENT OF MUSCULAR DYSTROPHY
|
|
US20200282074A1
(en)
|
2017-09-22 |
2020-09-10 |
Avidity Biosciences, Inc. |
Nucleic acid-polypeptide compositions and methods of inducing exon skipping
|
|
EA201991450A1
(ru)
|
2017-09-22 |
2019-12-30 |
Сарепта Терапьютикс, Инк. |
Конъюгаты олигомеров для пропуска экзона при мышечной дистрофии
|
|
WO2019067975A1
(en)
|
2017-09-28 |
2019-04-04 |
Sarepta Therapeutics, Inc. |
POLYTHERAPIES FOR TREATING MUSCLE DYSTROPHY
|
|
JP2020536058A
(ja)
|
2017-09-28 |
2020-12-10 |
サレプタ セラピューティクス， インコーポレイテッド |
筋ジストロフィーを処置するための併用療法
|
|
AU2018345772B2
(en)
|
2017-10-02 |
2025-04-17 |
Research Institute At Nationwide Children's Hospital |
MiRNA detargeting system for tissue specific interference
|
|
WO2019071028A1
(en)
|
2017-10-04 |
2019-04-11 |
Avidity Biosciences Llc |
NUCLEIC ACID-POLYPEPTIDE COMPOSITIONS AND USES THEREOF
|
|
WO2019079637A2
(en)
|
2017-10-18 |
2019-04-25 |
Sarepta Therapeutics, Inc. |
ANTISENSE OLIGOMERIC COMPOUNDS
|
|
US20210363521A1
(en)
|
2017-11-09 |
2021-11-25 |
Vertex Pharmaceuticals Incorporated |
CRISPR/CAS Systems For Treatment of DMD
|
|
JP7506601B2
(ja)
|
2017-12-06 |
2024-06-26 |
アビディティー バイオサイエンシーズ，インク． |
筋萎縮症と筋緊張性ジストロフィーを処置するための組成物および方法
|
|
EP3720504A1
(en)
|
2017-12-06 |
2020-10-14 |
Synaffix B.V. |
Enediyne conjugates
|
|
US11459564B2
(en)
|
2017-12-21 |
2022-10-04 |
Ionis Pharmaceuticals, Inc. |
Modulation of frataxin expression
|
|
MA51583A
(fr)
|
2018-01-04 |
2020-11-11 |
Avidity Biosciences Inc |
Molécules d'acide nucléique hétéroduplex et leurs utilisations
|
|
EP3735462A1
(en)
|
2018-01-05 |
2020-11-11 |
The Board of Regents of The University of Texas System |
Therapeutic crispr/cas9 compositions and methods of use
|
|
JP2021511803A
(ja)
|
2018-01-31 |
2021-05-13 |
ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム |
ヒト心筋細胞におけるジストロフィン変異を修正するための組成物および方法
|
|
US12458668B2
(en)
|
2018-02-02 |
2025-11-04 |
Fred Hutchinson Cancer Center |
Methods for treating facioscapulohumeral muscular dystrophy
|
|
AU2019215782A1
(en)
|
2018-02-05 |
2020-07-16 |
Jcr Pharmaceuticals Co., Ltd. |
Method for delivering drug to muscle
|
|
JP7779653B2
(ja)
|
2018-02-07 |
2025-12-03 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
治療用タンパク質送達のための方法および組成物
|
|
IL277889B2
(en)
|
2018-04-12 |
2025-01-01 |
Wave Life Sciences Ltd |
Oligonucleotide preparations and methods of using them
|
|
EP3784248A4
(en)
|
2018-04-26 |
2022-08-10 |
Sarepta Therapeutics, Inc. |
EXON-SKIPPING OLIGOMERS AND OLIGOMER CONJUGATES FOR MUSCULAR DYSTROPHY
|
|
US20210371860A1
(en)
|
2018-05-08 |
2021-12-02 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating myh7 expression
|
|
EP3790596A4
(en)
|
2018-05-11 |
2022-04-06 |
Wave Life Sciences Ltd. |
OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE
|
|
CA3098266A1
(en)
|
2018-05-11 |
2019-11-14 |
Alpha Anomeric Sas |
Oligonucleotides conjugates comprising 7'-5'-alpha-anomeric-bicyclic sugar nucleosides
|
|
AR126019A1
(es)
|
2018-05-30 |
2023-09-06 |
Novartis Ag |
Anticuerpos frente a entpd2, terapias de combinación y métodos de uso de los anticuerpos y las terapias de combinación
