JP2021533198A5 - - Google Patents
Info
- Publication number
- JP2021533198A5 JP2021533198A5 JP2021529259A JP2021529259A JP2021533198A5 JP 2021533198 A5 JP2021533198 A5 JP 2021533198A5 JP 2021529259 A JP2021529259 A JP 2021529259A JP 2021529259 A JP2021529259 A JP 2021529259A JP 2021533198 A5 JP2021533198 A5 JP 2021533198A5
- Authority
- JP
- Japan
- Prior art keywords
- muscle
- oligonucleotide
- transferrin receptor
- complex according
- complex
- Prior art date
Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024184975A JP7708957B2 (ja) | 2018-08-02 | 2024-10-21 | 筋標的化複合体およびそれらの使用 |
| JP2025112731A JP2025175995A (ja) | 2018-08-02 | 2025-07-03 | 筋標的化複合体およびそれらの使用 |
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862714010P | 2018-08-02 | 2018-08-02 | |
| US62/714,010 | 2018-08-02 | ||
| US201862779173P | 2018-12-13 | 2018-12-13 | |
| US62/779,173 | 2018-12-13 | ||
| US201962855781P | 2019-05-31 | 2019-05-31 | |
| US62/855,781 | 2019-05-31 | ||
| US201962858925P | 2019-06-07 | 2019-06-07 | |
| US62/858,925 | 2019-06-07 | ||
| US201962859694P | 2019-06-10 | 2019-06-10 | |
| US62/859,694 | 2019-06-10 | ||
| PCT/US2019/044982 WO2020028857A1 (en) | 2018-08-02 | 2019-08-02 | Muscle-targeting complexes and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024184975A Division JP7708957B2 (ja) | 2018-08-02 | 2024-10-21 | 筋標的化複合体およびそれらの使用 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021533198A JP2021533198A (ja) | 2021-12-02 |
| JPWO2020028857A5 JPWO2020028857A5 (https=) | 2022-08-10 |
| JP2021533198A5 true JP2021533198A5 (https=) | 2022-08-10 |
| JP7576542B2 JP7576542B2 (ja) | 2024-10-31 |
Family
ID=69232332
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021529259A Active JP7576542B2 (ja) | 2018-08-02 | 2019-08-02 | 筋標的化複合体およびそれらの使用 |
| JP2024184975A Active JP7708957B2 (ja) | 2018-08-02 | 2024-10-21 | 筋標的化複合体およびそれらの使用 |
| JP2025112731A Pending JP2025175995A (ja) | 2018-08-02 | 2025-07-03 | 筋標的化複合体およびそれらの使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024184975A Active JP7708957B2 (ja) | 2018-08-02 | 2024-10-21 | 筋標的化複合体およびそれらの使用 |
| JP2025112731A Pending JP2025175995A (ja) | 2018-08-02 | 2025-07-03 | 筋標的化複合体およびそれらの使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20210261680A1 (https=) |
| EP (1) | EP3829649A4 (https=) |
| JP (3) | JP7576542B2 (https=) |
| KR (1) | KR20210086602A (https=) |
| CN (1) | CN112930197A (https=) |
| AU (1) | AU2019315593A1 (https=) |
| CA (1) | CA3108335A1 (https=) |
| IL (3) | IL320597A (https=) |
| MX (1) | MX2021001282A (https=) |
| SG (1) | SG11202100931QA (https=) |
| WO (1) | WO2020028857A1 (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019513371A (ja) | 2016-04-01 | 2019-05-30 | アビディティー バイオサイエンシーズ エルエルシー | 核酸ポリペプチド組成物とその使用 |
| JP7506601B2 (ja) * | 2017-12-06 | 2024-06-26 | アビディティー バイオサイエンシーズ，インク． | 筋萎縮症と筋緊張性ジストロフィーを処置するための組成物および方法 |
| US12370264B1 (en) | 2018-08-02 | 2025-07-29 | Dyne Therapeutics, Inc. | Complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and method of delivering oligonucleotide to a subject |
| US11911484B2 (en) | 2018-08-02 | 2024-02-27 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| KR20210086601A (ko) * | 2018-08-02 | 2021-07-08 | 다인 세라퓨틱스, 인크. | 근육 표적화 복합체 및 프리드라이히 운동실조를 치료하기 위한 그의 용도 |
| US20220193250A1 (en) | 2018-08-02 | 2022-06-23 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy |
