|
US1000075A
(en)
|
1910-07-27 |
1911-08-08 |
William R Collins |
Tunneling-machine.
|
|
US4458066A
(en)
|
1980-02-29 |
1984-07-03 |
University Patents, Inc. |
Process for preparing polynucleotides
|
|
US4694778A
(en)
|
1984-05-04 |
1987-09-22 |
Anicon, Inc. |
Chemical vapor deposition wafer boat
|
|
US5166315A
(en)
|
1989-12-20 |
1992-11-24 |
Anti-Gene Development Group |
Sequence-specific binding polymers for duplex nucleic acids
|
|
US5185444A
(en)
|
1985-03-15 |
1993-02-09 |
Anti-Gene Deveopment Group |
Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages
|
|
JP3022967B2
(ja)
|
1985-03-15 |
2000-03-21 |
アンチバイラルズ インコーポレイテッド |
立体規則性ポリヌクレオチド結合ポリマー
|
|
US5521063A
(en)
|
1985-03-15 |
1996-05-28 |
Antivirals Inc. |
Polynucleotide reagent containing chiral subunits and methods of use
|
|
US5506337A
(en)
|
1985-03-15 |
1996-04-09 |
Antivirals Inc. |
Morpholino-subunit combinatorial library and method
|
|
US5034506A
(en)
|
1985-03-15 |
1991-07-23 |
Anti-Gene Development Group |
Uncharged morpholino-based polymers having achiral intersubunit linkages
|
|
US5217866A
(en)
|
1985-03-15 |
1993-06-08 |
Anti-Gene Development Group |
Polynucleotide assay reagent and method
|
|
US4828971A
(en)
|
1988-03-24 |
1989-05-09 |
Eastman Kodak Company |
Thermally processable element comprising a backing layer
|
|
CA1251835A
(en)
|
1988-04-05 |
1989-03-28 |
Wai-Cheung Tang |
Dielectric image-resonator multiplexer
|
|
WO1991004753A1
(en)
|
1989-10-02 |
1991-04-18 |
Cetus Corporation |
Conjugates of antisense oligonucleotides and therapeutic uses thereof
|
|
JP3257675B2
(ja)
|
1990-10-12 |
2002-02-18 |
マックス−プランク−ゲゼルシャフト ツール フェルデルング デル ビッセンシャフテン エー．ファウ． |
修飾リボザイム
|
|
DE4216134A1
(de)
|
1991-06-20 |
1992-12-24 |
Europ Lab Molekularbiolog |
Synthetische katalytische oligonukleotidstrukturen
|
|
EP0531597A1
(en)
|
1991-09-12 |
1993-03-17 |
Merrell Dow Pharmaceuticals Inc. |
Novel unsaturated acyclic phosphonate derivatives of purine and pyrimidine
|
|
GB9123947D0
(en)
*
|
1991-11-12 |
1992-01-02 |
Imp Cancer Res Tech |
Therapeutic compounds
|
|
US5652094A
(en)
|
1992-01-31 |
1997-07-29 |
University Of Montreal |
Nucleozymes
|
|
FI950730A7
(fi)
|
1992-08-17 |
1995-04-10 |
Quadra Logic Tech Inc |
Menetelmä ei-toivottujen solujen tai kudosten kasvun tuhoamiseksi tai ehkäisemiseksi
|
|
US5346981A
(en)
|
1993-01-13 |
1994-09-13 |
Miles Inc. |
Radiopaque polyurethanes
|
|
KR100361933B1
(ko)
|
1993-09-08 |
2003-02-14 |
라 졸라 파마슈티칼 컴파니 |
화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트
|
|
US5627053A
(en)
|
1994-03-29 |
1997-05-06 |
Ribozyme Pharmaceuticals, Inc. |
2'deoxy-2'-alkylnucleotide containing nucleic acid
|
|
DE69531543T2
(de)
|
1994-06-17 |
2004-06-24 |
F. Hoffmann-La Roche Ag |
N,n'-bis(chinolin-4-yl)-diamin derivate, deren herstellung und deren verwendung als antimalaria-mittel
|
|
US5716824A
(en)
|
1995-04-20 |
1998-02-10 |
Ribozyme Pharmaceuticals, Inc. |
2'-O-alkylthioalkyl and 2-C-alkylthioalkyl-containing enzymatic nucleic acids (ribozymes)
|
|
AU4188196A
(en)
|
1994-12-22 |
1996-07-10 |
Nissan Chemical Industries Ltd. |
Organobismuth derivatives and process for producing the same
|
|
US5889136A
(en)
|
1995-06-09 |
1999-03-30 |
The Regents Of The University Of Colorado |
Orthoester protecting groups in RNA synthesis
|
|
DE69637256T2
(de)
|
1996-01-16 |
2008-06-19 |
Sirna Therapeutics, Inc., Boulder |
Synthese von Methoxynukleoside und enzymatische Nukleisäure Moleküle
|
|
JP4046354B2
(ja)
|
1996-03-18 |
2008-02-13 |
ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム |
増大した半減期を有する免疫グロブリン様ドメイン
|
|
US9096636B2
(en)
|
1996-06-06 |
2015-08-04 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds and their use in gene modulation
|
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
|
US5849902A
(en)
|
1996-09-26 |
1998-12-15 |
Oligos Etc. Inc. |
Three component chimeric antisense oligonucleotides
|
|
DE69735445T2
(de)
|
1996-12-10 |
2006-08-10 |
Sequenom, Inc., San Diego |
Abspaltbare, nicht-flüchtige moleküle zur massenmarkierung
|
|
US20030073207A1
(en)
*
|
1997-01-31 |
2003-04-17 |
Saghir Akhtar |
Enzymatic nucleic acid treatment of diseases or conditions related to levels of epidermal growth factor receptors
|
|
US6506559B1
(en)
|
1997-12-23 |
2003-01-14 |
Carnegie Institute Of Washington |
Genetic inhibition by double-stranded RNA
|
|
US6111086A
(en)
|
1998-02-27 |
2000-08-29 |
Scaringe; Stephen A. |
Orthoester protecting groups
|
|
US6528624B1
(en)
|
1998-04-02 |
2003-03-04 |
Genentech, Inc. |
Polypeptide variants
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
ES2292236T3
(es)
|
1998-04-02 |
2008-03-01 |
Genentech, Inc. |
Variantes de anticuerpos y sus fragmentos.
