|
JPS5892644A
(ja)
|
1981-11-26 |
1983-06-02 |
Taiho Yakuhin Kogyo Kk |
新規なニトロ安息香酸アミド誘導体およびそれを含有する放射線増感剤
|
|
US4694778A
(en)
|
1984-05-04 |
1987-09-22 |
Anicon, Inc. |
Chemical vapor deposition wafer boat
|
|
JP3022967B2
(ja)
|
1985-03-15 |
2000-03-21 |
アンチバイラルズ インコーポレイテッド |
立体規則性ポリヌクレオチド結合ポリマー
|
|
US5185444A
(en)
|
1985-03-15 |
1993-02-09 |
Anti-Gene Deveopment Group |
Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages
|
|
US4866132A
(en)
|
1986-04-17 |
1989-09-12 |
The Research Foundation Of State University Of New York |
Novel radiopaque barium polymer complexes, compositions of matter and articles prepared therefrom
|
|
US5624925A
(en)
|
1986-09-25 |
1997-04-29 |
Sri International |
1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents
|
|
US4921963A
(en)
|
1987-04-13 |
1990-05-01 |
British Columbia Cancer Foundation |
Platinum complexes with one radiosensitizing ligand
|
|
JPH0819111B2
(ja)
|
1987-10-22 |
1996-02-28 |
ポーラ化成工業株式会社 |
２―ニトロイミダゾール誘導体及びこれを有効成分とする放射線増感剤
|
|
US5256334A
(en)
|
1988-09-08 |
1993-10-26 |
The Research Foundation Of The State University Of New York |
Homogeneous radiopaque polymer-organobismuth composites
|
|
WO1991004753A1
(en)
|
1989-10-02 |
1991-04-18 |
Cetus Corporation |
Conjugates of antisense oligonucleotides and therapeutic uses thereof
|
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
JP3257675B2
(ja)
|
1990-10-12 |
2002-02-18 |
マックス−プランク−ゲゼルシャフト ツール フェルデルング デル ビッセンシャフテン エー．ファウ． |
修飾リボザイム
|
|
DE4216134A1
(de)
|
1991-06-20 |
1992-12-24 |
Europ Lab Molekularbiolog |
Synthetische katalytische oligonukleotidstrukturen
|
|
US5652094A
(en)
|
1992-01-31 |
1997-07-29 |
University Of Montreal |
Nucleozymes
|
|
FI950730A7
(fi)
|
1992-08-17 |
1995-04-10 |
Quadra Logic Tech Inc |
Menetelmä ei-toivottujen solujen tai kudosten kasvun tuhoamiseksi tai ehkäisemiseksi
|
|
US5346981A
(en)
|
1993-01-13 |
1994-09-13 |
Miles Inc. |
Radiopaque polyurethanes
|
|
US5599796A
(en)
|
1993-12-02 |
1997-02-04 |
Emory University |
Treatment of urogenital cancer with boron neutron capture therapy
|
|
US5627053A
(en)
|
1994-03-29 |
1997-05-06 |
Ribozyme Pharmaceuticals, Inc. |
2'deoxy-2'-alkylnucleotide containing nucleic acid
|
|
DE69531543T2
(de)
|
1994-06-17 |
2004-06-24 |
F. Hoffmann-La Roche Ag |
N,n'-bis(chinolin-4-yl)-diamin derivate, deren herstellung und deren verwendung als antimalaria-mittel
|
|
US5716824A
(en)
|
1995-04-20 |
1998-02-10 |
Ribozyme Pharmaceuticals, Inc. |
2'-O-alkylthioalkyl and 2-C-alkylthioalkyl-containing enzymatic nucleic acids (ribozymes)
|
|
AU4188196A
(en)
|
1994-12-22 |
1996-07-10 |
Nissan Chemical Industries Ltd. |
Organobismuth derivatives and process for producing the same
|
|
US5700825A
(en)
|
1995-03-31 |
1997-12-23 |
Florida State University |
Radiosensitizing diamines and their pharmaceutical preparations
|
|
US5889136A
(en)
|
1995-06-09 |
1999-03-30 |
The Regents Of The University Of Colorado |
Orthoester protecting groups in RNA synthesis
|
|
DE69637256T2
(de)
|
1996-01-16 |
2008-06-19 |
Sirna Therapeutics, Inc., Boulder |
Synthese von Methoxynukleoside und enzymatische Nukleisäure Moleküle
|
|
JP4046354B2
(ja)
|
1996-03-18 |
2008-02-13 |
ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム |
増大した半減期を有する免疫グロブリン様ドメイン
|
|
US5849902A
(en)
|
1996-09-26 |
1998-12-15 |
Oligos Etc. Inc. |
Three component chimeric antisense oligonucleotides
|
|
DE69735445T2
(de)
|
1996-12-10 |
2006-08-10 |
Sequenom, Inc., San Diego |
Abspaltbare, nicht-flüchtige moleküle zur massenmarkierung
|
|
US6111086A
(en)
|
1998-02-27 |
2000-08-29 |
Scaringe; Stephen A. |
Orthoester protecting groups
|
|
AU3751299A
(en)
|
1998-04-20 |
1999-11-08 |
Ribozyme Pharmaceuticals, Inc. |
Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
|
|
GB9816575D0
(en)
|
1998-07-31 |
1998-09-30 |
Zeneca Ltd |
Novel compounds
|
|
GB9818731D0
(en)
|
1998-08-27 |
1998-10-21 |
Univ Portsmouth |
Compounds
|
|
GB9818730D0
(en)
|
1998-08-27 |
1998-10-21 |
Univ Portsmouth |
Collections of compounds
|
|
DE69930328T2
(de)
|
1998-08-27 |
2006-12-14 |
Spirogen Ltd., Ryde |
Dimere Pyrrolobenzodiazepine
|
|
US6849272B1
(en)
|
1999-04-21 |
2005-02-01 |
Massachusetts Institute Of Technology |
Endosomolytic agents and cell delivery systems
|
|
US8137695B2
(en)
|
2006-08-18 |
2012-03-20 |
Arrowhead Madison Inc. |
Polyconjugates for in vivo delivery of polynucleotides
|
|
CA2328356A1
(en)
|
1999-12-22 |
2001-06-22 |
Itty Atcravi |
Recreational vehicles
|
|
ATE344801T1
(de)
|
1999-12-29 |
2006-11-15 |
Immunogen Inc |
Doxorubicin- und daunorubicin-enthaltende, zytotoxische mittel und deren therapeutische anwendung
|
|
US8273866B2
(en)
|
2002-02-20 |
2012-09-25 |
Merck Sharp & Dohme Corp. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA)
|
|
US8202979B2
(en)
|
2002-02-20 |
2012-06-19 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
|
|
US7833992B2
(en)
|
2001-05-18 |
2010-11-16 |
Merck Sharpe & Dohme |
Conjugates and compositions for cellular delivery
|
|
US6884869B2
(en)
|
2001-04-30 |
2005-04-26 |
Seattle Genetics, Inc. |
Pentapeptide compounds and uses related thereto
|
|
MXPA05000511A
(es)
|
2001-07-12 |
2005-09-30 |
Jefferson Foote |
Anticuepros super humanizados.
|
|
US6942972B2
(en)
|
2001-10-24 |
2005-09-13 |
Beckman Coulter, Inc. |
Efficient synthesis of protein-oligonucleotide conjugates
|
|
US6716821B2
(en)
|
2001-12-21 |
2004-04-06 |
Immunogen Inc. |
Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same
|
|
US9657294B2
(en)
|
2002-02-20 |
2017-05-23 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
|
US9181551B2
(en)
|
2002-02-20 |
2015-11-10 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
|
AU2003207708A1
(en)
|
2002-02-20 |
2003-09-09 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of map kinase genes
|
|
US20040023220A1
(en)
|
2002-07-23 |
2004-02-05 |
Lawrence Greenfield |
Integrated method for PCR cleanup and oligonucleotide removal
|
|
SI1545613T1
(sl)
|
2002-07-31 |
2011-11-30 |
Seattle Genetics Inc |
Avristatinski konjugati in njihova uporaba za zdravljenje raka avtoimunske bolezni ali infekcijskebolezni
|
|
AU2003260370B2
(en)
|
2002-08-05 |
2008-05-22 |
Silence Therapeutics Gmbh |
Further novel forms of interfering RNA molecules
|
|
US7956176B2
(en)
|
2002-09-05 |
2011-06-07 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
|
US7250496B2
(en)
|
2002-11-14 |
2007-07-31 |
Rosetta Genomics Ltd. |
Bioinformatically detectable group of novel regulatory genes and uses thereof
|
