JP2011520898A5 - - Google Patents
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- JP2011520898A5 JP2011520898A5 JP2011509636A JP2011509636A JP2011520898A5 JP 2011520898 A5 JP2011520898 A5 JP 2011520898A5 JP 2011509636 A JP2011509636 A JP 2011509636A JP 2011509636 A JP2011509636 A JP 2011509636A JP 2011520898 A5 JP2011520898 A5 JP 2011520898A5
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- Prior art keywords
- amino acid
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- Prior art date
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12740308P | 2008-05-13 | 2008-05-13 | |
| US61/127,403 | 2008-05-13 | ||
| US19415608P | 2008-09-25 | 2008-09-25 | |
| US61/194,156 | 2008-09-25 | ||
| PCT/US2009/043734 WO2009140348A2 (en) | 2008-05-13 | 2009-05-13 | Anti-il-6/il-6r antibodies and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015062036A Division JP6195586B2 (ja) | 2008-05-13 | 2015-03-25 | 抗ｉｌ−６／ｉｌ−６ｒ抗体およびそれらの使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011520898A JP2011520898A (ja) | 2011-07-21 |
| JP2011520898A5 true JP2011520898A5 (enExample) | 2013-03-14 |
Family
ID=41319307
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011509636A Pending JP2011520898A (ja) | 2008-05-13 | 2009-05-13 | 抗ｉｌ−６／ｉｌ−６ｒ抗体およびそれらの使用方法 |
| JP2015062036A Active JP6195586B2 (ja) | 2008-05-13 | 2015-03-25 | 抗ｉｌ−６／ｉｌ−６ｒ抗体およびそれらの使用方法 |
| JP2017091252A Withdrawn JP2017128613A (ja) | 2008-05-13 | 2017-05-01 | 抗ｉｌ−６／ｉｌ−６ｒ抗体およびそれらの使用方法 |
| JP2020099264A Active JP6923709B2 (ja) | 2008-05-13 | 2020-06-08 | 抗ｉｌ−６／ｉｌ−６ｒ抗体およびそれらの使用方法 |
| JP2021124411A Active JP7297823B2 (ja) | 2008-05-13 | 2021-07-29 | 抗ｉｌ－６／ｉｌ－６ｒ抗体およびそれらの使用方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015062036A Active JP6195586B2 (ja) | 2008-05-13 | 2015-03-25 | 抗ｉｌ−６／ｉｌ−６ｒ抗体およびそれらの使用方法 |
| JP2017091252A Withdrawn JP2017128613A (ja) | 2008-05-13 | 2017-05-01 | 抗ｉｌ−６／ｉｌ−６ｒ抗体およびそれらの使用方法 |
| JP2020099264A Active JP6923709B2 (ja) | 2008-05-13 | 2020-06-08 | 抗ｉｌ−６／ｉｌ−６ｒ抗体およびそれらの使用方法 |
| JP2021124411A Active JP7297823B2 (ja) | 2008-05-13 | 2021-07-29 | 抗ｉｌ－６／ｉｌ－６ｒ抗体およびそれらの使用方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (6) | US8034344B2 (enExample) |
| EP (1) | EP2297202B1 (enExample) |
| JP (5) | JP2011520898A (enExample) |
| CN (1) | CN102089326B (enExample) |
| AU (1) | AU2009246430B2 (enExample) |
| CA (1) | CA2724279C (enExample) |
| DK (1) | DK2297202T3 (enExample) |
| ES (1) | ES2564635T3 (enExample) |
| IL (1) | IL209277A (enExample) |
| MX (1) | MX2010012031A (enExample) |
| WO (1) | WO2009140348A2 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006035617A1 (de) * | 2006-07-31 | 2008-02-21 | Siemens Ag | Automatische Bestimmung von Tumorlast |
| TW200831528A (en) | 2006-11-30 | 2008-08-01 | Astrazeneca Ab | Compounds |
| JP5424330B2 (ja) * | 2007-07-26 | 2014-02-26 | 国立大学法人大阪大学 | インターロイキン６受容体阻害剤を有効成分とする眼炎症疾患治療剤 |
| US8034344B2 (en) | 2008-05-13 | 2011-10-11 | Novimmune S.A. | Anti-IL-6/IL-6R antibodies and methods of use thereof |
| JP5913103B2 (ja) | 2009-09-14 | 2016-04-27 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイトＴＨＥ ＲＥＧＥＮＴＳ ＯＦ ＴＨＥ ＵＮＩＶＥＲＳＩＴＹ ＯＦ ＣＯＬＯＲＡＤＯ，ａ ｂｏｄｙ ｃｏｒｐｏｒａｔｅ | 酵母ベースの免疫療法組成物を含む組合せ物及び被験者のスクリーニング方法 |
| WO2012098238A1 (en) | 2011-01-21 | 2012-07-26 | Novimmune S.A. | Combination therapies and methods using anti-cd3 modulating agents and anti-il-6 antagonists |