|
|
AU3751299A
(en)
|
1998-04-20 |
1999-11-08 |
Ribozyme Pharmaceuticals, Inc. |
Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
|
|
GB9816575D0
(en)
|
1998-07-31 |
1998-09-30 |
Zeneca Ltd |
Novel compounds
|
|
DE69930328T2
(de)
|
1998-08-27 |
2006-12-14 |
Spirogen Ltd., Ryde |
Dimere Pyrrolobenzodiazepine
|
|
GB9818730D0
(en)
|
1998-08-27 |
1998-10-21 |
Univ Portsmouth |
Collections of compounds
|
|
GB9818731D0
(en)
|
1998-08-27 |
1998-10-21 |
Univ Portsmouth |
Compounds
|
|
DE19956568A1
(de)
|
1999-01-30 |
2000-08-17 |
Roland Kreutzer |
Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
|
|
ATE511543T1
(de)
|
1999-02-22 |
2011-06-15 |
Univ Georgetown |
Immunoliposome mit einem targeting- antikörperfragment zur systemischen genverabreichung
|
|
US6849272B1
(en)
|
1999-04-21 |
2005-02-01 |
Massachusetts Institute Of Technology |
Endosomolytic agents and cell delivery systems
|
|
US8137695B2
(en)
|
2006-08-18 |
2012-03-20 |
Arrowhead Madison Inc. |
Polyconjugates for in vivo delivery of polynucleotides
|
|
DE10100586C1
(de)
|
2001-01-09 |
2002-04-11 |
Ribopharma Ag |
Verfahren zur Hemmung der Expression eines Ziegens
|
|
US7829693B2
(en)
|
1999-11-24 |
2010-11-09 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of a target gene
|
|
DE10160151A1
(de)
|
2001-01-09 |
2003-06-26 |
Ribopharma Ag |
Verfahren zur Hemmung der Expression eines vorgegebenen Zielgens
|
|
CA2328356A1
(en)
|
1999-12-22 |
2001-06-22 |
Itty Atcravi |
Recreational vehicles
|
|
ATE344801T1
(de)
|
1999-12-29 |
2006-11-15 |
Immunogen Inc |
Doxorubicin- und daunorubicin-enthaltende, zytotoxische mittel und deren therapeutische anwendung
|
|
US8273866B2
(en)
|
2002-02-20 |
2012-09-25 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA)
|
|
US8202979B2
(en)
|
2002-02-20 |
2012-06-19 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
|
|
US7833992B2
(en)
|
2001-05-18 |
2010-11-16 |
Merck Sharpe & Dohme |
Conjugates and compositions for cellular delivery
|
|
PT1309726E
(pt)
|
2000-03-30 |
2010-03-08 |
Whitehead Biomedical Inst |
Mediadores de interferência por rna específicos de sequência de rna
|
|
BRPI0117338B1
(pt)
|
2000-03-30 |
2016-06-21 |
Massachusetts Inst Technology |
método para produzir células animais nocauteadas in vitro e método para produzir uma célula nocauteada
|
|
US6784291B2
(en)
|
2000-05-04 |
2004-08-31 |
Avi Biopharma, Inc. |
Splice-region antisense composition and method
|
|
JP2002095476A
(ja)
|
2000-09-20 |
2002-04-02 |
Eisai Co Ltd |
トランスフェリン受容体を介した遺伝子導入法
|
|
EP1191097A1
(en)
|
2000-09-21 |
2002-03-27 |
Leids Universitair Medisch Centrum |
Induction of exon skipping in eukaryotic cells
|
|
US20040259247A1
(en)
|
2000-12-01 |
2004-12-23 |
Thomas Tuschl |
Rna interference mediating small rna molecules
|
|
US8546143B2
(en)
|
2001-01-09 |
2013-10-01 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of a target gene
|
|
WO2003071872A1
(en)
|
2002-02-22 |
2003-09-04 |
University Of Maryland, Baltimore |
Novel treatment of neurodegenerative diseases by altering levels of trkb isoforms and/or trkc isoforms
|
|
US6884869B2
(en)
|
2001-04-30 |
2005-04-26 |
Seattle Genetics, Inc. |
Pentapeptide compounds and uses related thereto
|
|
DE10133858A1
(de)
|
2001-07-12 |
2003-02-06 |
Aventis Pharma Gmbh |
Synthetische doppelsträngige Oligonucleotide zur gezielten Hemmung der Genexpression
|
|
MXPA05000511A
(es)
|
2001-07-12 |
2005-09-30 |
Jefferson Foote |
Anticuepros super humanizados.
|
|
US6942972B2
(en)
|
2001-10-24 |
2005-09-13 |
Beckman Coulter, Inc. |
Efficient synthesis of protein-oligonucleotide conjugates
|
|
US6716821B2
(en)
|
2001-12-21 |
2004-04-06 |
Immunogen Inc. |
Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same
|
|
US20060009409A1
(en)
|
2002-02-01 |
2006-01-12 |
Woolf Tod M |
Double-stranded oligonucleotides
|
|
US9657294B2
(en)
|
2002-02-20 |
2017-05-23 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
|
US9181551B2
(en)
|
2002-02-20 |
2015-11-10 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
|
AU2003207708A1
(en)
|
2002-02-20 |
2003-09-09 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of map kinase genes
|
|
US20040012626A1
(en)
|
2002-07-22 |
2004-01-22 |
Brookins Timothy J. |
Method for creating configurable and customizable web user interfaces
|
|
US20040023220A1
(en)
|
2002-07-23 |
2004-02-05 |
Lawrence Greenfield |
Integrated method for PCR cleanup and oligonucleotide removal
|
|
SI1545613T1
(sl)
|
2002-07-31 |
2011-11-30 |
Seattle Genetics Inc |
Avristatinski konjugati in njihova uporaba za zdravljenje raka avtoimunske bolezni ali infekcijskebolezni
|
|
AU2003260370B2
(en)
|
2002-08-05 |
2008-05-22 |
Silence Therapeutics Gmbh |
Further novel forms of interfering RNA molecules
|
|
US7956176B2
(en)
|
2002-09-05 |
2011-06-07 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
|
EP2305812A3
(en)
|
2002-11-14 |
2012-06-06 |
Dharmacon, Inc. |
Fuctional and hyperfunctional sirna
|
|
WO2006006948A2
(en)
|
2002-11-14 |
2006-01-19 |
Dharmacon, Inc. |
METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY
|
|
US7250496B2
(en)
|
2002-11-14 |
2007-07-31 |
Rosetta Genomics Ltd. |
Bioinformatically detectable group of novel regulatory genes and uses thereof
|
|
JP4777777B2
(ja)
|
2002-11-25 |
2011-09-21 |
雅文 松尾 |
ｍＲＮＡ前駆体のスプライシングを修飾するＥＮＡ核酸医薬
|
|
US8084582B2
(en)
|
2003-03-03 |
2011-12-27 |
Xencor, Inc. |
Optimized anti-CD20 monoclonal antibodies having Fc variants
|
|
CA2524255C
(en)
|
2003-03-21 |
2014-02-11 |
Academisch Ziekenhuis Leiden |
Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure
|
|
WO2004090105A2
(en)
|
2003-04-02 |
2004-10-21 |
Dharmacon, Inc. |
Modified polynucleotides for use in rna interference
|
|
US20040224893A1
(en)
|
2003-05-06 |
2004-11-11 |
Li-Hsien Wang |
Methods of using IL-1 antagonists to treat neointimal hyperplasia
|
|
US7276497B2
(en)
|
2003-05-20 |
2007-10-02 |
Immunogen Inc. |
Cytotoxic agents comprising new maytansinoids
|
|
DK1633767T3
(en)
|
2003-06-02 |
2019-03-25 |
Univ Massachusetts |
METHODS AND COMPOSITIONS FOR MANAGING THE EFFECT OF RNA SILENCING
|
|
US7750144B2
(en)
|
2003-06-02 |
2010-07-06 |
University Of Massachusetts |
Methods and compositions for enhancing the efficacy and specificity of RNA silencing
|
|
ES2357116T5
(es)
|
2003-06-02 |
2021-09-03 |
Univ Massachusetts |
Métodos y composiciones para mejorar la eficacia y especificad de FNAi
|
|
AU2004263830B2
(en)
|
2003-06-13 |
2008-12-18 |
Alnylam Pharmaceuticals, Inc. |