| US12097263B2 (en) | 2018-08-02 | 2024-09-24 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| EP3829595A4 (en) | 2018-08-02 | 2022-08-24 | Dyne Therapeutics, Inc. | MUSCLE-DIRECTED COMPLEXES AND USES THEREOF IN THE TREATMENT OF DYSTROPHINOPATHIES |
| US11168141B2 (en) | 2018-08-02 | 2021-11-09 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| JP7576542B2 (ja) * | 2018-08-02 | 2024-10-31 | ダイン セラピューティクス，インコーポレーテッド | 筋標的化複合体およびそれらの使用 |
| US12018087B2 (en) | 2018-08-02 | 2024-06-25 | Dyne Therapeutics, Inc. | Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject |
| AU2021206234A1 (en) * | 2020-01-10 | 2022-09-01 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| AU2021241682B2 (en) | 2020-03-27 | 2026-02-12 | Avidity Biosciences, Inc. | Compositions and methods of treating muscle dystrophy |
| US20230330246A1 (en) * | 2020-05-05 | 2023-10-19 | Avidity Biosciences, Inc. | Compositions and methods of treating pompe disease |
| US20230201358A1 (en) * | 2020-05-08 | 2023-06-29 | Mpeg La, L.L.C. | Linker compounds |
| AU2021318851A1 (en) * | 2020-07-23 | 2023-03-16 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| WO2022020108A1 (en) * | 2020-07-23 | 2022-01-27 | Dyne Therapeutics, Inc. | Muscle-targeting complexes and uses thereof |
| US20240100177A1 (en) * | 2020-12-04 | 2024-03-28 | Dyne Therapeutics, Inc. | Antibody-oligonucleotide complexes and uses thereof |
| US20240117356A1 (en) * | 2020-12-31 | 2024-04-11 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| US20240166594A1 (en) * | 2021-03-16 | 2024-05-23 | University Of Massachusetts | Photocaged citrulline analogs and methods for site-specific incorporation of citrulline into proteins |
| IL309936A (en) * | 2021-07-09 | 2024-03-01 | Dyne Therapeutics Inc | Muscle targeting complexes and formulations for the treatment of dystrophinopathy |
| US11672872B2 (en) | 2021-07-09 | 2023-06-13 | Dyne Therapeutics, Inc. | Anti-transferrin receptor antibody and uses thereof |
| US11771776B2 (en) | 2021-07-09 | 2023-10-03 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| US11633498B2 (en) | 2021-07-09 | 2023-04-25 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| KR20240032945A (ko) * | 2021-07-09 | 2024-03-12 | 다인 세라퓨틱스, 인크. | 근육 표적화 복합체 및 디스트로핀병증을 치료하기 위한 그의 용도 |
| US11969475B2 (en) | 2021-07-09 | 2024-04-30 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy |
| US11638761B2 (en) | 2021-07-09 | 2023-05-02 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy |
| WO2023023031A2 (en) * | 2021-08-17 | 2023-02-23 | Blaze Bioscience, Inc. | Transferrin receptor targeting peptide oligonucleotide complexes and methods of use thereof |
| EP4396231A1 (en) | 2021-09-01 | 2024-07-10 | Biogen MA Inc. | Anti-transferrin receptor antibodies and uses thereof |
| WO2023056388A1 (en) * | 2021-09-29 | 2023-04-06 | Ionis Pharmaceuticals, Inc. | Conjugated oligonucleotides and uses thereof |
| JP2025500481A (ja) | 2021-12-22 | 2025-01-09 | サプリーム テクノロジーズ，ベー．フェー． | 筋消耗性障害を治療するための治療用核酸とサポニンとを含む組成物 |
| US20250057971A1 (en) | 2021-12-22 | 2025-02-20 | Sapreme Technologies B.V. | Targeted saponin-nucleic acid conjugates for treatment of muscle wasting disorders |
| JP2025501610A (ja) | 2021-12-22 | 2025-01-22 | サプリーム テクノロジーズ，ベー．フェー． | 筋消耗性障害の治療のための治療用核酸と標的型サポニンとを含む組成物 |
