|
US3927193A
(en)
|
1973-05-18 |
1975-12-16 |
Hoffmann La Roche |
Localization of tumors by radiolabelled antibodies
|
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
JPS6023084B2
(ja)
|
1979-07-11 |
1985-06-05 |
味の素株式会社 |
代用血液
|
|
US4348376A
(en)
|
1980-03-03 |
1982-09-07 |
Goldenberg Milton David |
Tumor localization and therapy with labeled anti-CEA antibody
|
|
US4460561A
(en)
|
1980-03-03 |
1984-07-17 |
Goldenberg M David |
Tumor localization and therapy with labeled antibodies specific to intracellular tumor-associated markers
|
|
US4331647A
(en)
|
1980-03-03 |
1982-05-25 |
Goldenberg Milton David |
Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers
|
|
US4460559A
(en)
|
1980-03-03 |
1984-07-17 |
Goldenberg Milton David |
Tumor localization and therapy with labeled antibodies specific to intracellular tumor-associated markers
|
|
US4361544A
(en)
|
1980-03-03 |
1982-11-30 |
Goldenberg Milton David |
Tumor localization and therapy with labeled antibodies specific to intracellular tumor-associated markers
|
|
US4444744A
(en)
|
1980-03-03 |
1984-04-24 |
Goldenberg Milton David |
Tumor localization and therapy with labeled antibodies to cell surface antigens
|
|
US4468457A
(en)
|
1981-06-01 |
1984-08-28 |
David M. Goldenberg |
Method for producing a CSAp tryptic peptide and anti-CSAp antibodies
|
|
IE54046B1
(en)
|
1981-08-25 |
1989-05-24 |
Celltech Ltd |
Expression vectors
|
|
US4640835A
(en)
|
1981-10-30 |
1987-02-03 |
Nippon Chemiphar Company, Ltd. |
Plasminogen activator derivatives
|
|
US4579821A
(en)
|
1981-11-23 |
1986-04-01 |
University Patents, Inc. |
Control of DNA sequence transcription
|
|
US4769330A
(en)
|
1981-12-24 |
1988-09-06 |
Health Research, Incorporated |
Modified vaccinia virus and methods for making and using the same
|
|
US4656134A
(en)
|
1982-01-11 |
1987-04-07 |
Board Of Trustees Of Leland Stanford Jr. University |
Gene amplification in eukaryotic cells
|
|
US4486533A
(en)
|
1982-09-02 |
1984-12-04 |
St. Louis University |
Filamentous fungi functional replicating extrachromosomal element
|
|
US4599311A
(en)
|
1982-08-13 |
1986-07-08 |
Kawasaki Glenn H |
Glycolytic promotersfor regulated protein expression: protease inhibitor
|
|
US4977092A
(en)
|
1985-06-26 |
1990-12-11 |
Amgen |
Expression of exogenous polypeptides and polypeptide products including hepatitis B surface antigen in yeast cells
|
|
US4601978A
(en)
|
1982-11-24 |
1986-07-22 |
The Regents Of The University Of California |
Mammalian metallothionein promoter system
|
|
US4713339A
(en)
|
1983-01-19 |
1987-12-15 |
Genentech, Inc. |
Polycistronic expression vector construction
|
|
US4818709A
(en)
|
1983-01-21 |
1989-04-04 |
Primus Frederick J |
CEA-family antigens, Anti-CEA antibodies and CEA immunoassay
|
|
US4460459A
(en)
|
1983-02-16 |
1984-07-17 |
Anschutz Mining Corporation |
Sequential flotation of sulfide ores
|
|
US4661454A
(en)
|
1983-02-28 |
1987-04-28 |
Collaborative Research, Inc. |
GAL1 yeast promoter linked to non galactokinase gene
|
|
US5139936A
(en)
|
1983-02-28 |
1992-08-18 |
Collaborative Research, Inc. |
Use of the GAL1 yeast promoter
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4624846A
(en)
|
1983-07-29 |
1986-11-25 |
Immunomedics, Inc. |
Method for enhancing target specificity of antibody localization and clearance of non-target diagnostic and therapeutic principles
|
|
US4870008A
(en)
|
1983-08-12 |
1989-09-26 |
Chiron Corporation |
Secretory expression in eukaryotes
|
|
US4496689A
(en)
|
1983-12-27 |
1985-01-29 |
Miles Laboratories, Inc. |
Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
|
|
US4782840A
(en)
|
1984-03-02 |
1988-11-08 |
Neoprobe Corporation |
Method for locating, differentiating, and removing neoplasms
|
|
US4931373A
(en)
|
1984-05-25 |
1990-06-05 |
Zymogenetics, Inc. |
Stable DNA constructs for expression of α-1 antitrypsin
|
|
US4766073A
(en)
|
1985-02-25 |
1988-08-23 |
Zymogenetics Inc. |
Expression of biologically active PDGF analogs in eucaryotic cells
|
|
US4990446A
(en)
|
1984-12-06 |
1991-02-05 |
Labofina, S.A. |
Promoters for the expression of foreign genes in yeast, plasmids comprising them, and use thereof for the production of polypeptides
|
|
US4906562A
(en)
|
1984-12-21 |
1990-03-06 |
Oncogen |
Monocolonal antibodies and antigen for human non-small cell lung carcinomas
|
|
US4935495A
(en)
|
1984-12-21 |
1990-06-19 |
Oncogen |
Monoclonal antibodies to the L6 glycolipid antigenic determinant found on human non-small cell lung carcinomas
|
|
GB8508845D0
(en)
|
1985-04-04 |
1985-05-09 |
Hoffmann La Roche |
Vaccinia dna
|
|
GR860984B
(en)
|
1985-04-17 |
1986-08-18 |
Zymogenetics Inc |
Expression of factor vii and ix activities in mammalian cells
|
|
DE3675588D1
(de)
|
1985-06-19 |
1990-12-20 |
Ajinomoto Kk |
Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
|
|
US4882279A
(en)
|
1985-10-25 |
1989-11-21 |
Phillips Petroleum Company |
Site selective genomic modification of yeast of the genus pichia
|
|
US5656266A
(en)
|
1985-11-19 |
1997-08-12 |
Schering Corporation |
Method of using interleukin-4
|
|
US4935349A
(en)
|
1986-01-17 |
1990-06-19 |
Zymogenetics, Inc. |
Expression of higher eucaryotic genes in aspergillus
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
GB8611832D0
(en)
|
1986-05-15 |
1986-06-25 |
Holland I B |
Polypeptide
|
|
US4791192A
(en)
|
1986-06-26 |
1988-12-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified protein with polyethyleneglycol
|
|
US4704692A
(en)
|
1986-09-02 |
1987-11-03 |
Ladner Robert C |
Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides
|
|
US5260203A
(en)
|
1986-09-02 |
1993-11-09 |
Enzon, Inc. |
Single polypeptide chain binding molecules
|
|
US5869620A
(en)
|
1986-09-02 |
1999-02-09 |
Enzon, Inc. |
Multivalent antigen-binding proteins
|
|
US6121424A
(en)
|
1991-11-25 |
2000-09-19 |
Enzon, Inc. |
Multivalent antigen-binding proteins
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US5075109A
(en)
|
1986-10-24 |
1991-12-24 |
Southern Research Institute |
Method of potentiating an immune response
|
|
US6893625B1
(en)
|
1986-10-27 |
2005-05-17 |
Royalty Pharma Finance Trust |
Chimeric antibody with specificity to human B cell surface antigen
|
|
US4932412A
(en)
|
1986-12-18 |
1990-06-12 |
Immunomedics, Inc. |
Intraoperative and endoscopic tumor detection and therapy
|
|
IL85035A0
(en)
|
1987-01-08 |
1988-06-30 |
Int Genetic Eng |
Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
|
|
US5063154A
(en)
|
1987-06-24 |
1991-11-05 |
Whitehead Institute For Biomedical Research |
Pheromone - inducible yeast promoter
|
|
US5892019A
(en)
|
1987-07-15 |
1999-04-06 |
The United States Of America, As Represented By The Department Of Health And Human Services |
Production of a single-gene-encoded immunoglobulin
|
|
US4897268A
(en)
|
1987-08-03 |
1990-01-30 |
Southern Research Institute |
Drug delivery system and method of making the same
|
|
WO1989001973A2
(en)
|
1987-09-02 |
1989-03-09 |
Applied Biotechnology, Inc. |
Recombinant pox virus for immunization against tumor-associated antigens
|
|
GB8720833D0
(en)
|
1987-09-04 |
1987-10-14 |
Celltech Ltd |
Recombinant dna product
|
|
US5677425A
(en)
|
1987-09-04 |
1997-10-14 |
Celltech Therapeutics Limited |
Recombinant antibody
|
|
JP3095168B2
(ja)
|
1988-02-05 |
2000-10-03 |
エル． モリソン，シェリー |
ドメイン‐変性不変部を有する抗体
|
|
HUT53672A
(en)
|
1988-02-25 |
1990-11-28 |
Gen Hospital Corp |
Quick immunoselective cloning process
|
|
US5506126A
(en)
|
1988-02-25 |
1996-04-09 |
The General Hospital Corporation |
Rapid immunoselection cloning method
|
|
US4861579A
(en)
|
1988-03-17 |
1989-08-29 |
American Cyanamid Company |
Suppression of B-lymphocytes in mammals by administration of anti-B-lymphocyte antibodies
|
|
US4956288A
(en)
|
1988-04-22 |
1990-09-11 |
Biogen, Inc. |
Method for producing cells containing stably integrated foreign DNA at a high copy number, the cells produced by this method, and the use of these cells to produce the polypeptides coded for by the foreign DNA
|
|
US5037743A
(en)
|
1988-08-05 |
1991-08-06 |
Zymogenetics, Inc. |
BAR1 secretion signal
|
|
US5601819A
(en)
|
1988-08-11 |
1997-02-11 |
The General Hospital Corporation |
Bispecific antibodies for selective immune regulation and for selective immune cell binding
|
|
US6352694B1
(en)
|
1994-06-03 |
2002-03-05 |
Genetics Institute, Inc. |
Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
|
|
US5217713A
(en)
|
1988-12-27 |
1993-06-08 |
Takeda Chemical Industries, Ltd. |
Cytotoxic bispecific monoclonal antibody, its production and use
|
|
CA2006408A1
(en)
|
1988-12-27 |
1990-06-27 |
Susumu Iwasa |
Bispecific monoclonal antibody, its production and use
|
|
US5162228A
(en)
|
1988-12-28 |
1992-11-10 |
Takeda Chemical Industries, Ltd. |
Gylceraldehyde-3-phosphate dehydrogenase gene and promoter
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
JP2752788B2
(ja)
|
1989-01-23 |
1998-05-18 |
カイロン コーポレイション |
感染および過剰増殖障害の為の組換え療法
|
|
US5098833A
(en)
|
1989-02-23 |
1992-03-24 |
Genentech, Inc. |
DNA sequence encoding a functional domain of a lymphocyte homing receptor
|
|
US5225538A
(en)
|
1989-02-23 |
1993-07-06 |
Genentech, Inc. |
Lymphocyte homing receptor/immunoglobulin fusion proteins
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
US5897861A
(en)
|
1989-06-29 |
1999-04-27 |
Medarex, Inc. |
Bispecific reagents for AIDS therapy
|
|
ES2096590T3
(es)
|
1989-06-29 |
1997-03-16 |
Medarex Inc |
Reactivos biespecificos para la terapia del sida.
