JP2011520898A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011520898A5 JP2011520898A5 JP2011509636A JP2011509636A JP2011520898A5 JP 2011520898 A5 JP2011520898 A5 JP 2011520898A5 JP 2011509636 A JP2011509636 A JP 2011509636A JP 2011509636 A JP2011509636 A JP 2011509636A JP 2011520898 A5 JP2011520898 A5 JP 2011520898A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- antibody
- acid sequence
- seq
- region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12740308P | 2008-05-13 | 2008-05-13 | |
| US61/127,403 | 2008-05-13 | ||
| US19415608P | 2008-09-25 | 2008-09-25 | |
| US61/194,156 | 2008-09-25 | ||
| PCT/US2009/043734 WO2009140348A2 (en) | 2008-05-13 | 2009-05-13 | Anti-il-6/il-6r antibodies and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015062036A Division JP6195586B2 (ja) | 2008-05-13 | 2015-03-25 | 抗ｉｌ−６／ｉｌ−６ｒ抗体およびそれらの使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011520898A JP2011520898A (ja) | 2011-07-21 |
| JP2011520898A5 true JP2011520898A5 (enExample) | 2013-03-14 |
Family
ID=41319307
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011509636A Pending JP2011520898A (ja) | 2008-05-13 | 2009-05-13 | 抗ｉｌ−６／ｉｌ−６ｒ抗体およびそれらの使用方法 |
| JP2015062036A Active JP6195586B2 (ja) | 2008-05-13 | 2015-03-25 | 抗ｉｌ−６／ｉｌ−６ｒ抗体およびそれらの使用方法 |
| JP2017091252A Withdrawn JP2017128613A (ja) | 2008-05-13 | 2017-05-01 | 抗ｉｌ−６／ｉｌ−６ｒ抗体およびそれらの使用方法 |
| JP2020099264A Active JP6923709B2 (ja) | 2008-05-13 | 2020-06-08 | 抗ｉｌ−６／ｉｌ−６ｒ抗体およびそれらの使用方法 |
| JP2021124411A Active JP7297823B2 (ja) | 2008-05-13 | 2021-07-29 | 抗ｉｌ－６／ｉｌ－６ｒ抗体およびそれらの使用方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015062036A Active JP6195586B2 (ja) | 2008-05-13 | 2015-03-25 | 抗ｉｌ−６／ｉｌ−６ｒ抗体およびそれらの使用方法 |
| JP2017091252A Withdrawn JP2017128613A (ja) | 2008-05-13 | 2017-05-01 | 抗ｉｌ−６／ｉｌ−６ｒ抗体およびそれらの使用方法 |
| JP2020099264A Active JP6923709B2 (ja) | 2008-05-13 | 2020-06-08 | 抗ｉｌ−６／ｉｌ−６ｒ抗体およびそれらの使用方法 |
| JP2021124411A Active JP7297823B2 (ja) | 2008-05-13 | 2021-07-29 | 抗ｉｌ－６／ｉｌ－６ｒ抗体およびそれらの使用方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (6) | US8034344B2 (enExample) |
| EP (1) | EP2297202B1 (enExample) |
| JP (5) | JP2011520898A (enExample) |
| CN (1) | CN102089326B (enExample) |
| AU (1) | AU2009246430B2 (enExample) |
| CA (1) | CA2724279C (enExample) |
| DK (1) | DK2297202T3 (enExample) |
| ES (1) | ES2564635T3 (enExample) |
| IL (1) | IL209277A (enExample) |
| MX (1) | MX2010012031A (enExample) |
| WO (1) | WO2009140348A2 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006035617A1 (de) * | 2006-07-31 | 2008-02-21 | Siemens Ag | Automatische Bestimmung von Tumorlast |
| TW200831528A (en) | 2006-11-30 | 2008-08-01 | Astrazeneca Ab | Compounds |
| WO2009014263A1 (ja) * | 2007-07-26 | 2009-01-29 | Osaka University | インターロイキン６受容体阻害剤を有効成分とする眼炎症疾患治療剤 |
| AU2009246430B2 (en) | 2008-05-13 | 2015-07-02 | Novimmune S.A. | Anti-IL-6/IL-6R antibodies and methods of use thereof |
| WO2011032119A1 (en) | 2009-09-14 | 2011-03-17 | The Regents Of The University Of Colorado | Modulation of yeast-based immunotherapy products and responses |
| WO2012098238A1 (en) | 2011-01-21 | 2012-07-26 | Novimmune S.A. | Combination therapies and methods using anti-cd3 modulating agents and anti-il-6 antagonists |