|
|
WO2019241385A2
(en)
|
2018-06-13 |
2019-12-19 |
Sarepta Therapeutics, Inc. |
Exon skipping oligomers for muscular dystropy
|
|
US20210261962A1
(en)
|
2018-06-21 |
2021-08-26 |
The Board Of Regents Of The University Of Texas System |
Correction of dystrophin exon 43, exon 45, or exon 52 deletions in duchenne muscular dystrophy
|
|
KR20210086601A
(ko)
|
2018-08-02 |
2021-07-08 |
다인 세라퓨틱스, 인크. |
근육 표적화 복합체 및 프리드라이히 운동실조를 치료하기 위한 그의 용도
|
|
EP3829595A4
(en)
|
2018-08-02 |
2022-08-24 |
Dyne Therapeutics, Inc. |
MUSCLE-DIRECTED COMPLEXES AND USES THEREOF IN THE TREATMENT OF DYSTROPHINOPATHIES
|
|
US20220193250A1
(en)
|
2018-08-02 |
2022-06-23 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
|
|
CA3108328A1
(en)
|
2018-08-02 |
2020-02-06 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating fibrodysplasia ossificans progressiva
|
|
US11168141B2
(en)
|
2018-08-02 |
2021-11-09 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating dystrophinopathies
|
|
WO2020028842A1
(en)
|
2018-08-02 |
2020-02-06 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating hypertrophic cardiomyopathy
|
|
IL321905A
(en)
|
2018-08-02 |
2025-09-01 |
Dyne Therapeutics Inc |
Muscle-targeted conjugates and their uses in the treatment of myotonia dystrophica
|
|
US11911484B2
(en)
|
2018-08-02 |
2024-02-27 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating myotonic dystrophy
|
|
JP2021533197A
(ja)
|
2018-08-02 |
2021-12-02 |
ダイン セラピューティクス, インコーポレーテッドDyne Therapeutics, Inc. |
ポンペ病を処置するための筋標的化複合体およびそれらの使用
|
|
EP3830130A4
(en)
|
2018-08-02 |
2022-05-18 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating centronuclear myopathy
|
|
US12018087B2
(en)
|
2018-08-02 |
2024-06-25 |
Dyne Therapeutics, Inc. |
Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject
|
|
JP7576542B2
(ja)
|
2018-08-02 |
2024-10-31 |
ダイン セラピューティクス，インコーポレーテッド |
筋標的化複合体およびそれらの使用
|
|
US12097263B2
(en)
|
2018-08-02 |
2024-09-24 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating myotonic dystrophy
|
|
CN112930193A
(zh)
|
2018-08-02 |
2021-06-08 |
达因疗法公司 |
肌肉靶向复合物及其在治疗肌肉萎缩中的用途
|
|
WO2020047282A1
(en)
|
2018-08-29 |
2020-03-05 |
University Of Copenhagen |
Lysosomal enzymes modified by cell based glycoengineering
|
|
IT201800009682A1
(it)
|
2018-10-22 |
2020-04-22 |
Ice Spa |
Coniugati di acidi biliari e loro derivati per la veicolazione di molecole attive
|
|
CN113260384A
(zh)
|
2018-11-05 |
2021-08-13 |
西纳福克斯股份有限公司 |
用于靶向表达trop-2的肿瘤的抗体缀合物
|
|
SG11202105626TA
(en)
|
2018-12-06 |
2021-06-29 |
Wave Life Sciences Ltd |
Oligonucleotide compositions and methods thereof
|
|
IL312067B2
(en)
|
2018-12-21 |
2025-08-01 |
Avidity Biosciences Inc |
Anti-transferrin receptor antibodies and uses thereof
|
|
AU2019419494B2
(en)
|
2018-12-31 |
2026-03-26 |
Research Institute At Nationwide Children's Hospital |
DUX4 RNA silencing using RNA targeting CRISPR-Cas13b
|
|
WO2020198268A1
(en)
|
2019-03-28 |
2020-10-01 |
Sarepta Therapeutics, Inc. |
Methods for treating muscular dystrophy with casimersen
|
|
