JP2023510351A5 - - Google Patents

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Publication number
JP2023510351A5
JP2023510351A5 JP2022542337A JP2022542337A JP2023510351A5 JP 2023510351 A5 JP2023510351 A5 JP 2023510351A5 JP 2022542337 A JP2022542337 A JP 2022542337A JP 2022542337 A JP2022542337 A JP 2022542337A JP 2023510351 A5 JP2023510351 A5 JP 2023510351A5
Authority
JP
Japan
Prior art keywords
cdr
seq
complex according
complex
oligonucleotide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022542337A
Other languages
English (en)
Japanese (ja)
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JP2023510351A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/012764 external-priority patent/WO2021142313A1/en
Publication of JP2023510351A publication Critical patent/JP2023510351A/ja
Publication of JP2023510351A5 publication Critical patent/JP2023510351A5/ja
Pending legal-status Critical Current

Links

JP2022542337A 2020-01-10 2021-01-08 筋標的化複合体およびそれらの使用 Pending JP2023510351A (ja)

Applications Claiming Priority (17)

Application Number Priority Date Filing Date Title
US202062959804P 2020-01-10 2020-01-10
US62/959,804 2020-01-10
US202062965754P 2020-01-24 2020-01-24
US62/965,754 2020-01-24
US202062968411P 2020-01-31 2020-01-31
US62/968,411 2020-01-31
US202062980925P 2020-02-24 2020-02-24
US62/980,925 2020-02-24
US202063055521P 2020-07-23 2020-07-23
US63/055,521 2020-07-23
US202063061836P 2020-08-06 2020-08-06
US63/061,836 2020-08-06
US202063069067P 2020-08-23 2020-08-23
US63/069,067 2020-08-23
US202063132929P 2020-12-31 2020-12-31
US63/132,929 2020-12-31
PCT/US2021/012764 WO2021142313A1 (en) 2020-01-10 2021-01-08 Muscle-targeting complexes and uses thereof

Publications (2)

Publication Number Publication Date
JP2023510351A JP2023510351A (ja) 2023-03-13
JP2023510351A5 true JP2023510351A5 (https=) 2024-01-17

Family

ID=76788871

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022542337A Pending JP2023510351A (ja) 2020-01-10 2021-01-08 筋標的化複合体およびそれらの使用

Country Status (6)

Country Link
US (1) US20230226212A1 (https=)
EP (1) EP4087876A4 (https=)
JP (1) JP2023510351A (https=)
CN (1) CN115427448A (https=)
CA (1) CA3163608A1 (https=)
WO (1) WO2021142313A1 (https=)

