JP2020028294A5 - - Google Patents
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- Publication number
- JP2020028294A5 JP2020028294A5 JP2019181243A JP2019181243A JP2020028294A5 JP 2020028294 A5 JP2020028294 A5 JP 2020028294A5 JP 2019181243 A JP2019181243 A JP 2019181243A JP 2019181243 A JP2019181243 A JP 2019181243A JP 2020028294 A5 JP2020028294 A5 JP 2020028294A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- acid sequence
- amino acid
- bispecific
- immunoconjugate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 50
- 229940127121 immunoconjugate Drugs 0.000 claims 41
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 38
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 claims 25
- 150000001413 amino acids Chemical class 0.000 claims 22
- 201000010099 disease Diseases 0.000 claims 22
- 102000052645 human CD38 Human genes 0.000 claims 21
- 208000035475 disorder Diseases 0.000 claims 16
- 208000026278 immune system disease Diseases 0.000 claims 10
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 9
- 150000007523 nucleic acids Chemical group 0.000 claims 9
- 206010025323 Lymphomas Diseases 0.000 claims 8
- 238000007792 addition Methods 0.000 claims 8
- 230000037430 deletion Effects 0.000 claims 8
- 238000012217 deletion Methods 0.000 claims 8
- 238000006467 substitution reaction Methods 0.000 claims 8
- 201000003444 follicular lymphoma Diseases 0.000 claims 6
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 5
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 claims 4
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 4
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 4
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 4
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 4
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 4
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 4
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 4
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 4
- 210000001744 T-lymphocyte Anatomy 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 208000034578 Multiple myelomas Diseases 0.000 claims 3
- 231100000588 tumorigenic Toxicity 0.000 claims 3
- 230000000381 tumorigenic effect Effects 0.000 claims 3
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 2
- 208000036762 Acute promyelocytic leukaemia Diseases 0.000 claims 2
- 206010073478 Anaplastic large-cell lymphoma Diseases 0.000 claims 2
- 208000003950 B-cell lymphoma Diseases 0.000 claims 2
- 208000017604 Hodgkin disease Diseases 0.000 claims 2
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 2
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 2
- 208000030289 Lymphoproliferative disease Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000008691 Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 2
- 208000033826 Promyelocytic Acute Leukemia Diseases 0.000 claims 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
- 208000033559 Waldenström macroglobulinemia Diseases 0.000 claims 2
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 201000001268 lymphoproliferative syndrome Diseases 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 210000000822 natural killer cell Anatomy 0.000 claims 2