EP3954395A4
(en)
|
2019-04-08 |
2023-06-28 |
National University Corporation Tokyo Medical and Dental University |
Pharmaceutical composition for muscle disease treatment
|
|
EP3955966A1
(en)
|
2019-04-18 |
2022-02-23 |
Sarepta Therapeutics, Inc. |
Compositions for treating muscular dystrophy
|
|
US12497615B2
(en)
|
2019-04-25 |
2025-12-16 |
Avidity Biosciences, Inc. |
Nucleic acid compositions and methods of multi-exon skipping
|
|
JP7592034B2
(ja)
|
2019-06-06 |
2024-11-29 |
アビディティー バイオサイエンシーズ，インク． |
核酸ポリペプチド組成物およびその使用
|
|
KR20220019259A
(ko)
|
2019-06-06 |
2022-02-16 |
어비디티 바이오사이언시스 인크. |
Una 아미다이트 및 이의 용도
|
|
CN119874910A
(zh)
|
2019-06-07 |
2025-04-25 |
达因疗法公司 |
制备蛋白质-寡核苷酸复合物的方法
|
|
EP3987029A1
(en)
|
2019-06-19 |
2022-04-27 |
Sarepta Therapeutics, Inc. |
Methods for treating muscular dystrophy
|
|
US20220288218A1
(en)
|
2019-07-09 |
2022-09-15 |
The Governors Of The University Of Alberta |
Exons 45-55 skipping using mutation-tailored cocktails of antisense morpholinos in the dmd gene
|
|
US20240148891A1
(en)
|
2019-10-18 |
2024-05-09 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating myotonic dystrophy
|
|
KR20220147575A
(ko)
|
2019-11-27 |
2022-11-03 |
디티엑스 파마, 인크. |
뒤시엔느 근위축증의 치료를 위한 화합물 및 방법
|
|
KR20220129547A
(ko)
|
2019-12-20 |
2022-09-23 |
코덱시스, 인코포레이티드 |
조작된 산성 알파-글루코시다제 변이체
|
|
WO2021142313A1
(en)
|
2020-01-10 |
2021-07-15 |
Dyne Therapeutics, Inc. |
Muscle-targeting complexes and uses thereof
|
|
WO2021142260A1
(en)
|
2020-01-10 |
2021-07-15 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for modulation of acvr1
|
|
WO2021142217A1
(en)
|
2020-01-10 |
2021-07-15 |
Dyne Thereapeutics, Inc. |
Muscle targeting complexes and uses thereof for modulation of milck1
|
|
WO2021142269A1
(en)
|
2020-01-10 |
2021-07-15 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for modulation of genes associated with muscle atrophy
|
|
AU2021206234A1
(en)
|
2020-01-10 |
2022-09-01 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating myotonic dystrophy
|
|
KR20220125801A
(ko)
|
2020-01-10 |
2022-09-14 |
다인 세라퓨틱스, 인크. |
근육 표적화 복합체 및 안면견갑상완 근육 이영양증을 치료하기 위한 그의 용도
|
|
WO2023283531A2
(en)
|
2021-07-09 |
2023-01-12 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for modulation of genes associated with muscle health
|
|
US20230203180A1
(en)
|
2020-01-10 |
2023-06-29 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for modulation of genes associated with muscle health
|
|
CA3163283A1
(en)
|
2020-01-10 |
2021-07-15 |
Romesh R. Subramanian |
Muscle targeting complexes and uses thereof for modulation of genes associated with muscle health
|
|
WO2021142331A1
(en)
|
2020-01-10 |
2021-07-15 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for modulation of genes associated with cardiac muscle disease
|
|
JP7780691B2
(ja)
|
2020-01-10 |
2025-12-05 |
ダイン セラピューティクス，インコーポレーテッド |
ジストロフィン異常症を処置するための筋標的化複合体およびそれらの使用
|
|
WO2021150382A1
(en)
|
2020-01-24 |
2021-07-29 |
Dyne Therapeutics, Inc. |
Muscle-targeting complexes and uses thereof in treating muscle atrophy
|
|
CN115427059A
(zh)
|
2020-01-31 |