|
|
US6020145A
(en)
|
1989-06-30 |
2000-02-01 |
Bristol-Myers Squibb Company |
Methods for determining the presence of carcinoma using the antigen binding region of monoclonal antibody BR96
|
|
US5980896A
(en)
|
1989-06-30 |
1999-11-09 |
Bristol-Myers Squibb Company |
Antibodies reactive with human carcinomas
|
|
US5162222A
(en)
|
1989-07-07 |
1992-11-10 |
Guarino Linda A |
Use of baculovirus early promoters for expression of foreign genes in stably transformed insect cells or recombinant baculoviruses
|
|
JP4041535B2
(ja)
|
1989-08-18 |
2008-01-30 |
オックスフォード バイオメディカ（ユーケー）リミテッド |
標的細胞にベクター構造体を運搬する組換レトロウィルス
|
|
US5605690A
(en)
|
1989-09-05 |
1997-02-25 |
Immunex Corporation |
Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor
|
|
DK0493418T3
(da)
|
1989-09-20 |
1997-11-03 |
Abbott Lab |
Fremgangsmåde til fremstilling af fusionsproteiner
|
|
US6018031A
(en)
|
1989-10-20 |
2000-01-25 |
Trustees Of Dartmouth College |
Binding agents specific for IgA receptor
|
|
GB8928874D0
(en)
|
1989-12-21 |
1990-02-28 |
Celltech Ltd |
Humanised antibodies
|
|
US6150584A
(en)
|
1990-01-12 |
2000-11-21 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US5314995A
(en)
|
1990-01-22 |
1994-05-24 |
Oncogen |
Therapeutic interleukin-2-antibody based fusion proteins
|
|
SG70982A1
(en)
|
1990-01-23 |
2000-03-21 |
Tanox Biosystems Inc |
Extracellular segments of human and immunoglobulin anchoring peptides and antibodies specific therefor
|
|
US5283173A
(en)
|
1990-01-24 |
1994-02-01 |
The Research Foundation Of State University Of New York |
System to detect protein-protein interactions
|
|
EP0517754A1
(en)
|
1990-03-02 |
1992-12-16 |
Repligen Corporation |
Antibody constructs with enhanced binding affinity
|
|
US6641809B1
(en)
|
1990-03-26 |
2003-11-04 |
Bristol-Myers Squibb Company |
Method of regulating cellular processes mediated by B7 and CD28
|
|
US20030219446A1
(en)
|
1990-03-26 |
2003-11-27 |
Bristol-Myers Squibb Company |
Ligand for CD28 receptor on B cells and methods
|
|
GB9009106D0
(en)
|
1990-04-23 |
1990-06-20 |
3I Res Expl Ltd |
Processes and intermediates for synthetic antibody derivatives
|
|
WO1992000092A1
(en)
|
1990-07-02 |
1992-01-09 |
Bristol-Myers Squibb Company |
Ligand for cd28 receptor on b cells and methods
|
|
EP0557300B1
(en)
|
1990-10-29 |
1997-11-19 |
Chiron Corporation |
Bispecific antibodies, method of production, and uses thereof
|
|
US5709859A
(en)
|
1991-01-24 |
1998-01-20 |
Bristol-Myers Squibb Company |
Mixed specificity fusion proteins
|
|
JPH06506358A
(ja)
|
1991-03-28 |
1994-07-21 |
ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミネソタ |
ナチュラルキラー細胞に特異的なｄｎａおよびアミノ酸配列
|
|
DK0636173T3
(da)
|
1991-05-31 |
1999-05-31 |
Genentech Inc |
Behandling af HIV associeret immunthrombocytopenisk purpura
|
|
DE4118120A1
(de)
|
1991-06-03 |
1992-12-10 |
Behringwerke Ag |
Tetravalente bispezifische rezeptoren, ihre herstellung und verwendung
|
|
US5770197A
(en)
|
1991-06-27 |
1998-06-23 |
Bristol-Myers Squibb Company |
Methods for regulating the immune response using B7 binding molecules and IL4-binding molecules
|
|
US5844095A
(en)
|
1991-06-27 |
1998-12-01 |
Bristol-Myers Squibb Company |
CTLA4 Ig fusion proteins
|
|
US5637481A
(en)
|
1993-02-01 |
1997-06-10 |
Bristol-Myers Squibb Company |
Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell
|
|
US6090914A
(en)
|
1991-06-27 |
2000-07-18 |
Bristol-Myers Squibb Company |
CTLA4/CD28Ig hybrid fusion proteins and uses thereof
|
|
DE69226871T3
(de)
|
1991-06-27 |
2009-09-24 |
Bristol-Myers Squibb Co. |
CTL4A-Rezeptor, ihn enthaltenden Fusionsproteine und deren Verwendung
|
|
DE69207603T2
(de)
|
1991-08-16 |
1996-09-12 |
Vical Inc |
Zusammensetzung und verfahren zur behandlung von zystischer fibrose
|
|
US5298418A
(en)
|
1991-09-16 |
1994-03-29 |
Boyce Thompson Institute For Plant Research, Inc. |
Cell line isolated from larval midgut tissue of Trichoplusia ni
|
|
US5962406A
(en)
|
1991-10-25 |
1999-10-05 |
Immunex Corporation |
Recombinant soluble CD40 ligand polypeptide and pharmaceutical composition containing the same
|
|
DE69232137T2
(de)
|
1991-11-25 |
2002-05-29 |
Enzon Inc |
Multivalente antigen-bindende proteine
|
|
US5932448A
(en)
|
1991-11-29 |
1999-08-03 |
Protein Design Labs., Inc. |
Bispecific antibody heterodimers
|
|
ES2341666T3
(es)
|
1991-12-02 |
2010-06-24 |
Medimmune Limited |
Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos.
|
|
CA2089229C
(en)
|
1992-02-14 |
2010-04-13 |
Alejandro A. Aruffo |
Cd40cr receptor and ligands therefor
|
|
US6472510B1
(en)
|
1992-02-14 |
2002-10-29 |
Bristol-Myers Squibb Company |
CD40 receptor ligands
|
|
US6129914A
(en)
|
1992-03-27 |
2000-10-10 |
Protein Design Labs, Inc. |
Bispecific antibody effective to treat B-cell lymphoma and cell line
|
|
US7381803B1
(en)
|
1992-03-27 |
2008-06-03 |
Pdl Biopharma, Inc. |
Humanized antibodies against CD3
|
|
EP0650370A4
(en)
|
1992-06-08 |
1995-11-22 |
Univ California |
METHODS AND COMPOSITIONS TARGETED ON SPECIFIC TISSUES.
|
|
CA2137361A1
(en)
|
1992-06-10 |
1993-12-23 |
W. French Anderson |
Vector particles resistant to inactivation by human serum
|
|
GB2269175A
(en)
|
1992-07-31 |
1994-02-02 |
Imperial College |
Retroviral vectors
|
|
DK0586002T3
(da)
|
1992-08-18 |
2000-06-19 |
Centro Inmunologia Molecular |
Monoklonale antistoffer, som genkender epidermisvækstfaktor-receptoren, celler og fremgangsmåder heraf og præparater indeho
|
|
AU701578B2
(en)
|
1992-08-21 |
1999-02-04 |
Vrije Universiteit Brussel |
Immunoglobulins devoid of light chains
|
|
ZA936260B
(en)
|
1992-09-09 |
1994-03-18 |
Smithkline Beecham Corp |
Novel antibodies for conferring passive immunity against infection by a pathogen in man
|
|
WO1994006463A1
(en)
|
1992-09-14 |
1994-03-31 |
Pfizer Inc |
Immortalized cells and uses therefor
|
|
US6066718A
(en)
|
1992-09-25 |
2000-05-23 |
Novartis Corporation |
Reshaped monoclonal antibodies against an immunoglobulin isotype
|
|
WO1994009034A1
(en)
|
1992-10-12 |
1994-04-28 |
Agen Limited |
Clot directed anticoagulant, process for making same and methods of use
|
|
US5736137A
(en)
|
1992-11-13 |
1998-04-07 |
Idec Pharmaceuticals Corporation |
Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
|
|
MD1367C2
(ro)
|
1992-11-13 |
2000-11-30 |
Idec Pharmaceuticals Corporation |
Metode de tratament al limfomului celulelor B, anticorpi anti-CD20, hibridom.
|
|
GB9225453D0
(en)
|
1992-12-04 |
1993-01-27 |
Medical Res Council |
Binding proteins
|
|
ATE199392T1
(de)
|
1992-12-04 |
2001-03-15 |
Medical Res Council |
Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung
|
|
US5773253A
(en)
|
1993-01-22 |
1998-06-30 |
Bristol-Myers Squibb Company |
MYPPPY variants of CTL A4 and uses thereof
|
|
US6482919B2
(en)
|
1993-02-01 |
2002-11-19 |
Bristol-Myers Squibb Company |
Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell
|
|
US5597707A
(en)
|
1993-04-15 |
1997-01-28 |
Bristol-Myers Squibb Company |
Tumor associated antigen recognized by the murine monoclonal antibody L6, its oligonucleotide sequence and methods for their use
|
|
WO1994025591A1
(en)
|
1993-04-29 |
1994-11-10 |
Unilever N.V. |
PRODUCTION OF ANTIBODIES OR (FUNCTIONALIZED) FRAGMENTS THEREOF DERIVED FROM HEAVY CHAIN IMMUNOGLOBULINS OF $i(CAMELIDAE)
|
|
US5795572A
(en)
|
1993-05-25 |
1998-08-18 |
Bristol-Myers Squibb Company |
Monoclonal antibodies and FV specific for CD2 antigen
|
|
US5885573A
(en)
|
1993-06-01 |
1999-03-23 |
Arch Development Corporation |
Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies
|
|
US20030108548A1
(en)
|
1993-06-01 |
2003-06-12 |
Bluestone Jeffrey A. |
Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies
|
|
US5747654A
(en)
|
1993-06-14 |
1998-05-05 |
The United States Of America As Represented By The Department Of Health And Human Services |
Recombinant disulfide-stabilized polypeptide fragments having binding specificity
|
|
US6476198B1
(en)
|
1993-07-13 |
2002-11-05 |
The Scripps Research Institute |
Multispecific and multivalent antigen-binding polypeptide molecules
|
|
US5417972A
(en)
|
1993-08-02 |
1995-05-23 |
The Board Of Trustees Of The Leland Stanford Junior University |
Method of killing B-cells in a complement independent and an ADCC independent manner using antibodies which specifically bind CDIM
|
|
DK0721469T3
(da)
|
1993-09-02 |
2000-05-01 |
Dartmouth College |
Anti-gp39-antistoffer og anvendelse deraf
|
|
US5869049A
(en)
|
1993-09-02 |
1999-02-09 |
Trustees Of Dartmouth College |
Methods of inducing T cell unresponsiveness to bone marrow with gp39 antagonists
|
|
US5595721A
(en)
|
1993-09-16 |
1997-01-21 |
Coulter Pharmaceutical, Inc. |
Radioimmunotherapy of lymphoma using anti-CD20
|
|
DE69414870T2
(de)
|
1993-09-22 |
1999-05-12 |
Medical Research Council, London |
Antikoerper mit geaenderter zielrichtung
|
|
GB9412166D0
(en)
|
1993-09-22 |
1994-08-10 |
Medical Res Council |
Retargetting antibodies
|
|
WO1995009917A1
(en)
|
1993-10-07 |
1995-04-13 |
The Regents Of The University Of California |
Genetically engineered bispecific tetravalent antibodies
|
|
ES2229236T3
(es)
|
1994-01-11 |
2005-04-16 |
Dyax Corporation |
Inhibidores de la plasmina humana derivados de los dominios de kunitz.
