JP2023535078A5 - - Google Patents
Info
- Publication number
- JP2023535078A5 JP2023535078A5 JP2023504653A JP2023504653A JP2023535078A5 JP 2023535078 A5 JP2023535078 A5 JP 2023535078A5 JP 2023504653 A JP2023504653 A JP 2023504653A JP 2023504653 A JP2023504653 A JP 2023504653A JP 2023535078 A5 JP2023535078 A5 JP 2023535078A5
- Authority
- JP
- Japan
- Prior art keywords
- complex according
- seq
- antibody
- oligonucleotide
- consecutive nucleotides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063055749P | 2020-07-23 | 2020-07-23 | |
| US63/055,749 | 2020-07-23 | ||
| US202063069075P | 2020-08-23 | 2020-08-23 | |
| US63/069,075 | 2020-08-23 | ||
| US202163143827P | 2021-01-30 | 2021-01-30 | |
| US63/143,827 | 2021-01-30 | ||
| PCT/US2021/040986 WO2022026152A2 (en) | 2020-07-23 | 2021-07-09 | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023535078A JP2023535078A (ja) | 2023-08-15 |
| JP2023535078A5 true JP2023535078A5 (https=) | 2024-07-18 |
Family
ID=80038121
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023504653A Pending JP2023535078A (ja) | 2020-07-23 | 2021-07-09 | 筋緊張性ジストロフィーを処置するための筋標的化複合体およびその使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20240016952A1 (https=) |
| EP (1) | EP4185383A4 (https=) |
| JP (1) | JP2023535078A (https=) |
| KR (1) | KR20230042713A (https=) |
| CN (1) | CN116438304A (https=) |
| AU (1) | AU2021318851A1 (https=) |
| BR (1) | BR112023001126A8 (https=) |
| CA (1) | CA3186742A1 (https=) |
| IL (1) | IL299663A (https=) |
| MX (1) | MX2023000958A (https=) |
| WO (1) | WO2022026152A2 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3108282A1 (en) | 2018-08-02 | 2020-02-06 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| US11911484B2 (en) | 2018-08-02 | 2024-02-27 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| US12097263B2 (en) | 2018-08-02 | 2024-09-24 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| SG11202100928QA (en) | 2018-08-02 | 2021-02-25 | Dyne Therapeutics Inc | Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy |
| US12370264B1 (en) | 2018-08-02 | 2025-07-29 | Dyne Therapeutics, Inc. | Complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and method of delivering oligonucleotide to a subject |
| US11168141B2 (en) | 2018-08-02 | 2021-11-09 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| US12018087B2 (en) | 2018-08-02 | 2024-06-25 | Dyne Therapeutics, Inc. | Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject |
| CN116194470B (zh) * | 2020-07-23 | 2025-10-03 | 达因疗法公司 | 肌肉靶向复合物及其用途 |
| EP4208173A4 (en) * | 2020-09-03 | 2025-11-26 | Dyne Therapeutics Inc | PROCESSES FOR PREPARING PROTEIN-OLIGONUCLEOTIC COMPLEXES |
| CA3202832A1 (en) * | 2020-12-31 | 2022-07-07 | Romesh R. Subramanian | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| US11771776B2 (en) | 2021-07-09 | 2023-10-03 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| US11969475B2 (en) | 2021-07-09 | 2024-04-30 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy |
| JP2024525608A (ja) | 2021-07-09 | 2024-07-12 | ダイン セラピューティクス，インコーポレーテッド | ジストロフィン異常症を処置するための筋標的化複合体および製剤 |
| US11638761B2 (en) | 2021-07-09 | 2023-05-02 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy |
| US11633498B2 (en) | 2021-07-09 | 2023-04-25 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| US11672872B2 (en) | 2021-07-09 | 2023-06-13 | Dyne Therapeutics, Inc. | Anti-transferrin receptor antibody and uses thereof |
| CN119256008A (zh) * | 2022-04-15 | 2025-01-03 | 达因疗法公司 | 用于治疗强直性肌营养不良的肌肉靶向复合物及其用途 |