2022-12-02 |
达因疗法公司 |
抗转铁蛋白受体（tfr）抗体及其用途
|
|
WO2021154477A1
(en)
|
2020-01-31 |
2021-08-05 |
Dyne Therapeutics, Inc. |
Anti-transferrin receptor (tfr) antibody and uses thereof
|
|
US11555190B2
(en)
|
2020-03-19 |
2023-01-17 |
Avidity Biosciences, Inc. |
Compositions and methods of treating Facioscapulohumeral muscular dystrophy
|
|
AU2021241682B2
(en)
|
2020-03-27 |
2026-02-12 |
Avidity Biosciences, Inc. |
Compositions and methods of treating muscle dystrophy
|
|
US20230330246A1
(en)
|
2020-05-05 |
2023-10-19 |
Avidity Biosciences, Inc. |
Compositions and methods of treating pompe disease
|
|
KR20230044242A
(ko)
|
2020-07-23 |
2023-04-03 |
다인 세라퓨틱스, 인크. |
근육 표적화 복합체 및 디스트로핀병증을 치료하기 위한 그의 용도
|
|
KR20230046297A
(ko)
|
2020-07-23 |
2023-04-05 |
다인 세라퓨틱스, 인크. |
근육 표적화 복합체 및 안면견갑상완 근육 이영양증을 치료하기 위한 그의 용도
|
|
US20230346966A1
(en)
|
2020-07-23 |
2023-11-02 |
Dyne Therapeutics, Inc. |
Muscle-targeting complexes and uses thereof in treating muscle atrophy
|
|
AU2021318851A1
(en)
|
2020-07-23 |
2023-03-16 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating myotonic dystrophy
|
|
WO2022020108A1
(en)
|
2020-07-23 |
2022-01-27 |
Dyne Therapeutics, Inc. |
Muscle-targeting complexes and uses thereof
|
|
CN116348138A
(zh)
|
2020-07-23 |
2023-06-27 |
达因疗法公司 |
抗转铁蛋白受体（tfr）抗体及其用途
|
|
AR123420A1
(es)
|
2020-09-01 |
2022-11-30 |
Ultragenyx Pharmaceutical Inc |
Inhibidores de dux4 y métodos de uso de estos
|
|
WO2022051665A1
(en)
|
2020-09-03 |
2022-03-10 |
Dyne Therapeutics, Inc. |
Methods of preparing protein-oligonucleotide complexes
|
|
IL301187A
(en)
|
2020-09-11 |
2023-05-01 |
Arrowhead Pharmaceuticals Inc |
RNAi agents for suppressing DUX4 expression, preparations containing them and uses thereof
|
|
IL303230A
(en)
|
2020-11-30 |
2023-07-01 |
Res Inst Nationwide Childrens Hospital |
Compositions and methods for treating facioscapulohumeral muscular dystrophy (fshd)
|
|
US20240100177A1
(en)
|
2020-12-04 |
2024-03-28 |
Dyne Therapeutics, Inc. |
Antibody-oligonucleotide complexes and uses thereof
|
|
US20240117356A1
(en)
|
2020-12-31 |
2024-04-11 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating myotonic dystrophy
|
|
JP2024501872A
(ja)
|
2020-12-31 |
2024-01-16 |
ダイン セラピューティクス，インコーポレーテッド |
顔面肩甲上腕筋ジストロフィーを処置するための筋標的化複合体およびそれらの使用
|
|
US20240336915A1
(en)
|
2021-01-22 |
2024-10-10 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for reducing dux4 expression
|
|
US20250243244A1
(en)
|
2021-03-31 |
2025-07-31 |
Entrada Therapeutics, Inc. |
Cyclic cell penetrating peptides
|
|
WO2022212886A1
(en)
|
2021-04-02 |
2022-10-06 |
Avidity Biosciences, Inc. |
Antibody-oligonucleotide conjugate and antibody-peptide-oligonucleotide conjugate compositions and methods of inducing exon skipping
|
|
WO2022217366A1
(en)
|
2021-04-14 |
2022-10-20 |
The Royal Institution For The Advancement Of Learning/Mcgill University |
Modified oligonucleotides for the treatment of duchenne muscular dystrophy
|
|
MX2023012559A
(es)
|
2021-04-30 |
2023-12-15 |
Sarepta Therapeutics Inc |
Métodos de tratamiento para la distrofia muscular.