|
EP2305812A3
(en)
|
2002-11-14 |
2012-06-06 |
Dharmacon, Inc. |
Fuctional and hyperfunctional sirna
|
|
WO2004090105A2
(en)
|
2003-04-02 |
2004-10-21 |
Dharmacon, Inc. |
Modified polynucleotides for use in rna interference
|
|
US7276497B2
(en)
|
2003-05-20 |
2007-10-02 |
Immunogen Inc. |
Cytotoxic agents comprising new maytansinoids
|
|
GB0416511D0
(en)
|
2003-10-22 |
2004-08-25 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
US7498298B2
(en)
|
2003-11-06 |
2009-03-03 |
Seattle Genetics, Inc. |
Monomethylvaline compounds capable of conjugation to ligands
|
|
US8389710B2
(en)
|
2004-02-27 |
2013-03-05 |
Operational Technologies Corporation |
Therapeutic nucleic acid-3′-conjugates
|
|
JP5166861B2
(ja)
|
2004-03-09 |
2013-03-21 |
スピロゲン リミティッド |
ピロロベンゾジアゼピン
|
|
KR101147147B1
(ko)
|
2004-04-01 |
2012-05-25 |
머크 샤프 앤드 돔 코포레이션 |
Ｒｎａ 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드
|
|
ATE498685T1
(de)
|
2004-06-28 |
2011-03-15 |
Univ Western Australia |
Antisense-oligonukleotide zur induktion von exon- skipping sowie verfahren zur verwendung davon
|
|
WO2006132670A2
(en)
|
2004-11-12 |
2006-12-14 |
Seattle Genetics, Inc. |
Auristatins having an aminobenzoic acid unit at the n terminus
|
|
PL1879901T3
(pl)
|
2005-04-21 |
2010-06-30 |
Medimmune Ltd |
Pirolobenzodiazepiny
|
|
US8871720B2
(en)
|
2005-07-07 |
2014-10-28 |
Seattle Genetics, Inc. |
Monomethylvaline compounds having phenylalanine carboxy modifications at the C-terminus
|
|
SI1813614T1
(sl)
|
2006-01-25 |
2012-01-31 |
Sanofi 174 |
Citotoksična sredstva, ki obsegajo nove tomajmicinske derivate
|
|
US7750116B1
(en)
|
2006-02-18 |
2010-07-06 |
Seattle Genetics, Inc. |
Antibody drug conjugate metabolites
|
|
DK2735568T3
(da)
|
2006-05-10 |
2017-11-13 |
Sarepta Therapeutics Inc |
Oligonukleotidanaloger med kationiske bindinger mellem underenheder
|
|
US7521232B2
(en)
|
2006-05-31 |
2009-04-21 |
Icx Nomadics, Inc. |
Emissive species for clinical imaging
|
|
CN101563105B
(zh)
|
2006-07-10 |
2013-01-23 |
拜奥根Idec马萨诸塞公司 |
用于抑制smad4-缺陷癌症的组合物和方法
|
|
AU2007282224B2
(en)
|
2006-08-11 |
2013-08-29 |
Vico Therapeutics B.V. |
Methods and means for treating DNA repeat instability associated genetic disorders
|
|
US8980833B2
(en)
|
2007-05-10 |
2015-03-17 |
R&D-Biopharmaceuticals Gmbh |
Tubulysine derivatives
|
|
PL2019104T3
(pl)
|
2007-07-19 |
2014-03-31 |
Sanofi Sa |
Środki cytotoksyczne obejmujące nowe pochodne tomaymycyny i ich zastosowanie terapeutyczne
|
|
JP2010537640A
(ja)
|
2007-08-27 |
2010-12-09 |
ボストン バイオメディカル， インコーポレイテッド |
マイクロｒｎａ模倣剤または阻害剤としての非対称性ｒｎａ二重鎖の組成物
|
|
CA2704737A1
(en)
|
2007-09-18 |
2009-09-03 |
Intradigm Corporation |
Compositions comprising k-ras sirna and methods of use
|
|
AU2008317566B2
(en)
|
2007-10-26 |
2014-05-01 |
Academisch Ziekenhuis Leiden |
Means and methods for counteracting muscle disorders
|
|
US20110081362A1
(en)
|
2008-01-31 |
2011-04-07 |
The Brigham And Women's Hospital, Inc. |
Treatment of cancer
|
|
WO2009099942A2
(en)
|
2008-01-31 |
2009-08-13 |
Alnylam Pharmaceuticals, Inc. |
Chemically modified oligonucleotides and uses thereof
|
|
MX2010008024A
(es)
|
2008-02-01 |
2010-12-21 |
Ascendis Pharma As |
Profarmaco que comprende un enlazador que se puede separar por si mismo.
