CA3019568A1 - Nucleic acid-polypeptide compositions and uses thereof - Google Patents

Nucleic acid-polypeptide compositions and uses thereof Download PDF

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Publication number
CA3019568A1
CA3019568A1 CA3019568A CA3019568A CA3019568A1 CA 3019568 A1 CA3019568 A1 CA 3019568A1 CA 3019568 A CA3019568 A CA 3019568A CA 3019568 A CA3019568 A CA 3019568A CA 3019568 A1 CA3019568 A1 CA 3019568A1
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Prior art keywords
instances
molecule
acid molecule
polynucleic acid
polynucleotide
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CA3019568A
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English (en)
French (fr)
Inventor
Andrew John Geall
Venkata Ramana Doppalapudi
David Sai-Ho CHU
Michael Caramian COCHRAN
Rachel Elizabeth JOHNS
Palani Balu
Rob BURKE
Beatrice Diana DARIMONT
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Avidity Biosciences Inc
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Avidity Biosciences Inc
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Publication of CA3019568A1 publication Critical patent/CA3019568A1/en
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    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • A61K31/7088Compounds having three or more nucleosides or nucleotides
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    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/712Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
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    • A61K47/6889Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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