IT201800009682A1 - Coniugati di acidi biliari e loro derivati per la veicolazione di molecole attive - Google Patents
Coniugati di acidi biliari e loro derivati per la veicolazione di molecole attiveInfo
- Publication number
- IT201800009682A1 IT201800009682A1 IT102018000009682A IT201800009682A IT201800009682A1 IT 201800009682 A1 IT201800009682 A1 IT 201800009682A1 IT 102018000009682 A IT102018000009682 A IT 102018000009682A IT 201800009682 A IT201800009682 A IT 201800009682A IT 201800009682 A1 IT201800009682 A1 IT 201800009682A1
- Authority
- IT
- Italy
- Prior art keywords
- conjugates
- carriage
- derivatives
- active molecules
- biliary acids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Botany (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102018000009682A IT201800009682A1 (it) | 2018-10-22 | 2018-10-22 | Coniugati di acidi biliari e loro derivati per la veicolazione di molecole attive |
| PCT/IB2019/059014 WO2020084488A1 (en) | 2018-10-22 | 2019-10-22 | Conjugates of bile acids and their derivatives for active molecules delivery |
| JP2021547966A JP2022513392A (ja) | 2018-10-22 | 2019-10-22 | 活性分子送達のための胆汁酸及びそれらの誘導体の抱合体 |
| US17/287,416 US20220267780A1 (en) | 2018-10-22 | 2019-10-22 | Conjugates of bile acids and their derivatives for active molecules delivery |
| EP19808885.8A EP3870230A1 (en) | 2018-10-22 | 2019-10-22 | Conjugates of bile acids and their derivatives for active molecules delivery |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102018000009682A IT201800009682A1 (it) | 2018-10-22 | 2018-10-22 | Coniugati di acidi biliari e loro derivati per la veicolazione di molecole attive |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IT201800009682A1 true IT201800009682A1 (it) | 2020-04-22 |
Family
ID=65244483
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT102018000009682A IT201800009682A1 (it) | 2018-10-22 | 2018-10-22 | Coniugati di acidi biliari e loro derivati per la veicolazione di molecole attive |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20220267780A1 (it) |
| EP (1) | EP3870230A1 (it) |
| JP (1) | JP2022513392A (it) |
| IT (1) | IT201800009682A1 (it) |
| WO (1) | WO2020084488A1 (it) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3108282A1 (en) | 2018-08-02 | 2020-02-06 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| KR20210081324A (ko) | 2018-08-02 | 2021-07-01 | 다인 세라퓨틱스, 인크. | 근육 표적화 복합체 및 안면견갑상완 근육 이영양증을 치료하기 위한 그의 용도 |
| US11911484B2 (en) | 2018-08-02 | 2024-02-27 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| US11168141B2 (en) | 2018-08-02 | 2021-11-09 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| US12018087B2 (en) | 2018-08-02 | 2024-06-25 | Dyne Therapeutics, Inc. | Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject |
| US11638761B2 (en) | 2021-07-09 | 2023-05-02 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy |
| US11969475B2 (en) | 2021-07-09 | 2024-04-30 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy |
| US11633498B2 (en) | 2021-07-09 | 2023-04-25 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating myotonic dystrophy |
| US11648318B2 (en) | 2021-07-09 | 2023-05-16 | Dyne Therapeutics, Inc. | Anti-transferrin receptor (TFR) antibody and uses thereof |
| US11771776B2 (en) | 2021-07-09 | 2023-10-03 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
| US11931421B2 (en) | 2022-04-15 | 2024-03-19 | Dyne Therapeutics, Inc. | Muscle targeting complexes and formulations for treating myotonic dystrophy |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140323544A1 (en) * | 2013-03-14 | 2014-10-30 | Sarepta Therapeutics, Inc. | Exon skipping compositions for treating muscular dystrophy |
| WO2018031933A2 (en) * | 2016-08-12 | 2018-02-15 | University Of Massachusetts | Conjugated oligonucleotides |
-
2018
- 2018-10-22 IT IT102018000009682A patent/IT201800009682A1/it unknown
-
2019
- 2019-10-22 US US17/287,416 patent/US20220267780A1/en active Pending
- 2019-10-22 JP JP2021547966A patent/JP2022513392A/ja active Pending
- 2019-10-22 EP EP19808885.8A patent/EP3870230A1/en active Pending
- 2019-10-22 WO PCT/IB2019/059014 patent/WO2020084488A1/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140323544A1 (en) * | 2013-03-14 | 2014-10-30 | Sarepta Therapeutics, Inc. | Exon skipping compositions for treating muscular dystrophy |
| WO2018031933A2 (en) * | 2016-08-12 | 2018-02-15 | University Of Massachusetts | Conjugated oligonucleotides |
Non-Patent Citations (8)
| Title |
|---|
| "Remington: The Science and Practice of Pharmacy", 2005, LIPPINCOTT WILLIAMS |
| "Remington's Pharmaceutical Sciences", 1985, MACK PUBLISHING CO. |
| "Remington's Pharmaceutical Sciences", 2000, WILLIAMS & WILKINS PA |
| DEBART F ET AL: "Chemical modifications to improve the cellular uptake of oligonucleotides", CURRENT TOPICS IN MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBLISHERS LTD.HILVERSUM, NL, vol. 7, no. 7, 1 January 2007 (2007-01-01), pages 727 - 737, XP002562043, ISSN: 1568-0266, DOI: 10.2174/156802607780487704 * |
| LEHMANN T J ET AL: "Synthesis and Properties of Bile Acid Phosphoramidites 5'-Tethered to Antisense Oligodeoxynucleotides against HCV", BIOORGANIC & MEDICINAL CHEMISTRY : A TETRAHEDRON PUBLICATION FOR THE RAPID DISSEMINATION OF FULL ORIGINAL RESEARCH PAPERS AND CRITICAL REVIEWS ON BIOMOLECULAR CHEMISTRY, MEDICINAL CHEMISTRY AND RELATED DISCIPLINES, ELSEVIER, NL, vol. 9, no. 7, 1 July 2001 (2001-07-01), pages 1827 - 1835, XP027414418, ISSN: 0968-0896, [retrieved on 20010701] * |
| LOYD V. ALLEN; HOWARD C. ANSEL: "Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems", 2014 |
| MANOHARAN M ET AL: "CHEMICAL MODIFICATIONS TO IMPROVE UPTAKE AND BIOAVAILABILITY OF ANTISENSE OLIGONUCLEOTIDES", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, NEW YORK ACADEMY OF SCIENCES, US, vol. 660, 1 January 1992 (1992-01-01), pages 306 - 309, XP000198020, ISSN: 0077-8923, DOI: 10.1111/J.1749-6632.1992.TB21095.X * |
| NATURE MEDICINE, vol. 21, 2015, pages 270 - 279 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2020084488A1 (en) | 2020-04-30 |
| JP2022513392A (ja) | 2022-02-07 |
| US20220267780A1 (en) | 2022-08-25 |
| EP3870230A1 (en) | 2021-09-01 |
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