|
|
EP2265283B1
(en)
|
2008-03-18 |
2014-09-03 |
Seattle Genetics, Inc. |
Auristatin drug linker conjugates
|
|
WO2009126933A2
(en)
|
2008-04-11 |
2009-10-15 |
Alnylam Pharmaceuticals, Inc. |
Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
|
|
EP2119783A1
(en)
|
2008-05-14 |
2009-11-18 |
Prosensa Technologies B.V. |
Method for efficient exon (44) skipping in Duchenne Muscular Dystrophy and associated means
|
|
US20110130346A1
(en)
|
2008-05-30 |
2011-06-02 |
Isis Innovation Limited |
Peptide conjugates for delvery of biologically active compounds
|
|
GB0813432D0
(en)
|
2008-07-22 |
2008-08-27 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
JP5583667B2
(ja)
|
2008-08-08 |
2014-09-03 |
ジェニスフィア・エルエルシー |
長時間作用型ｄｎａデンドリマーおよびその方法
|
|
US8084601B2
(en)
|
2008-09-11 |
2011-12-27 |
Royal Holloway And Bedford New College Royal Holloway, University Of London |
Oligomers
|
|
CN112574988A
(zh)
|
2008-10-24 |
2021-03-30 |
萨雷普塔治疗公司 |
用于dmd的多外显子跳跃组合物
|
|
RU2572826C2
(ru)
|
2008-12-02 |
2016-01-20 |
Чиралджен, Лтд. |
Способ синтеза модифицированных по атому фосфора нуклеиновых кислот
|
|
CN102365021B
(zh)
|
2009-02-05 |
2015-07-15 |
伊缪诺金公司 |
新型苯并二氮杂*衍生物
|
|
US8481698B2
(en)
|
2009-03-19 |
2013-07-09 |
The President And Fellows Of Harvard College |
Parallel proximity ligation event analysis
|
|
CA2757354A1
(en)
|
2009-04-02 |
2010-10-07 |
Laura P.W. Ranum |
Nucleotide repeat expansion-associated polypeptides and uses thereof
|
|
BRPI1011269A2
(pt)
|
2009-05-05 |
2016-09-27 |
Altermune Technologies Llc |
imunidade quimicamente programável
|
|
CA2763935A1
(en)
|
2009-06-04 |
2010-12-09 |
Novartis Ag |
Methods for identification of sites for igg conjugation
|
|
SG177560A1
(en)
|
2009-07-06 |
2012-03-29 |
Hoffmann La Roche |
Bi-specific digoxigenin binding antibodies
|
|
IT1394860B1
(it)
|
2009-07-22 |
2012-07-20 |
Kemotech S R L |
Composti farmaceutici
|
|
US20120258104A1
(en)
|
2009-07-22 |
2012-10-11 |
Cenix Bioscience Gmbh |
Delivery System and Conjugates For Compound Delivery Via Naturally Occurring Intracellular Transport Routes
|
|
US20120172415A1
(en)
|
2009-08-31 |
2012-07-05 |
Thomas Voit |
Exon Skipping Therapy for Functional Amelioration of Semifunctional Dystrophin in Becker and Duchenne Muscular Dystrophy
|
|
LT2499249T
(lt)
|
2009-11-12 |
2018-12-27 |
The University Of Western Australia |
Priešprasmės molekulės ir patologijų gydymo būdai
|
|
US8846875B2
(en)
|
2010-02-12 |
2014-09-30 |
Solulink, Inc. |
Preparation and/or purification of oligonucleotide conjugates
|
|
US8697688B2
(en)
|
2010-04-15 |
2014-04-15 |
Seattle Genetics Inc. |
Pyrrolobenzodiazepines used to treat proliferative diseases
|
|
MX391454B
(es)
|
2010-04-15 |
2025-03-05 |
Seagen Inc |
Compuesto de engarce-fármaco para conjugación a una unidad de ligando.