| AU2012223449A1 (en) * | 2011-03-03 | 2013-05-02 | Apexigen, Inc. | Anti-IL-6 receptor antibodies and methods of use |
| WO2013075027A2 (en) * | 2011-11-17 | 2013-05-23 | Emergent Product Development Seattle, Llc | Anti-sil6xr complex binding domains and methods of use |
| KR101510302B1 (ko) | 2012-05-11 | 2015-04-10 | 가톨릭대학교 산학협력단 | Ｉｌ-６ 수용체를 표적으로 하는 항체가 생성되도록 미니서클 벡터를 통해 형질전환된 줄기세포 치료제 |
| US10504132B2 (en) | 2012-11-27 | 2019-12-10 | American Express Travel Related Services Company, Inc. | Dynamic rewards program |
| AU2015232352B2 (en) * | 2014-03-17 | 2021-02-18 | Mitsubishi Tanabe Pharma Corporation | Antibody-fynomer conjugates |
| KR102709681B1 (ko) | 2015-07-31 | 2024-09-26 | 메디뮨 리미티드 | 헵시딘 매개 장애의 치료 방법 |
| EP3371224A1 (en) * | 2015-11-03 | 2018-09-12 | Sanofi Biotechnology | Compositions comprising il6r antibodies for the treatment of uveitis and macular edema and methods of using same |
| US20190192692A1 (en) * | 2016-05-05 | 2019-06-27 | The Trustees Of The University Of Pennsylvania | DNA Monoclonal Antibodies Targeting IL-6 and CD126 |
| WO2018112237A1 (en) | 2016-12-14 | 2018-06-21 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with an il-6r inhibitor |
| WO2018112232A1 (en) | 2016-12-14 | 2018-06-21 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with an il-12/il-23 inhibitor released using an ingestible device |
| EP3554541B1 (en) | 2016-12-14 | 2023-06-07 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor |
| GB2558223B (en) | 2016-12-22 | 2021-03-31 | Heraeus Electro Nite Int | Method for measuring a temperature of a molten metal bath |
| WO2018144773A1 (en) | 2017-02-01 | 2018-08-09 | Yale University | Treatment of diuretic resistance |
| US20210138213A1 (en) | 2017-03-30 | 2021-05-13 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immune modulatory agent released using an ingestible device |
| CN111051343B (zh) * | 2017-09-13 | 2022-11-22 | 江苏恒瑞医药股份有限公司 | Il-6r抗体、其抗原结合片段及医药用途 |
| JP7395479B2 (ja) | 2018-01-05 | 2023-12-11 | ノヴォ ノルディスク アー／エス | 免疫抑制なしにｉｌ－６媒介性炎症を処置する方法 |
| WO2019221601A1 (en) * | 2018-05-15 | 2019-11-21 | Erasmus University Medical Center Rotterdam | Treatments and biomarkers for the prognosis of zika virus infection |
| WO2019246317A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease or condition in a tissue originating from the endoderm |
| WO2019246271A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an il-12/il-23 inhibitor |
| WO2019246312A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immunomodulator |
| CN110055224B (zh) * | 2019-04-03 | 2023-06-30 | 深圳市体内生物医药科技有限公司 | 一种基因修饰的免疫细胞及其制备方法和应用 |
| MA55760A (fr) | 2019-04-24 | 2022-03-02 | Regeneron Pharma | Procédés de diagnostic et de traitement de la polyarthrite rhumatoïde |
| JP2022534794A (ja) | 2019-06-04 | 2022-08-03 | サノフィ・バイオテクノロジー | 関節リウマチを有する対象における疼痛を治療するための組成物および方法 |
| US20200405883A1 (en) | 2019-06-20 | 2020-12-31 | Baxalta Incorporated | Method of treatment with viral-based gene therapy |
| WO2021150970A1 (en) | 2020-01-22 | 2021-07-29 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Bi-specific chimeric antigen receptor t cells targeting cd83 and interleukin 6 receptor |
| CN115697403A (zh) * | 2020-03-10 | 2023-02-03 | 迪赞纳生命科学公开有限公司 | Il-6/il-6r抗体的组合物及其使用方法 |
