JP2019531764A5 - - Google Patents

Info

Publication number

JP2019531764A5

JP2019531764A5 JP2019537049A JP2019537049A JP2019531764A5 JP 2019531764 A5 JP2019531764 A5 JP 2019531764A5 JP 2019537049 A JP2019537049 A JP 2019537049A JP 2019537049 A JP2019537049 A JP 2019537049A JP 2019531764 A5 JP2019531764 A5 JP 2019531764A5

Authority

JP

Japan

Prior art keywords

seq

amino acid

acid sequence

set forth

binding domain

Prior art date

2017-09-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 125000003275 alpha amino acid group Chemical group 0.000 claims 36
• 229920001184 polypeptide Polymers 0.000 claims 26
• 102000004196 processed proteins & peptides Human genes 0.000 claims 26
• 108090000765 processed proteins & peptides Proteins 0.000 claims 26
• 238000006467 substitution reaction Methods 0.000 claims 6
• 101001008255 Homo sapiens Immunoglobulin kappa variable 1D-8 Proteins 0.000 claims 4
• 101001047628 Homo sapiens Immunoglobulin kappa variable 2-29 Proteins 0.000 claims 4
• 101001008321 Homo sapiens Immunoglobulin kappa variable 2D-26 Proteins 0.000 claims 4
• 101001047619 Homo sapiens Immunoglobulin kappa variable 3-20 Proteins 0.000 claims 4
• 101001008263 Homo sapiens Immunoglobulin kappa variable 3D-15 Proteins 0.000 claims 4
• 102100022949 Immunoglobulin kappa variable 2-29 Human genes 0.000 claims 4
• 239000000539 dimer Substances 0.000 claims 4
• 101000998953 Homo sapiens Immunoglobulin heavy variable 1-2 Proteins 0.000 claims 3
• 102100036887 Immunoglobulin heavy variable 1-2 Human genes 0.000 claims 3
• 108091008874 T cell receptors Proteins 0.000 claims 3
• 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 3
• 210000001744 T-lymphocyte Anatomy 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 2
• FXWALQSAZZPDOT-NMUGVGKYSA-N Arg-Thr-Cys-Cys Chemical compound SC[C@@H](C(O)=O)NC(=O)[C@H](CS)NC(=O)[C@H]([C@H](O)C)NC(=O)[C@@H](N)CCCNC(N)=N FXWALQSAZZPDOT-NMUGVGKYSA-N 0.000 claims 2
• 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims 2
• 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 claims 2
• 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims 2
• 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 2
• 206010028980 Neoplasm Diseases 0.000 claims 2
• 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims 2
• 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 2
• 230000009827 complement-dependent cellular cytotoxicity Effects 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 230000000694 effects Effects 0.000 claims 2
• 208000004736 B-Cell Leukemia Diseases 0.000 claims 1
• 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 1
• 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 1
• 208000017604 Hodgkin disease Diseases 0.000 claims 1
• 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
• 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
• 108060003951 Immunoglobulin Proteins 0.000 claims 1
• 102000009786 Immunoglobulin Constant Regions Human genes 0.000 claims 1
• 108010009817 Immunoglobulin Constant Regions Proteins 0.000 claims 1
• 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 1
• 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 1
• 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 1
• 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 1
• 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 1
• 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 1
• 208000009527 Refractory anemia Diseases 0.000 claims 1
• 206010072684 Refractory cytopenia with unilineage dysplasia Diseases 0.000 claims 1
• 230000006044 T cell activation Effects 0.000 claims 1
• 230000006052 T cell proliferation Effects 0.000 claims 1
• 230000001154 acute effect Effects 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 208000035269 cancer or benign tumor Diseases 0.000 claims 1
• 210000004027 cell Anatomy 0.000 claims 1
• 230000009089 cytolysis Effects 0.000 claims 1
• 230000003013 cytotoxicity Effects 0.000 claims 1
• 231100000135 cytotoxicity Toxicity 0.000 claims 1
• 230000001419 dependent effect Effects 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 201000009277 hairy cell leukemia Diseases 0.000 claims 1
• 102000018358 immunoglobulin Human genes 0.000 claims 1
• 208000032839 leukemia Diseases 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 230000002018 overexpression Effects 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 230000001568 sexual effect Effects 0.000 claims 1