| BR112013021863A2 (pt) * | 2011-03-03 | 2016-11-22 | Apexigen Inc | anticorpos anti-receptor il-6 e métodos de uso |
| WO2013075027A2 (en) * | 2011-11-17 | 2013-05-23 | Emergent Product Development Seattle, Llc | Anti-sil6xr complex binding domains and methods of use |
| KR101510302B1 (ko) | 2012-05-11 | 2015-04-10 | 가톨릭대학교 산학협력단 | Ｉｌ-６ 수용체를 표적으로 하는 항체가 생성되도록 미니서클 벡터를 통해 형질전환된 줄기세포 치료제 |
| US10504132B2 (en) | 2012-11-27 | 2019-12-10 | American Express Travel Related Services Company, Inc. | Dynamic rewards program |
| HUE055424T2 (hu) * | 2014-03-17 | 2021-11-29 | Mitsubishi Tanabe Pharma Corp | Antitest-fynomer konjugátumok |
| BR112018001853A2 (pt) | 2015-07-31 | 2018-09-25 | Astrazeneca Pharmaceuticals Lp | métodos para tratamento de um distúrbio e para melhoria do tratamento de um distúrbio |
| TWI729022B (zh) * | 2015-11-03 | 2021-06-01 | 法商賽諾菲生物技術公司 | 用於治療葡萄膜炎及黃斑水腫之包含ｉｌ６ｒ抗體的組合物與其使用方法 |
| KR20190031439A (ko) * | 2016-05-05 | 2019-03-26 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Il-6 및 cd126을 표적으로 하는 dna 단클론성 항체 |
| CA3045310A1 (en) | 2016-12-14 | 2018-06-21 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor |
| WO2018112237A1 (en) | 2016-12-14 | 2018-06-21 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with an il-6r inhibitor |
| WO2018112232A1 (en) | 2016-12-14 | 2018-06-21 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with an il-12/il-23 inhibitor released using an ingestible device |
| GB2558223B (en) | 2016-12-22 | 2021-03-31 | Heraeus Electro Nite Int | Method for measuring a temperature of a molten metal bath |
| SG11201906852XA (en) | 2017-02-01 | 2019-08-27 | Univ Yale | Treatment of diuretic resistance |
| US20210138213A1 (en) | 2017-03-30 | 2021-05-13 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immune modulatory agent released using an ingestible device |
| RU2020111737A (ru) * | 2017-09-13 | 2021-10-13 | Цзянсу Хэнжуй Медицин Ко., Лтд. | Антитело против il-6r и его антигенсвязывающий фрагмент и медицинское применение |
| SG11202006157VA (en) | 2018-01-05 | 2020-07-29 | Corvidia Therapeutics Inc | Methods for treating il-6 mediated inflammation without immunosuppression |
| EP3793582A1 (en) * | 2018-05-15 | 2021-03-24 | Erasmus University Medical Center Rotterdam | Treatments and biomarkers for the prognosis of zika virus infection |
| WO2019246317A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease or condition in a tissue originating from the endoderm |
| US20230041197A1 (en) | 2018-06-20 | 2023-02-09 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immunomodulator |
| EP3810268A1 (en) | 2018-06-20 | 2021-04-28 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an il-12/il-23 inhibitor |
| CN110055224B (zh) * | 2019-04-03 | 2023-06-30 | 深圳市体内生物医药科技有限公司 | 一种基因修饰的免疫细胞及其制备方法和应用 |
| EP3959240A1 (en) | 2019-04-24 | 2022-03-02 | Sanofi Biotechnology | Methods of diagnosis and treatment of rheumatoid arthritis |
| AU2020288561A1 (en) | 2019-06-04 | 2021-12-23 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for treating pain in subjects with rheumatoid arthritis |
| US20200405883A1 (en) | 2019-06-20 | 2020-12-31 | Baxalta Incorporated | Method of treatment with viral-based gene therapy |
| US20230390391A1 (en) | 2020-01-22 | 2023-12-07 | Regents Of The University Of Minnesota | Bi-specific chimeric antigen receptor t cells targeting cd83 and interleukin 6 receptor |