| WO2021207697A1 (en) | 2020-04-10 | 2021-10-14 | Cantex Pharmaceuticals, Inc. | Treatment of acute lung injury |
| JP2023529853A (ja) * | 2020-06-17 | 2023-07-12 | ティジアーナ ライフ サイエンシズ パブリック リミティド カンパニー | キメラ抗原受容体（ｃａｒ）ｔ細胞療法を増強するための組成物および方法 |
| US20240316008A1 (en) | 2020-06-22 | 2024-09-26 | Tranquis Therapeutics, Inc. | Treatment of systemic immune activation syndromes |
| AR122933A1 (es) | 2020-07-10 | 2022-10-19 | Novo Nordisk As | Métodos para tratar la enfermedad cardiovascular |
| WO2022040604A1 (en) | 2020-08-21 | 2022-02-24 | BioAge Labs, Inc. | Use of dp1 receptor antagonists for the treatment of viral respiratory tract infections and dysregulated immune response in aged and aging patients |
| US20230263827A1 (en) | 2020-09-02 | 2023-08-24 | Serhat Gumrukcu | Expanded memory subsets of gamma delta t cells for immunotherapy |
| EP4323404A1 (en) * | 2021-04-16 | 2024-02-21 | Tiziana Life Sciences PLC | Subcutaneous administration of antibodies for the treatment of disease |
| CA3227511A1 (en) | 2021-08-06 | 2023-02-09 | Lætitia LINARES | Methods for the treatment of cancer |
| AR131388A1 (es) | 2022-12-15 | 2025-03-12 | Univ Aarhus | Activación sintética de receptores transmembrana multiméricos |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6428979B1 (en) * | 1988-01-22 | 2002-08-06 | Tadamitsu Kishimoto | Receptor protein for human B cell stimulatory factor-2 |
| US5670373A (en) * | 1988-01-22 | 1997-09-23 | Kishimoto; Tadamitsu | Antibody to human interleukin-6 receptor |
| US5171840A (en) | 1988-01-22 | 1992-12-15 | Tadamitsu Kishimoto | Receptor protein for human B cell stimulatory factor-2 |
| IL88375A (en) * | 1988-11-14 | 1995-07-31 | Yeda Res & Dev | Monoclonal antibodies that specifically bind interferon-bia 2 natural and recombinant and a natural and recombinant interferon-beta 2 purification method and method |
| EP0409607B1 (en) | 1989-07-20 | 1996-10-30 | Tadamitsu Kishimoto | Antibody to human interleukin-6 receptor |
| DK0504307T3 (da) | 1989-12-04 | 1994-03-21 | Schering Corp | Fremgangsmåde til behandling af septisk shock |
| ES2134212T3 (es) * | 1991-04-25 | 1999-10-01 | Chugai Pharmaceutical Co Ltd | Anticuerpo humano reconstituido contra el receptor de la interleuquina 6 humano. |
| JPH04325095A (ja) | 1991-04-26 | 1992-11-13 | Tosoh Corp | 抗ヒトｉｌ−６モノクロ−ナル抗体及び該抗体を使用するｉｌ−６の測定方法 |
| US5888510A (en) * | 1993-07-21 | 1999-03-30 | Chugai Seiyaku Kabushiki Kaisha | Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component |
| WO1995009873A1 (en) | 1993-10-06 | 1995-04-13 | Board Of Regents, The University Of Texas System | A monoclonal anti-human il-6 receptor antibody |
| CA2168963C (en) * | 1994-06-07 | 2007-01-16 | Masayuki Miyata | Drug for prevention and therapy of diseases caused by fibrinoid formation or thrombus formation in the lung and model animals of the diseases |
| EP0783893B1 (en) | 1994-10-07 | 2012-04-04 | Chugai Seiyaku Kabushiki Kaisha | Inhibition of abnormal growth of synovial cells using il-6 antagonist as active ingredient |
| WO1996012503A1 (en) | 1994-10-21 | 1996-05-02 | Chugai Seiyaku Kabushiki Kaisha | Remedy for diseases caused by il-6 production |
| ES2319340T3 (es) * | 1995-09-28 | 2009-05-06 | Yeda Research And Development Co., Ltd. | Peptidos sinteticos que inhiben la actividad de il-6. |