|
|
KR101869570B1
(ko)
|
2010-04-28 |
2018-06-20 |
아이오니스 파마수티컬즈, 인코포레이티드 |
변형된 뉴클레오사이드 및 그로부터 제조된 올리고머 화합물
|
|
KR20200133284A
(ko)
|
2010-05-28 |
2020-11-26 |
사렙타 쎄러퓨틱스, 인코퍼레이티드 |
변형된 서브유니트간 결합 및/또는 말단 그룹을 갖는 올리고뉴클레오타이드 유사체
|
|
IT1400425B1
(it)
|
2010-06-08 |
2013-05-31 |
Amsterdam Molecular Therapeutics Bv |
Modified snrnas for use in therapy.
|
|
EP2580326A1
(en)
|
2010-06-11 |
2013-04-17 |
Antisense Pharma GmbH |
Method for selective oligonucleotide modification
|
|
EP2409983A1
(en)
|
2010-07-19 |
2012-01-25 |
Leibniz-Institut für Pflanzenbiochemie (IPB) |
Tubulysin analogues
|
|
WO2012012467A2
(en)
|
2010-07-19 |
2012-01-26 |
Isis Pharmaceuticals, Inc. |
Modulation of nuclear-retained rna
|
|
WO2012024535A2
(en)
|
2010-08-18 |
2012-02-23 |
Fred Hutchinson Cancer Research Center |
Methods for determining the presence or risk of developing facioscapulohumeral dystrophy (fshd)
|
|
US20130195799A1
(en)
|
2010-08-19 |
2013-08-01 |
Peg Biosciences, Inc. |
Synergistic biomolecule-polymer conjugates
|
|
US20120225034A1
(en)
|
2010-09-02 |
2012-09-06 |
Universite De Mons |
Agents useful in treating facioscapulohumeral muscular dystrophy
|
|
WO2012058210A1
(en)
|
2010-10-29 |
2012-05-03 |
Merck Sharp & Dohme Corp. |
RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA)
|
|
CN103269712B
(zh)
|
2010-11-03 |
2016-09-21 |
伊缪诺金公司 |
包含新型安丝菌素衍生物的细胞毒性剂
|
|
US8501930B2
(en)
|
2010-12-17 |
2013-08-06 |
Arrowhead Madison Inc. |
Peptide-based in vivo siRNA delivery system
|
|
NZ611656A
(en)
|
2010-12-29 |
2014-10-31 |
Arrowhead Res Corp |
In vivo polynucleotide delivery conjugates having enzyme sensitive linkages
|
|
EP2686345B1
(en)
|
2011-03-16 |
2018-04-25 |
Amgen Inc. |
Fc variants
|
|
CN103648532A
(zh)
|
2011-06-21 |
2014-03-19 |
伊缪诺金公司 |
具有肽连接子的新型美登木素生物碱衍生物及其偶联物
|
|
EP2732035A2
(en)
|
2011-07-15 |
2014-05-21 |
Sarepta Therapeutics, Inc. |
Methods and compositions for manipulating translation of protein isoforms from alternative initiation start sites
|
|
AU2012284265B2
(en)
|
2011-07-19 |
2017-08-17 |
Wave Life Sciences Ltd. |
Methods for the synthesis of functionalized nucleic acids
|
|
AU2012286994B2
(en)
|
2011-07-25 |
2017-08-10 |
Nationwide Children's Hospital, Inc. |
Recombinant virus products and methods for inhibition of expression of DUX4
|
|
EP3453761A1
(en)
|
2011-08-29 |
2019-03-13 |
Ionis Pharmaceuticals, Inc. |
Oligomer-conjugate complexes and their use
|
|
ES2945932T3
(es)
|
2011-10-14 |
2023-07-10 |
Seagen Inc |
Pirrolobenzodiazepinas y conjugados dirigidos
|
|
WO2013071079A1