|
|
US6380369B1
(en)
|
1994-01-27 |
2002-04-30 |
Human Genome Sciences, Inc. |
Human DNA mismatch repair proteins
|
|
CA2182498A1
(en)
|
1994-02-01 |
1995-08-10 |
William J. Larochelle |
Fusion proteins that include antibody and nonantibody portions
|
|
JPH09510201A
(ja)
|
1994-03-07 |
1997-10-14 |
メダレツクス・インコーポレーテツド |
臨床的効用を有する二重特異性分子
|
|
CZ292061B6
(cs)
|
1994-03-17 |
2003-07-16 |
Merck Patent Gmbh |
Jednořetězcové fragmenty protilátek a protilátky proti receptoru epidermálního růstového faktoru, způsob jejich přípravy a farmaceutický prostředek, který je obsahuje
|
|
AU694222B2
(en)
|
1994-05-02 |
1998-07-16 |
Bernd Groner |
Bifunctional protein, preparation and use
|
|
US5945273A
(en)
|
1997-06-03 |
1999-08-31 |
Human Genome Sciences, Inc. |
Human oxalyl-coa decarboxylase
|
|
US5888773A
(en)
|
1994-08-17 |
1999-03-30 |
The United States Of America As Represented By The Department Of Health And Human Services |
Method of producing single-chain Fv molecules
|
|
ATE198492T1
(de)
|
1994-08-26 |
2001-01-15 |
Aventis Pharma Gmbh |
Gentherapie von erkrankungen, die durch das immunsystem bedingt sind, mit hilfe eines zellspezifischen zellzyklusregulierten wirkstoffes
|
|
US6380169B1
(en)
|
1994-08-31 |
2002-04-30 |
Isis Pharmaceuticals, Inc. |
Metal complex containing oligonucleoside cleavage compounds and therapies
|
|
US5736524A
(en)
|
1994-11-14 |
1998-04-07 |
Merck & Co.,. Inc. |
Polynucleotide tuberculosis vaccine
|
|
US6383814B1
(en)
|
1994-12-09 |
2002-05-07 |
Genzyme Corporation |
Cationic amphiphiles for intracellular delivery of therapeutic molecules
|
|
US5876950A
(en)
|
1995-01-26 |
1999-03-02 |
Bristol-Myers Squibb Company |
Monoclonal antibodies specific for different epitopes of human GP39 and methods for their use in diagnosis and therapy
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
EP0739981A1
(en)
|
1995-04-25 |
1996-10-30 |
Vrije Universiteit Brussel |
Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes
|
|
US6410690B1
(en)
|
1995-06-07 |
2002-06-25 |
Medarex, Inc. |
Therapeutic compounds comprised of anti-Fc receptor antibodies
|
|
US6696248B1
(en)
|
1995-08-18 |
2004-02-24 |
Morphosys Ag |
Protein/(poly)peptide libraries
|
|
GB9518220D0
(en)
|
1995-09-06 |
1995-11-08 |
Medical Res Council |
Checkpoint gene
|
|
US5866330A
(en)
|
1995-09-12 |
1999-02-02 |
The Johns Hopkins University School Of Medicine |
Method for serial analysis of gene expression
|
|
JPH11513669A
(ja)
|
1995-10-13 |
1999-11-24 |
アメリカ合衆国 |
ジスルフィド安定化抗体フラグメントを含む免疫毒素
|
|
US6440418B1
(en)
|
1995-11-07 |
2002-08-27 |
Idec Pharmaceuticals Corporation |
Methods of treating autoimmune diseases with gp39-specific antibodies
|
|
US5955349A
(en)
|
1996-08-26 |
1999-09-21 |
Zymogenetics, Inc. |
Compositions and methods for producing heterologous polypeptides in Pichia methanolica
|
|
US5716808A
(en)
|
1995-11-09 |
1998-02-10 |
Zymogenetics, Inc. |
Genetic engineering of pichia methanolica
|
|
US6379966B2
(en)
|
1999-02-26 |
2002-04-30 |
Mirus Corporation |
Intravascular delivery of non-viral nucleic acid
|
|
US6750334B1
(en)
|
1996-02-02 |
2004-06-15 |
Repligen Corporation |
CTLA4-immunoglobulin fusion proteins having modified effector functions and uses therefor
|
|
GB2310894A
(en)
|
1996-03-06 |
1997-09-10 |
Clive William Efford |
Multi-engine drive unit
|
|
IL125928A
(en)
|
1996-03-20 |
2002-11-10 |
Bristol Myers Squibb Co |
The use of soluble ligands that react with CTLA4, B7, CD40, gp39 and / or CD28 for the preparation of pharmaceutical preparations
|
|
EP1186300A1
(en)
|
1996-03-20 |
2002-03-13 |
Bristol-Myers Squibb Company |
Pharmaceutical compositions useful for inhibiting an immune response by blocking the GP39/CD40 and CTLA4/CD28/B7 pathways
|
|
US6962981B1
(en)
|
1996-03-25 |
2005-11-08 |
Medarex, Inc. |
Monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen
|
|
US6150508A
(en)
|
1996-03-25 |
2000-11-21 |
Northwest Biotherapeutics, Inc. |
Monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen
|
|
US7381407B1
(en)
|
1996-03-25 |
2008-06-03 |
Medarex, Inc. |
Monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen
|
|
WO1997035616A1
(en)
|
1996-03-25 |
1997-10-02 |
Pacific Northwest Cancer Foundation |
Monoclonal antibodies specific for the extracellular domain of prostate specific membrane antigen
|
|
DE19613691A1
(de)
|
1996-04-05 |
1997-10-09 |
Boehringer Ingelheim Int |
Arzneimittel für die Behandlung von Tumorerkrankungen
|
|
US5834597A
(en)
|
1996-05-20 |
1998-11-10 |
Protein Design Labs, Inc. |
Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same
|
|
US5922845A
(en)
|
1996-07-11 |
1999-07-13 |
Medarex, Inc. |
Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies
|
|
WO1998002540A1
(en)
|
1996-07-12 |
1998-01-22 |
Genentech, Inc. |
Chimeric heteromultimer adhesins
|
|
CA2267620A1
(en)
|
1996-07-16 |
1998-01-22 |
Andreas Pluckthun |
Immunoglobulin superfamily domains and fragments with increased solubility
|
|
US5736383A
(en)
|
1996-08-26 |
1998-04-07 |
Zymogenetics, Inc. |
Preparation of Pichia methanolica auxotrophic mutants
|
|
US5854039A
(en)
|
1996-07-17 |
1998-12-29 |
Zymogenetics, Inc. |
Transformation of pichia methanolica
|
|
CA2260752A1
(en)
|
1996-07-23 |
1998-01-29 |
Tanox Pharma B.V. |
Induction of t cell tolerance using a soluble molecule that can simultaneously block two costimulatory pathways
|
|
US5846948A
(en)
|
1996-08-30 |
1998-12-08 |
Arch Development Corporation |
Herpes simplex virus ORF P is a repressor of viral protein synthesis
|
|
ATE218143T1
(de)
|
1996-09-03 |
2002-06-15 |
Gsf Forschungszentrum Umwelt |
Verwendung bi-und trispezifischer antikörper zur induktion einer tumorimmunität
|
|
GB9618477D0
(en)
|
1996-09-04 |
1996-10-16 |
Univ Leeds |
Gene therapy
|
|
US5972361A
(en)
|
1996-10-25 |
1999-10-26 |
The Procter & Gamble Company |
Cleansing products
|
|
DE19651443A1
(de)
|
1996-12-11 |
1998-06-18 |
Hoechst Ag |
Selbstverstärkende, pharmakologisch kontrollierbare Expressionssysteme
|
|
EP0860445A1
(en)
|
1997-02-18 |
1998-08-26 |
Hoechst Aktiengesellschaft |
New nucleotide sequences for the cell cycle regulated expression of structural genes
|
|
US6133426A
(en)
|
1997-02-21 |
2000-10-17 |
Genentech, Inc. |
Humanized anti-IL-8 monoclonal antibodies
|
|
NZ337376A
(en)
|
1997-03-11 |
2002-02-01 |
Aeterna Lab Inc |
Compositions for treating tumors containing shark cartilage extracts and anti-neoplastic agents
|
|
IL131978A0
(en)
|
1997-03-20 |
2001-03-19 |
Univ Washington |
Solvent for biopolymer synthesis solvent microdots and methods of use
|
|
US6306393B1
(en)
|
1997-03-24 |
2001-10-23 |
Immunomedics, Inc. |
Immunotherapy of B-cell malignancies using anti-CD22 antibodies
|
|
US6384203B1
(en)
|
1999-05-12 |
2002-05-07 |
Immunex Corporation |
Family of immunoregulators designated leukocyte immunoglobulin-like receptors (LIR)
|
|
US6217900B1
(en)
|
1997-04-30 |
2001-04-17 |
American Home Products Corporation |
Vesicular complexes and methods of making and using the same
|
|
US20020062010A1
(en)
|
1997-05-02 |
2002-05-23 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
|
US6171586B1
(en)
|
1997-06-13 |
2001-01-09 |
Genentech, Inc. |
Antibody formulation
|
|
EP0999853B1
(en)
|
1997-06-13 |
2003-01-02 |
Genentech, Inc. |
Stabilized antibody formulation
|
|
ATE296315T1
(de)
|
1997-06-24 |
2005-06-15 |
Genentech Inc |
Galactosylierte glykoproteine enthaltende zusammensetzungen und verfahren zur deren herstellung
|
|
US5994511A
(en)
|
1997-07-02 |
1999-11-30 |
Genentech, Inc. |
Anti-IgE antibodies and methods of improving polypeptides
|
|
AU8296098A
(en)
|
1997-07-08 |
1999-02-08 |
Board Of Regents, The University Of Texas System |
Compositions and methods for homoconjugates of antibodies which induce growth arrest or apoptosis of tumor cells
|
|
US6165476A
(en)
|
1997-07-10 |
2000-12-26 |
Beth Israel Deaconess Medical Center |
Fusion proteins with an immunoglobulin hinge region linker
|
|
US6207805B1
(en)
|
1997-07-18 |
2001-03-27 |
University Of Iowa Research Foundation |
Prostate cell surface antigen-specific antibodies
|
|
US6342220B1
(en)
|
1997-08-25 |
2002-01-29 |
Genentech, Inc. |
Agonist antibodies
|
|
US6383746B1
(en)
|
1997-10-23 |
2002-05-07 |
The United States Of America As Represented By The Department Of Health And Human Services |
Functional promoter for CCR5
|
|
WO1999022764A1
(en)
|
1997-10-31 |
1999-05-14 |
Genentech, Inc. |
Methods and compositions comprising glycoprotein glycoforms
|
|
US6383811B2
(en)
|
1997-12-30 |
2002-05-07 |
Mirus Corporation |
Polyampholytes for delivering polyions to a cell
|
|
ES2234241T3
(es)
|
1998-01-23 |
2005-06-16 |
Vlaams Interuniversitair Instituut Voor Biotechnologie |
Derivados de anticuerpo de multiples fines.
|
|
AU3295299A
(en)
|
1998-02-19 |
1999-09-06 |
Xcyte Therapies, Inc. |
Compositions and methods for regulating lymphocyte activation
|
|
CZ20003099A3
(cs)
|
1998-02-25 |
2002-04-17 |
Lexigen Pharmaceuticals Corporation |
Zvýąení doby poloviční ľivotnosti cirkulujících fúzních proteinů odvozených od protilátek
|
|
AUPP221098A0
(en)
|
1998-03-06 |
1998-04-02 |
Diatech Pty Ltd |
V-like domain binding molecules
|
|
US6383481B1
(en)
|
1998-03-30 |
2002-05-07 |
Japan Immunoresearch Laboratories Co., Ltd. |
Method for transplantation of hemopoietic stem cells
|
|
US6528624B1
(en)
|
1998-04-02 |
2003-03-04 |
Genentech, Inc. |
Polypeptide variants
|
|
ES2292236T3
(es)
|
1998-04-02 |
2008-03-01 |
Genentech, Inc. |
Variantes de anticuerpos y sus fragmentos.