- 208000031223 plasma cell leukemia Diseases 0.000 claims 2
- 208000022256 primary systemic amyloidosis Diseases 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 201000006845 reticulosarcoma Diseases 0.000 claims 2
- 208000029922 reticulum cell sarcoma Diseases 0.000 claims 2
- 208000016683 Adult T-cell leukemia/lymphoma Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000004736 B-Cell Leukemia Diseases 0.000 claims 1
- 208000036170 B-Cell Marginal Zone Lymphoma Diseases 0.000 claims 1
- 208000025324 B-cell acute lymphoblastic leukemia Diseases 0.000 claims 1
- 208000028564 B-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
- 208000032568 B-cell prolymphocytic leukaemia Diseases 0.000 claims 1
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
- 208000011691 Burkitt lymphomas Diseases 0.000 claims 1
- 208000016778 CD4+/CD56+ hematodermic neoplasm Diseases 0.000 claims 1
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
- 108010036949 Cyclosporine Proteins 0.000 claims 1
- 208000016937 Extranodal nasal NK/T cell lymphoma Diseases 0.000 claims 1
- 102000009109 Fc receptors Human genes 0.000 claims 1
- 108010087819 Fc receptors Proteins 0.000 claims 1
- 206010018364 Glomerulonephritis Diseases 0.000 claims 1
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 208000005531 Immunoglobulin Light-chain Amyloidosis Diseases 0.000 claims 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
- 208000006404 Large Granular Lymphocytic Leukemia Diseases 0.000 claims 1
- 208000032004 Large-Cell Anaplastic Lymphoma Diseases 0.000 claims 1
- 208000005777 Lupus Nephritis Diseases 0.000 claims 1
- 208000028018 Lymphocytic leukaemia Diseases 0.000 claims 1
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
- 201000007224 Myeloproliferative neoplasm Diseases 0.000 claims 1
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 claims 1
- 208000027190 Peripheral T-cell lymphomas Diseases 0.000 claims 1
- 208000007452 Plasmacytoma Diseases 0.000 claims 1
- 206010036711 Primary mediastinal large B-cell lymphomas Diseases 0.000 claims 1
- 208000035416 Prolymphocytic B-Cell Leukemia Diseases 0.000 claims 1
- 208000033759 Prolymphocytic T-Cell Leukemia Diseases 0.000 claims 1
- 208000010502 Subcutaneous panniculitis-like T-cell lymphoma Diseases 0.000 claims 1
- 208000031672 T-Cell Peripheral Lymphoma Diseases 0.000 claims 1
- 206010042971 T-cell lymphoma Diseases 0.000 claims 1
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
- 208000026651 T-cell prolymphocytic leukemia Diseases 0.000 claims 1
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims 1
- 201000006966 adult T-cell leukemia Diseases 0.000 claims 1
- 208000015230 aggressive NK-cell leukemia Diseases 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 229960001265 ciclosporin Drugs 0.000 claims 1
- 229930182912 cyclosporin Natural products 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 208000024908 graft versus host disease Diseases 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 201000009277 hairy cell leukemia Diseases 0.000 claims 1
- 208000025750 heavy chain disease Diseases 0.000 claims 1