Double-stranded ribonucleic acid with increased effectiveness in an organism
|
|
GB0416511D0
(en)
|
2003-10-22 |
2004-08-25 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
US8133733B2
(en)
|
2003-10-24 |
2012-03-13 |
Gencia Corporation |
Nonviral vectors for delivering polynucleotides to target tissues
|
|
US7498298B2
(en)
|
2003-11-06 |
2009-03-03 |
Seattle Genetics, Inc. |
Monomethylvaline compounds capable of conjugation to ligands
|
|
US7494925B2
(en)
|
2004-02-23 |
2009-02-24 |
Micron Technology, Inc. |
Method for making through-hole conductors for semiconductor substrates
|
|
US8389710B2
(en)
|
2004-02-27 |
2013-03-05 |
Operational Technologies Corporation |
Therapeutic nucleic acid-3′-conjugates
|
|
JP5166861B2
(ja)
|
2004-03-09 |
2013-03-21 |
スピロゲン リミティッド |
ピロロベンゾジアゼピン
|
|
AU2005222965B8
(en)
|
2004-03-15 |
2010-07-01 |
City Of Hope |
Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
|
|
WO2005094364A2
(en)
*
|
2004-03-31 |
2005-10-13 |
Chimeric Technologies, Inc. |
Iga antibody protein as a cytotoxic drug
|
|
KR101147147B1
(ko)
|
2004-04-01 |
2012-05-25 |
머크 샤프 앤드 돔 코포레이션 |
Ｒｎａ 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드
|
|
EP2399924B1
(en)
|
2004-05-27 |
2015-01-28 |
Alnylam Pharmaceuticals, Inc. |
Nuclease resistant double-stranded ribonucleic acid
|
|
ATE498685T1
(de)
|
2004-06-28 |
2011-03-15 |
Univ Western Australia |
Antisense-oligonukleotide zur induktion von exon- skipping sowie verfahren zur verwendung davon
|
|
FR2874384B1
(fr)
|
2004-08-17 |
2010-07-30 |
Genethon |
Vecteur viral adeno-associe pour realiser du saut d'exons dans un gene codant une proteine a domaines dispensables
|
|
WO2006132670A2
(en)
|
2004-11-12 |
2006-12-14 |
Seattle Genetics, Inc. |
Auristatins having an aminobenzoic acid unit at the n terminus
|
|
US7429482B2
(en)
|
2005-01-13 |
2008-09-30 |
United States Of America As Represented By The Department Of Veterans Affairs |
Screening tools for discovery of novel anabolic agents
|
|
CA2602663A1
(en)
*
|
2005-03-31 |
2006-10-05 |
Xencor, Inc. |
Fc variants with optimized properties
|
|
PL1879901T3
(pl)
|
2005-04-21 |
2010-06-30 |
Medimmune Ltd |
Pirolobenzodiazepiny
|
|
NZ563206A
(en)
|
2005-04-22 |
2009-09-25 |
Academisch Ziekenhuis Leiden |
Modulation of exon recognition in pre-mRNA by interfering with the binding or SR proteins and by interfering with secondary RNA structure
|
|
KR20080028886A
(ko)
*
|
2005-05-26 |
2008-04-02 |
앙상블 디스커버리 코포레이션 |
핵산-템플레이팅된 화학 반응에 의한 생검출
|
|
US7736647B2
(en)
*
|
2005-06-15 |
2010-06-15 |
Monoclonal Antibodies Therapeutics |
Anti-CD71 monoclonal antibodies and uses thereof for treating malignant tumor cells
|
|
US8871720B2
(en)
|
2005-07-07 |
2014-10-28 |
Seattle Genetics, Inc. |
Monomethylvaline compounds having phenylalanine carboxy modifications at the C-terminus
|
|
CA2619533C
(en)
*
|
2005-08-17 |
2014-02-04 |
Bioneer Corporation |
Sirna-hydrophilic polymer conjugates for intracellular delivery of sirna and method thereof
|
|
WO2007027894A2
(en)
|
2005-08-29 |
2007-03-08 |
Isis Pharmaceuticals, Inc. |
Antisense compounds having enhanced anti-microrna activity
|
|
WO2007028065A2
(en)
|
2005-08-30 |
2007-03-08 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds for modulation of splicing
|
|
KR100699874B1
(ko)
*
|
2005-11-08 |
2007-03-28 |
삼성전자주식회사 |
삽입형 연결부를 갖는 비. 지. 에이 패키지 그 제조방법 및이를 포함하는 보드 구조
|
|
SI1813614T1
(sl)
|
2006-01-25 |
2012-01-31 |
Sanofi 174 |
Citotoksična sredstva, ki obsegajo nove tomajmicinske derivate
|
|
US7750116B1
(en)
|
2006-02-18 |
2010-07-06 |
Seattle Genetics, Inc. |
Antibody drug conjugate metabolites
|
|
DK2735568T3
(da)
|
2006-05-10 |
2017-11-13 |
Sarepta Therapeutics Inc |
Oligonukleotidanaloger med kationiske bindinger mellem underenheder
|
|
WO2007136758A2
(en)
*
|
2006-05-19 |
2007-11-29 |
Board Of Regents, The University Of Texas System |
Sirna inhibition of p13k p85, p110, and akt2 and methods of use
|
|
EP1857548A1
(en)
|
2006-05-19 |
2007-11-21 |
Academisch Ziekenhuis Leiden |
Means and method for inducing exon-skipping
|
|
US8598333B2
(en)
|
2006-05-26 |
2013-12-03 |
Alnylam Pharmaceuticals, Inc. |
SiRNA silencing of genes expressed in cancer
|
|
US7521232B2
(en)
|
2006-05-31 |
2009-04-21 |
Icx Nomadics, Inc. |
Emissive species for clinical imaging
|
|
CN101563105B
(zh)
|
2006-07-10 |
2013-01-23 |
拜奥根Idec马萨诸塞公司 |
用于抑制smad4-缺陷癌症的组合物和方法
|
|
AU2007282224B2
(en)
|
2006-08-11 |
2013-08-29 |
Vico Therapeutics B.V. |
Methods and means for treating DNA repeat instability associated genetic disorders
|
|
US9371348B2
(en)
|
2006-11-27 |
2016-06-21 |
The Trustees Of The University Of Pennsylvania |
Photocleavable oligonucleotide and uses thereof
|
|
US8980833B2
(en)
|
2007-05-10 |
2015-03-17 |
R&D-Biopharmaceuticals Gmbh |
Tubulysine derivatives
|
|
US9063129B2
(en)
|
2007-06-15 |
2015-06-23 |
Idexx Laboratories, Inc. |
Device, kit and method for hookworm antigen capture and detection
|
|
EP3443976A1
(en)
|
2007-06-29 |
2019-02-20 |
Sarepta Therapeutics, Inc. |
Tissue specific peptide conjugates and methods
|
|
PL2019104T3
(pl)
|
2007-07-19 |
2014-03-31 |
Sanofi Sa |
Środki cytotoksyczne obejmujące nowe pochodne tomaymycyny i ich zastosowanie terapeutyczne
|
|
JP2010537640A
(ja)
|
2007-08-27 |
2010-12-09 |
ボストン バイオメディカル， インコーポレイテッド |
マイクロｒｎａ模倣剤または阻害剤としての非対称性ｒｎａ二重鎖の組成物
|
|
CA2704737A1
(en)
|
2007-09-18 |
2009-09-03 |
Intradigm Corporation |
Compositions comprising k-ras sirna and methods of use
|
|
DK2548962T3
(en)
|
2007-09-19 |
2016-04-11 |
Applied Biosystems Llc |
Sirna sequence-independent modification formats to reduce off-target phenotype effects in RNAI and stabilized forms thereof
|
|
RU2476441C2
(ru)
|
2007-10-19 |
2013-02-27 |
Сиэтл Дженетикс, Инк. |
Cd19-связывающие средства и их применение
|
|
AU2008317566B2
(en)
|
2007-10-26 |
2014-05-01 |
Academisch Ziekenhuis Leiden |
Means and methods for counteracting muscle disorders
|
|
EP2220102B1
(en)
|
2007-11-06 |
2014-04-16 |
Clinical Micro Sensors, Inc. |
Baseless nucleotide analogues and uses thereof
|
|
JP2011509675A
(ja)
|
2008-01-18 |
2011-03-31 |
メディミューン，エルエルシー |
部位特異的コンジュゲーションのためのシステイン操作抗体
|
|
WO2009099942A2
(en)
|
2008-01-31 |
2009-08-13 |
Alnylam Pharmaceuticals, Inc. |
Chemically modified oligonucleotides and uses thereof
|
|
US20110081362A1
(en)
|
2008-01-31 |
2011-04-07 |
The Brigham And Women's Hospital, Inc. |
Treatment of cancer
|
|
MX2010008024A
(es)
|
2008-02-01 |
2010-12-21 |
Ascendis Pharma As |
Profarmaco que comprende un enlazador que se puede separar por si mismo.