| JP2023517611A (ja) * | 2020-03-10 | 2023-04-26 | ティジアーナ ライフ サイエンシズ パブリック リミティド カンパニー | Ｉｌ－６／ｉｌ－６ｒ抗体の組成物及びその使用方法 |
| WO2021207697A1 (en) | 2020-04-10 | 2021-10-14 | Cantex Pharmaceuticals, Inc. | Treatment of acute lung injury |
| IL297697A (en) | 2020-06-17 | 2022-12-01 | Tiziana Life Sciences Plc | Preparations and methods for improving chimeric antigen receptor t cell therapies |
| EP4171551A1 (en) | 2020-06-22 | 2023-05-03 | Tranquis Therapeutics, Inc. | Treatment of systemic immune activation syndromes |
| AR122933A1 (es) | 2020-07-10 | 2022-10-19 | Novo Nordisk As | Métodos para tratar la enfermedad cardiovascular |
| WO2022040604A1 (en) | 2020-08-21 | 2022-02-24 | BioAge Labs, Inc. | Use of dp1 receptor antagonists for the treatment of viral respiratory tract infections and dysregulated immune response in aged and aging patients |
| CA3191388A1 (en) | 2020-09-02 | 2022-03-10 | Serhat GUMRUKCU | Expanded memory subsets of gamma delta t cells for immunotherapy |
| WO2022221767A1 (en) | 2021-04-16 | 2022-10-20 | Tiziana Life Sciences Plc | Subcutaneous administration of antibodies for the treatment of disease |
| CN118019548A (zh) | 2021-08-06 | 2024-05-10 | 蒙彼利埃癌症研究所 | 用于治疗癌症的方法 |
| EP4634214A1 (en) | 2022-12-15 | 2025-10-22 | Aarhus Universitet | Synthetic activation of multimeric transmembrane receptors |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5670373A (en) * | 1988-01-22 | 1997-09-23 | Kishimoto; Tadamitsu | Antibody to human interleukin-6 receptor |
| US6428979B1 (en) * | 1988-01-22 | 2002-08-06 | Tadamitsu Kishimoto | Receptor protein for human B cell stimulatory factor-2 |
| US5171840A (en) * | 1988-01-22 | 1992-12-15 | Tadamitsu Kishimoto | Receptor protein for human B cell stimulatory factor-2 |
| IL88375A (en) * | 1988-11-14 | 1995-07-31 | Yeda Res & Dev | Monoclonal antibodies that specifically bind interferon-bia 2 natural and recombinant and a natural and recombinant interferon-beta 2 purification method and method |
| DE69029015T2 (de) | 1989-07-20 | 1998-01-22 | Tadamitsu Kishimoto | Antikörper gegen menschlichen Interleukin-6-Rezeptor |
| WO1991007986A1 (en) | 1989-12-04 | 1991-06-13 | Schering Corporation | Method of treating septic shock |
| US5795965A (en) * | 1991-04-25 | 1998-08-18 | Chugai Seiyaku Kabushiki Kaisha | Reshaped human to human interleukin-6 receptor |
| JPH04325095A (ja) | 1991-04-26 | 1992-11-13 | Tosoh Corp | 抗ヒトｉｌ−６モノクロ−ナル抗体及び該抗体を使用するｉｌ−６の測定方法 |
| US5888510A (en) * | 1993-07-21 | 1999-03-30 | Chugai Seiyaku Kabushiki Kaisha | Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component |
| WO1995009873A1 (en) | 1993-10-06 | 1995-04-13 | Board Of Regents, The University Of Texas System | A monoclonal anti-human il-6 receptor antibody |
| DE69534075T2 (de) * | 1994-06-07 | 2005-07-21 | Chugai Seiyaku K.K. | Vorbeugungs- und heilmittel für erkrankungen, die durch fibrin- oder thrombusbildung hervorgerufen werden |
| AU700819B2 (en) * | 1994-10-07 | 1999-01-14 | Chugai Seiyaku Kabushiki Kaisha | Rheumatoid arthritis remedy containing IL-6 antagonist as effective component |
| WO1996012503A1 (en) | 1994-10-21 | 1996-05-02 | Chugai Seiyaku Kabushiki Kaisha | Remedy for diseases caused by il-6 production |
| DE69637845D1 (de) * | 1995-09-28 | 2009-04-09 | Yeda Res & Dev | Synthetische peptide mit il-6 aktivitäthemmung |
| JPH1066582A (ja) | 1996-08-27 | 1998-03-10 | Tosoh Corp | Ｉｌ−６のヘリックスｄ領域を認識する抗体の遺伝子断片等 |