| JPH1066582A (ja) | 1996-08-27 | 1998-03-10 | Tosoh Corp | Ｉｌ−６のヘリックスｄ領域を認識する抗体の遺伝子断片等 |
| AU736282B2 (en) | 1997-03-21 | 2001-07-26 | Chugai Seiyaku Kabushiki Kaisha | A preventive or therapeutic agent for sensitized T cell- mediated diseases comprising IL-6 antagonist as an active ingredient |
| US20020187150A1 (en) | 1997-08-15 | 2002-12-12 | Chugai Seiyaku Kabushiki Kaisha | Preventive and/or therapeutic agent for systemic lupus erythematosus comprising anti-IL-6 receptor antibody as an active ingredient |
| HU225539B1 (en) * | 1998-03-17 | 2007-02-28 | Chugai Pharmaceutical Co Ltd | Preventives or remedies for inflammatory intestinal diseases containing as the active ingredient antibody against il-6 receptor |
| US6261250B1 (en) * | 1998-08-20 | 2001-07-17 | Rle Corporation | Method and apparatus for enhancing cardiovascular activity and health through rhythmic limb elevation |
| WO2000010607A1 (en) | 1998-08-24 | 2000-03-02 | Chugai Seiyaku Kabushiki Kaisha | Preventives or remedies for pancreatitis containing il-6 antagonists as the active ingredient |
| US6419944B2 (en) * | 1999-02-24 | 2002-07-16 | Edward L. Tobinick | Cytokine antagonists for the treatment of localized disorders |
| JP4325095B2 (ja) | 2000-09-08 | 2009-09-02 | 株式会社デンソー | ＳｉＣ素子の製造方法 |
| AU2002210952B2 (en) | 2000-10-25 | 2007-01-11 | Chugai Seiyaku Kabushiki Kaisha | Preventives or remedies for psoriasis containing as the active ingredient IL-6 antagonist |
| AU2000279624A1 (en) | 2000-10-27 | 2002-05-15 | Chugai Seiyaku Kabushiki Kaisha | Blooe vegf level-lowering agent containing il-6 antagonist as the active ingredient |
| JP4889187B2 (ja) | 2000-10-27 | 2012-03-07 | 中外製薬株式会社 | Ｉｌ−６アンタゴニストを有効成分として含有する血中ｍｍｐ−３濃度低下剤 |
| UA80091C2 (en) | 2001-04-02 | 2007-08-27 | Chugai Pharmaceutical Co Ltd | Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist |
| JP4293792B2 (ja) | 2001-04-27 | 2009-07-08 | ダイセル化学工業株式会社 | 多環式構造を有する多糖誘導体よりなる分離剤 |
| ES2436206T3 (es) | 2001-11-14 | 2013-12-27 | Janssen Biotech, Inc. | Anticuerpos anti il-6, composiciones, métodos y usos |
| CA2496523A1 (en) | 2002-08-30 | 2004-03-11 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Human antihuman interleukin-6 antibody and fragment of the antibody |
| MXPA05008713A (es) | 2003-02-24 | 2005-09-20 | Chugai Pharmaceutical Co Ltd | Agente terapeutico para dano de medula espinal que comprende antagonista de interluceina-6. |
| GB2401040A (en) | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases |
| CN1849138B (zh) * | 2003-07-15 | 2011-11-30 | 安姆根有限公司 | 作为选择性ngf途径抑制剂的人抗ngf中和抗体 |
| US20050100550A1 (en) | 2003-11-10 | 2005-05-12 | Mohit Trikha | Anti-angiogenic uses of IL-6 antagonists |
| US8617550B2 (en) | 2003-12-19 | 2013-12-31 | Chugai Seiyaku Kabushiki Kaisha | Treatment of vasculitis with IL-6 antagonist |
| WO2005080429A2 (en) | 2004-02-11 | 2005-09-01 | Warner-Lambert Company Llc | Methods of treating osteoarthritis with anti-il-6 or anti-il6 receptor antibodies |
| AR048335A1 (es) | 2004-03-24 | 2006-04-19 | Chugai Pharmaceutical Co Ltd | Agentes terapeuticos para trastornos del oido interno que contienen un antagonista de il- 6 como un ingrediente activo |