- 206010066957 hepatosplenic T-cell lymphoma Diseases 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 229940124589 immunosuppressive drug Drugs 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 102000008616 interleukin-15 receptor activity proteins Human genes 0.000 claims 1
- 108040002039 interleukin-15 receptor activity proteins Proteins 0.000 claims 1
- 208000026876 intravascular large B-cell lymphoma Diseases 0.000 claims 1
- 230000003902 lesion Effects 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 208000003747 lymphoid leukemia Diseases 0.000 claims 1
- 201000007919 lymphoplasmacytic lymphoma Diseases 0.000 claims 1
- 230000036210 malignancy Effects 0.000 claims 1
- 201000007924 marginal zone B-cell lymphoma Diseases 0.000 claims 1
- 208000021937 marginal zone lymphoma Diseases 0.000 claims 1
- 201000000638 mature B-cell neoplasm Diseases 0.000 claims 1
- 208000020968 mature T-cell and NK-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
- 229960000485 methotrexate Drugs 0.000 claims 1
- 201000005962 mycosis fungoides Diseases 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 208000010915 neoplasm of mature B-cells Diseases 0.000 claims 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N phenylalanine group Chemical group N[C@@H](CC1=CC=CC=C1)C(=O)O COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 1
- 210000004180 plasmocyte Anatomy 0.000 claims 1
- 208000000814 primary cutaneous anaplastic large cell lymphoma Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 1
- 210000000952 spleen Anatomy 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021077001A JP2021121195A (ja) | 2005-03-23 | 2021-04-30 | 多発性骨髄腫の治療のためのｃｄ３８に対する抗体 |
| JP2022167345A JP2023017781A (ja) | 2005-03-23 | 2022-10-19 | 多発性骨髄腫の治療のためのｃｄ３８に対する抗体 |
| JP2024032651A JP2024059959A (ja) | 2005-03-23 | 2024-03-05 | 多発性骨髄腫の治療のためのｃｄ３８に対する抗体 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200500429 | 2005-03-23 | ||
| DKPA200500429 | 2005-03-23 | ||
| US66757905P | 2005-04-01 | 2005-04-01 | |
| US60/667,579 | 2005-04-01 | ||
| US69616305P | 2005-07-01 | 2005-07-01 | |
| US60/696,163 | 2005-07-01 | ||
| US72856105P | 2005-10-20 | 2005-10-20 | |
| US60/728,561 | 2005-10-20 | ||
| JP2019025048A JP6777779B2 (ja) | 2005-03-23 | 2019-02-15 | 多発性骨髄腫の治療のためのｃｄ３８に対する抗体 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019025048A Division JP6777779B2 (ja) | 2005-03-23 | 2019-02-15 | 多発性骨髄腫の治療のためのｃｄ３８に対する抗体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021077001A Division JP2021121195A (ja) | 2005-03-23 | 2021-04-30 | 多発性骨髄腫の治療のためのｃｄ３８に対する抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020028294A JP2020028294A (ja) | 2020-02-27 |
| JP2020028294A5 true JP2020028294A5 (enExample) | 2020-04-09 |
| JP6952088B2 JP6952088B2 (ja) | 2021-10-20 |
Family
ID=36617365
Family Applications (12)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008502252A Active JP5225069B2 (ja) | 2005-03-23 | 2006-03-23 | 多発性骨髄腫の治療のためのｃｄ３８に対する抗体 |
| JP2011229506A Active JP5971918B2 (ja) | 2005-03-23 | 2011-10-19 | 多発性骨髄腫の治療のためのｃｄ３８に対する抗体 |
| JP2014028055A Withdrawn JP2014110800A (ja) | 2005-03-23 | 2014-02-18 | 多発性骨髄腫の治療のためのｃｄ３８に対する抗体 |
| JP2016114979A Withdrawn JP2016169226A (ja) | 2005-03-23 | 2016-06-09 | 多発性骨髄腫の治療のためのｃｄ３８に対する抗体 |
| JP2017233007A Active JP6494053B2 (ja) | 2005-03-23 | 2017-12-05 | 多発性骨髄腫の治療のためのｃｄ３８に対する抗体 |