(en)
|
2011-11-09 |
2013-05-16 |
President And Fellows Of Harvard College |
Lin28/let-7 crystal structures, purification protocols, and molecular probes suitable for screening assays and therapeutics
|
|
EP2780454A2
(en)
|
2011-11-18 |
2014-09-24 |
Alnylam Pharmaceuticals, Inc. |
Modified rnai agents
|
|
CN104244718A
(zh)
|
2011-12-05 |
2014-12-24 |
伊格尼卡生物治疗公司 |
抗体-药物缀合物以及相关化合物、组合物和方法
|
|
WO2013121175A1
(en)
|
2012-02-16 |
2013-08-22 |
Ucl Business Plc |
Lysosome-cleavable linker
|
|
CA2864872C
(en)
|
2012-02-24 |
2022-07-05 |
Alteogen Inc. |
Modified antibody in which motif comprising cysteine residue is bound
|
|
EP3272868A1
(en)
|
2012-05-02 |
2018-01-24 |
Arrowhead Pharmaceuticals, Inc. |
Organic compositions to treat kras-related diseases
|
|
AR090905A1
(es)
|
2012-05-02 |
2014-12-17 |
Merck Sharp & Dohme |
Conjugados que contienen tetragalnac y peptidos y procedimientos para la administracion de oligonucleotidos, composicion farmaceutica
|
|
US9981046B2
(en)
|
2012-05-15 |
2018-05-29 |
Concortis Biosystems, Corp., a wholly owned Subsidiary of Sorrento Therapeutics, Inc. |
Drug-conjugates, conjugation methods, and uses thereof
|
|
US9504756B2
(en)
|
2012-05-15 |
2016-11-29 |
Seattle Genetics, Inc. |
Self-stabilizing linker conjugates
|
|
JP6453212B2
(ja)
|
2012-07-13 |
2019-01-16 |
ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． |
キラル制御
|
|
US9950001B2
(en)
|
2012-08-20 |
2018-04-24 |
The Regents Of The University Of California |
Polynucleotides having bioreversible groups
|
|
KR102058381B1
(ko)
|
2012-08-24 |
2019-12-24 |
강원대학교산학협력단 |
인간 ｌ１ｃａｍ에 대한 인간화 항체 및 그의 제조 방법
|
|
CN104837502B
(zh)
|
2012-10-12 |
2018-08-10 |
麦迪穆有限责任公司 |
吡咯并苯并二氮杂卓及其结合物
|
|
US10077443B2
(en)
|
2012-11-15 |
2018-09-18 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotide conjugates
|
|
US10131682B2
(en)
|
2012-11-24 |
2018-11-20 |
Hangzhou Dac Biotech Co., Ltd. |
Hydrophilic linkers and their uses for conjugation of drugs to a cell binding molecules
|
|
RU2015129800A
(ru)
|
2012-12-21 |
2017-01-30 |
Биоэллаенс К. В. |
Гидрофильные саморазрушающиеся линкеры и их конъюгаты
|
|
US9481905B2
(en)
|
2013-02-19 |
2016-11-01 |
Orizhan Bioscience Limited |
Method of using neutrilized DNA (N-DNA) as surface probe for high throughput detection platform
|
|
SG11201507214SA
(en)
|
2013-03-13 |
2015-10-29 |
Medimmune Ltd |
Pyrrolobenzodiazepines and conjugates thereof
|
|
MX379256B
(es)
|
2013-03-15 |
2025-03-10 |
Regeneron Pharma |
Moleculas biologicamente activas, conjugados de las mismas, y usos terapeuticos.
