CN116438304A - 肌肉靶向复合物及其用于治疗强直性肌营养不良的用途 - Google Patents

肌肉靶向复合物及其用于治疗强直性肌营养不良的用途 Download PDF

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CN116438304A
CN116438304A CN202180064935.4A CN202180064935A CN116438304A CN 116438304 A CN116438304 A CN 116438304A CN 202180064935 A CN202180064935 A CN 202180064935A CN 116438304 A CN116438304 A CN 116438304A
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amino acid
acid sequence
antibody
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罗梅什·R·苏布拉马尼亚
穆罕默德·T·卡塔纳尼
蒂莫西·威登
科迪·A·德雅尔丹
布伦丹·奎因
约翰·纳吉姆
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Dyne Therapeutics Inc
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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CN202180064935.4A 2020-07-23 2021-07-09 肌肉靶向复合物及其用于治疗强直性肌营养不良的用途 Pending CN116438304A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202063055749P 2020-07-23 2020-07-23
US63/055,749 2020-07-23
US202063069075P 2020-08-23 2020-08-23
US63/069,075 2020-08-23
US202163143827P 2021-01-30 2021-01-30
US63/143,827 2021-01-30
PCT/US2021/040986 WO2022026152A2 (en) 2020-07-23 2021-07-09 Muscle targeting complexes and uses thereof for treating myotonic dystrophy

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CN116438304A true CN116438304A (zh) 2023-07-14

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US (1) US20240016952A1 (https=)
EP (1) EP4185383A4 (https=)
JP (1) JP2023535078A (https=)
KR (1) KR20230042713A (https=)
CN (1) CN116438304A (https=)
AU (1) AU2021318851A1 (https=)
BR (1) BR112023001126A8 (https=)
CA (1) CA3186742A1 (https=)
IL (1) IL299663A (https=)
MX (1) MX2023000958A (https=)
WO (1) WO2022026152A2 (https=)

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CA3108282A1 (en) 2018-08-02 2020-02-06 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
US11911484B2 (en) 2018-08-02 2024-02-27 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating myotonic dystrophy
US12097263B2 (en) 2018-08-02 2024-09-24 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating myotonic dystrophy
SG11202100928QA (en) 2018-08-02 2021-02-25 Dyne Therapeutics Inc Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
US12370264B1 (en) 2018-08-02 2025-07-29 Dyne Therapeutics, Inc. Complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and method of delivering oligonucleotide to a subject
US11168141B2 (en) 2018-08-02 2021-11-09 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
US12018087B2 (en) 2018-08-02 2024-06-25 Dyne Therapeutics, Inc. Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject
CN116194470B (zh) * 2020-07-23 2025-10-03 达因疗法公司 肌肉靶向复合物及其用途
EP4208173A4 (en) * 2020-09-03 2025-11-26 Dyne Therapeutics Inc PROCESSES FOR PREPARING PROTEIN-OLIGONUCLEOTIC COMPLEXES
CA3202832A1 (en) * 2020-12-31 2022-07-07 Romesh R. Subramanian Muscle targeting complexes and uses thereof for treating myotonic dystrophy
US11771776B2 (en) 2021-07-09 2023-10-03 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
US11969475B2 (en) 2021-07-09 2024-04-30 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
JP2024525608A (ja) 2021-07-09 2024-07-12 ダイン セラピューティクス，インコーポレーテッド ジストロフィン異常症を処置するための筋標的化複合体および製剤
US11638761B2 (en) 2021-07-09 2023-05-02 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy
US11633498B2 (en) 2021-07-09 2023-04-25 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating myotonic dystrophy
US11672872B2 (en) 2021-07-09 2023-06-13 Dyne Therapeutics, Inc. Anti-transferrin receptor antibody and uses thereof
CN119256008A (zh) * 2022-04-15 2025-01-03 达因疗法公司 用于治疗强直性肌营养不良的肌肉靶向复合物及其用途
IL316143A (en) 2022-04-15 2024-12-01 Dyne Therapeutics Inc Muscle targeting complexes and formulations for the treatment of myotonic dystrophy
KR20250004771A (ko) * 2022-04-15 2025-01-08 다인 세라퓨틱스, 인크. 근긴장성 이영양증을 치료하기 위한 근육 표적화 복합체의 투여
US20250352672A1 (en) * 2022-05-13 2025-11-20 University Of Washington Method for treatment of myotonic dystrophy combining protein expression and rna interference vector delivery with tissue detargeting
WO2025006955A2 (en) * 2023-06-30 2025-01-02 Ionis Pharmaceuticals, Inc. Cd29 targeted oligonucleotides and uses thereof
AU2024299328A1 (en) 2023-07-21 2026-01-22 Marrow Therapeutics, Inc. Hematopoietic cell targeting conjugates and related methods

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CN103534272A (zh) * 2011-05-09 2014-01-22 株式会社英仙蛋白质科学 能够特异性识别转铁蛋白受体的抗体
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WO2020028857A1 (en) * 2018-08-02 2020-02-06 Dyne Therapeutics, Inc. Muscle-targeting complexes and uses thereof

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AU2019314538B2 (en) * 2018-08-02 2025-03-13 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating myotonic dystrophy
WO2020028836A1 (en) * 2018-08-02 2020-02-06 Dyne Therapeutics, Inc. Muscle-targeting complexes and uses thereof in treating muscle atrophy
IL312067B2 (en) * 2018-12-21 2025-08-01 Avidity Biosciences Inc Anti-transferrin receptor antibodies and uses thereof

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US20120225013A1 (en) * 2010-12-20 2012-09-06 Mark Dennis Anti-mesothelin antibodies and immunoconjugates
CN103534272A (zh) * 2011-05-09 2014-01-22 株式会社英仙蛋白质科学 能够特异性识别转铁蛋白受体的抗体
EP3315606A1 (en) * 2015-06-24 2018-05-02 JCR Pharmaceuticals Co., Ltd. Anti-human transferrin receptor antibody permeating blood-brain barrier
US20190153083A1 (en) * 2016-04-12 2019-05-23 Universite Francois Rabelais Novel peptide structures and use thereof in the treatment of toxoplasmosis
WO2019113393A1 (en) * 2017-12-06 2019-06-13 Avidity Biosciences Llc Compositions and methods of treating muscle atrophy and myotonic dystrophy
WO2020028857A1 (en) * 2018-08-02 2020-02-06 Dyne Therapeutics, Inc. Muscle-targeting complexes and uses thereof

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AU2021318851A1 (en) 2023-03-16
US20240016952A1 (en) 2024-01-18
EP4185383A4 (en) 2024-07-31
EP4185383A2 (en) 2023-05-31
BR112023001126A2 (pt) 2023-02-14
IL299663A (en) 2023-03-01
KR20230042713A (ko) 2023-03-29
CA3186742A1 (en) 2022-02-03
MX2023000958A (es) 2023-04-14
BR112023001126A8 (pt) 2023-03-14
WO2022026152A2 (en) 2022-02-03
WO2022026152A3 (en) 2022-06-16

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