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
US6242195B1
(en)
|
1998-04-02 |
2001-06-05 |
Genentech, Inc. |
Methods for determining binding of an analyte to a receptor
|
|
WO1999054484A1
(en)
|
1998-04-20 |
1999-10-28 |
The Regents Of The University Of California |
Modified immunoglobulin molecules and methods for use thereof
|
|
JP2002512361A
(ja)
|
1998-04-22 |
2002-04-23 |
ジェンベク、インコーポレイティッド |
アデノウイルスの効率的精製
|
|
GB9809280D0
(en)
|
1998-04-30 |
1998-07-01 |
Rpms Technology Ltd |
Immunosupression
|
|
DE19819846B4
(de)
|
1998-05-05 |
2016-11-24 |
Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts |
Multivalente Antikörper-Konstrukte
|
|
AU5203199A
(en)
|
1998-05-26 |
1999-12-13 |
Procter & Gamble Company, The |
Chimeric molecules comprising an extracellular ligand binding domain of a receptor and an ige fc or constant region, and their use in an assay system
|
|
US7833528B2
(en)
|
1998-06-22 |
2010-11-16 |
Immunomedics, Inc. |
Use of multispecific, non-covalent complexes for targeted delivery of therapeutics
|
|
US7405320B2
(en)
|
1998-06-22 |
2008-07-29 |
Immunomedics, Inc. |
Therapeutic and diagnostic conjugates for use with multispecific antibodies
|
|
US7052872B1
(en)
|
1999-06-22 |
2006-05-30 |
Immunomedics, Inc. |
Bi-specific antibodies for pre-targeting diagnosis and therapy
|
|
WO1999066951A2
(en)
|
1998-06-22 |
1999-12-29 |
Immunomedics, Inc. |
Use of bi-specific antibodies for pre-targeting diagnosis and therapy
|
|
US6818213B1
(en)
|
1998-07-13 |
2004-11-16 |
Board Of Regents, The University Of Texas System |
Cancer treatment compositions comprising therapeutic conjugates that bind to aminophospholipids
|
|
US7067109B1
(en)
|
1998-07-13 |
2006-06-27 |
Board Of Regents, The University Of Texas System |
Cancer treatment kits comprising therapeutic conjugates that bind to aminophospholipids
|
|
EP1100830B1
(en)
|
1998-07-28 |
2003-10-01 |
Micromet AG |
Heterominibodies
|
|
CA2340091C
(en)
|
1998-08-11 |
2013-02-05 |
Idec Pharmaceuticals Corporation |
Combination therapies for b-cell lymphomas comprising administration of anti-cd20 antibody
|
|
US6383794B1
(en)
|
1998-08-24 |
2002-05-07 |
Uab Research Foundation |
Methods of producing high titer recombinant adeno-associated virus
|
|
US6472179B2
(en)
|
1998-09-25 |
2002-10-29 |
Regeneron Pharmaceuticals, Inc. |
Receptor based antagonists and methods of making and using
|
|
US6224866B1
(en)
|
1998-10-07 |
2001-05-01 |
Biocrystal Ltd. |
Immunotherapy of B cell involvement in progression of solid, nonlymphoid tumors
|
|
WO2000023573A2
(en)
|
1998-10-20 |
2000-04-27 |
City Of Hope |
Cd20-specific redirected t cells and their use in cellular immunotherapy of cd20+ malignancies
|
|
US6660843B1
(en)
|
1998-10-23 |
2003-12-09 |
Amgen Inc. |
Modified peptides as therapeutic agents
|
|
US6197294B1
(en)
|
1998-10-26 |
2001-03-06 |
Neurotech S.A. |
Cell surface molecule-induced macrophage activation
|
|
WO2000027885A1
(en)
|
1998-11-05 |
2000-05-18 |
Kyowa Hakko Kogyo Co., Ltd. |
Novel chimeric polypeptide
|
|
EP1131093A4
(en)
|
1998-11-09 |
2002-05-02 |
Idec Pharma Corp |
TREATMENT OF HEMATOLOGICAL VILTIES ASSOCIATED WITH CIRCULATING TUMOR CELLS USING CHIMERIC ANTI-CD20 ANTIBODIES
|
|
KR20010099788A
(ko)
|
1998-11-09 |
2001-11-09 |
케네쓰 제이. 울코트 |
Ｂｍｔ 또는 ｐｂｓｃ 이식을 받은 환자의 키메라항-ｃｄ２０ 항체 치료법
|
|
US6380371B1
(en)
|
1998-12-10 |
2002-04-30 |
The Regents Of The University Of California |
Endoglycan: a novel protein having selectin ligand and chemokine presentation activity
|
|
HU230769B1
(hu)
|
1999-01-15 |
2018-03-28 |
Genentech Inc. |
Módosított effektor-funkciójú polipeptid-változatok
|
|
US6897044B1
(en)
|
1999-01-28 |
2005-05-24 |
Biogen Idec, Inc. |
Production of tetravalent antibodies
|
|
CN1345334A
(zh)
|
1999-01-29 |
2002-04-17 |
伊姆克罗尼系统公司 |
对kdr特异的抗体及其应用
|
|
EP1035172A3
(en)
|
1999-03-12 |
2002-11-27 |
Fuji Photo Film Co., Ltd. |
Azomethine compound and oily magenta ink
|
|
US6383753B1
(en)
|
1999-03-31 |
2002-05-07 |
Regents Of The University Of Michigan |
Yeast mammalian regulators of cell proliferation
|
|
AU4476600A
(en)
|
1999-04-22 |
2000-11-10 |
Vanderbilt University |
Polymeric encapsulation system promoting angiogenesis
|
|
GB9909925D0
(en)
|
1999-04-29 |
1999-06-30 |
Pharmacia & Upjohn Spa |
Combined preparations comprising anthracycline derivatives
|
|
MXPA01011279A
(es)
|
1999-05-07 |
2002-07-02 |
Genentech Inc |
Tratamiento de enfermedades autoinmunes con antagonistas que se unene a los marcadores de superficie, de celulas b.
|
|
ATE369384T1
(de)
|
1999-05-19 |
2007-08-15 |
Emd Lexigen Res Ct Corp |
Expression und export von interferon-alpha proteinen als fc fusionsproteine
|
|
CA2375912C
(en)
|
1999-06-09 |
2014-03-11 |
Immunomedics, Inc. |
Immunotherapy of autoimmune disorders using antibodies which target b-cells
|
|
ITMI991299A1
(it)
|
1999-06-11 |
2000-12-11 |
Consiglio Nazionale Ricerche |
Uso di anticorpi contro antigeni di superficie per il trattamento della malattia trapianto contro ospite
|
|
US6380382B1
(en)
|
1999-06-30 |
2002-04-30 |
Millennium Pharmaceuticals, Inc. |
Gene encoding a protein having diagnostic, preventive, therapeutic, and other uses
|
|
DE19930748C2
(de)
|
1999-07-02 |
2001-05-17 |
Infineon Technologies Ag |
Verfahren zur Herstellung von EEPROM- und DRAM-Grabenspeicherzellbereichen auf einem Chip
|
|
WO2001003734A1
(en)
|
1999-07-12 |
2001-01-18 |
Genentech, Inc. |
Blocking immune response to a foreign antigen using an antagonist which binds to cd20
|
|
DE60037896D1
(de)
|
1999-07-29 |
2008-03-13 |
Medarex Inc |
Menschliche antikörper gegen her2/neu
|
|
CA2380783C
(en)
|
1999-07-29 |
2009-01-27 |
Yashwant Deo |
Human monoclonal antibodies to prostate specific membrane antigen
|
|
DE60036388D1
(de)
|
1999-07-30 |
2007-10-25 |
Medarex Inc |
Therapeutische verbindungen bestehend aus fc rezeptor bindenden wirkstoffen
|
|
US8557244B1
(en)
|
1999-08-11 |
2013-10-15 |
Biogen Idec Inc. |
Treatment of aggressive non-Hodgkins lymphoma with anti-CD20 antibody
|
|
CN100389825C
(zh)
|
1999-08-11 |
2008-05-28 |
拜奥根Idec公司 |
用抗cd20抗体治疗累及骨髓的非霍奇金淋巴瘤患者
|
|
US6451284B1
(en)
|
1999-08-11 |
2002-09-17 |
Idec Pharmaceuticals Corporation |
Clinical parameters for determining hematologic toxicity prior to radioimmunotheraphy
|
|
AU6929100A
(en)
|
1999-08-23 |
2001-03-19 |
Biocrystal Limited |
Methods and compositions for immunotherapy of b cell involvement in promotion ofa disease condition comprising multiple sclerosis
|
|
RU2305561C2
(ru)
|
1999-11-08 |
2007-09-10 |
Байоджен Айдек Инк. |
Лечение в-клеточных злокачественных опухолей с использованием антител против cd40l в комбинации с антителами против cd20 и/или химиотерапией и лучевой терапией
|
|
US20020006404A1
(en)
|
1999-11-08 |
2002-01-17 |
Idec Pharmaceuticals Corporation |
Treatment of cell malignancies using combination of B cell depleting antibody and immune modulating antibody related applications
|
|
US6380362B1
(en)
|
1999-12-23 |
2002-04-30 |
Genesis Research & Development Corporation Ltd. |
Polynucleotides, polypeptides expressed by the polynucleotides and methods for their use
|
|
EP1257197A4
(en)
|
2000-02-25 |
2008-07-16 |
Health Research Inc |
PROCESS FOR TRANSDERMAL SAMPLING OF ANALYTES
|
|
AU2001247737A1
(en)
|
2000-03-24 |
2001-10-08 |
Chiron Corporation |
Methods of therapy for non-hodgkin's lymphoma using a combination of an antibodyto cd20 and interleuking-2
|
|
CN1981868A
(zh)
|
2000-03-31 |
2007-06-20 |
拜奥根Idec公司 |
抗细胞因子抗体或拮抗剂与抗－cd20在b细胞淋巴瘤治疗中的联合应用
|
|
CN101289511A
(zh)
|
2000-04-11 |
2008-10-22 |
杰南技术公司 |
多价抗体及其应用
|
|
US6667300B2
(en)
|
2000-04-25 |
2003-12-23 |
Icos Corporation |
Inhibitors of human phosphatidylinositol 3-kinase delta
|
|
ES2788383T3
(es)
|
2000-04-25 |
2020-10-21 |
Icos Corp |
Inhibidores de delta fosfatidilo-inositol 3-quinasa humana
|
|
AU5914201A
(en)
|
2000-04-25 |
2001-11-07 |
Idec Pharma Corp |
Intrathecal administration of rituximab for treatment of central nervous system lymphomas
|
|
ATE553131T1
(de)
|
2000-05-08 |
2012-04-15 |
Celldex Res Corp |
Humane monoklonale antikörper gegen dendritische zellen
|
|
US7560534B2
(en)
|
2000-05-08 |
2009-07-14 |
Celldex Research Corporation |
Molecular conjugates comprising human monoclonal antibodies to dendritic cells
|
|
EP1299419A2
(en)
|