|
|
CA2906812A1
(en)
|
2013-03-15 |
2014-09-18 |
Sarepta Therapeutics, Inc. |
Improved compositions for treating muscular dystrophy
|
|
EP2777714A1
(en)
|
2013-03-15 |
2014-09-17 |
NBE-Therapeutics LLC |
Method of producing an immunoligand/payload conjugate by means of a sequence-specific transpeptidase enzyme
|
|
CN105378083B
(zh)
|
2013-03-27 |
2018-09-21 |
伊萨纳治疗有限公司 |
修饰的TGF-β寡核苷酸
|
|
US9295731B2
(en)
|
2013-04-01 |
2016-03-29 |
Mark Quang Nguyen |
Cleavable drug conjugates, compositions thereof and methods of use
|
|
WO2014177042A1
(zh)
|
2013-04-28 |
2014-11-06 |
Qin Gang |
一种新型的连接子及其制备方法和用途
|
|
WO2014189973A2
(en)
|
2013-05-20 |
2014-11-27 |
Genentech, Inc. |
Anti-transferrin receptor antibodies and methods of use
|
|
US11229711B2
(en)
|
2013-06-06 |
2022-01-25 |
Magenta Therapeutics, Inc. |
Linkers for antibody-drug conjugates and related compounds, compositions, and methods of use
|
|
WO2014197871A2
(en)
|
2013-06-06 |
2014-12-11 |
Igenica Biotherapeutics, Inc. |
Antibody-drug conjugates, compositions and methods of use
|
|
TW201536329A
(zh)
|
2013-08-09 |
2015-10-01 |
Isis Pharmaceuticals Inc |
用於調節失養性肌強直蛋白質激酶(dmpk)表現之化合物及方法
|
|
EP2845607A1
(en)
|
2013-09-09 |
2015-03-11 |
University of Vienna |
Antisense oligonucleotides with improved pharmacokinetic properties
|
|
WO2015038426A1
(en)
|
2013-09-13 |
2015-03-19 |
Asana Biosciences, Llc |
Self-immolative linkers containing mandelic acid derivatives, drug-ligand conjugates for targeted therapies and uses thereof
|
|
ES2826398T3
(es)
|
2013-10-15 |
2021-05-18 |
Seagen Inc |
Enlazadores-fármacos pegilados para una mejor farmacocinética de los conjugados ligando-fármaco
|
|
WO2015057876A1
(en)
|
2013-10-15 |
2015-04-23 |
Sorrento Therapeutics Inc. |
Drug-conjugates with a targeting molecule and two different drugs
|
|
WO2015069587A2
(en)
|
2013-11-06 |
2015-05-14 |
Merck Sharp & Dohme Corp. |
Peptide containing conjugates for dual molecular delivery of oligonucleotides
|
|
US10378017B2
(en)
|
2013-12-02 |
2019-08-13 |
Brandeis University |
High temperature selection of nucleotide-supported carbohydrate vaccines and resulting glycosylated oligonucleotides
|
|
ES2917473T3
(es)
|
2014-01-16 |
2022-07-08 |
Wave Life Sciences Ltd |
Diseño quiral
|
|
WO2015113922A1
(en)
|
2014-01-30 |
2015-08-06 |
Roche Innovation Center Copenhagen A/S |
Poly oligomer compound with biocleavable conjugates
|
|
RU2695430C2
(ru)
|
2014-06-17 |
2019-07-23 |
Ниппон Синяку Ко., Лтд. |
Антисмысловые нуклеиновые кислоты
|
|
IL316808A
(en)
|
2014-08-20 |
2025-01-01 |
Alnylam Pharmaceuticals Inc |
Modified double-stranded RNA materials and their uses
|
|
EP3221362B1
(en)
|
2014-11-19 |
2019-07-24 |
F.Hoffmann-La Roche Ag |
Anti-transferrin receptor antibodies and methods of use
|
|
US10538763B2
(en)
|
2015-01-16 |
2020-01-21 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulation of DUX4
|
|
EP3286318A2
(en)
|
2015-04-22 |
2018-02-28 |
Mina Therapeutics Limited |
Sarna compositions and methods of use
|
|
EP3297649B1
(en)
|
2015-05-19 |
2023-10-11 |
Sarepta Therapeutics, Inc. |
Peptide oligonucleotide conjugates
|
|
MX391086B
(es)
|
2015-06-24 |
2025-03-21 |
Hoffmann La Roche |
Anticuerpos anti-receptor de transferrina con afinidad diseñada.
|
|
WO2017007886A2
(en)
|
2015-07-08 |
2017-01-12 |
Idera Pharmaceuticals, Inc. |
Compositions for inhibiting dux4 gene expression and uses thereof
|
|
JP6749589B2
(ja)
|
2015-07-31 |
2020-09-02 |
国立大学法人北海道大学 |
抗Ｅｖａ１タンパク質抗体
|
|
JP2019513371A
(ja)
|
2016-04-01 |
2019-05-30 |
アビディティー バイオサイエンシーズ エルエルシー |
核酸ポリペプチド組成物とその使用
|
|
WO2017192679A1
(en)
|
2016-05-04 |
2017-11-09 |
Wave Life Sciences Ltd. |
Methods and compositions of biologically active agents
|
|
CN109310765A
(zh)
|
2016-06-20 |
2019-02-05 |
领先基因生物技术股份有限公司 |
抗体-药物偶联物
|
|
US11427838B2
(en)
|
2016-06-29 |
2022-08-30 |
Vertex Pharmaceuticals Incorporated |
Materials and methods for treatment of myotonic dystrophy type 1 (DM1) and other related disorders
|
|
KR102645243B1
(ko)
|
2016-11-23 |
2024-03-11 |
알닐람 파마슈티칼스 인코포레이티드 |
표적외 효과가 감소된 변형 rna 작용제
|
|
MX2019008199A
(es)
|
2017-01-06 |
2019-11-25 |
Avidity Biosciences Llc |
Composiciones de acido nucleico polipeptido y metodos de induccion de la omision de exon.