| IL316143A (en) | 2022-04-15 | 2024-12-01 | Dyne Therapeutics Inc | Muscle targeting complexes and formulations for the treatment of myotonic dystrophy |
| KR20250004771A (ko) * | 2022-04-15 | 2025-01-08 | 다인 세라퓨틱스, 인크. | 근긴장성 이영양증을 치료하기 위한 근육 표적화 복합체의 투여 |
| US20250352672A1 (en) * | 2022-05-13 | 2025-11-20 | University Of Washington | Method for treatment of myotonic dystrophy combining protein expression and rna interference vector delivery with tissue detargeting |
| WO2025006955A2 (en) * | 2023-06-30 | 2025-01-02 | Ionis Pharmaceuticals, Inc. | Cd29 targeted oligonucleotides and uses thereof |
| AU2024299328A1 (en) | 2023-07-21 | 2026-01-22 | Marrow Therapeutics, Inc. | Hematopoietic cell targeting conjugates and related methods |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112013014527A2 (pt) * | 2010-12-20 | 2017-03-07 | Genentech Inc | anticorpo isolado, ácido nucleico isolado, célula hospedeira, método para produzir um anticorpo, imunoconjugado, formulação farmacêutica, uso do imunoconjugado, método para tratamento de um indivíduo que tem um câncer positivo para mesotelina, para inibição de proliferação de uma célula positiva para mesotelina, para detecção de mesotelina humana em uma amostra biológica e para detectar um câncer positivo para mesotelina |
| CA2835603A1 (en) * | 2011-05-09 | 2012-11-15 | Perseus Proteomics Inc. | Antibody capable of specifically recognizing transferrin receptor |
| EA039366B1 (ru) * | 2015-06-24 | 2022-01-19 | Джей Си Ар ФАРМАСЬЮТИКАЛЗ КО., ЛТД. | Антитело к рецептору трансферрина человека, проникающее через гематоэнцефалический барьер |
| FR3049951A1 (fr) * | 2016-04-12 | 2017-10-13 | Univ Rabelais Francois | Nouvelles constructions peptidiques et leur utilisation dans le traitement de la toxoplasmose |
| BR112018074453A2 (pt) * | 2016-05-27 | 2019-03-19 | Abbvie Biotherapeutics Inc. | proteínas de ligação biespecíficas ligando uma protéina imunomoduladora e um antígeno tumoral |
| AU2018378812B2 (en) * | 2017-12-06 | 2025-05-22 | Avidity Biosciences, Inc. | Compositions and methods of treating muscle atrophy and myotonic dystrophy |
| WO2020028842A1 (en) * | 2018-08-02 | 2020-02-06 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating hypertrophic cardiomyopathy |
| IL280536B2 (en) * | 2018-08-02 | 2024-12-01 | Dyne Therapeutics Inc | Complexes targeting transferrin receptor and uses thereof |
| AU2019314538B2 (en) * | 2018-08-02 | 2025-03-13 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| WO2020028836A1 (en) * | 2018-08-02 | 2020-02-06 | Dyne Therapeutics, Inc. | Muscle-targeting complexes and uses thereof in treating muscle atrophy |
| IL312067B2 (en) * | 2018-12-21 | 2025-08-01 | Avidity Biosciences Inc | Anti-transferrin receptor antibodies and uses thereof |
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2021
- 2021-07-09 JP JP2023504653A patent/JP2023535078A/ja active Pending
- 2021-07-09 CA CA3186742A patent/CA3186742A1/en active Pending
- 2021-07-09 BR BR112023001126A patent/BR112023001126A8/pt unknown
- 2021-07-09 EP EP21850418.1A patent/EP4185383A4/en active Pending
- 2021-07-09 WO PCT/US2021/040986 patent/WO2022026152A2/en not_active Ceased
- 2021-07-09 AU AU2021318851A patent/AU2021318851A1/en active Pending
- 2021-07-09 KR KR1020237005830A patent/KR20230042713A/ko active Pending
- 2021-07-09 MX MX2023000958A patent/MX2023000958A/es unknown
- 2021-07-09 US US18/017,170 patent/US20240016952A1/en active Pending
- 2021-07-09 IL IL299663A patent/IL299663A/en unknown
- 2021-07-09 CN CN202180064935.4A patent/CN116438304A/zh active Pending