| JP2018167493A Active JP6578423B2 (ja) | 2005-03-23 | 2018-09-07 | 多発性骨髄腫の治療のためのｃｄ３８に対する抗体 |
| JP2019025048A Active JP6777779B2 (ja) | 2005-03-23 | 2019-02-15 | 多発性骨髄腫の治療のためのｃｄ３８に対する抗体 |
| JP2019181243A Active JP6952088B2 (ja) | 2005-03-23 | 2019-10-01 | 多発性骨髄腫の治療のためのｃｄ３８に対する抗体 |
| JP2020085757A Withdrawn JP2020141689A (ja) | 2005-03-23 | 2020-05-15 | 多発性骨髄腫の治療のためのｃｄ３８に対する抗体 |
| JP2021077001A Withdrawn JP2021121195A (ja) | 2005-03-23 | 2021-04-30 | 多発性骨髄腫の治療のためのｃｄ３８に対する抗体 |
| JP2022167345A Withdrawn JP2023017781A (ja) | 2005-03-23 | 2022-10-19 | 多発性骨髄腫の治療のためのｃｄ３８に対する抗体 |
| JP2024032651A Withdrawn JP2024059959A (ja) | 2005-03-23 | 2024-03-05 | 多発性骨髄腫の治療のためのｃｄ３８に対する抗体 |
Family Applications Before (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008502252A Active JP5225069B2 (ja) | 2005-03-23 | 2006-03-23 | 多発性骨髄腫の治療のためのｃｄ３８に対する抗体 |
| JP2011229506A Active JP5971918B2 (ja) | 2005-03-23 | 2011-10-19 | 多発性骨髄腫の治療のためのｃｄ３８に対する抗体 |
| JP2014028055A Withdrawn JP2014110800A (ja) | 2005-03-23 | 2014-02-18 | 多発性骨髄腫の治療のためのｃｄ３８に対する抗体 |
| JP2016114979A Withdrawn JP2016169226A (ja) | 2005-03-23 | 2016-06-09 | 多発性骨髄腫の治療のためのｃｄ３８に対する抗体 |
| JP2017233007A Active JP6494053B2 (ja) | 2005-03-23 | 2017-12-05 | 多発性骨髄腫の治療のためのｃｄ３８に対する抗体 |
| JP2018167493A Active JP6578423B2 (ja) | 2005-03-23 | 2018-09-07 | 多発性骨髄腫の治療のためのｃｄ３８に対する抗体 |
| JP2019025048A Active JP6777779B2 (ja) | 2005-03-23 | 2019-02-15 | 多発性骨髄腫の治療のためのｃｄ３８に対する抗体 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020085757A Withdrawn JP2020141689A (ja) | 2005-03-23 | 2020-05-15 | 多発性骨髄腫の治療のためのｃｄ３８に対する抗体 |
| JP2021077001A Withdrawn JP2021121195A (ja) | 2005-03-23 | 2021-04-30 | 多発性骨髄腫の治療のためのｃｄ３８に対する抗体 |
| JP2022167345A Withdrawn JP2023017781A (ja) | 2005-03-23 | 2022-10-19 | 多発性骨髄腫の治療のためのｃｄ３８に対する抗体 |
| JP2024032651A Withdrawn JP2024059959A (ja) | 2005-03-23 | 2024-03-05 | 多発性骨髄腫の治療のためのｃｄ３８に対する抗体 |
Country Status (27)
| Country | Link |
|---|---|
| US (5) | US7829673B2 (enExample) |
| EP (6) | EP2567976B1 (enExample) |
| JP (12) | JP5225069B2 (enExample) |
| KR (1) | KR101433381B1 (enExample) |
| CN (4) | CN112480257A (enExample) |
| AU (1) | AU2006226733C9 (enExample) |
| BR (1) | BRPI0608927B1 (enExample) |
| CA (1) | CA2602375C (enExample) |
| CY (3) | CY1118369T1 (enExample) |
| DK (1) | DK2567976T3 (enExample) |
| EA (2) | EA015584B1 (enExample) |
| ES (1) | ES2716874T3 (enExample) |
| FR (1) | FR18C1003I2 (enExample) |
| HR (2) | HRP20161766T1 (enExample) |
| IL (8) | IL296666A (enExample) |
| LT (1) | LTC2567976I2 (enExample) |
| LU (1) | LUC00053I9 (enExample) |
| ME (1) | ME03528B (enExample) |
| MX (1) | MX2007011064A (enExample) |
| NL (1) | NL300915I2 (enExample) |
| NZ (2) | NZ586780A (enExample) |
| PL (1) | PL2567976T3 (enExample) |
| RS (1) | RS59399B1 (enExample) |
| SG (1) | SG10201912554TA (enExample) |
| SI (1) | SI2567976T1 (enExample) |
| WO (1) | WO2006099875A1 (enExample) |
| ZA (1) | ZA200709003B (enExample) |
Families Citing this family (251)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003202297C1 (en) | 2002-01-25 | 2006-05-18 | G2 Therapies Ltd | Anti-C5aR antibodies and uses thereof |
| US9200061B2 (en) | 2004-02-06 | 2015-12-01 | Morpho Sys AG | Generation and profiling of fully human HuCAL gold®-derived therapeutic antibodies specific for human CD3i |