| US20070036788A1 (en) | 2004-09-22 | 2007-02-15 | Ahmed Sheriff | Use of a compound for reducing the biological effectiveness of il-6 |
| KR100595113B1 (ko) | 2005-03-07 | 2006-06-30 | 삼성에스디아이 주식회사 | 펌프 진동 및 소음 방지 구조가 구비된 연료 전지 시스템 |
| PA8672101A1 (es) | 2005-04-29 | 2006-12-07 | Centocor Inc | Anticuerpos anti-il-6, composiciones, métodos y usos |
| JP5183484B2 (ja) | 2005-12-09 | 2013-04-17 | ユセベ ファルマ ソシエテ アノニム | ヒトｉｌ−６に対して特異性を有する抗体分子 |
| CN101346395A (zh) * | 2005-12-30 | 2009-01-14 | 默克专利有限公司 | 阻止复合有IL-6Rα的IL-6与GP130结合的抗IL-6抗体 |
| RS52176B (sr) | 2006-06-02 | 2012-08-31 | Regeneron Pharmaceuticals Inc. | Antitela visokog afiniteta prema humanom il-6 receptoru |
| JP4743037B2 (ja) | 2006-07-28 | 2011-08-10 | 株式会社デンソー | 車両検出装置 |
| BRPI0715115A2 (pt) | 2006-08-03 | 2013-06-04 | Vaccinex Inc | anticorpo monoclonal isolado, molÉcula de Ácido nucleico isolada, vetor de expressço, cÉlula hospedeira, mÉtodos para tratar uma doenÇa, e para produzir um anticorpo monoclonal isolado, uso do anticorpo monoclonal isolado, e, composiÇço farmacÊutica |
| CA2660519A1 (en) | 2006-08-10 | 2008-02-21 | Roy C. Levitt | Localized therapy of lower airways inflammatory disorders with proinflammatory cytokine inhibitors |
| EP2074146B1 (en) * | 2006-11-30 | 2013-08-07 | Medlmmune Limited | Antibodies specific for the complex of interleukin-6 and the interleukin-6 receptor |
| TW200831528A (en) | 2006-11-30 | 2008-08-01 | Astrazeneca Ab | Compounds |
| JP2010512734A (ja) | 2006-12-13 | 2010-04-30 | アブリンクス エン．ヴェー． | Ｉｌ−６／ｉｌ−６受容体複合体等受容体介在性シグナル伝達に関与する複合体に特異的なポリペプチド |
| TWI363414B (en) | 2007-01-29 | 2012-05-01 | Touch Micro System Tech | Interposer for connecting a plurality of chips and method for manufacturing the same |
| AU2009246430B2 (en) | 2008-05-13 | 2015-07-02 | Novimmune S.A. | Anti-IL-6/IL-6R antibodies and methods of use thereof |
-
2009
- 2009-05-13 AU AU2009246430A patent/AU2009246430B2/en active Active
- 2009-05-13 EP EP09747432.4A patent/EP2297202B1/en active Active
- 2009-05-13 CN CN200980127494.7A patent/CN102089326B/zh active Active
- 2009-05-13 CA CA2724279A patent/CA2724279C/en active Active
- 2009-05-13 MX MX2010012031A patent/MX2010012031A/es active IP Right Grant
- 2009-05-13 US US12/465,295 patent/US8034344B2/en active Active
- 2009-05-13 ES ES09747432.4T patent/ES2564635T3/es active Active
- 2009-05-13 DK DK09747432.4T patent/DK2297202T3/en active
- 2009-05-13 JP JP2011509636A patent/JP2011520898A/ja active Pending
- 2009-05-13 WO PCT/US2009/043734 patent/WO2009140348A2/en not_active Ceased
-
2010
- 2010-11-11 IL IL209277A patent/IL209277A/en active IP Right Grant
-
2011
- 2011-09-07 US US13/227,157 patent/US8337849B2/en active Active
-
2012
- 2012-12-21 US US13/723,694 patent/US9234034B2/en active Active
-
2015
- 2015-03-25 JP JP2015062036A patent/JP6195586B2/ja active Active
-
2016
- 2016-01-12 US US14/993,153 patent/US9828430B2/en active Active
-
2017
- 2017-05-01 JP JP2017091252A patent/JP2017128613A/ja not_active Withdrawn
- 2017-11-27 US US15/823,086 patent/US10759862B2/en active Active
-
2020
- 2020-06-08 JP JP2020099264A patent/JP6923709B2/ja active Active
- 2020-07-31 US US16/944,828 patent/US11613582B2/en active Active
-
2021
- 2021-07-29 JP JP2021124411A patent/JP7297823B2/ja active Active