|
|
US10131904B2
(en)
|
2008-02-11 |
2018-11-20 |
Rxi Pharmaceuticals Corporation |
Modified RNAi polynucleotides and uses thereof
|
|
EP2265283B1
(en)
|
2008-03-18 |
2014-09-03 |
Seattle Genetics, Inc. |
Auristatin drug linker conjugates
|
|
TWI465247B
(zh)
|
2008-04-11 |
2014-12-21 |
Catalyst Biosciences Inc |
經修飾的因子ｖｉｉ多肽和其用途
|
|
WO2009126933A2
(en)
|
2008-04-11 |
2009-10-15 |
Alnylam Pharmaceuticals, Inc. |
Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
|
|
JP5667043B2
(ja)
|
2008-04-15 |
2015-02-12 |
アメリカ合衆国ＧＯＶＥＲＮＭＥＮＴ ＯＦ ＴＨＥ ＵＮＩＴＥＤ ＳＴＡＴＥＳ ＯＦ ＡＭＥＲＩＣＡ， ａｓ ｒｅｐｒｅｓｅｎｔｅｄ ｂｙ ＴＨＥ ＳＥＣＲＥＴＡＲＹ， ＤＥＰＡＲＴＭＥＮＴ ＯＦ ＨＥＡＬＴＨＡＮＤ ＨＵＭＡＮ ＳＥＲＶＩＣＥＳ |
阻害性オリゴヌクレオチドを送達するための組成物および方法
|
|
US8248352B2
(en)
|
2008-04-25 |
2012-08-21 |
Lg Display Co., Ltd. |
Driving circuit of liquid crystal display
|
|
EP2119783A1
(en)
|
2008-05-14 |
2009-11-18 |
Prosensa Technologies B.V. |
Method for efficient exon (44) skipping in Duchenne Muscular Dystrophy and associated means
|
|
US20110130346A1
(en)
|
2008-05-30 |
2011-06-02 |
Isis Innovation Limited |
Peptide conjugates for delvery of biologically active compounds
|
|
US8575305B2
(en)
|
2008-06-04 |
2013-11-05 |
Medical Research Council |
Cell penetrating peptides
|
|
WO2010005740A2
(en)
*
|
2008-06-16 |
2010-01-14 |
Bind Biosciences, Inc. |
Methods for the preparation of targeting agent functionalized diblock copolymers for use in fabrication of therapeutic targeted nanoparticles
|
|
GB0813432D0
(en)
|
2008-07-22 |
2008-08-27 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
JP5028355B2
(ja)
*
|
2008-08-01 |
2012-09-19 |
株式会社オティックス |
可変動弁機構
|
|
JP5583667B2
(ja)
|
2008-08-08 |
2014-09-03 |
ジェニスフィア・エルエルシー |
長時間作用型ｄｎａデンドリマーおよびその方法
|
|
WO2010019718A2
(en)
|
2008-08-13 |
2010-02-18 |
California Institute Of Technology |
Carrier nanoparticles and related compositions, methods and systems
|
|
US9433684B2
(en)
|
2008-08-19 |
2016-09-06 |
Nektar Therapeutics |
Conjugates of small-interfering nucleic acids
|
|
EP3208337A1
(en)
|
2008-09-02 |
2017-08-23 |
Alnylam Pharmaceuticals, Inc. |
Compositions for combined inhibition of mutant egfr and il-6 expression
|
|
US8084601B2
(en)
|
2008-09-11 |
2011-12-27 |
Royal Holloway And Bedford New College Royal Holloway, University Of London |
Oligomers
|
|
CA2746527A1
(en)
|
2008-09-22 |
2010-03-25 |
Rxi Pharmaceuticals Corporation |
Rna interference in skin indications
|
|
AU2013204438B2
(en)
|
2008-10-24 |
2016-12-22 |
Sarepta Therapeutics, Inc. |
Multiple exon skipping compositions for DMD
|
|
CN112574988A
(zh)
|
2008-10-24 |
2021-03-30 |
萨雷普塔治疗公司 |
用于dmd的多外显子跳跃组合物
|
|
JP5786109B2
(ja)
|
2008-10-27 |
2015-09-30 |
プロセンサ テクノロジーズ ベー．フェー． |
Ｄｕｃｈｅｎｎｅ型筋ジストロフィーｍＲＮＡ前駆体のエクソン４５の効率的なスキッピングのための方法及び手段
|
|
KR101602431B1
(ko)
|
2008-11-05 |
2016-03-10 |
삼성전자 주식회사 |
냉장고
|
|
RU2572826C2
(ru)
|
2008-12-02 |
2016-01-20 |
Чиралджен, Лтд. |
Способ синтеза модифицированных по атому фосфора нуклеиновых кислот
|
|
US20100249214A1
(en)
|
2009-02-11 |
2010-09-30 |
Dicerna Pharmaceuticals |
Multiplex dicer substrate rna interference molecules having joining sequences
|
|
CN102365021B
(zh)
|
2009-02-05 |
2015-07-15 |
伊缪诺金公司 |
新型苯并二氮杂*衍生物
|
|
US8481698B2
(en)
|
2009-03-19 |
2013-07-09 |
The President And Fellows Of Harvard College |
Parallel proximity ligation event analysis
|
|
TWI507205B
(zh)
*
|
2009-03-25 |
2015-11-11 |
Genentech Inc |
抗ｆｇｆｒ３抗體及使用方法
|
|
CA2757354A1
(en)
|
2009-04-02 |
2010-10-07 |
Laura P.W. Ranum |
Nucleotide repeat expansion-associated polypeptides and uses thereof
|
|
US20120149756A1
(en)
|
2009-04-10 |
2012-06-14 |
Associatin Institut de Myologie |
Tricyclo-dna antisense oligonucleotides, compositions, and methods for the treatment of disease
|
|
CA2759899A1
(en)
|
2009-04-24 |
2010-10-28 |
Prosensa Technologies B.V. |
Oligonucleotide comprising an inosine for treating dmd
|
|
BRPI1011269A2
(pt)
|
2009-05-05 |
2016-09-27 |
Altermune Technologies Llc |
imunidade quimicamente programável
|
|
CA2763935A1
(en)
|
2009-06-04 |
2010-12-09 |
Novartis Ag |
Methods for identification of sites for igg conjugation
|
|
AU2010270979B2
(en)
|
2009-06-22 |
2015-04-23 |
Medimmune, Llc |
Engineered Fc regions for site-specific conjugation
|
|
US20110269665A1
(en)
|
2009-06-26 |
2011-11-03 |
Avi Biopharma, Inc. |
Compound and method for treating myotonic dystrophy
|
|
SG177560A1
(en)
*
|
2009-07-06 |
2012-03-29 |
Hoffmann La Roche |
Bi-specific digoxigenin binding antibodies
|
|
US8927513B2
(en)
|
2009-07-07 |
2015-01-06 |
Alnylam Pharmaceuticals, Inc. |
5′ phosphate mimics
|
|
IT1394860B1
(it)
|
2009-07-22 |
2012-07-20 |
Kemotech S R L |
Composti farmaceutici
|
|
US20120258104A1
(en)
*
|
2009-07-22 |
2012-10-11 |