2000-05-24 |
2003-04-09 |
Imclone Systems, Inc. |
Bispecific immunoglobulin-like antigen binding proteins and method of production
|
|
CA2411102A1
(en)
|
2000-06-20 |
2001-12-27 |
Idec Pharmaceutical Corporation |
Cold anti-cd20 antibody/radiolabeled anti-cd22 antibody combination
|
|
AU2001270134B2
(en)
|
2000-06-22 |
2006-06-15 |
University Of Iowa Research Foundation |
Methods for enhancing antibody-induced cell lysis and treating cancer
|
|
KR100919593B1
(ko)
|
2000-06-29 |
2009-09-29 |
아보트 러보러터리즈 |
이중 특이성 항체 및 이의 제조 방법 및 이를 포함하는 조성물
|
|
CA2410551A1
(en)
|
2000-06-30 |
2002-01-10 |
Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw (Vib) |
Heterodimeric fusion proteins
|
|
SG136804A1
(en)
|
2000-07-12 |
2007-11-29 |
Idec Pharma Corp |
Treatment of b cell malignancies using combination of b cell depleting antibody and immune modulating antibody related applications
|
|
AU2001272733A1
(en)
|
2000-07-19 |
2002-02-05 |
Orbotech Ltd. |
Apparatus and method for electrical testing of electrical circuits
|
|
US20020025317A1
(en)
|
2000-07-20 |
2002-02-28 |
Schering Ag |
Bispecific monoclonal antibodies to IL-12 and IL-18
|
|
ATE360035T1
(de)
|
2000-08-11 |
2007-05-15 |
Univ Ruprecht Karls Heidelberg |
Fv-konstrukte mit beeinflussbarer affinitat zu einer zu bindenden substanz
|
|
DE10043437A1
(de)
|
2000-09-04 |
2002-03-28 |
Horst Lindhofer |
Verwendung von trifunktionellen bispezifischen und trispezifischen Antikörpern zur Behandlung von malignem Aszites
|
|
US6946292B2
(en)
|
2000-10-06 |
2005-09-20 |
Kyowa Hakko Kogyo Co., Ltd. |
Cells producing antibody compositions with increased antibody dependent cytotoxic activity
|
|
US20020128448A1
(en)
|
2000-10-20 |
2002-09-12 |
Idec Pharmaceuticals Corporation |
Variant IgG3 Rituxan and therapeutic use thereof
|
|
WO2002040545A2
(en)
|
2000-11-17 |
2002-05-23 |
The Government Of The United States, As Represented By The Secretary Of The Department Of Health And Human Services |
Reduction of the nonspecific animal toxicity of immunotoxins by mutating the framework regions of the fv to lower the isoelectric point
|
|
RU2179862C1
(ru)
|
2000-12-26 |
2002-02-27 |
Общество с ограниченной ответственностью Научно-производственный центр "МедБиоСпектр" |
Лекарственное средство для предотвращения отторжения трансплантата, моноклональное антитело к cd3-антигену т-лимфоцитов человека, гибридома и способ лечения больных, имеющих реакцию острого отторжения трансплантата после пересадки почки
|
|
US20030133939A1
(en)
|
2001-01-17 |
2003-07-17 |
Genecraft, Inc. |
Binding domain-immunoglobulin fusion proteins
|
|
US7754208B2
(en)
|
2001-01-17 |
2010-07-13 |
Trubion Pharmaceuticals, Inc. |
Binding domain-immunoglobulin fusion proteins
|
|
AU2002241922B2
(en)
|
2001-01-17 |
2007-10-25 |
Aptevo Research And Development Llc |
Binding domain-immunoglobulin fusion proteins
|
|
US7829084B2
(en)
|
2001-01-17 |
2010-11-09 |
Trubion Pharmaceuticals, Inc. |
Binding constructs and methods for use thereof
|
|
BR0206985A
(pt)
|
2001-01-29 |
2005-04-19 |
Idec Pharma Corp |
Anticorpos modificados e métodos de uso
|
|
AU2002327164A1
(en)
|
2001-01-29 |
2002-12-09 |
Idec Pharmaceuticals Corporation |
Engineered tetravalent antibodies and methods of use
|
|
CN1312181C
(zh)
|
2001-02-12 |
2007-04-25 |
米德列斯公司 |
抗Fcα受体(CD89)的人单克隆抗体
|
|
AU2002248571B2
(en)
|
2001-03-07 |
2007-01-18 |
Merck Patent Gmbh |
Expression technology for proteins containing a hybrid isotype antibody moiety
|
|
AU2002240751A1
(en)
|
2001-03-09 |
2002-09-24 |
William Herman |
Targeted ligands
|
|
US20030003097A1
(en)
|
2001-04-02 |
2003-01-02 |
Idec Pharmaceutical Corporation |
Recombinant antibodies coexpressed with GnTIII
|
|
IL157946A0
(en)
|
2001-04-02 |
2004-03-28 |
Genentech Inc |
Combination therapy
|
|
US20040058445A1
(en)
|
2001-04-26 |
2004-03-25 |
Ledbetter Jeffrey Alan |
Activation of tumor-reactive lymphocytes via antibodies or genes recognizing CD3 or 4-1BB
|
|
US7666414B2
(en)
|
2001-06-01 |
2010-02-23 |
Cornell Research Foundation, Inc. |
Methods for treating prostate cancer using modified antibodies to prostate-specific membrane antigen
|
|
US7514078B2
(en)
|
2001-06-01 |
2009-04-07 |
Cornell Research Foundation, Inc. |
Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies
|
|
EP2277542B1
(en)
|
2001-06-01 |
2014-04-16 |
Cornell Research Foundation Inc. |
Modified antibodies to prostrate-specific membrane antigen and uses thereof
|
|
NZ530212A
(en)
|
2001-06-13 |
2006-09-29 |
Genmab As |
An isolated human monoclonal antibody that binds to human epidermal growth factor receptor (EGFR)
|
|
WO2002102312A2
(en)
|
2001-06-14 |
2002-12-27 |
Intermune, Inc. |
Combination therapy of gamma-interferon and b cell specific antibodies
|
|
MXPA05000511A
(es)
|
2001-07-12 |
2005-09-30 |
Jefferson Foote |
Anticuepros super humanizados.
|
|
US20030026780A1
(en)
|
2001-07-18 |
2003-02-06 |
Hood Leroy E. |
Innate immunity mediated methods of treating pathological conditions
|
|
US20030064053A1
(en)
|
2001-08-31 |
2003-04-03 |
Shengjiang Liu |
Multivalent protein conjugate with multiple ligand-binding domains of receptors
|
|
DE60124912T2
(de)
|
2001-09-14 |
2007-06-14 |
Affimed Therapeutics Ag |
Multimerische, einzelkettige, Tandem-Fv-Antikörper
|
|
US20040044182A1
(en)
|
2001-09-17 |
2004-03-04 |
Hunt Joan S |
Expression, preparation,uses, and sequence of recombinantly-derived soluble hla-g
|
|
EP1487487A2
(en)
|
2001-09-28 |
2004-12-22 |
Elusys Therapeutics, Inc. |
Methods and compositions for prevention, diagnosis, and treatment of cancer using bispecific molecules
|
|
CA2462883A1
(en)
|
2001-10-12 |
2003-04-17 |
Schering Corporation |
Use of bispecific antibodies to regulate immune responses
|
|
WO2003034903A2
(en)
|
2001-10-23 |
2003-05-01 |
Psma Development Company, L.L.C. |
Psma antibodies and protein multimers
|
|
US20050215472A1
(en)
|
2001-10-23 |
2005-09-29 |
Psma Development Company, Llc |
PSMA formulations and uses thereof
|
|
DE10156482A1
(de)
|
2001-11-12 |
2003-05-28 |
Gundram Jung |
Bispezifisches Antikörper-Molekül
|
|
ES2283368T3
(es)
|
2001-11-14 |
2007-11-01 |
Affimed Therapeutics Ag |
Anticuerpos biespecificos anti-cd19 y anti-cd16 y usos de los mismos.
|
|
CN1189483C
(zh)
|
2001-11-23 |
2005-02-16 |
上海中信国健药业有限公司 |
人源化抗cd3单克隆抗体
|
|
EP1468097A4
(en)
|
2001-12-26 |
2006-01-11 |
Immunomedics Inc |
PROCESS FOR GENERATING MULTI-QUALITY REAGENTS WITH MULTIPLE SPECIFICITY FROM V SB H / SB AND V SB L / SB DOMAINS
|
|
US7638326B2
(en)
|
2002-01-03 |
2009-12-29 |
The Trustees Of The University Of Pennsylvania |
Activation and expansion of T-cells using an engineered multivalent signaling platform
|
|
BR0307216A
(pt)
|
2002-01-28 |
2005-12-20 |
Medarex Inc |
Anticorpos monoclonais humanos para antìgeno de membrana especìfica de próstata (psma)
|
|
KR101033196B1
(ko)
|
2002-02-14 |
2011-05-09 |
이뮤노메딕스, 인코오포레이티드 |
항-ｃｄ20 항체 및 그 융합 단백질 및 이들의 이용방법
|
|
CA2478011C
(en)
|
2002-03-01 |
2013-05-21 |
Immunomedics, Inc. |
Bispecific antibody point mutations for enhancing rate of clearance
|
|
US7317091B2
(en)
|
2002-03-01 |
2008-01-08 |
Xencor, Inc. |
Optimized Fc variants
|
|
US20030219436A1
(en)
|
2002-03-15 |
2003-11-27 |
Ledbetter Jeffrey A. |
Compositions and methods to regulate an immune response using CD83 gene expressed in tumors and using soluble CD83-Ig fusion protein
|
|
US7332585B2
(en)
|
2002-04-05 |
2008-02-19 |
The Regents Of The California University |
Bispecific single chain Fv antibody molecules and methods of use thereof
|
|
US7332580B2
(en)
|
2002-04-05 |
2008-02-19 |
The Regents Of The University Of California |
Bispecific single chain Fv antibody molecules and methods of use thereof
|
|
CA2379586A1
(en)
|
2002-04-10 |
2003-10-10 |
William Herman |
Fluid targeted ligands
|
|
DE60327199D1
(de)
|
2002-04-26 |
2009-05-28 |
Chugai Pharmaceutical Co Ltd |
Verfahren zum screening auf agonistische antikörper
|
|
AU2003247483A1
(en)
|
2002-05-30 |
2003-12-31 |
The Children's Hospital Of Philadelphia |
Methods for treatment of acute lymphocytic leukemia
|
|
US8034904B2
(en)
|
2002-06-14 |
2011-10-11 |
Immunogen Inc. |
Anti-IGF-I receptor antibody
|
|
ES2263984T3
(es)
|
2002-06-28 |
2006-12-16 |
Domantis Limited |
Ligandos doble-especificos con una vida media serica aumentada.