|
|
EP4359534A1
(en)
|
2021-06-21 |
2024-05-01 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating pompe disease
|
|
CN118251238A
(zh)
|
2021-06-21 |
2024-06-25 |
达因疗法公司 |
肌肉靶向复合物及其用于治疗弗里德赖希共济失调的用途
|
|
WO2022270585A1
(ja)
|
2021-06-23 |
2022-12-29 |
日本新薬株式会社 |
アンチセンスオリゴマーの組み合わせ
|
|
KR20240032945A
(ko)
|
2021-07-09 |
2024-03-12 |
다인 세라퓨틱스, 인크. |
근육 표적화 복합체 및 디스트로핀병증을 치료하기 위한 그의 용도
|
|
US11771776B2
(en)
|
2021-07-09 |
2023-10-03 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating dystrophinopathies
|
|
EP4366783A4
(en)
|
2021-07-09 |
2025-08-27 |
Dyne Therapeutics Inc |
MUSCLE TARGETING COMPLEXES AND THEIR USES FOR THE TREATMENT OF DYSTROPHINOPATHIES
|
|
AU2022306307A1
(en)
|
2021-07-09 |
2024-02-01 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating myotonic dystrophy
|
|
IL309912A
(en)
|
2021-07-09 |
2024-03-01 |
Dyne Therapeutics Inc |
Muscle targeting complexes and their uses for the treatment of dystrophinopathy
|
|
WO2023283629A1
(en)
|
2021-07-09 |
2023-01-12 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and formulations thereof for treating facioscapulohumeral muscular dystrophy
|
|
US11672872B2
(en)
|
2021-07-09 |
2023-06-13 |
Dyne Therapeutics, Inc. |
Anti-transferrin receptor antibody and uses thereof
|
|
IL309936A
(en)
|
2021-07-09 |
2024-03-01 |
Dyne Therapeutics Inc |
Muscle targeting complexes and formulations for the treatment of dystrophinopathy
|
|
US11969475B2
(en)
|
2021-07-09 |
2024-04-30 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
|
|
US11638761B2
(en)
|
2021-07-09 |
2023-05-02 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy
|
|
CA3226300A1
(en)
|
2021-07-09 |
2023-01-12 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating dystrophinopathies
|
|
MX2024000490A
(es)
|
2021-07-09 |
2024-04-10 |
Dyne Therapeutics Inc |
Complejos dirigidos al musculo y usos de los mismos para tratar las distrofinopatías.
|
|
US11633498B2
(en)
|
2021-07-09 |
2023-04-25 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating myotonic dystrophy
|
|
US20250339459A1
(en)
|
2021-08-19 |
2025-11-06 |
National University Corporation Tokyo Medical And Dental University |
Modified heteronucleic acid containing morpholino nucleic acid
|
|
US20240390508A1
(en)
|
2021-08-21 |
2024-11-28 |
Takeda Pharmaceutical Company Limited |
Human transferrin receptor binding peptide-drug conjugate
|
|
US20240417429A1
(en)
|
2021-09-01 |
2024-12-19 |
Entrada Therapeutics, Inc. |
Compositions and methods for skipping exon 45 in duchenne muscular dystrophy
|
|
MX2024003266A
(es)
|
2021-09-16 |
2024-04-03 |
Avidity Biosciences Inc |
Composiciones y metodos de tratamiento de la distrofia muscular facioescapulohumeral.