Cenix Bioscience Gmbh |
Delivery System and Conjugates For Compound Delivery Via Naturally Occurring Intracellular Transport Routes
|
|
US20120172415A1
(en)
|
2009-08-31 |
2012-07-05 |
Thomas Voit |
Exon Skipping Therapy for Functional Amelioration of Semifunctional Dystrophin in Becker and Duchenne Muscular Dystrophy
|
|
WO2011044368A1
(en)
|
2009-10-07 |
2011-04-14 |
Macrogenics, Inc. |
Fc region-containing polypeptides that exhibit improved effector function due to alterations of the extent of fucosylation, and methods for their use
|
|
LT2499249T
(lt)
|
2009-11-12 |
2018-12-27 |
The University Of Western Australia |
Priešprasmės molekulės ir patologijų gydymo būdai
|
|
WO2011078797A2
(en)
|
2009-12-22 |
2011-06-30 |
Singapore Health Services Pte. Ltd |
Antisense oligonucleotides and uses threreof
|
|
MX339083B
(es)
|
2010-01-28 |
2016-04-01 |
Glaxo Group Ltd |
Proteinas de enlace a cd127.
|
|
US8846875B2
(en)
|
2010-02-12 |
2014-09-30 |
Solulink, Inc. |
Preparation and/or purification of oligonucleotide conjugates
|
|
DK2558578T3
(en)
|
2010-04-13 |
2016-01-25 |
Life Technologies Corp |
CONFIGURATIONS AND METHODS FOR INHIBITION OF nucleic acid function
|
|
MX391454B
(es)
|
2010-04-15 |
2025-03-05 |
Seagen Inc |
Compuesto de engarce-fármaco para conjugación a una unidad de ligando.
|
|
US8697688B2
(en)
|
2010-04-15 |
2014-04-15 |
Seattle Genetics Inc. |
Pyrrolobenzodiazepines used to treat proliferative diseases
|
|
KR101869570B1
(ko)
|
2010-04-28 |
2018-06-20 |
아이오니스 파마수티컬즈, 인코포레이티드 |
변형된 뉴클레오사이드 및 그로부터 제조된 올리고머 화합물
|
|
WO2011139699A2
(en)
|
2010-04-28 |
2011-11-10 |
Isis Pharmaceuticals, Inc. |
5' modified nucleosides and oligomeric compounds prepared therefrom
|
|
KR20200133284A
(ko)
|
2010-05-28 |
2020-11-26 |
사렙타 쎄러퓨틱스, 인코퍼레이티드 |
변형된 서브유니트간 결합 및/또는 말단 그룹을 갖는 올리고뉴클레오타이드 유사체
|
|
IT1400425B1
(it)
|
2010-06-08 |
2013-05-31 |
Amsterdam Molecular Therapeutics Bv |
Modified snrnas for use in therapy.
|
|
EP2580326A1
(en)
|
2010-06-11 |
2013-04-17 |
Antisense Pharma GmbH |
Method for selective oligonucleotide modification
|
|
WO2012012467A2
(en)
|
2010-07-19 |
2012-01-26 |
Isis Pharmaceuticals, Inc. |
Modulation of nuclear-retained rna
|
|
EP2409983A1
(en)
|
2010-07-19 |
2012-01-25 |
Leibniz-Institut für Pflanzenbiochemie (IPB) |
Tubulysin analogues
|
|
WO2012024535A2
(en)
|
2010-08-18 |
2012-02-23 |
Fred Hutchinson Cancer Research Center |
Methods for determining the presence or risk of developing facioscapulohumeral dystrophy (fshd)
|
|
US20130195799A1
(en)
|
2010-08-19 |
2013-08-01 |
Peg Biosciences, Inc. |
Synergistic biomolecule-polymer conjugates
|
|
WO2012031243A2
(en)
|
2010-09-03 |
2012-03-08 |
Avi Biopharma, Inc. |
dsRNA MOLECULES COMPRISING OLIGONUCLEOTIDE ANALOGS HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS
|
|
WO2012058210A1
(en)
|
2010-10-29 |
2012-05-03 |
Merck Sharp & Dohme Corp. |
RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA)
|
|
CN103269712B
(zh)
|
2010-11-03 |
2016-09-21 |
伊缪诺金公司 |
包含新型安丝菌素衍生物的细胞毒性剂
|
|
US8501930B2
(en)
|
2010-12-17 |
2013-08-06 |
Arrowhead Madison Inc. |
Peptide-based in vivo siRNA delivery system
|
|
NZ611656A
(en)
*
|
2010-12-29 |
2014-10-31 |
Arrowhead Res Corp |
In vivo polynucleotide delivery conjugates having enzyme sensitive linkages
|
|
EP2672977A1
(en)
|
2011-02-08 |
2013-12-18 |
The Charlotte-Mecklenburg Hospital Authority d/b/a Carolina Healthcare System |
Antisense oligonucleotides
|
|
US9045750B2
(en)
|
2011-03-18 |
2015-06-02 |
Yuelong Ma |
Humanized lewis-Y specific antibody-based delivery of dicer substrate siRNA (D-siRNA) against STAT3
|
|
SG10201602394QA
(en)
|
2011-03-29 |
2016-05-30 |
Roche Glycart Ag |
Antibody FC Variants
|
|
US20140128449A1
(en)
|
2011-04-07 |
2014-05-08 |
The Board Of Regents Of The University Of Texas System |
Oligonucleotide modulation of splicing
|
|
US9161948B2
(en)
|
2011-05-05 |
2015-10-20 |
Sarepta Therapeutics, Inc. |
Peptide oligonucleotide conjugates
|
|
US9598496B2
(en)
*
|
2011-05-09 |
2017-03-21 |
Perseus Proteomics Inc. |
Antibody capable of specifically recognizing transferrin receptor
|
|
CN103648532A
(zh)
|
2011-06-21 |
2014-03-19 |
伊缪诺金公司 |
具有肽连接子的新型美登木素生物碱衍生物及其偶联物
|
|
EP2732035A2
(en)
|
2011-07-15 |
2014-05-21 |
Sarepta Therapeutics, Inc. |
Methods and compositions for manipulating translation of protein isoforms from alternative initiation start sites
|
|
AU2012284265B2
(en)
|
2011-07-19 |
2017-08-17 |
Wave Life Sciences Ltd. |
Methods for the synthesis of functionalized nucleic acids
|
|
US9418216B2
(en)
|
2011-07-21 |
2016-08-16 |
Microsoft Technology Licensing, Llc |
Cloud service authentication
|
|
AU2012286994B2
(en)
|
2011-07-25 |