|
|
EP1534335B9
(en)
|
2002-08-14 |
2016-01-13 |
Macrogenics, Inc. |
Fcgammariib-specific antibodies and methods of use thereof
|
|
US20040091503A1
(en)
|
2002-08-20 |
2004-05-13 |
Genitrix, Llc |
Lectin compositions and methods for modulating an immune response to an antigen
|
|
WO2004029207A2
(en)
|
2002-09-27 |
2004-04-08 |
Xencor Inc. |
Optimized fc variants and methods for their generation
|
|
CN101972478B
(zh)
|
2002-10-08 |
2012-10-31 |
免疫医疗公司 |
抗体治疗
|
|
ES2533963T3
(es)
|
2002-10-10 |
2015-04-16 |
Merck Patent Gmbh |
Composiciones farmacéuticas dirigidas a receptores Erb-B1
|
|
US7820166B2
(en)
|
2002-10-11 |
2010-10-26 |
Micromet Ag |
Potent T cell modulating molecules
|
|
SI2301965T1
(sl)
|
2002-10-16 |
2015-07-31 |
Purdue Pharma L.P. |
Protitelesa, ki vežejo celično- povezan CA 125 / O722P in metode uporabe le-teh
|
|
CN101928344B
(zh)
|
2002-10-17 |
2014-08-13 |
根马布股份公司 |
抗cd20的人单克隆抗体
|
|
CA2511013A1
(en)
|
2002-12-20 |
2004-07-15 |
Biogen Idec Ma Inc. |
Multivalent lymphotoxin beta receptor agonists and therapeutic uses thereof
|
|
CA2510315C
(en)
|
2002-12-20 |
2014-01-28 |
Abbvie Biotherapeutics Inc. |
Antibodies against gpr64 and uses thereof
|
|
DE60335024D1
(de)
|
2002-12-23 |
2010-12-30 |
Bristol Myers Squibb Co |
Produktqualitätsverbesserung in säugerzellkulturverfahrenzur proteinproduktion
|
|
CA2414148A1
(en)
|
2002-12-30 |
2004-06-30 |
William Herman |
Targeted ligands
|
|
US7534427B2
(en)
|
2002-12-31 |
2009-05-19 |
Immunomedics, Inc. |
Immunotherapy of B cell malignancies and autoimmune diseases using unconjugated antibodies and conjugated antibodies and antibody combinations and fusion proteins
|
|
JP2006524039A
(ja)
|
2003-01-09 |
2006-10-26 |
マクロジェニクス，インコーポレーテッド |
変異型Ｆｃ領域を含む抗体の同定および作製ならびにその利用法
|
|
EP1587837B1
(en)
|
2003-01-28 |
2012-06-13 |
Proscan RX Pharma Inc. |
Epitope sequences for prostate cancer diagnosis and treatment
|
|
JP3803790B2
(ja)
|
2003-02-17 |
2006-08-02 |
株式会社東北テクノアーチ |
新規なダイアボディ型二重特異性抗体
|
|
EP2862878B1
(en)
|
2003-02-25 |
2022-11-02 |
Nykode Therapeutics ASA |
Modified antibody
|
|
CA2522586C
(en)
|
2003-05-31 |
2017-02-21 |
Micromet Ag |
Pharmaceutical compositions comprising bispecific anti-cd3, anti-cd19 antibody constructs for the treatment of b-cell related disorders
|
|
SI1629011T1
(sl)
|
2003-05-31 |
2010-05-31 |
Micromet Ag |
Humane molekule za vezavo anti hu cd
|
|
US20050008649A1
(en)
|
2003-06-02 |
2005-01-13 |
University Of Miami |
Chimeric molecules and methods of use
|
|
CN1279056C
(zh)
|
2003-06-06 |
2006-10-11 |
马菁 |
肿瘤相关抗原sm5－1的特异性抗体及其应用
|
|
CA2529027C
(en)
|
2003-06-13 |
2013-09-10 |
Immunomedics, Inc. |
D-amino acid peptides
|
|
CA2529945A1
(en)
|
2003-06-27 |
2005-01-06 |
Biogen Idec Ma Inc. |
Use of hydrophobic-interaction-chromatography or hinge-region modifications for the production of homogeneous antibody-solutions
|
|
KR20060041205A
(ko)
|
2003-07-01 |
2006-05-11 |
이뮤노메딕스, 인코오포레이티드 |
양특이성 항체들의 다가 담체들
|
|
US7754209B2
(en)
|
2003-07-26 |
2010-07-13 |
Trubion Pharmaceuticals |
Binding constructs and methods for use thereof
|
|
FR2858235B1
(fr)
|
2003-07-31 |
2006-02-17 |
Lab Francais Du Fractionnement |
Utilisation d'anticorps optimises en adcc pour traiter les patients faibles repondeurs
|
|
US20050079184A1
(en)
|
2003-08-08 |
2005-04-14 |
Immunomedics, Inc. |
Bispecific antibodies for inducing apoptosis of tumor and diseased cells
|
|
US20080241884A1
(en)
|
2003-10-08 |
2008-10-02 |
Kenya Shitara |
Fused Protein Composition
|
|
DE602004030811D1
(de)
|
2003-10-16 |
2011-02-10 |
Micromet Ag |
Multispezifische deimmunisierte cd3-bindende moleküle
|
|
ATE555133T1
(de)
|
2003-11-13 |
2012-05-15 |
Hanmi Holdings Co Ltd |
Igg fc fragment für einen arzneimittelträger und verfahren zu dessen herstellung
|
|
AU2004293182B2
(en)
|
2003-11-28 |
2010-02-18 |
Amgen Research (Munich) Gmbh |
Compositions comprising polypeptides
|
|
KR100956913B1
(ko)
|
2003-12-19 |
2010-05-11 |
제넨테크, 인크. |
치료제로서 유용한 일가 항체 단편
|
|
US20050249723A1
(en)
|
2003-12-22 |
2005-11-10 |
Xencor, Inc. |
Fc polypeptides with novel Fc ligand binding sites
|
|
US7235641B2
(en)
|
2003-12-22 |
2007-06-26 |
Micromet Ag |
Bispecific antibodies
|
|
US20050202020A1
(en)
|
2004-01-09 |
2005-09-15 |
Jeffrey Ross |
Diagnosing and treating cancer
|
|
WO2005070966A2
(en)
|
2004-01-16 |
2005-08-04 |
Regeneron Pharmaceuticals, Inc. |
Fusion polypeptides capable of activating receptors
|
|
DK1716178T3
(da)
|
2004-02-16 |
2010-09-20 |
Micromet Ag |
Mindre immunogene bindingsmolekyler
|
|
ES2375481T3
(es)
|
2004-03-30 |
2012-03-01 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem |
Anticuerpos biespecíficos para elegir como diana células que participan en reacciones de tipo alérgico, composiciones y usos de los mismos.
|
|
EP1756166A4
(en)
|
2004-04-19 |
2008-08-27 |
Proscan Rx Pharma |
DIAGNOSIS AND TREATMENT OF PROSTATE CANCER
|
|
WO2005103081A2
(en)
|
2004-04-20 |
2005-11-03 |
Genmab A/S |
Human monoclonal antibodies against cd20
|
|
EP1765870A2
(en)
|
2004-06-03 |
2007-03-28 |
Medarex, Inc. |
Human monoclonal antibodies to fc gamma receptor i (cd64)
|
|
US20070237712A1
(en)
|
2004-06-14 |
2007-10-11 |
Rajasekaran Ayyappan K |
Methods of Redistributing Apical Target Antigens to Detect and Treat Cellular Proliferative Disease
|
|
US20060008415A1
(en)
|
2004-06-25 |
2006-01-12 |
Protein Design Labs, Inc. |
Stable liquid and lyophilized formulation of proteins
|
|
AU2005263555B2
(en)
|
2004-07-16 |
2011-01-27 |
Amgen Research (Munich) Gmbh |
Expression-enhanced polypeptides
|
|
JP2008512352A
(ja)
|
2004-07-17 |
2008-04-24 |
イムクローン システムズ インコーポレイティド |
新規な四価の二重特異性抗体
|
|
SI2311874T1
(sl)
|
2004-07-22 |
2017-12-29 |
Erasmus University Medical Center Rotterdam Department of Cell Biology and Genetics |
Vezavne molekule
|
|
BRPI0514259A
(pt)
|
2004-08-11 |
2008-06-03 |
Trubion Pharmaceuticals Inc |
proteìna de fusão de domìnio de ligação
|
|
EP1789446A2
(en)
|
2004-09-02 |
2007-05-30 |
Genentech, Inc. |
Heteromultimeric molecules
|
|
US7393662B2
(en)
|
2004-09-03 |
2008-07-01 |
Centocor, Inc. |
Human EPO mimetic hinge core mimetibodies, compositions, methods and uses
|
|
US8066989B2
(en)
|
2004-11-30 |
2011-11-29 |
Trion Pharma Gmbh |
Method of treating tumor growth and metastasis by using trifunctional antibodies to reduce the risk for GvHD in allogeneic antitumor cell therapy
|
|
EP1666500B1
(en)
|
2004-12-01 |
2011-09-21 |
Trion Pharma Gmbh |
Use of trifunctionel antibodies to reduce the risk for GvHD in allogeneic antitumor cell therapy
|
|
WO2006063150A2
(en)
|
2004-12-08 |
2006-06-15 |
Immunomedics, Inc. |
Methods and compositions for immunotherapy and detection of inflammatory and immune-dysregulatory disease, infectious disease, pathologic angiogenesis and cancer
|
|
WO2006074399A2
(en)
|
2005-01-05 |
2006-07-13 |
Biogen Idec Ma Inc. |
Multispecific binding molecules comprising connecting peptides
|
|
CN103555733A
(zh)
|
2005-01-05 |
2014-02-05 |
F-星生物技术研究与开发有限公司 |
分子中互补决定区以外的区域中工程改造了的具有结合特性的合成免疫球蛋白结构域
|
|
KR100616666B1
(ko)
|
2005-01-27 |
2006-08-28 |
삼성전기주식회사 |
카본나노튜브에 구아니딘기를 형성하는 방법,구아니딘기가 형성된 카본나노튜브를 기판에 부착하는방법 및 이에 따라 제조된 카본나노튜브 및 기판
|
|
BRPI0607796A2
(pt)
|
2005-02-18 |
2009-06-13 |
Medarex Inc |
composto ou um sal farmaceuticamente aceitável do mesmo, processo para preparação e uso do mesmo, e, composição farmacêutica
|
|
NZ556661A
(en)
|
2005-02-18 |
2010-10-29 |
Medarex Inc |
Human monoclonal antibodies to prostate specific membrance antigen (PSMA)
|
|
GB0504767D0
(en)
|
2005-03-08 |
2005-04-13 |
Ares Trading Sa |
Lipocalin protein
|
|
EP3050963B1
(en)
|
2005-03-31 |
2019-09-18 |
Chugai Seiyaku Kabushiki Kaisha |