| AU736282B2 (en) | 1997-03-21 | 2001-07-26 | Chugai Seiyaku Kabushiki Kaisha | A preventive or therapeutic agent for sensitized T cell- mediated diseases comprising IL-6 antagonist as an active ingredient |
| US20020187150A1 (en) | 1997-08-15 | 2002-12-12 | Chugai Seiyaku Kabushiki Kaisha | Preventive and/or therapeutic agent for systemic lupus erythematosus comprising anti-IL-6 receptor antibody as an active ingredient |
| PT1074268E (pt) * | 1998-03-17 | 2008-02-28 | Chugai Pharmaceutical Co Ltd | Agentes profilácticos ou terapêuticos para doenças intestinais inflamatórias contendo anticorpos antagonistas do receptor il-6 |
| US6261250B1 (en) * | 1998-08-20 | 2001-07-17 | Rle Corporation | Method and apparatus for enhancing cardiovascular activity and health through rhythmic limb elevation |
| PT1108435E (pt) | 1998-08-24 | 2007-04-30 | Chugai Pharmaceutical Co Ltd | Agentes preventivos ou terapêuticos para pancreatite contendo antagonistas da il-6 como ingrediente activo |
| US6419944B2 (en) * | 1999-02-24 | 2002-07-16 | Edward L. Tobinick | Cytokine antagonists for the treatment of localized disorders |
| JP4325095B2 (ja) | 2000-09-08 | 2009-09-02 | 株式会社デンソー | ＳｉＣ素子の製造方法 |
| WO2002034292A1 (fr) | 2000-10-25 | 2002-05-02 | Chugai Seiyaku Kabushiki Kaisha | Agents preventifs ou therapeutiques contre le psoriasis renfermant l'antagoniste de l'il-6 comme substance active |
| JP4889187B2 (ja) | 2000-10-27 | 2012-03-07 | 中外製薬株式会社 | Ｉｌ−６アンタゴニストを有効成分として含有する血中ｍｍｐ−３濃度低下剤 |
| WO2002036164A1 (en) | 2000-10-27 | 2002-05-10 | Chugai Seiyaku Kabushiki Kaisha | Blooe vegf level-lowering agent containing il-6 antagonist as the active ingredient |
| UA80091C2 (en) | 2001-04-02 | 2007-08-27 | Chugai Pharmaceutical Co Ltd | Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist |
| US7156989B2 (en) | 2001-04-27 | 2007-01-02 | Daicel Chemical Industries, Ltd. | Separating agent including polysaccharide derivative having a polycyclic structure |
| MXPA04004671A (es) | 2001-11-14 | 2005-08-25 | Johnson & Johnson | Anticuerpos anti-interleucina-6, composiciones, metodos y usos. |
| AU2003261787B2 (en) | 2002-08-30 | 2008-11-06 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Human antihuman interleukin-6 antibody and fragment of the antibody |
| KR101142624B1 (ko) | 2003-02-24 | 2012-06-15 | 추가이 세이야쿠 가부시키가이샤 | 인터루킨-6 길항제를 함유하는 척수손상 치료제 |
| GB2401040A (en) | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases |
| EA013614B1 (ru) * | 2003-07-15 | 2010-06-30 | Амджен Инк. | Изолированное антитело к фактору роста нервов (ngf) и способы его применения |
| US20050100550A1 (en) | 2003-11-10 | 2005-05-12 | Mohit Trikha | Anti-angiogenic uses of IL-6 antagonists |
| US8617550B2 (en) | 2003-12-19 | 2013-12-31 | Chugai Seiyaku Kabushiki Kaisha | Treatment of vasculitis with IL-6 antagonist |
| BRPI0506679A (pt) | 2004-02-11 | 2007-05-15 | Warner Lambert Co | métodos de tratar osteoartrite com antagonistas de il-6 |
| AR048335A1 (es) | 2004-03-24 | 2006-04-19 | Chugai Pharmaceutical Co Ltd | Agentes terapeuticos para trastornos del oido interno que contienen un antagonista de il- 6 como un ingrediente activo |
| US20070036788A1 (en) | 2004-09-22 | 2007-02-15 | Ahmed Sheriff | Use of a compound for reducing the biological effectiveness of il-6 |
| KR100595113B1 (ko) | 2005-03-07 | 2006-06-30 | 삼성에스디아이 주식회사 | 펌프 진동 및 소음 방지 구조가 구비된 연료 전지 시스템 |