|
|
IL311507A
(en)
|
2021-09-16 |
2024-05-01 |
Dyne Therapeutics Inc |
Dosing of muscle targeting complexes for the treatment of dystrophinopathy
|
|
JP2024540199A
(ja)
|
2021-11-01 |
2024-10-31 |
ダイン セラピューティクス，インコーポレーテッド |
ジストロフィノパチーを処置するための筋標的化複合体
|
|
KR20240099448A
(ko)
|
2021-11-12 |
2024-06-28 |
다인 세라퓨틱스, 인크. |
안면견갑상완 근육 이영양증을 치료하기 위한 근육 표적화 복합체
|
|
JP2025500481A
(ja)
|
2021-12-22 |
2025-01-09 |
サプリーム テクノロジーズ，ベー．フェー． |
筋消耗性障害を治療するための治療用核酸とサポニンとを含む組成物
|
|
US20250057971A1
(en)
|
2021-12-22 |
2025-02-20 |
Sapreme Technologies B.V. |
Targeted saponin-nucleic acid conjugates for treatment of muscle wasting disorders
|
|
JP2025501610A
(ja)
|
2021-12-22 |
2025-01-22 |
サプリーム テクノロジーズ，ベー．フェー． |
筋消耗性障害の治療のための治療用核酸と標的型サポニンとを含む組成物
|
|
US20250114464A1
(en)
|
2022-01-27 |
2025-04-10 |
The Governors Of The University Of Alberta |
Pre-mrna slice modulating peptide-conjugated antisense therapeutics for the treatment of diseases
|
|
WO2023154807A2
(en)
|
2022-02-09 |
2023-08-17 |
Locanabio, Inc. |
Compositions and methods for modulating pre-mrna splicing
|
|
WO2023168427A1
(en)
|
2022-03-03 |
2023-09-07 |
Yale University |
Compositions and methods for delivering therapeutic polynucleotides for exon skipping
|
|
JP2025079347A
(ja)
|
2022-03-11 |
2025-05-22 |
日本新薬株式会社 |
キャリアペプチドが連結された核酸
|
|
JP2025509438A
(ja)
|
2022-03-17 |
2025-04-11 |
サレプタ セラピューティクス， インコーポレイテッド |
ホスホロジアミデートモルホリノオリゴマーコンジュゲート
|
|
US12071621B2
(en)
|
2022-04-05 |
2024-08-27 |
Avidity Biosciences, Inc. |
Anti-transferrin receptor antibody-PMO conjugates for inducing DMD exon 44 skipping
|
|
EP4508091A1
(en)
|
2022-04-15 |
2025-02-19 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating myotonic dystrophy
|
|
WO2023201318A1
(en)
|
2022-04-15 |
2023-10-19 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and formulations for treating myotonic dystrophy
|
|
US20250339553A1
(en)
|
2022-04-15 |
2025-11-06 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and formulations for treating myotonic dystrophy
|
|
KR20250004771A
(ko)
|
2022-04-15 |
2025-01-08 |
다인 세라퓨틱스, 인크. |
근긴장성 이영양증을 치료하기 위한 근육 표적화 복합체의 투여
|
|
KR20250034419A
(ko)
|
2022-07-06 |
2025-03-11 |
다인 세라퓨틱스, 인크. |
근육 표적화 복합체 및 안면견갑상완 근육 이영양증을 치료하기 위한 그의 용도
|
|
MA71403A
(fr)
|
2022-07-06 |
2025-04-30 |
Dyne Therapeutics, Inc. |
Complexes de ciblage du snc et leurs utilisations
|
|
WO2024064237A2
(en)
|
2022-09-21 |
2024-03-28 |
Sarepta Therapeutics, Inc. |
Dmd antisense oligonucleotide-mediated exon skipping efficiency
|
|
JP2026503873A
(ja)
|
2022-10-31 |
2026-02-02 |
ダイン セラピューティクス，インコーポレーテッド |
Ｄｍｄ遺伝子のエクソン４５をスキップするための筋肉標的化複合体およびその使用
|
|
IL321025A
(en)
|
2022-11-21 |
2025-07-01 |
Pepgen Inc |
Cell-penetrating peptides, conjugates thereof, and methods of their use
|
|
IL321969A
(en)
|
2023-01-10 |
2025-09-01 |
Ausperbio Therapeutics Inc |
Multi-stranded antisense oligonucleotides modified for use
|
|
CN121241139A
(zh)
|
2023-02-27 |
2025-12-30 |
达因疗法公司 |
抑制肌内纤维化进展的方法和组合物
|