Process for production of polypeptide by regulation of assembly
|
|
CA2606081C
(en)
|
2005-04-26 |
2013-09-17 |
Markus M. Heiss |
Combination of the application of antibodies for immunostimulation together with glucocorticoids
|
|
EP1885396A2
(en)
|
2005-05-04 |
2008-02-13 |
Quark Pharmaceuticals, Inc. |
Recombinant antibodies against cd55 and cd59 and uses thereof
|
|
US20060263367A1
(en)
|
2005-05-23 |
2006-11-23 |
Fey Georg H |
Bispecific antibody devoid of Fc region and method of treatment using same
|
|
EP1726650A1
(en)
|
2005-05-27 |
2006-11-29 |
Universitätsklinikum Freiburg |
Monoclonal antibodies and single chain antibody fragments against cell-surface prostate specific membrane antigen
|
|
US7736647B2
(en)
|
2005-06-15 |
2010-06-15 |
Monoclonal Antibodies Therapeutics |
Anti-CD71 monoclonal antibodies and uses thereof for treating malignant tumor cells
|
|
NZ565075A
(en)
|
2005-06-20 |
2011-05-27 |
Psma Dev Company Llc |
PSMA antibody-drug conjugates
|
|
HRP20140338T1
(hr)
|
2005-07-25 |
2014-06-20 |
Emergent Product Development Seattle, Llc |
Smanjenje broja b-stanica upotrebom molekula koje se specifiäśno vežu na cd37 i cd20
|
|
JP2009502936A
(ja)
|
2005-07-25 |
2009-01-29 |
トルビオン ファーマシューティカルズ， インコーポレイテッド |
Ｃｄ２０特異的結合分子の単一投与量
|
|
US20080279850A1
(en)
|
2005-07-25 |
2008-11-13 |
Trubion Pharmaceuticals, Inc. |
B-Cell Reduction Using CD37-Specific and CD20-Specific Binding Molecules
|
|
KR20130108481A
(ko)
|
2005-08-19 |
2013-10-02 |
아보트 러보러터리즈 |
이원 가변 도메인 면역글로불린 및 이의 용도
|
|
US7612181B2
(en)
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
|
AU2006301492B2
(en)
|
2005-10-11 |
2011-06-09 |
Amgen Research (Munich) Gmbh |
Compositions comprising cross-species-specific antibodies and uses thereof
|
|
AR056142A1
(es)
|
2005-10-21 |
2007-09-19 |
Amgen Inc |
Metodos para generar el anticuerpo igg monovalente
|
|
US10183986B2
(en)
|
2005-12-15 |
2019-01-22 |
Industrial Technology Research Institute |
Trimeric collagen scaffold antibodies
|
|
EP1979378B1
(en)
|
2005-12-20 |
2012-07-25 |
MorphoSys AG |
Novel collection of hcdr3 regions and uses therefor
|
|
WO2007095338A2
(en)
|
2006-02-15 |
2007-08-23 |
Imclone Systems Incorporated |
Functional antibodies
|
|
KR101263294B1
(ko)
|
2006-03-30 |
2013-06-04 |
글락소 그룹 리미티드 |
아밀로이드베타 펩티드에 대한 항체
|
|
ES2892925T3
(es)
|
2006-03-31 |
2022-02-07 |
Chugai Pharmaceutical Co Ltd |
Métodos para controlar la farmacocinética en sangre de anticuerpos
|
|
JP2009539841A
(ja)
|
2006-06-06 |
2009-11-19 |
トラークス，インコーポレイテッド |
自己免疫疾患の治療における抗ｃｄ３抗体の投与
|
|
WO2007146968A2
(en)
|
2006-06-12 |
2007-12-21 |
Trubion Pharmaceuticals, Inc. |
Single-chain multivalent binding proteins with effector function
|
|
US20100056759A1
(en)
|
2006-10-19 |
2010-03-04 |
Tolerx, Inc. |
Methods and Compositions for Efficient Removal of Protein A from Binding Molecule Preparations
|
|
US7846434B2
(en)
|
2006-10-24 |
2010-12-07 |
Trubion Pharmaceuticals, Inc. |
Materials and methods for improved immunoglycoproteins
|
|
CA2663536A1
(en)
|
2006-10-24 |
2008-05-02 |
Trubion Pharmaceuticals, Inc. |
Materials and methods for improved immunoglycoproteins
|
|
US20100015142A1
(en)
|
2006-12-21 |
2010-01-21 |
Macrogenics Inc. |
Methods for the treatment of lada and other adult- onset autoimmune using immunosuppressive monoclonal antibodies with reduced toxicity
|
|
WO2008119566A2
(en)
|
2007-04-03 |
2008-10-09 |
Micromet Ag |
Cross-species-specific bispecific binders
|
|
EP2144930A1
(en)
|
2007-04-18 |
2010-01-20 |
ZymoGenetics, Inc. |
Single chain fc, methods of making and methods of treatment
|
|
WO2008153636A1
(en)
|
2007-05-04 |
2008-12-18 |
Cellsignaling Technology, Inc. |
Phospho-specific antibodies to p13k regulatory subunit and uses thereof
|
|
CA2684932A1
(en)
|
2007-05-09 |
2008-11-20 |
Novartis Ag |
Substituted imidazopyridazines as pi3k lipid kinase inhibitors
|
|
MX2009012343A
(es)
|
2007-05-14 |
2010-02-10 |
Biogen Idec Inc |
Regiones fc (sc fc) de cadena sencilla, polipeptidos de enlace que comprenden las mismas, y metodos relacionados con ello.
|
|
US20090258005A1
(en)
|
2007-05-29 |
2009-10-15 |
Trubion Pharmaceuticals Inc. |
Therapeutic compositions and methods
|
|
WO2008152394A1
(en)
|
2007-06-12 |
2008-12-18 |
F.Hoffmann-La Roche Ag |
Pharmaceutical compounds
|
|
WO2008152387A1
(en)
|
2007-06-12 |
2008-12-18 |
F.Hoffmann-La Roche Ag |
Quinazoline derivatives as pi3 kinase inhibitors
|
|
US7893060B2
(en)
|
2007-06-12 |
2011-02-22 |
F. Hoffmann-La Roche Ag |
Thiazolopyrimidines and their use as inhibitors of phosphatidylinositol-3 kinase
|
|
JP2010532764A
(ja)
|
2007-07-06 |
2010-10-14 |
トゥルビオン・ファーマシューティカルズ・インコーポレーテッド |
Ｃ末端に配置された特異的結合性ドメインを有する結合性ペプチド
|
|
WO2009017823A2
(en)
|
2007-08-01 |
2009-02-05 |
The Government Of The United States Of America, As Represented By The Secretary, Department Of Health Of Human Services, National Institutes Of Health |
A fold-back diabody diphtheria toxin immunotoxin and methods of use
|
|
PE20140196A1
(es)
|
2007-08-09 |
2014-03-19 |
Boehringer Ingelheim Int |
Anticuerpos anti-cd37
|
|
EP2033657A1
(de)
|
2007-09-04 |
2009-03-11 |
Trion Pharma Gmbh |
Intraoperative trifunktionale Antikörper-Applikation zur Prophylaxe intraperitonealer Tumorzelldissemination
|
|
AU2008298948B2
(en)
|
2007-09-12 |
2014-09-04 |
F. Hoffmann-La Roche Ag |
Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use
|
|
JP2010539239A
(ja)
|
2007-09-17 |
2010-12-16 |
グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー |
Ｐｉ３キナーゼ阻害剤としてのピリドピリミジン誘導体
|
|
WO2009042607A1
(en)
|
2007-09-24 |
2009-04-02 |
Genentech, Inc. |
Thiazolopyrimidine p13k inhibitor compounds and methods of use
|
|
HRP20151128T1
(hr)
|
2007-09-27 |
2015-11-20 |
Fundación Centro Nacional De Investigaciones Oncológicas Carlos Iii |
Imidazolotiadiazoli za uporabu kao inhibitori protein kinaze
|
|
WO2009046294A2
(en)
|
2007-10-03 |
2009-04-09 |
Cornell University |
Treatment of proliferative disorders using antibodies to psma
|
|
GB2467670B
(en)
|
2007-10-04 |
2012-08-01 |
Intellikine Inc |
Chemical entities and therapeutic uses thereof
|
|
EP2209785A1
(en)
|
2007-10-05 |
2010-07-28 |
S*BIO Pte Ltd |
2-morpholinylpurines as inhibitors of pi3k
|
|
BRPI0817503B8
(pt)
|
2007-10-05 |
2021-05-25 |
Sstarbio Pte Ltd |
derivados de purina substituídos por pirimidina, composição farmacêutica compreendendo ditos compostos e uso dos mesmos para a prevenção ou tratamento de uma condição proliferativa
|
|
US8129371B2
(en)
|
2007-10-16 |
2012-03-06 |
Wyeth Llc |
Thienopyrimidine and pyrazolopyrimidine compounds and their use as mTOR kinase and PI3 kinase inhibitors
|
|
US20100311736A1
(en)
|
2007-10-22 |
2010-12-09 |
Glaxosmithkline Llc |
Pyridosulfonamide derivatives as p13 kinase inhibitors
|
|
CN101835779B
(zh)
|
2007-10-26 |
2014-01-29 |
霍夫曼-拉罗奇有限公司 |
作为pi3激酶抑制剂的嘌呤衍生物
|
|
GB0721095D0
(en)
|
2007-10-26 |
2007-12-05 |
Piramed Ltd |
Pharmaceutical compounds
|
|
WO2009058361A1
(en)
|
2007-10-31 |
2009-05-07 |
Dynavax Technologies Corp. |
Inhibition of type i ifn production
|
|
US7951832B2
(en)
|
2007-10-31 |
2011-05-31 |
Burnham Institute For Medical Research |
Pyrazole derivatives as kinase inhibitors
|
|
CA2716334A1
(en)
|
2007-11-13 |
2009-05-22 |
Icos Corporation |
Inhibitors of human phosphatidyl-inositol 3-kinase delta
|
|
WO2009066084A1
(en)
|
2007-11-21 |
2009-05-28 |
F. Hoffmann-La Roche Ag |
2 -morpholinopyrimidines and their use as pi3 kinase inhibitors
|
|
WO2009070524A1
(en)
|
2007-11-27 |
2009-06-04 |
Wyeth |
Pyrrolo[3,2-d]pyrimidine compounds and their use as pi3 kinase and mtor kinase inhibitors
|
|
MX2010005700A
(es)
|
2007-11-27 |
2010-06-11 |
Cellzome Ltd |
Amino triazoles como inhibidores pi3k.