| CA3242927A1 (en) * | 2022-01-07 | 2023-07-13 | Genzyme Corporation | TISSUE-SPECIFIC IMAGING AND THERAPEUTIC AGENTS TARGETING PROTEINS EXPRESSED ON MUSCLE CELL SURFACE |
| US20250339553A1 (en) | 2022-04-15 | 2025-11-06 | Dyne Therapeutics, Inc. | Muscle targeting complexes and formulations for treating myotonic dystrophy |
| IL320016A (en) * | 2022-11-04 | 2025-06-01 | Regeneron Pharma | Calcium voltage-gated channel auxiliary subunit gamma 1 (cacng1) binding proteins and cacng1-mediated delivery to skeletal muscle |
| AU2024314571A1 (en) * | 2023-06-22 | 2025-12-18 | Centre National De La Recherche Scientifique | Transferrin receptor-binding molecules, conjugates thereof and their uses to prevent or treat muscular diseases |
| EP4480964A1 (en) * | 2023-06-22 | 2024-12-25 | Vect-Horus | Transferrin receptor-binding molecules, conjugates thereof and their uses to prevent or treat muscular diseases |
| WO2025160275A1 (en) | 2024-01-24 | 2025-07-31 | Arrowhead Pharmaceuticals, Inc. | Anti-transferrin receptor antibodies, conjugates thereof, and uses thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040063654A1 (en) * | 2001-11-02 | 2004-04-01 | Davis Mark E. | Methods and compositions for therapeutic use of RNA interference |
| US20120122801A1 (en) * | 2005-01-05 | 2012-05-17 | Prosensa B.V. | Mannose-6-phosphate receptor mediated gene transfer into muscle cells |
| US20130079382A1 (en) * | 2009-10-12 | 2013-03-28 | Larry J. Smith | Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro |
| JP2014523884A (ja) * | 2011-06-24 | 2014-09-18 | セントローズ， エルエルシー | 細胞外標的化薬物複合体 |
| FI2911699T4 (fi) * | 2012-10-23 | 2025-12-09 | Synaffix Bv | Muokattu vasta-aine, vasta-ainekonjugaatti ja menetelmä niiden valmistamiseksi |
| ES2886531T3 (es) * | 2013-01-07 | 2021-12-20 | Omniox Inc | Formas poliméricas de proteínas H-NOX |
| GB201507926D0 (en) * | 2015-05-08 | 2015-06-24 | Proqr Therapeutics N V | Improved treatments using oligonucleotides |
| CN109310765A (zh) * | 2016-06-20 | 2019-02-05 | 领先基因生物技术股份有限公司 | 抗体-药物偶联物 |
| MX2019008199A (es) * | 2017-01-06 | 2019-11-25 | Avidity Biosciences Llc | Composiciones de acido nucleico polipeptido y metodos de induccion de la omision de exon. |
| JP7576542B2 (ja) | 2018-08-02 | 2024-10-31 | ダイン セラピューティクス，インコーポレーテッド | 筋標的化複合体およびそれらの使用 |
-
2019
- 2019-08-02 JP JP2021529259A patent/JP7576542B2/ja active Active
- 2019-08-02 WO PCT/US2019/044982 patent/WO2020028857A1/en not_active Ceased
- 2019-08-02 IL IL320597A patent/IL320597A/en unknown
- 2019-08-02 MX MX2021001282A patent/MX2021001282A/es unknown
- 2019-08-02 US US17/264,998 patent/US20210261680A1/en not_active Abandoned
- 2019-08-02 AU AU2019315593A patent/AU2019315593A1/en active Pending
- 2019-08-02 CN CN201980064587.3A patent/CN112930197A/zh active Pending
- 2019-08-02 IL IL280536A patent/IL280536B2/en unknown
- 2019-08-02 SG SG11202100931QA patent/SG11202100931QA/en unknown
- 2019-08-02 KR KR1020217006030A patent/KR20210086602A/ko active Pending
- 2019-08-02 EP EP19843251.0A patent/EP3829649A4/en active Pending
- 2019-08-02 IL IL314102A patent/IL314102B2/en unknown
- 2019-08-02 CA CA3108335A patent/CA3108335A1/en active Pending
-
2021
- 2021-03-18 US US17/205,139 patent/US20210228730A1/en active Pending
-
2024
- 2024-10-21 JP JP2024184975A patent/JP7708957B2/ja active Active
-
2025
- 2025-07-03 JP JP2025112731A patent/JP2025175995A/ja active Pending
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