2017-08-10 |
Nationwide Children's Hospital, Inc. |
Recombinant virus products and methods for inhibition of expression of DUX4
|
|
EP3453761A1
(en)
|
2011-08-29 |
2019-03-13 |
Ionis Pharmaceuticals, Inc. |
Oligomer-conjugate complexes and their use
|
|
CN103998458B
(zh)
|
2011-08-30 |
2018-10-09 |
医学研究理事会 |
具有中央疏水域的细胞穿透肽
|
|
ES2945932T3
(es)
|
2011-10-14 |
2023-07-10 |
Seagen Inc |
Pirrolobenzodiazepinas y conjugados dirigidos
|
|
WO2013071079A1
(en)
|
2011-11-09 |
2013-05-16 |
President And Fellows Of Harvard College |
Lin28/let-7 crystal structures, purification protocols, and molecular probes suitable for screening assays and therapeutics
|
|
EP2780454A2
(en)
|
2011-11-18 |
2014-09-24 |
Alnylam Pharmaceuticals, Inc. |
Modified rnai agents
|
|
CN104244718A
(zh)
|
2011-12-05 |
2014-12-24 |
伊格尼卡生物治疗公司 |
抗体-药物缀合物以及相关化合物、组合物和方法
|
|
AU2012353330B2
(en)
*
|
2011-12-16 |
2018-04-19 |
National University Corporation Tokyo Medical And Dental University |
Chimeric double-stranded nucleic acid
|
|
JP2015502397A
(ja)
|
2011-12-23 |
2015-01-22 |
ファイザー・インク |
部位特異的コンジュゲーションのための操作された抗体定常領域、ならびにそのための方法および使用
|
|
TW201333040A
(zh)
*
|
2012-01-06 |
2013-08-16 |
Bioalliance Cv |
抗－輸鐵蛋白受器之抗體及其使用方法
|
|
US9234048B2
(en)
*
|
2012-01-18 |
2016-01-12 |
Wisconsin Alumni Research Foundation |
Boronate-mediated delivery of molecules into cells
|
|
CN112251436A
(zh)
|
2012-01-27 |
2021-01-22 |
比奥马林技术公司 |
治疗杜兴型肌营养不良症和贝克型肌营养不良症的具有改善特性的rna调节性寡核苷酸
|
|
WO2013121175A1
(en)
|
2012-02-16 |
2013-08-22 |
Ucl Business Plc |
Lysosome-cleavable linker
|
|
CA2864872C
(en)
|
2012-02-24 |
2022-07-05 |
Alteogen Inc. |
Modified antibody in which motif comprising cysteine residue is bound
|
|
US9610362B2
(en)
|
2012-03-16 |
2017-04-04 |
Valerion Therapeutics, Llc |
Antisense conjugates for decreasing expression of DMPK
|
|
AR090905A1
(es)
|
2012-05-02 |
2014-12-17 |
Merck Sharp & Dohme |
Conjugados que contienen tetragalnac y peptidos y procedimientos para la administracion de oligonucleotidos, composicion farmaceutica
|
|
EP3272868A1
(en)
|
2012-05-02 |
2018-01-24 |
Arrowhead Pharmaceuticals, Inc. |
Organic compositions to treat kras-related diseases
|
|
US9981046B2
(en)
|
2012-05-15 |
2018-05-29 |
Concortis Biosystems, Corp., a wholly owned Subsidiary of Sorrento Therapeutics, Inc. |
Drug-conjugates, conjugation methods, and uses thereof
|
|
US9504756B2
(en)
|
2012-05-15 |
2016-11-29 |
Seattle Genetics, Inc. |
Self-stabilizing linker conjugates
|
|
EP2870246B1
(en)
|
2012-07-03 |
2019-09-11 |
BioMarin Technologies B.V. |
Oligonucleotide for the treatment of muscular dystrophy patients
|
|
JP6453212B2
(ja)
|
2012-07-13 |
2019-01-16 |
ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． |
キラル制御
|
|
US9950001B2
(en)
|
2012-08-20 |
2018-04-24 |
The Regents Of The University Of California |
Polynucleotides having bioreversible groups
|
|
CN104837502B
(zh)
|
2012-10-12 |
2018-08-10 |
麦迪穆有限责任公司 |
吡咯并苯并二氮杂卓及其结合物
|
|
AU2013336581A1
(en)
|
2012-10-26 |
2015-06-11 |
Nlife Therapeutics, S.L. |
Compositions and methods for the treatment of Parkinson disease by the selective delivery of oligonucleotide molecules to specific neuron types
|
|
EP2915815B1
(en)
|
2012-10-31 |
2018-01-17 |
Takeda Pharmaceutical Company Limited |
New modified nucleic acid
|
|
US10077443B2
(en)
*
|
2012-11-15 |
2018-09-18 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotide conjugates
|
|
US10131682B2
(en)
|
2012-11-24 |
2018-11-20 |
Hangzhou Dac Biotech Co., Ltd. |
Hydrophilic linkers and their uses for conjugation of drugs to a cell binding molecules
|
|
CA2894899A1
(en)
|
2012-12-20 |
2014-06-26 |
Sarepta Therapeutics, Inc. |
Improved exon skipping compositions for treating muscular dystrophy
|
|
RU2015129800A
(ru)
|
2012-12-21 |
2017-01-30 |
Биоэллаенс К. В. |
Гидрофильные саморазрушающиеся линкеры и их конъюгаты
|
|
US9481905B2
(en)
|
2013-02-19 |
2016-11-01 |
Orizhan Bioscience Limited |
Method of using neutrilized DNA (N-DNA) as surface probe for high throughput detection platform
|
|
US9319764B2
(en)
|
2013-03-08 |
2016-04-19 |
Merry Electronics Co., Ltd. |
MEMS microphone packaging structure
|
|
SG11201507214SA
(en)
|
2013-03-13 |
2015-10-29 |
Medimmune Ltd |
Pyrrolobenzodiazepines and conjugates thereof
|
|
NZ731587A
(en)
|
2013-03-14 |
2021-07-30 |
Sarepta Therapeutics Inc |
Exon skipping compositions for treating muscular dystrophy
|
|
CA2906812A1
(en)
|
2013-03-15 |
2014-09-18 |
Sarepta Therapeutics, Inc. |
Improved compositions for treating muscular dystrophy
|
|
MX379256B
(es)
|
2013-03-15 |
2025-03-10 |
Regeneron Pharma |
Moleculas biologicamente activas, conjugados de las mismas, y usos terapeuticos.