| JO3058B1 (ar) | 2005-04-29 | 2017-03-15 | Applied Molecular Evolution Inc | الاجسام المضادة لمضادات -اي ال-6,تركيباتها طرقها واستعمالاتها |
| RS53708B1 (sr) | 2005-12-09 | 2015-04-30 | Ucb Pharma S.A. | Molekuli antitela koji poseduju specifičnost za humani il-6 |
| EP1966244B1 (en) * | 2005-12-30 | 2012-03-21 | Merck Patent GmbH | Anti-il-6 antibodies preventing the binding of il-6 complexed with il-6ralpha to gp130 |
| CA2652976C (en) | 2006-06-02 | 2015-08-11 | Regeneron Pharmaceuticals, Inc. | High affinity antibodies to human il-6 receptor |
| JP4743037B2 (ja) | 2006-07-28 | 2011-08-10 | 株式会社デンソー | 車両検出装置 |
| CA2657763C (en) | 2006-08-03 | 2016-05-31 | Vaccinex Inc. | Anti-il-6 monoclonal antibodies and uses thereof |
| CA2660519A1 (en) | 2006-08-10 | 2008-02-21 | Roy C. Levitt | Localized therapy of lower airways inflammatory disorders with proinflammatory cytokine inhibitors |
| EP2074146B1 (en) * | 2006-11-30 | 2013-08-07 | Medlmmune Limited | Antibodies specific for the complex of interleukin-6 and the interleukin-6 receptor |
| TW200831528A (en) | 2006-11-30 | 2008-08-01 | Astrazeneca Ab | Compounds |
| JP2010512734A (ja) | 2006-12-13 | 2010-04-30 | アブリンクス エン．ヴェー． | Ｉｌ−６／ｉｌ−６受容体複合体等受容体介在性シグナル伝達に関与する複合体に特異的なポリペプチド |
| TWI363414B (en) | 2007-01-29 | 2012-05-01 | Touch Micro System Tech | Interposer for connecting a plurality of chips and method for manufacturing the same |
| US8034344B2 (en) | 2008-05-13 | 2011-10-11 | Novimmune S.A. | Anti-IL-6/IL-6R antibodies and methods of use thereof |
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2009
- 2009-05-13 US US12/465,295 patent/US8034344B2/en active Active
- 2009-05-13 CA CA2724279A patent/CA2724279C/en active Active
- 2009-05-13 CN CN200980127494.7A patent/CN102089326B/zh active Active
- 2009-05-13 ES ES09747432.4T patent/ES2564635T3/es active Active
- 2009-05-13 JP JP2011509636A patent/JP2011520898A/ja active Pending
- 2009-05-13 WO PCT/US2009/043734 patent/WO2009140348A2/en not_active Ceased
- 2009-05-13 DK DK09747432.4T patent/DK2297202T3/en active
- 2009-05-13 MX MX2010012031A patent/MX2010012031A/es active IP Right Grant
- 2009-05-13 EP EP09747432.4A patent/EP2297202B1/en active Active
- 2009-05-13 AU AU2009246430A patent/AU2009246430B2/en active Active
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2010
- 2010-11-11 IL IL209277A patent/IL209277A/en active IP Right Grant
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2011
- 2011-09-07 US US13/227,157 patent/US8337849B2/en active Active
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2012
- 2012-12-21 US US13/723,694 patent/US9234034B2/en active Active
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2015
- 2015-03-25 JP JP2015062036A patent/JP6195586B2/ja active Active
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2016
- 2016-01-12 US US14/993,153 patent/US9828430B2/en active Active
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2017
- 2017-05-01 JP JP2017091252A patent/JP2017128613A/ja not_active Withdrawn
- 2017-11-27 US US15/823,086 patent/US10759862B2/en active Active
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2020
- 2020-06-08 JP JP2020099264A patent/JP6923709B2/ja active Active
- 2020-07-31 US US16/944,828 patent/US11613582B2/en active Active
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2021
- 2021-07-29 JP JP2021124411A patent/JP7297823B2/ja active Active