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MX2019008199A (es) 2017-01-06 2019-11-25 Avidity Biosciences Llc Composiciones de acido nucleico polipeptido y metodos de induccion de la omision de exon.
CA3108282A1 (en) 2018-08-02 2020-02-06 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
US12097263B2 (en) 2018-08-02 2024-09-24 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating myotonic dystrophy
US12370264B1 (en) 2018-08-02 2025-07-29 Dyne Therapeutics, Inc. Complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and method of delivering oligonucleotide to a subject
SG11202100928QA (en) 2018-08-02 2021-02-25 Dyne Therapeutics Inc Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
US11911484B2 (en) 2018-08-02 2024-02-27 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating myotonic dystrophy
US12018087B2 (en) 2018-08-02 2024-06-25 Dyne Therapeutics, Inc. Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject
US11168141B2 (en) 2018-08-02 2021-11-09 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
JP7780691B2 (ja) * 2020-01-10 2025-12-05 ダイン セラピューティクス,インコーポレーテッド ジストロフィン異常症を処置するための筋標的化複合体およびそれらの使用
AU2021206234A1 (en) * 2020-01-10 2022-09-01 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating myotonic dystrophy
WO2022270585A1 (ja) 2021-06-23 2022-12-29 日本新薬株式会社 アンチセンスオリゴマーの組み合わせ
US11638761B2 (en) 2021-07-09 2023-05-02 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy
US11633498B2 (en) 2021-07-09 2023-04-25 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating myotonic dystrophy
US11672872B2 (en) 2021-07-09 2023-06-13 Dyne Therapeutics, Inc. Anti-transferrin receptor antibody and uses thereof
JP2024525611A (ja) * 2021-07-09 2024-07-12 ダイン セラピューティクス,インコーポレーテッド 筋標的化複合体およびジストロフィノパチーを処置するためのその使用
US11969475B2 (en) 2021-07-09 2024-04-30 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
US11771776B2 (en) 2021-07-09 2023-10-03 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
AU2022309238A1 (en) * 2021-07-09 2024-01-25 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
JP2024525608A (ja) * 2021-07-09 2024-07-12 ダイン セラピューティクス,インコーポレーテッド ジストロフィン異常症を処置するための筋標的化複合体および製剤
US20240390508A1 (en) * 2021-08-21 2024-11-28 Takeda Pharmaceutical Company Limited Human transferrin receptor binding peptide-drug conjugate
WO2023034409A1 (en) 2021-09-01 2023-03-09 Biogen Ma Inc. Anti-transferrin receptor antibodies and uses thereof
US20250177433A1 (en) * 2021-09-01 2025-06-05 Ionis Pharmaceuticals, Inc. Compounds and methods for reducing dmpk expression
WO2023034870A2 (en) * 2021-09-01 2023-03-09 Ionis Pharmaceuticals, Inc. Compounds and methods for reducing dmpk expression
US12071621B2 (en) * 2022-04-05 2024-08-27 Avidity Biosciences, Inc. Anti-transferrin receptor antibody-PMO conjugates for inducing DMD exon 44 skipping
IL316143A (en) 2022-04-15 2024-12-01 Dyne Therapeutics Inc Muscle targeting complexes and formulations for the treatment of myotonic dystrophy
JP2025522433A (ja) 2022-06-15 2025-07-15 アローヘッド ファーマシューティカルズ インコーポレイテッド スーパーオキシドジスムターゼ1(SOD1)の発現を阻害するためのRNAi剤、その組成物、及び使用の方法
WO2025072886A1 (en) * 2023-09-28 2025-04-03 Wave Life Sciences Ltd. Oligonucleotide compositions and methods thereof
US20250121085A1 (en) * 2023-10-02 2025-04-17 Avidity Biosciences, Inc. Antibody-oligonucleotide conjugate compositions and methods of inducing dmd exon 45 skipping
WO2025085810A2 (en) * 2023-10-18 2025-04-24 Sarepta Therapeutics, Inc. Antisense oligomers for treatment of centronuclear myopathies
WO2025160275A1 (en) 2024-01-24 2025-07-31 Arrowhead Pharmaceuticals, Inc. Anti-transferrin receptor antibodies, conjugates thereof, and uses thereof
CN118531138B (zh) * 2024-06-18 2025-04-01 湖北省农业科学院畜牧兽医研究所 猪肉品质和胴体关联的snp及应用
WO2025262186A2 (en) * 2024-06-20 2025-12-26 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Therapeutic oligonucleotides for treating diseases being associated with or caused by a missense, nonsense or in-frame indel mutation
CN118516348B (zh) * 2024-07-23 2025-01-17 深川生物科技(山东)股份公司 单链核酸或双链核酸及在制备治疗杜氏肌营养不良的药物中的应用

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Publication number Priority date Publication date Assignee Title
US7241444B2 (en) * 2002-01-18 2007-07-10 Pierre Fabre Medicament Anti-IGF-IR antibodies and uses thereof
BR112014020826A8 (pt) * 2012-02-24 2017-09-19 Stem Centrx Inc Anticorpo que se liga especificamente a um epítopo, ácido nucleico, vetor ou célula hospedeira, conjugado de fármaco – anticorpo, composição farmacêutica compreendendo o referido anticorpo, uso do mesmo, kit e método de preparação do conjugado
MX2019008199A (es) * 2017-01-06 2019-11-25 Avidity Biosciences Llc Composiciones de acido nucleico polipeptido y metodos de induccion de la omision de exon.
JP7303110B2 (ja) * 2017-01-18 2023-07-04 ビステラ, インコーポレイテッド 抗体分子-薬物コンジュゲートおよびその使用
AU2018378812B2 (en) * 2017-12-06 2025-05-22 Avidity Biosciences, Inc. Compositions and methods of treating muscle atrophy and myotonic dystrophy

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