|
|
US9577459B2
(en)
|
2013-03-15 |
2017-02-21 |
Sequana Medical Ag |
Systems and methods for regulating inductive energy transfer to an implantable system
|
|
EP2777714A1
(en)
|
2013-03-15 |
2014-09-17 |
NBE-Therapeutics LLC |
Method of producing an immunoligand/payload conjugate by means of a sequence-specific transpeptidase enzyme
|
|
CN105378083B
(zh)
*
|
2013-03-27 |
2018-09-21 |
伊萨纳治疗有限公司 |
修饰的TGF-β寡核苷酸
|
|
US9295731B2
(en)
|
2013-04-01 |
2016-03-29 |
Mark Quang Nguyen |
Cleavable drug conjugates, compositions thereof and methods of use
|
|
WO2014169049A1
(en)
|
2013-04-09 |
2014-10-16 |
Duke University |
2' fluoro-modified rnas as immunostimulators
|
|
US9849066B2
(en)
|
2013-04-24 |
2017-12-26 |
Corning Incorporated |
Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
|
|
WO2014177042A1
(zh)
|
2013-04-28 |
2014-11-06 |
Qin Gang |
一种新型的连接子及其制备方法和用途
|
|
WO2014189973A2
(en)
|
2013-05-20 |
2014-11-27 |
Genentech, Inc. |
Anti-transferrin receptor antibodies and methods of use
|
|
WO2014190441A1
(en)
|
2013-05-31 |
2014-12-04 |
Zymeworks Inc. |
Heteromultimers with reduced or silenced effector function
|
|
EP3004370B1
(en)
|
2013-06-05 |
2024-08-21 |
Duke University |
Rna-guided gene editing and gene regulation
|
|
US11229711B2
(en)
|
2013-06-06 |
2022-01-25 |
Magenta Therapeutics, Inc. |
Linkers for antibody-drug conjugates and related compounds, compositions, and methods of use
|
|
WO2014197871A2
(en)
|
2013-06-06 |
2014-12-11 |
Igenica Biotherapeutics, Inc. |
Antibody-drug conjugates, compositions and methods of use
|
|
TW201536329A
(zh)
|
2013-08-09 |
2015-10-01 |
Isis Pharmaceuticals Inc |
用於調節失養性肌強直蛋白質激酶(dmpk)表現之化合物及方法
|
|
EP2845607A1
(en)
|
2013-09-09 |
2015-03-11 |
University of Vienna |
Antisense oligonucleotides with improved pharmacokinetic properties
|
|
WO2015038426A1
(en)
|
2013-09-13 |
2015-03-19 |
Asana Biosciences, Llc |
Self-immolative linkers containing mandelic acid derivatives, drug-ligand conjugates for targeted therapies and uses thereof
|
|
EP3052654A4
(en)
|
2013-09-30 |
2017-05-03 |
The Regents of the University of California |
Identification of structurally similar small molecules that enhance therapeutic exon skipping
|
|
WO2015057876A1
(en)
|
2013-10-15 |
2015-04-23 |
Sorrento Therapeutics Inc. |
Drug-conjugates with a targeting molecule and two different drugs
|
|
ES2826398T3
(es)
|
2013-10-15 |
2021-05-18 |
Seagen Inc |
Enlazadores-fármacos pegilados para una mejor farmacocinética de los conjugados ligando-fármaco
|
|
WO2015069587A2
(en)
|
2013-11-06 |
2015-05-14 |
Merck Sharp & Dohme Corp. |
Peptide containing conjugates for dual molecular delivery of oligonucleotides
|
|
WO2015075747A1
(en)
|
2013-11-19 |
2015-05-28 |
Council Of Scientific And Industrial Research |
Cell-penetrating peptide for biomolecule delivery
|
|
US10378017B2
(en)
|
2013-12-02 |
2019-08-13 |
Brandeis University |
High temperature selection of nucleotide-supported carbohydrate vaccines and resulting glycosylated oligonucleotides
|
|
ES2917473T3
(es)
|
2014-01-16 |
2022-07-08 |
Wave Life Sciences Ltd |
Diseño quiral
|
|
WO2015113922A1
(en)
|
2014-01-30 |
2015-08-06 |
Roche Innovation Center Copenhagen A/S |
Poly oligomer compound with biocleavable conjugates
|
|
SMT201900169T1
(it)
|
2014-03-12 |
2019-05-10 |
Nippon Shinyaku Co Ltd |
Acido nucleico antisenso
|
|
TWI731535B
(zh)
*
|
2014-03-21 |
2021-06-21 |
美商艾伯維有限公司 |
抗-egfr抗體及抗體藥物結合物
|
|
WO2015168661A1
(en)
|
2014-05-01 |
2015-11-05 |
Smith Larry J |
METHODS AND MODIFICATIONS THAT PRODUCE ssRNAi COMPOUNDS WITH ENHANCED ACTIVITY, POTENCY AND DURATION OF EFFECT
|
|
US20170182189A1
(en)
|
2014-05-23 |
2017-06-29 |
Genzyme Corporation |
Inhibiting or downregulating glycogen synthase by creating premature stop codons using antisense oligonucleotides
|
|
RU2695430C2
(ru)
|
2014-06-17 |
2019-07-23 |
Ниппон Синяку Ко., Лтд. |
Антисмысловые нуклеиновые кислоты
|
|
TWI695011B
(zh)
|
2014-06-18 |
2020-06-01 |
美商梅爾莎納醫療公司 |
抗ｈｅｒ２表位之單株抗體及其使用之方法
|
|
CN106795515B
(zh)
|
2014-06-23 |
2021-06-08 |
孟山都技术公司 |
用于经由rna干扰调控基因表达的组合物和方法
|
|
IL316808A
(en)
|
2014-08-20 |
2025-01-01 |
Alnylam Pharmaceuticals Inc |
Modified double-stranded RNA materials and their uses
|
|
EP3221362B1
(en)
|
2014-11-19 |
2019-07-24 |
F.Hoffmann-La Roche Ag |
Anti-transferrin receptor antibodies and methods of use
|
|
AU2016206475B2
(en)
|
2015-01-16 |
2021-11-04 |
City Of Hope |
Cell penetrating antibodies
|
|
SMT202000454T1
(it)
|
2015-04-03 |
2020-11-10 |
Univ Massachusetts |
Cmposti oligonucleotidici per bersagliare l'mrn della huntingtina
|
|
EP3286318A2
(en)
|
2015-04-22 |
2018-02-28 |
Mina Therapeutics Limited |
Sarna compositions and methods of use
|
|
US20180344817A1
(en)
|
2015-05-01 |
2018-12-06 |
Precision Biosciences, Inc. |
Precise deletion of chromosomal sequences in vivo and treatment of nucleotide repeat expansion disorders using engineered nucleases
|
|
EP3297649B1
(en)
|
2015-05-19 |
2023-10-11 |
Sarepta Therapeutics, Inc. |
Peptide oligonucleotide conjugates
|
|
MX391086B
(es)
|
2015-06-24 |
2025-03-21 |
Hoffmann La Roche |
Anticuerpos anti-receptor de transferrina con afinidad diseñada.