|
|
DK3444010T3
(da)
|
2017-08-14 |
2021-03-15 |
Scandiedge Therapeutics Ab |
Pklr-inhibering i behandlingen af nafld og hcc
|
|
US20200282074A1
(en)
|
2017-09-22 |
2020-09-10 |
Avidity Biosciences, Inc. |
Nucleic acid-polypeptide compositions and methods of inducing exon skipping
|
|
AU2018345772B2
(en)
*
|
2017-10-02 |
2025-04-17 |
Research Institute At Nationwide Children's Hospital |
MiRNA detargeting system for tissue specific interference
|
|
WO2019071028A1
(en)
|
2017-10-04 |
2019-04-11 |
Avidity Biosciences Llc |
NUCLEIC ACID-POLYPEPTIDE COMPOSITIONS AND USES THEREOF
|
|
WO2019071147A1
(en)
|
2017-10-05 |
2019-04-11 |
Fulcrum Therapeutics, Inc. |
INHIBITORS OF KINASE P38 REDUCING EXPRESSION OF DUX4 GENE AND DOWNSTREAM GENES FOR THE TREATMENT OF FSHD
|
|
JP7506601B2
(ja)
|
2017-12-06 |
2024-06-26 |
アビディティー バイオサイエンシーズ，インク． |
筋萎縮症と筋緊張性ジストロフィーを処置するための組成物および方法
|
|
EP3829595A4
(en)
|
2018-08-02 |
2022-08-24 |
Dyne Therapeutics, Inc. |
MUSCLE-DIRECTED COMPLEXES AND USES THEREOF IN THE TREATMENT OF DYSTROPHINOPATHIES
|
|
CN112930193A
(zh)
|
2018-08-02 |
2021-06-08 |
达因疗法公司 |
肌肉靶向复合物及其在治疗肌肉萎缩中的用途
|
|
US20220193250A1
(en)
*
|
2018-08-02 |
2022-06-23 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
|
|
IL312067B2
(en)
|
2018-12-21 |
2025-08-01 |
Avidity Biosciences Inc |
Anti-transferrin receptor antibodies and uses thereof
|
|
AU2019419494B2
(en)
|
2018-12-31 |
2026-03-26 |
Research Institute At Nationwide Children's Hospital |
DUX4 RNA silencing using RNA targeting CRISPR-Cas13b
|
|
TW202104595A
(zh)
|
2019-03-29 |
2021-02-01 |
日商田邊三菱製藥股份有限公司 |
用來調節ｄｕｘ４的表現之化合物、方法及醫藥組成物
|
|
KR20220019259A
(ko)
*
|
2019-06-06 |
2022-02-16 |
어비디티 바이오사이언시스 인크. |
Una 아미다이트 및 이의 용도
|
|
KR20220125801A
(ko)
|
2020-01-10 |
2022-09-14 |
다인 세라퓨틱스, 인크. |
근육 표적화 복합체 및 안면견갑상완 근육 이영양증을 치료하기 위한 그의 용도
|
|
US11555190B2
(en)
|
2020-03-19 |
2023-01-17 |
Avidity Biosciences, Inc. |
Compositions and methods of treating Facioscapulohumeral muscular dystrophy
|
|
AR123420A1
(es)
|
2020-09-01 |
2022-11-30 |
Ultragenyx Pharmaceutical Inc |
Inhibidores de dux4 y métodos de uso de estos
|
|
US11638761B2
(en)
*
|
2021-07-09 |
2023-05-02 |
Dyne Therapeutics, Inc. |
Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy
|
|
EP4370678A2
(en)
|
2021-07-14 |
2024-05-22 |
Mirecule, Inc. |
Oligonucleotides and compositions thereof for neuromuscular disorders
|
|
MX2024003266A
(es)
|
2021-09-16 |
2024-04-03 |
Avidity Biosciences Inc |
Composiciones y metodos de tratamiento de la distrofia muscular facioescapulohumeral.
|