|
|
US8227577B2
(en)
|
2007-12-21 |
2012-07-24 |
Hoffman-La Roche Inc. |
Bivalent, bispecific antibodies
|
|
US9266967B2
(en)
|
2007-12-21 |
2016-02-23 |
Hoffmann-La Roche, Inc. |
Bivalent, bispecific antibodies
|
|
EP2365003A1
(en)
|
2008-04-11 |
2011-09-14 |
Emergent Product Development Seattle, LLC |
CD37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof
|
|
WO2009127046A1
(en)
|
2008-04-14 |
2009-10-22 |
Proscan Rx Pharma Inc. |
Prostate specific membrane antigen antibodies and antigen binding fragments
|
|
ITTO20080313A1
(it)
|
2008-04-22 |
2009-10-23 |
Marco Colombatti |
Anticorpo monoclonale isolato o suo frammento legante l'antigene specifico di membrana della prostata, suoi coniugati e suoi usi
|
|
CN102171247A
(zh)
|
2008-07-02 |
2011-08-31 |
特鲁比昂药品公司 |
TNF-α拮抗剂多靶点结合蛋白
|
|
EA019512B1
(ru)
|
2008-07-02 |
2014-04-30 |
Эмерджент Продакт Дивелопмент Сиэтл, Ллс |
Il-6-опосредованная иммунотерапия
|
|
NZ590667A
(en)
|
2008-07-02 |
2013-01-25 |
Emergent Product Dev Seattle |
Tgf-b antagonist multi-target binding proteins
|
|
WO2010014629A1
(en)
|
2008-07-28 |
2010-02-04 |
Trubion Pharmaceuticals, Inc. |
Multi-specific binding proteins targeting b cell disorders
|
|
EP2326350B1
(en)
|
2008-09-08 |
2013-09-04 |
Psma Development Company, L.L.C. |
Compounds for killing psma-expressing, taxane-resistant cancer cells
|
|
AU2009296297A1
(en)
|
2008-09-26 |
2010-04-01 |
Roche Glycart Ag |
Bispecific anti-EGFR/anti-IGF-1R antibodies
|
|
JP6126782B2
(ja)
|
2008-10-01 |
2017-05-10 |
アムゲン リサーチ （ミュンヘン） ゲーエムベーハー |
異種間特異的ｐｓｍａ×ｃｄ３二重特異性単鎖抗体
|
|
CA2738568C
(en)
|
2008-10-01 |
2024-02-20 |
Micromet Ag |
Cross-species-specific single domain bispecific single chain antibody
|
|
PL2352763T5
(pl)
|
2008-10-01 |
2023-01-30 |
Amgen Research (Munich) Gmbh |
Bispecyficzne przeciwciała jednołańcuchowe o specyficzności wobec antygenów docelowych o dużej masie cząsteczkowej
|
|
NZ592420A
(en)
|
2008-10-02 |
2012-12-21 |
Emergent Product Dev Seattle |
Cd86 antagonist multi-target binding proteins
|
|
US8268314B2
(en)
|
2008-10-08 |
2012-09-18 |
Hoffmann-La Roche Inc. |
Bispecific anti-VEGF/anti-ANG-2 antibodies
|
|
CN105218673A
(zh)
|
2008-10-10 |
2016-01-06 |
新兴产品开发西雅图有限公司 |
Tcr复合物免疫治疗剂
|
|
RU2526156C2
(ru)
|
2008-11-13 |
2014-08-20 |
ЭМЕРДЖЕНТ ПРОДАКТ ДИВЕЛОПМЕНТ СИЭТЛ, ЭлЭлСи |
Cd37-иммунотерапевтическая комбинированная терапия и ее применения
|
|
EP3912643B8
(en)
|
2009-02-13 |
2023-08-23 |
Immunomedics, Inc. |
Immunoconjugates with an intracellularly-cleavable linkage
|
|
US8629247B2
(en)
|
2009-04-14 |
2014-01-14 |
Proscan Rx Pharma Inc. |
Antibodies against prostate specific membrane antigen
|
|
JP2012525149A
(ja)
|
2009-04-27 |
2012-10-22 |
オンコメッド ファーマシューティカルズ インコーポレイテッド |
ヘテロ多量体分子を作製するための方法
|
|
TW201100543A
(en)
|
2009-05-27 |
2011-01-01 |
Hoffmann La Roche |
Tri-or tetraspecific antibodies
|
|
JP2012531212A
(ja)
|
2009-07-03 |
2012-12-10 |
アビペップ ピーティーワイ リミテッド |
イムノコンジュゲート及びその作製方法
|
|
US20130052195A1
(en)
|
2009-12-23 |
2013-02-28 |
Emergent Product Development Seattle,LLC |
Compositions Comprising TNF-alpha and IL-6 Antagonists and Methods of Use Thereof
|
|
SG181814A1
(en)
|
2009-12-23 |
2012-07-30 |
Avipep Pty Ltd |
Immuno-conjugates and methods for producing them 2
|
|
US20130129723A1
(en)
|
2009-12-29 |
2013-05-23 |
Emergent Product Development Seattle, Llc |
Heterodimer Binding Proteins and Uses Thereof
|
|
CN102958942A
(zh)
|
2009-12-29 |
2013-03-06 |
新兴产品开发西雅图有限公司 |
异二聚体结合蛋白及其应用
|
|
TWI653333B
(zh)
|
2010-04-01 |
2019-03-11 |
安進研究（慕尼黑）有限責任公司 |
跨物種專一性之ＰＳＭＡｘＣＤ３雙專一性單鏈抗體
|
|
WO2011123830A2
(en)
|
2010-04-02 |
2011-10-06 |
Amunix Operating Inc. |
Alpha 1-antitrypsin compositions and methods of making and using same
|
|
EP2601216B1
(en)
|
2010-08-02 |
2018-01-03 |
MacroGenics, Inc. |
Covalent diabodies and uses thereof
|
|
US8962804B2
(en)
|
2010-10-08 |
2015-02-24 |
City Of Hope |
Meditopes and meditope-binding antibodies and uses thereof
|
|
RS67768B1
(sr)
|
2010-11-30 |
2026-03-31 |
Chugai Pharmaceutical Co Ltd |
Terapijski agens koji indukuje citotoksičnost
|
|
WO2012088290A2
(en)
|
2010-12-22 |
2012-06-28 |
Abbott Laboratories |
Tri-variable domain binding proteins and uses thereof
|
|
JP2014515598A
(ja)
|
2011-03-10 |
2014-07-03 |
エイチシーオー アンティボディ， インク． |
二重特異性三鎖抗体様分子
|
|
EP2686345B1
(en)
|
2011-03-16 |
2018-04-25 |
Amgen Inc. |
Fc variants
|
|
TWI588156B
(zh)
|
2011-03-28 |
2017-06-21 |
賽諾菲公司 |
具有交叉結合區定向之雙重可變區類抗體結合蛋白
|
|
UA118950C2
(uk)
|
2011-04-22 |
2019-04-10 |
Аптево Рісьорч Енд Девелопмент Ллс |
Поліпептид, який зв'язує специфічний мембранний антиген простати та комплекс т-клітинного рецептора
|
|
WO2012158818A2
(en)
|
2011-05-16 |
2012-11-22 |
Fabion Pharmaceuticals, Inc. |
Multi-specific fab fusion proteins and methods of use
|
|
EP2525222A1
(en)
|
2011-05-17 |
2012-11-21 |
Markus M. Heiss |
Initial relative lymphocyte count as predictive biomarker
|
|
DK2714733T3
(da)
*
|
2011-05-21 |
2019-05-06 |
Macrogenics Inc |
Cd3-bindende molekyler, der er i stand til at binde til human og ikke-human cd3
|
|
BR112014004168A2
(pt)
|
2011-08-23 |
2017-12-12 |
Roche Glycart Ag |
anticorpo biespecífico, composição farmacêutica, uso do anticorpo biespecífico, célula hospedeira procariótica ou eucariótica, método de produção de anticorpo e invenção
|
|
MY169358A
(en)
|
2011-08-23 |
2019-03-26 |
Roche Glycart Ag |
Bispecific t cell activating antigen binding molecules
|
|
LT2794658T
(lt)
|
2011-12-19 |
2017-05-10 |
Synimmune Gmbh |
Bispecifinė antikūno molekulė
|
|
KR101963230B1
(ko)
|
2011-12-26 |
2019-03-29 |
삼성전자주식회사 |
복수개의 단일 항체를 포함하는 단백질 복합체
|
|
PT2802607T
(pt)
|
2012-01-13 |
2018-01-03 |
Univ Wuerzburg J Maximilians |
Complementação funcional bipartida induzida por duplo antigénio
|
|
WO2013121175A1
(en)
|
2012-02-16 |
2013-08-22 |
Ucl Business Plc |
Lysosome-cleavable linker
|
|
GB201203442D0
(en)
|
2012-02-28 |
2012-04-11 |
Univ Birmingham |
Immunotherapeutic molecules and uses
|
|
EP2820047B1
(en)
|
2012-03-01 |
2018-04-25 |
Amgen Research (Munich) GmbH |
Long life polypeptide binding molecules
|
|
JP2015510877A
(ja)
|
2012-03-09 |
2015-04-13 |
ユーシーエル ビジネス パブリック リミテッド カンパニー |
抗体の化学修飾
|
|
SG10201608307WA
(en)
|
2012-04-20 |
2016-11-29 |
Emergent Product Dev Seattle |
Cd3 binding polypeptides
|
|
CA2871116A1
(en)
|
2012-05-14 |
2013-11-21 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
|
US9745381B2
(en)
|
2012-05-18 |
2017-08-29 |
Scott & White Healthcare (Swh) |
Bispecific scFv immunofusion (BIf)
|
|
US20130309234A1
(en)
|
2012-05-18 |
2013-11-21 |
Trion Pharma Gmbh |
Correlation of de novo-induced tumor-associated humoral immune responses with improved clinical outcome
|
|
EP2854845B1
(en)
|
2012-06-01 |
2018-03-28 |
IBC Pharmaceuticals, Inc. |
Multimeric complexes with improved in vivo stability, pharmacokinetics and efficacy
|
|
BR112015000167B1
(pt)
|
2012-07-06 |
2021-11-23 |
Genmab B.V. |
Proteína dimérica, proteína, composição, kit de partes e seus usos, bem como método para aumentar a oligomerização em solução de uma proteína dimérica compreendendo um primeiro e segundo polipeptídeo, cada um compreendendo pelo menos as regiões ch2 e ch3 de uma cadeia pesada de igg1 humana e proteína dimérica variante
|
|
WO2014012085A2
(en)
|
2012-07-13 |
2014-01-16 |
Zymeworks Inc. |
Bispecific asymmetric heterodimers comprising anti-cd3 constructs
|
|
AU2013302696B9
(en)
|
2012-08-14 |
2018-08-09 |
Ibc Pharmaceuticals, Inc. |
T-cell redirecting bispecific antibodies for treatment of disease
|
|
US9682143B2
(en)
|
2012-08-14 |
2017-06-20 |
Ibc Pharmaceuticals, Inc. |
Combination therapy for inducing immune response to disease
|
|
WO2014043208A1
(en)
|
2012-09-11 |
2014-03-20 |
Medivation Prostate Therapeutics, Inc. |
Formulations of enzalutamide
|
|
KR20140036905A
(ko)
|
2012-09-18 |
2014-03-26 |
삼성전자주식회사 |
이중특이 항체를 포함하는 단백질 복합체
|
|
JOP20200236A1
(ar)
|
2012-09-21 |
2017-06-16 |
Regeneron Pharma |
الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها
|
|
EP2904016B1
(en)
|
2012-10-08 |
2018-11-14 |
Roche Glycart AG |
Fc-free antibodies comprising two fab-fragments and methods of use
|
|
KR101911438B1
(ko)
|
2012-10-31 |
2018-10-24 |
삼성전자주식회사 |
이중 특이 항원 결합 단백질 복합체 및 이중 특이 항체의 제조 방법
|
|
CN104936621A
(zh)
|
2012-11-07 |
2015-09-23 |
辉瑞公司 |
抗IL-13受体α2抗体和抗体-药物缀合物
|
|
CN104271602B
(zh)
|
2012-11-21 |
2020-08-21 |
武汉友芝友生物制药有限公司 |
双特异性抗体
|
|
WO2014100490A1
(en)
|
2012-12-19 |
2014-06-26 |
Adimab, Llc |
Multivalent antibody analogs, and methods of their preparation and use
|
|
US10329350B2
(en)
|
2012-12-26 |
2019-06-25 |
Industrial Technology Research Institute |
Method for producing a multivalent fab fragment with collagen-like peptide
|
|
EA201591153A1
(ru)
|
2013-01-02 |
2016-01-29 |
Гленмарк Фармасьютикалс С.А. |
Антитела, связывающиеся с tl1a, и их применение
|
|
CA2898100C
(en)
|
2013-01-14 |
2023-10-10 |
Xencor, Inc. |
Novel heterodimeric proteins
|
|
WO2014143807A2
(en)
|
2013-03-15 |
2014-09-18 |
Stromatt Scott |
Anti-cd37 antibody and bcr pathway antagonist combination therapy for treatment of b-cell malignancies and disorders
|
|
WO2014151438A1
(en)
|
2013-03-15 |
2014-09-25 |
Emergent Product Development Seattle, Llc |
Multispecific anti-cd37 antibodies and related compositions and methods
|
|
JP7020909B2
(ja)
*
|
2014-07-25 |
2022-02-16 |
シトムクス セラピューティクス，インコーポレイティド |
抗－ｃｄ３抗体、活性化可能抗－ｃｄ３抗体、多重特異的抗－ｃｄ３抗体、多重特異的活性化可能抗－ｃｄ３抗体、及びそれらの使用方法
|
|
WO2016094873A2
(en)
|
2014-12-12 |
2016-06-16 |
Emergent Product Development Seattle, Llc |
Receptor tyrosine kinase-like orphan receptor 1 binding proteins and related compositions and methods
|
|
EP3256495A4
(en)
|
2015-02-11 |
2018-09-19 |
Aptevo Research and Development LLC |
Compositions and methods for combination therapy with prostate-specific membrane antigen binding proteins
|