|
|
KR20180038465A
(ko)
|
2015-08-07 |
2018-04-16 |
애로우헤드 파마슈티컬스 인코포레이티드 |
Ｂ형 간염 바이러스 감염에 대한 ｒｎａｉ 치료법
|
|
EA201890811A1
(ru)
|
2015-09-30 |
2018-09-28 |
Сарепта Терапьютикс, Инк. |
Способы лечения мышечной дистрофии
|
|
GB2545898B
(en)
|
2015-12-21 |
2019-10-09 |
Sutura Therapeutics Ltd |
Improved drug delivery by conjugating oligonucleotides to stitched/stapled peptides
|
|
WO2017148880A1
(en)
|
2016-03-01 |
2017-09-08 |
F. Hoffmann-La Roche Ag |
Obinutuzumab variants having altered cell death induction
|
|
WO2017173304A1
(en)
|
2016-04-01 |
2017-10-05 |
Avidity Biosciences Llc |
Kras nucleic acids and uses thereof
|
|
JP2019513371A
(ja)
|
2016-04-01 |
2019-05-30 |
アビディティー バイオサイエンシーズ エルエルシー |
核酸ポリペプチド組成物とその使用
|
|
WO2017192679A1
(en)
|
2016-05-04 |
2017-11-09 |
Wave Life Sciences Ltd. |
Methods and compositions of biologically active agents
|
|
CN109310765A
(zh)
|
2016-06-20 |
2019-02-05 |
领先基因生物技术股份有限公司 |
抗体-药物偶联物
|
|
US11427838B2
(en)
|
2016-06-29 |
2022-08-30 |
Vertex Pharmaceuticals Incorporated |
Materials and methods for treatment of myotonic dystrophy type 1 (DM1) and other related disorders
|
|
EP3532614A1
(en)
|
2016-10-28 |
2019-09-04 |
Genethon |
Compositions and methods for the treatment of myotonic dystrophy
|
|
CN110234762A
(zh)
|
2016-10-28 |
2019-09-13 |
吉尼松公司 |
用于治疗肌强直性营养不良的组合物和方法
|
|
KR102645243B1
(ko)
|
2016-11-23 |
2024-03-11 |
알닐람 파마슈티칼스 인코포레이티드 |
표적외 효과가 감소된 변형 rna 작용제
|
|
SMT202200366T1
(it)
|
2016-12-19 |
2022-11-18 |
Sarepta Therapeutics Inc |
Coniugati di oligomeri per salto di esone per distrofia muscolare
|
|
MX2019008199A
(es)
|
2017-01-06 |
2019-11-25 |
Avidity Biosciences Llc |
Composiciones de acido nucleico polipeptido y metodos de induccion de la omision de exon.
|
|
GB201711809D0
(en)
|
2017-07-21 |
2017-09-06 |
Governors Of The Univ Of Alberta |
Antisense oligonucleotide
|
|
DK3444010T3
(da)
|
2017-08-14 |
2021-03-15 |
Scandiedge Therapeutics Ab |
Pklr-inhibering i behandlingen af nafld og hcc
|
|
US20200282074A1
(en)
|
2017-09-22 |
2020-09-10 |
Avidity Biosciences, Inc. |
Nucleic acid-polypeptide compositions and methods of inducing exon skipping
|
|
WO2019071028A1
(en)
|
2017-10-04 |
2019-04-11 |
Avidity Biosciences Llc |
NUCLEIC ACID-POLYPEPTIDE COMPOSITIONS AND USES THEREOF
|
|
JP7506601B2
(ja)
|
2017-12-06 |
2024-06-26 |
アビディティー バイオサイエンシーズ，インク． |
筋萎縮症と筋緊張性ジストロフィーを処置するための組成物および方法
|
|
MA51583A
(fr)
|
2018-01-04 |
2020-11-11 |
Avidity Biosciences Inc |
Molécules d'acide nucléique hétéroduplex et leurs utilisations
|
|
US10910559B2
(en)
|
2018-06-01 |
2021-02-02 |
Massachusetts Institute Of Technology |
Optoelectronic memristor devices including one or more solid electrolytes with electrically controllable optical properties
|
|
JP7576542B2
(ja)
|
2018-08-02 |
2024-10-31 |
ダイン セラピューティクス，インコーポレーテッド |
筋標的化複合体およびそれらの使用
|
|
US20220193250A1
(en)
|
2018-08-02 |
2022-06-23 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
|
|
EP3829595A4
(en)
|
2018-08-02 |
2022-08-24 |
Dyne Therapeutics, Inc. |
MUSCLE-DIRECTED COMPLEXES AND USES THEREOF IN THE TREATMENT OF DYSTROPHINOPATHIES
|
|
CN109020990A
(zh)
|
2018-09-20 |
2018-12-18 |
广西壮族自治区药用植物园 |
苯基苯并呋喃化合物、及其制备方法、组合物和医药用途
|
|
IL312067B2
(en)
|
2018-12-21 |
2025-08-01 |
Avidity Biosciences Inc |
Anti-transferrin receptor antibodies and uses thereof
|
|
JP7592034B2
(ja)
|
2019-06-06 |
2024-11-29 |
アビディティー バイオサイエンシーズ，インク． |
核酸ポリペプチド組成物およびその使用
|
|
KR20220019259A
(ko)
|
2019-06-06 |
2022-02-16 |
어비디티 바이오사이언시스 인크. |
Una 아미다이트 및 이의 용도
|
|
US20220288218A1
(en)
|
2019-07-09 |
2022-09-15 |
The Governors Of The University Of Alberta |
Exons 45-55 skipping using mutation-tailored cocktails of antisense morpholinos in the dmd gene
|
|
US11555190B2
(en)
|
2020-03-19 |
2023-01-17 |
Avidity Biosciences, Inc. |
Compositions and methods of treating Facioscapulohumeral muscular dystrophy
|
|
AU2021241682B2
(en)
|
2020-03-27 |
2026-02-12 |
Avidity Biosciences, Inc. |
Compositions and methods of treating muscle dystrophy
|
|
US20230330246A1
(en)
|
2020-05-05 |
2023-10-19 |
Avidity Biosciences, Inc. |
Compositions and methods of treating pompe disease
|
|
EP4366783A4
(en)
|
2021-07-09 |
2025-08-27 |
Dyne Therapeutics Inc |
MUSCLE TARGETING COMPLEXES AND THEIR USES FOR THE TREATMENT OF DYSTROPHINOPATHIES
|
|
US11638761B2
(en)
|
2021-07-09 |
2023-05-02 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy
|
|
MX2024003266A
(es)
|
2021-09-16 |
2024-04-03 |
Avidity Biosciences Inc |
Composiciones y metodos de tratamiento de la distrofia muscular facioescapulohumeral.
|
|
US12071621B2
(en)
|
2022-04-05 |
2024-08-27 |
Avidity Biosciences, Inc. |
Anti-transferrin receptor antibody-PMO conjugates for inducing DMD exon 44 skipping
|