| CA2555185C (en) * | 2004-02-06 | 2020-03-24 | Morphosys Ag | Anti-cd38 human antibodies and uses therefor |
| EA015584B1 (ru) * | 2005-03-23 | 2011-10-31 | Генмаб А/С | Антитело к cd38 человека и его применение |
| JP5362359B2 (ja) | 2005-10-12 | 2013-12-11 | モルフォシス アーゲー | ヒトＣＤ３８に特異的な完全ヒトＨｕＣＡＬＧＯＬＤ由来の治療抗体の生成とプロファイリング |
| EP1963370A1 (en) * | 2005-12-06 | 2008-09-03 | Domantis Limited | Bispecific ligands with binding specificity to cell surface targets and methods of use therefor |
| EP2046383B1 (en) | 2006-07-04 | 2014-11-19 | Genmab A/S | Cd20 binding molecules for the treatment of copd |
| US20090029904A1 (en) * | 2006-07-21 | 2009-01-29 | Sean Oldham | Compositions and methods for treatment of insulin-resistance diseases |
| EP2073843A4 (en) * | 2006-09-15 | 2010-07-28 | Sloan Kettering Inst Cancer | METHOD FOR DIAGNOSING, TREATING OR PREVENTING PLASMA CELL DISEASES |
| HRP20191115T1 (hr) * | 2006-09-26 | 2019-09-20 | Genmab A/S | Anti-cd38 u kombinaciji s kortikosteroidima zajedno s jednim ne-kortikosteroidnim kemoterapeutikom za liječenje tumora |
| WO2008040348A2 (en) * | 2006-10-03 | 2008-04-10 | Genmab A/S | High througput methods for characterization of antibodies |
| AU2013209322A1 (en) * | 2006-10-19 | 2013-08-15 | Sanofi-Aventis | Novel anti-cd38 antibodies for the treatment of cancer |
| EP1914242A1 (en) * | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Novel anti-CD38 antibodies for the treatment of cancer |
| US8143014B2 (en) * | 2007-10-02 | 2012-03-27 | Mayo Foundation For Medical Education And Research | CD38 and obesity |
| JP2011507933A (ja) | 2007-12-26 | 2011-03-10 | バイオテスト・アクチエンゲゼルシヤフト | 免疫複合体の細胞傷害性副作用の低減及び有効性の改善方法 |
| JP5817034B2 (ja) | 2007-12-26 | 2015-11-18 | バイオテスト・アクチエンゲゼルシヤフト | Ｃｄ１３８を標的とする免疫複合体及びその使用 |
| BRPI0821417A2 (pt) | 2007-12-26 | 2015-06-16 | Biotest Ag | Método para diminuir a adesão de células de estroma a células tumorais que expressam cd138 em células tumorais de um indivíduo em necessidade do mesmo |
| US9221914B2 (en) | 2007-12-26 | 2015-12-29 | Biotest Ag | Agents targeting CD138 and uses thereof |
| KR20100117120A (ko) | 2008-02-20 | 2010-11-02 | 지투 인플레메이션 피티와이 엘티디 | 인간화된 항-Ｃ5ａＲ 항체 |
| GB0808350D0 (en) * | 2008-05-09 | 2008-06-18 | Airbus Uk Ltd | Self-cleaning surfaces |
| KR20110013409A (ko) * | 2008-05-23 | 2011-02-09 | 삼성전자주식회사 | 항체-펩티드 융합 상승체 |
| US8188235B2 (en) * | 2008-06-18 | 2012-05-29 | Pfizer Inc. | Antibodies to IL-6 and their uses |
| EP2191843A1 (en) * | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and cyclophosphamide |
| EP2191842A1 (en) * | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and cytarabine |
| EP2191841A1 (en) * | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and vincristine |
| EP2191840A1 (en) * | 2008-11-28 | 2010-06-02 | Sanofi-Aventis | Antitumor combinations containing antibodies recognizing specifically CD38 and melphalan |
| AU2013201618B2 (en) * | 2009-05-06 | 2016-06-02 | Biotest Ag | Uses of immunoconjugates targeting CD138 |
| AU2010244428B2 (en) | 2009-05-06 | 2015-01-29 | Biotest Ag | Uses of immunoconjugates targeting CD138 |
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